Pharmacological, derivate and microbiological study of beebread based immunomodulatory drug was conducted. Iimmunomodulating properties of pellets ＂Apimun＂ in the form of antibodies formation in response to the EB a...Pharmacological, derivate and microbiological study of beebread based immunomodulatory drug was conducted. Iimmunomodulating properties of pellets ＂Apimun＂ in the form of antibodies formation in response to the EB antigen were studied. Clear immunostimulatory properties of pellets ＂Apimun＂ were reproduced in mature rats and mice with normal immune status. Pellets ＂Apimun＂ at doses 1.5 and 2.0 g/kg showed increased activity ofphagocytosis and processes of antibody formation inhibition of delayed hypersensitivity reactions. Antimicrobial activity of pellets ＂Apimun＂ was studied. It was proved that it did not have antimicrobial properties. Derivate studies were conducted and showed that the active substance and composition of the IMP was stable at normal temperature. The results of pharmacological, microbiological and derivate studies show the effectiveness of the pellets ＂Apimun＂ and prospects for further research in order to create a product for immune status improvement.展开更多
文摘Pharmacological, derivate and microbiological study of beebread based immunomodulatory drug was conducted. Iimmunomodulating properties of pellets ＂Apimun＂ in the form of antibodies formation in response to the EB antigen were studied. Clear immunostimulatory properties of pellets ＂Apimun＂ were reproduced in mature rats and mice with normal immune status. Pellets ＂Apimun＂ at doses 1.5 and 2.0 g/kg showed increased activity ofphagocytosis and processes of antibody formation inhibition of delayed hypersensitivity reactions. Antimicrobial activity of pellets ＂Apimun＂ was studied. It was proved that it did not have antimicrobial properties. Derivate studies were conducted and showed that the active substance and composition of the IMP was stable at normal temperature. The results of pharmacological, microbiological and derivate studies show the effectiveness of the pellets ＂Apimun＂ and prospects for further research in order to create a product for immune status improvement.
