化脓性链球菌即A组链球菌(group A Streptococcus,GAS)作为成人社区获得性肺炎的病原体并不常见,临床上易被忽视而漏诊。本文报道1例青年男性因急性化脓性扁桃体炎治疗不规范引发肺炎,病原菌为GAS,伴抗链球菌溶血素O(Antistreptolysin O...化脓性链球菌即A组链球菌(group A Streptococcus,GAS)作为成人社区获得性肺炎的病原体并不常见,临床上易被忽视而漏诊。本文报道1例青年男性因急性化脓性扁桃体炎治疗不规范引发肺炎,病原菌为GAS,伴抗链球菌溶血素O(Antistreptolysin O,ASO)增高,予患者静脉注射万古霉素控制感染后,其ASO抗体滴度仍维持在高水平,遂序贯给予苄星青霉素肌肉注射每月1次,共5个月。之后随访6个月,患者未再有发热咽痛等症状,ASO水平正常,未出现风湿性多脏器损伤。近年,全球GAS感染仍有报道,且可引起一系列并发症,如风湿热、风湿性心脏病等,严重者可导致死亡。GAS感染的早诊、早治至关重要。展开更多
[Objective] The paper was to explore the relationship between the occurrence of canine rheumatism and blood-associated agent by detecting blood routine indexes and changes in content of anti streptolysin O( ASO),C-rea...[Objective] The paper was to explore the relationship between the occurrence of canine rheumatism and blood-associated agent by detecting blood routine indexes and changes in content of anti streptolysin O( ASO),C-reactive protein( CRP) and antinuclear antibody( ANA). [Method]Totally 13 cases of dogs which had been diagnosed with rheumatism by the reference standard of clinical examinations and laboratory diagnosis were selected for treatment,and their venous blood was collected on the day of diagnosis and at 1,3,5 d after treatment,respectively. Another 13 healthy dogs were selected randomly to collect venous blood as well. The white blood cells( WBC) count,neutrophilic granulocyte( Gran#),lymphocyte count( Lymph#) and blood routine index were determined using automatic animal blood cell analyzer. The content of ASO,CRP and ANA were determined using enzyme-linked immunosorbent assay( ELISA). [Result]Blood routine examination showed that there were significant differences in WBC between untreated rheumatismal dogs and healthy dogs( P < 0. 05),but no significant difference was observed on the day of diagnosis and duration of therepay( P > 0. 05). Detection results of blood-associated agent in rheumatismal dogs showed that there were extremely significant differences in ASO and ANA content between the day of diagnosis and duration of therapy( P < 0. 01); there were significant differences in Lymph# and Gran# content of CRP between the day of diagnosis and duration of therapy( P < 0. 05). The ASO,ANA and CRP content in the serum of untreated rheumatismal dogs were higher than those in healthy dogs,and the content of various indicators decreased significantly after treatment,but were still higher than that in healthy dogs. [Conclusion]The incidence of canine rheumatism is positively correlated with WBC count,ASO content,CRP content and ANA content. The variation of CRP content is the most sensitive indicator of the disease.展开更多
文摘化脓性链球菌即A组链球菌(group A Streptococcus,GAS)作为成人社区获得性肺炎的病原体并不常见,临床上易被忽视而漏诊。本文报道1例青年男性因急性化脓性扁桃体炎治疗不规范引发肺炎,病原菌为GAS,伴抗链球菌溶血素O(Antistreptolysin O,ASO)增高,予患者静脉注射万古霉素控制感染后,其ASO抗体滴度仍维持在高水平,遂序贯给予苄星青霉素肌肉注射每月1次,共5个月。之后随访6个月,患者未再有发热咽痛等症状,ASO水平正常,未出现风湿性多脏器损伤。近年,全球GAS感染仍有报道,且可引起一系列并发症,如风湿热、风湿性心脏病等,严重者可导致死亡。GAS感染的早诊、早治至关重要。
基金Supported by Talent Revitalizing Discipline Plan of Hebei Agricultural University(03018011)
文摘[Objective] The paper was to explore the relationship between the occurrence of canine rheumatism and blood-associated agent by detecting blood routine indexes and changes in content of anti streptolysin O( ASO),C-reactive protein( CRP) and antinuclear antibody( ANA). [Method]Totally 13 cases of dogs which had been diagnosed with rheumatism by the reference standard of clinical examinations and laboratory diagnosis were selected for treatment,and their venous blood was collected on the day of diagnosis and at 1,3,5 d after treatment,respectively. Another 13 healthy dogs were selected randomly to collect venous blood as well. The white blood cells( WBC) count,neutrophilic granulocyte( Gran#),lymphocyte count( Lymph#) and blood routine index were determined using automatic animal blood cell analyzer. The content of ASO,CRP and ANA were determined using enzyme-linked immunosorbent assay( ELISA). [Result]Blood routine examination showed that there were significant differences in WBC between untreated rheumatismal dogs and healthy dogs( P < 0. 05),but no significant difference was observed on the day of diagnosis and duration of therepay( P > 0. 05). Detection results of blood-associated agent in rheumatismal dogs showed that there were extremely significant differences in ASO and ANA content between the day of diagnosis and duration of therapy( P < 0. 01); there were significant differences in Lymph# and Gran# content of CRP between the day of diagnosis and duration of therapy( P < 0. 05). The ASO,ANA and CRP content in the serum of untreated rheumatismal dogs were higher than those in healthy dogs,and the content of various indicators decreased significantly after treatment,but were still higher than that in healthy dogs. [Conclusion]The incidence of canine rheumatism is positively correlated with WBC count,ASO content,CRP content and ANA content. The variation of CRP content is the most sensitive indicator of the disease.
