Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino rats.Methods: Acute toxicity study was done to check the toxicity of T. aphylla...Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino rats.Methods: Acute toxicity study was done to check the toxicity of T. aphylla(L. Karst)methanol extract. T. aphylla leaves extract was administered intraperitoneally(100 mg,250 mg and 400 mg/kg body weight per day) to diabetic Wister rats for 21 days. The various parameters were studied including fasting blood glucose levels, haemoglobin and glycosylated haemoglobin.Results: The treatment groups with the extract at three dose levels expressively abridged the intensities of blood glucose and Glycosylated Haemoglobin. The earlier detected reduced level of plasma haemoglobin of the diabetic rats was raised to near normalcy with treatment of extract.Conclusions: The results of the current study confirm that the leaves extract of T. aphylla are nontoxic and have antidiabetic nature.展开更多
The fourth most predominant overwhelming type of trauma is burn injuries worldwide.Ideal wound healing dressings help in the wound healing process in a lower time with less pain.Commonly used dry wound dressing,like a...The fourth most predominant overwhelming type of trauma is burn injuries worldwide.Ideal wound healing dressings help in the wound healing process in a lower time with less pain.Commonly used dry wound dressing,like absorbent gauze or absorbent cotton,possess limited therapeutic effects and require repeated use,which further exaggerates patients’suffering.In contrast,hydrogels films present a promising alternative to improve healing by guaranteeing a moisture balance at the wound site.The aim of the current study was to synthesize Tamarix aphylla(T.aphylla)extract-loaded hydrogel film with Na-CMC and pectin and to study their wound healing properties.The Na-CMC/Pectin hydrogels films were synthesized and characterized for HPLC analysis,FTIR,surface morphology,rheology,tensile strength,swelling behavior,drug release kinetics,and in vivo wound healing in an animal model.FTIR confirmed the existence of strong interaction between both polymers but no interaction with the extract.SEM photographs showed successful embedding of extract in small pores of hydrogel film and showed smooth and homogenous morphology.Rheological and texture profiles indicated that hydrogels behaved as strong gels.Swelling and erosion were dependent on the amount of the CMC.HPLC showed drug content of three selected formulation(A3,E3 and S3)as 85±0.1%,82.5±0.4%and 80±0.3%,respectively.The release of the drug from the hydrogel was controlled by a Fickian diffusion mechanism.In vivo wound healing activity of hydrogel film confirmed that T.aphylla extract successfully promoted healing rate by significantly reducing(P<0.05)the size of wound closure compared to the control group,evidenced by intensive collagen formation in histopathological and biochemical analysis.The capability of these hydrogels for burn wounds could be valuable for medical uses as a new window of safe and effective medication.展开更多
Biogeochemical investigation of Tamarix aphylla,a plant species, of the Las-bela area has been made.This area mainly consists of ophiolites associated with sed-imentary rocks of Jurassic and Cretaceous age .Quantitati...Biogeochemical investigation of Tamarix aphylla,a plant species, of the Las-bela area has been made.This area mainly consists of ophiolites associated with sed-imentary rocks of Jurassic and Cretaceous age .Quantitative estimations of important biogenic trace elements such as Fe,Mn,Pb,Zn,Cu,Cr,Ni, and Co have been carried out .Anomalous concentrations of these elements in plant species of certain regions can be used to locate possible occurrences of ore deposits in the area.The comparative strdy also reveals appreciable variations in the composition of trace elements in plants.The possible causes of variation in the constitrents of Tamarix aphylla from different localities have been discussed in the light of bed rock nature, mo-bility of element and average abundance in the plant.展开更多
Objective To study the chemical constituents from the aerial parts of Anabasis aphylla. Methods The chemical constituents were isolated and purified by silica gel column and Sephadex LH-20 column chromatography. Spect...Objective To study the chemical constituents from the aerial parts of Anabasis aphylla. Methods The chemical constituents were isolated and purified by silica gel column and Sephadex LH-20 column chromatography. Spectroscopic methods such as MS and NMR spectra were used for the structural identification. Results A new caffeate ester, named eicosyl-(Z)-caffeate (1), along with fourteen known compounds was isolated from the EtOAc part. Conclusion Compound 1 is a new compound and compounds 2-13 are isolated from the plants of Anabasis L. for the first time.展开更多
The development of a technology employing materials containing specific alkaloids from biomasses of agricultural production would be extremely beneficial and relatively inexpensive for the remediation of polluted soil...The development of a technology employing materials containing specific alkaloids from biomasses of agricultural production would be extremely beneficial and relatively inexpensive for the remediation of polluted soils and may represent a possible new industrial and commercial opportunity. We have studied detoxification and degradation of persistent chloroorganic pesticides by using plant extracts, which contained alkaloids. Reactions DDT with alkaloid Anabasine and extractive sum of alkaloids, isolated from ground up part plant Anabasis аphylla proceed more easy without solvent. It is established, that at interaction alkaloids of Anabasis aphylla with pesticide DDT occurs degradation to formation of less toxic DDE. Results the carried out researches on studying interaction sum of alkaloids, isolated from ground up part plant Anabasis Ahylla, with DDT in various ratio (1:1, 2:1, 3:1) have shown, that thus there are detoxification pesticide DDT on 35% - 45%, 75% - 80% and 80% - 85% according to formation dichlorodiphenyldichloroethylene (DDE), and in presence humic acids the degree degradation achieves to 95% - 97%.展开更多
基金supported by Institute of Basic Medical Sciences, Khyber Medical University with grant no. of 06472414
文摘Objective: To evaluate the antihyperglycemic potential of Tamarix aphylla(T. aphylla)leaves in STZ–NIC induced diabetes in Wister Albino rats.Methods: Acute toxicity study was done to check the toxicity of T. aphylla(L. Karst)methanol extract. T. aphylla leaves extract was administered intraperitoneally(100 mg,250 mg and 400 mg/kg body weight per day) to diabetic Wister rats for 21 days. The various parameters were studied including fasting blood glucose levels, haemoglobin and glycosylated haemoglobin.Results: The treatment groups with the extract at three dose levels expressively abridged the intensities of blood glucose and Glycosylated Haemoglobin. The earlier detected reduced level of plasma haemoglobin of the diabetic rats was raised to near normalcy with treatment of extract.Conclusions: The results of the current study confirm that the leaves extract of T. aphylla are nontoxic and have antidiabetic nature.
