Anxiety disorder is a common mental disorder. It is necessary to establish a rapid, stable and specific anxiety model to provide a theoretical basis for further research on the pathogenesis of anxiety and drug develop...Anxiety disorder is a common mental disorder. It is necessary to establish a rapid, stable and specific anxiety model to provide a theoretical basis for further research on the pathogenesis of anxiety and drug development. A single intraperitoneal injection of m-chlorophenylpipera-zine (mCPP) (1, 2, 4 mg/kg) was given to male ICR mice to establish an anxiety model, and the effects of mCPP on anxiety behavior, pain, athletic ability, passive avoidance response ability and depressive behavior of male ICR mice were evaluated. A single intraperitoneal injection of mCPP shortened the time in open arms and decreased the percentage of time in open arms of mice in the elevated plus-maze test. mCPP also shortened center zone distance and reduced the number of entries to the central zone in the open field test. Moreover, mCPP reduced head-dip counts and increased the head-dip latency of mice in the hole-board test. After being administrated with a single intraperitoneal injection of mCPP for 24h, the mice showed no significant difference in the entry into the light side and the percentage of time in the light side of the light-dark box test. A single intraperitoneal injection of mCPP had no effects on tail flick latency, rotating time, number of errors and the step-down latency, the immobility time of mice in the tail-flick test, rotarod test, step-down test and TST respectively. In conclusion, we established a rapid and stable anxiety mouse model by single intraperitoneal injection of mCPP.展开更多
Thirty-two Chinese EFL learners took part in a true experiment on the effects of a Speaking Anxiety Reduction Model （SARM） developed from the Rational Emotive Behavioral Therapy （REBT）. The participants were rando...Thirty-two Chinese EFL learners took part in a true experiment on the effects of a Speaking Anxiety Reduction Model （SARM） developed from the Rational Emotive Behavioral Therapy （REBT）. The participants were randomly assigned to the treatment and the control group. Both groups received a pre- and post- test of their Speaking Anxiety （SA）, Speaking State Anxiety （SAstate） as well as speaking performance. Those involved in the treatment group also received a treatment with the SARM between the tests. The results showed that, with the effects of Language Achievement （LA） being controlled： （1） the SARM could significantly reduce the SA, SAstate, and increase the total number of words in Communication Units （CUs）; and （2） the effects of the SARM did not differ significantly in terms of gender.展开更多
文摘Anxiety disorder is a common mental disorder. It is necessary to establish a rapid, stable and specific anxiety model to provide a theoretical basis for further research on the pathogenesis of anxiety and drug development. A single intraperitoneal injection of m-chlorophenylpipera-zine (mCPP) (1, 2, 4 mg/kg) was given to male ICR mice to establish an anxiety model, and the effects of mCPP on anxiety behavior, pain, athletic ability, passive avoidance response ability and depressive behavior of male ICR mice were evaluated. A single intraperitoneal injection of mCPP shortened the time in open arms and decreased the percentage of time in open arms of mice in the elevated plus-maze test. mCPP also shortened center zone distance and reduced the number of entries to the central zone in the open field test. Moreover, mCPP reduced head-dip counts and increased the head-dip latency of mice in the hole-board test. After being administrated with a single intraperitoneal injection of mCPP for 24h, the mice showed no significant difference in the entry into the light side and the percentage of time in the light side of the light-dark box test. A single intraperitoneal injection of mCPP had no effects on tail flick latency, rotating time, number of errors and the step-down latency, the immobility time of mice in the tail-flick test, rotarod test, step-down test and TST respectively. In conclusion, we established a rapid and stable anxiety mouse model by single intraperitoneal injection of mCPP.
文摘Thirty-two Chinese EFL learners took part in a true experiment on the effects of a Speaking Anxiety Reduction Model （SARM） developed from the Rational Emotive Behavioral Therapy （REBT）. The participants were randomly assigned to the treatment and the control group. Both groups received a pre- and post- test of their Speaking Anxiety （SA）, Speaking State Anxiety （SAstate） as well as speaking performance. Those involved in the treatment group also received a treatment with the SARM between the tests. The results showed that, with the effects of Language Achievement （LA） being controlled： （1） the SARM could significantly reduce the SA, SAstate, and increase the total number of words in Communication Units （CUs）; and （2） the effects of the SARM did not differ significantly in terms of gender.
