Traditional Chinese Medicine(TCM)owns a long history of fighting viral diseases.TCM has acumulated a large amount of clinical experiences to treat viral diseases.Inner Canon of the Yellow Emperor(Huangdi Neijing,300 B...Traditional Chinese Medicine(TCM)owns a long history of fighting viral diseases.TCM has acumulated a large amount of clinical experiences to treat viral diseases.Inner Canon of the Yellow Emperor(Huangdi Neijing,300 BC)mentioned:When the five epidemics arrive,they are all infected by the same disease,regardless of their size,and have similar symptoms.Treatise on Cold Pathogenic Diseases(Shanghan Lun,220 AD)described the plague sweeping across the country and killed almost all people.And,numerous prescriptions in Treatise on Cold Pathogenic Diseases(Shanghan Lun)were used until today.Pestilence Theory(Wenyi Lun,1642)written by Wu Youxing differed from Treatise on Cold Pathogenic Diseases in its analysis of the characteristics of epidemics and therapeutic methods.A large number of classical antiviral traditional Chinese medicines and recipes have been accumulated.On the ground of traditional Chinese medicine,modern scientific methods were used to screen out a large number of antiviral traditional Chinese medicines to find new antiviral contents or form new recipes.Despite the disputation around the researchers,TCM provided effective therapeutics in the fight against the Coronavirus Disease(2019 COVID-19)epidemic in China.It demonstrated the potential advantages of Chinese medicines as antiviral medicines with broad research value and prospects.展开更多
The effects of the extracts of 20 Chinese medicinal herbs and an antiviral drug foscarnet on duck hepatitis B virus (DHBV) endogenous DNA polymerase (DNAp) activity were compared. The extracts of P. urinaria showed a ...The effects of the extracts of 20 Chinese medicinal herbs and an antiviral drug foscarnet on duck hepatitis B virus (DHBV) endogenous DNA polymerase (DNAp) activity were compared. The extracts of P. urinaria showed a dose-dependent inhibition on DHBV DNAp. And those of other herbs showed little inhibition effect. Primary duck hepatocyte (PDH) cultures were used for evaluating effects of the extract of P. urinaria, foscarnet and acyclovir (ACV) on DHBV, and all the drugs or the extracts showed inhibition of DHBV DNA replication. Furthermore, in vivo trials were carried out. Peking ducks infected with LJ-76 strain of DHBV were treated with the extract of P. urinaria or ACV and compared with placebo treated control ducks. The treatment results in the loss or reduction of circulating viral DHBV DNA and DHBsAg.展开更多
文摘Traditional Chinese Medicine(TCM)owns a long history of fighting viral diseases.TCM has acumulated a large amount of clinical experiences to treat viral diseases.Inner Canon of the Yellow Emperor(Huangdi Neijing,300 BC)mentioned:When the five epidemics arrive,they are all infected by the same disease,regardless of their size,and have similar symptoms.Treatise on Cold Pathogenic Diseases(Shanghan Lun,220 AD)described the plague sweeping across the country and killed almost all people.And,numerous prescriptions in Treatise on Cold Pathogenic Diseases(Shanghan Lun)were used until today.Pestilence Theory(Wenyi Lun,1642)written by Wu Youxing differed from Treatise on Cold Pathogenic Diseases in its analysis of the characteristics of epidemics and therapeutic methods.A large number of classical antiviral traditional Chinese medicines and recipes have been accumulated.On the ground of traditional Chinese medicine,modern scientific methods were used to screen out a large number of antiviral traditional Chinese medicines to find new antiviral contents or form new recipes.Despite the disputation around the researchers,TCM provided effective therapeutics in the fight against the Coronavirus Disease(2019 COVID-19)epidemic in China.It demonstrated the potential advantages of Chinese medicines as antiviral medicines with broad research value and prospects.
文摘The effects of the extracts of 20 Chinese medicinal herbs and an antiviral drug foscarnet on duck hepatitis B virus (DHBV) endogenous DNA polymerase (DNAp) activity were compared. The extracts of P. urinaria showed a dose-dependent inhibition on DHBV DNAp. And those of other herbs showed little inhibition effect. Primary duck hepatocyte (PDH) cultures were used for evaluating effects of the extract of P. urinaria, foscarnet and acyclovir (ACV) on DHBV, and all the drugs or the extracts showed inhibition of DHBV DNA replication. Furthermore, in vivo trials were carried out. Peking ducks infected with LJ-76 strain of DHBV were treated with the extract of P. urinaria or ACV and compared with placebo treated control ducks. The treatment results in the loss or reduction of circulating viral DHBV DNA and DHBsAg.
