Objective: Obstructive sleep apnea-hypopnea syndrome (OSA) is a disease of obstructive apnea or hypopnea caused by a repeated partial or complete collapse of the upper airway during sleep. The inspiratory part of the ...Objective: Obstructive sleep apnea-hypopnea syndrome (OSA) is a disease of obstructive apnea or hypopnea caused by a repeated partial or complete collapse of the upper airway during sleep. The inspiratory part of the flow-volume curve (F-V curve) can be used as an auxiliary means to evaluate upper airway obstruction in adults. This study is to evaluate the ability of the F-V curve to predict the OSA and explore inspiratory indicators related to airway obstruction during sleep. Methods: There were 332 patients included in this cross-sectional study, who were accompanied by snoring, daytime sleepiness and other symptoms, with suspicion of OSA. According to the nocturnal polysomnography, the subjects were distributed into mild to moderate OSA group, severe OSA group and non-OSA group. A pulmonary function test was used to collect the subjects’ spirometry and F-V curves. Results: There was no significant difference in a variety of indices derived from the F-V curve between OSA and normal subjects, including 25% inspiratory flow rate, middle inspiratory flow rate, 75% inspiratory flow rate, peak flow rate, and forced inspiratory flow rate in the first second. The pulmonary function parameters were significantly correlated with the weight, age and sex of the subjects. Conclusion: These findings suggest that the inspiratory curve of pulmonary function cannot evaluate the upper airway abnormalities in patients with obstructive apnea-hypopnea syndrome.展开更多
目的:探讨阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)与认知功能、抑郁及焦虑的关系,并分析影响认知功能的因素。方法:纳入2022年1月至2023年6月,安徽医科大学第三附属医院滨湖院区行多导睡眠监测(polysomnography,PSG)的患者共...目的:探讨阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)与认知功能、抑郁及焦虑的关系,并分析影响认知功能的因素。方法:纳入2022年1月至2023年6月,安徽医科大学第三附属医院滨湖院区行多导睡眠监测(polysomnography,PSG)的患者共102例,根据PSG结果分为无或轻度OSA组及中、重度OSA组,完善蒙特利尔认知评估量表(MoCA-Beijing)、Stroop色词试验(stroop Color and Word Tset,SCWT)、数字广度测验(digit Span Test,DST)、抑郁自评量表(self-rating depression scale,SDS)、焦虑自评量表(self-rating anxiety scale,SAS),记录各量表的评分值,并分析差异性及相关性等。结果:中-重度OSA组的颈围、BMI、SCWT-A、B、C耗时数、SIE、SAS、SDS显著高于无-轻度OSA组,MoCA视空间与执行能力、记忆、语言、抽象、延迟回忆、定向及MoCA总分、最低血氧饱和度(LSaO_(2))、平均血氧饱和度、DST-b、DST-f得分显著低于无-轻度OSA组(P均<0.05)。颈围、AHI、SAS与MoCA评分相关(OR=1.401,95%CI:1.702~1.803;OR=1.028,95%CI:1.007~1.050;OR=1.070,95%CI:0.991~1.155,P均<0.05),AHI与SDS、SAS评分相关(OR=1.001,95%CI:0.979~.025,P=0.003)。结论:中-重度OSA患者常合并认知功能障碍及抑郁、焦虑相关情绪问题,与AHI、LSaO_(2)、平均血氧饱和度指标密切相关,OSA合并焦虑与认知功能障碍具有显著相关性。展开更多
To investigate the possible correlation between obstructive sleep apnea(OSA) and central retinal vein occlusion(CRVO). Thirty consecutive patients with a recent(<3 mo)CRVO and an age-and sex-matched group of 30 con...To investigate the possible correlation between obstructive sleep apnea(OSA) and central retinal vein occlusion(CRVO). Thirty consecutive patients with a recent(<3 mo)CRVO and an age-and sex-matched group of 30 control subjects were recruited. All subjects underwent full-night polysomnography to measure apnea-hypopnea index(AHI)and oxygen desaturation index(ODI). The average AHI and ODI were significantly higher in CRVO patients(AHI:13.86±8.63, ODI: 9.21±4.47) than in control subjects(AHI:8.51±6.36, ODI: 5.87±3.18;P=0.008 and 0.001 respectively).Additionally, the AHI was positively correlated with body mass index(BMI;r=0.476, P=0.017) and ODI(r=0.921,P<0.01) in both CRVO and control subjects. According to AHI scores, twenty-two(73.33%) CRVO patients had OSA and 12(40.00%) control subjects had OSA, a difference that was statistically significant(P=0.019). OSA may be a risk factor for or a trigger of CRVO development.展开更多