文摘The fourth most predominant overwhelming type of trauma is burn injuries worldwide.Ideal wound healing dressings help in the wound healing process in a lower time with less pain.Commonly used dry wound dressing,like absorbent gauze or absorbent cotton,possess limited therapeutic effects and require repeated use,which further exaggerates patients’suffering.In contrast,hydrogels films present a promising alternative to improve healing by guaranteeing a moisture balance at the wound site.The aim of the current study was to synthesize Tamarix aphylla(T.aphylla)extract-loaded hydrogel film with Na-CMC and pectin and to study their wound healing properties.The Na-CMC/Pectin hydrogels films were synthesized and characterized for HPLC analysis,FTIR,surface morphology,rheology,tensile strength,swelling behavior,drug release kinetics,and in vivo wound healing in an animal model.FTIR confirmed the existence of strong interaction between both polymers but no interaction with the extract.SEM photographs showed successful embedding of extract in small pores of hydrogel film and showed smooth and homogenous morphology.Rheological and texture profiles indicated that hydrogels behaved as strong gels.Swelling and erosion were dependent on the amount of the CMC.HPLC showed drug content of three selected formulation(A3,E3 and S3)as 85±0.1%,82.5±0.4%and 80±0.3%,respectively.The release of the drug from the hydrogel was controlled by a Fickian diffusion mechanism.In vivo wound healing activity of hydrogel film confirmed that T.aphylla extract successfully promoted healing rate by significantly reducing(P<0.05)the size of wound closure compared to the control group,evidenced by intensive collagen formation in histopathological and biochemical analysis.The capability of these hydrogels for burn wounds could be valuable for medical uses as a new window of safe and effective medication.
文摘Biogeochemical investigation of Tamarix aphylla,a plant species, of the Las-bela area has been made.This area mainly consists of ophiolites associated with sed-imentary rocks of Jurassic and Cretaceous age .Quantitative estimations of important biogenic trace elements such as Fe,Mn,Pb,Zn,Cu,Cr,Ni, and Co have been carried out .Anomalous concentrations of these elements in plant species of certain regions can be used to locate possible occurrences of ore deposits in the area.The comparative strdy also reveals appreciable variations in the composition of trace elements in plants.The possible causes of variation in the constitrents of Tamarix aphylla from different localities have been discussed in the light of bed rock nature, mo-bility of element and average abundance in the plant.
基金National Science and Technology Major Projects (2009zx09504-004)
文摘Objective To study the chemical constituents from the aerial parts of Anabasis aphylla. Methods The chemical constituents were isolated and purified by silica gel column and Sephadex LH-20 column chromatography. Spectroscopic methods such as MS and NMR spectra were used for the structural identification. Results A new caffeate ester, named eicosyl-(Z)-caffeate (1), along with fourteen known compounds was isolated from the EtOAc part. Conclusion Compound 1 is a new compound and compounds 2-13 are isolated from the plants of Anabasis L. for the first time.
文摘The development of a technology employing materials containing specific alkaloids from biomasses of agricultural production would be extremely beneficial and relatively inexpensive for the remediation of polluted soils and may represent a possible new industrial and commercial opportunity. We have studied detoxification and degradation of persistent chloroorganic pesticides by using plant extracts, which contained alkaloids. Reactions DDT with alkaloid Anabasine and extractive sum of alkaloids, isolated from ground up part plant Anabasis аphylla proceed more easy without solvent. It is established, that at interaction alkaloids of Anabasis aphylla with pesticide DDT occurs degradation to formation of less toxic DDE. Results the carried out researches on studying interaction sum of alkaloids, isolated from ground up part plant Anabasis Ahylla, with DDT in various ratio (1:1, 2:1, 3:1) have shown, that thus there are detoxification pesticide DDT on 35% - 45%, 75% - 80% and 80% - 85% according to formation dichlorodiphenyldichloroethylene (DDE), and in presence humic acids the degree degradation achieves to 95% - 97%.