Summary： Obstructive sleep apnea-hypopnea syndrome （OSAHS） is a serious health issue, which can impact the hormone secretion. The aim of this study is to analyze the relationship between serum sex hormone concentra...Summary： Obstructive sleep apnea-hypopnea syndrome （OSAHS） is a serious health issue, which can impact the hormone secretion. The aim of this study is to analyze the relationship between serum sex hormone concentrations and different severity degree of OSAHS, and to evaluate the influence of OSAHS on sex hormone levels. We enrolled 116 subjects who were subjected to polysomnography （PSG）. They were divided into three groups： control group （n=10） [apnea hypopnea index （AHI） 〈5/h], mild-moderate OSAHS group ,（n=15） （5〈AHI〈30/h）, and severe OSAHS group （n=91） （AHI〉30/h）. The patients in OSAHS group were subdivided into obesity and non-obesity subgroups. The parameters such as AHI, body mass index （BMI）, lowest oxygen saturation （LSaO2）, and mean oxygen saturation （MSaO2） were recorded. Serum levels of testosterone, polactin, estradiol, follicle stimulating hormone （FSH） and luteinizing hormone （LH） were determined in the morning immediately after waking up. Mean levels of hormones were compared among groups. The correlation between hormone levels and sleep-breathing parameters was analyzed. No significant differences in serum sex hormone levels were found among control, mild-moderate OSAHS, and severe OSAHS groups （P〉0.05）. There was no cor- relation between AHI and sex hormone levels （P〉0.05）. Testosterone was significantly negatively cor- related with BMI （P〈0.05）. These results suggested that BMI might have a direct effect on testosterone level, and it might be an important factor affecting testosterone level in male OSAHS patients, and there may be no correlation between severity of OSAHS and sex hormones levels.展开更多
文摘Objective: Obstructive sleep apnea-hypopnea syndrome (OSA) is a disease of obstructive apnea or hypopnea caused by a repeated partial or complete collapse of the upper airway during sleep. The inspiratory part of the flow-volume curve (F-V curve) can be used as an auxiliary means to evaluate upper airway obstruction in adults. This study is to evaluate the ability of the F-V curve to predict the OSA and explore inspiratory indicators related to airway obstruction during sleep. Methods: There were 332 patients included in this cross-sectional study, who were accompanied by snoring, daytime sleepiness and other symptoms, with suspicion of OSA. According to the nocturnal polysomnography, the subjects were distributed into mild to moderate OSA group, severe OSA group and non-OSA group. A pulmonary function test was used to collect the subjects’ spirometry and F-V curves. Results: There was no significant difference in a variety of indices derived from the F-V curve between OSA and normal subjects, including 25% inspiratory flow rate, middle inspiratory flow rate, 75% inspiratory flow rate, peak flow rate, and forced inspiratory flow rate in the first second. The pulmonary function parameters were significantly correlated with the weight, age and sex of the subjects. Conclusion: These findings suggest that the inspiratory curve of pulmonary function cannot evaluate the upper airway abnormalities in patients with obstructive apnea-hypopnea syndrome.
文摘目的:探讨阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)与认知功能、抑郁及焦虑的关系,并分析影响认知功能的因素。方法:纳入2022年1月至2023年6月,安徽医科大学第三附属医院滨湖院区行多导睡眠监测(polysomnography,PSG)的患者共102例,根据PSG结果分为无或轻度OSA组及中、重度OSA组,完善蒙特利尔认知评估量表(MoCA-Beijing)、Stroop色词试验(stroop Color and Word Tset,SCWT)、数字广度测验(digit Span Test,DST)、抑郁自评量表(self-rating depression scale,SDS)、焦虑自评量表(self-rating anxiety scale,SAS),记录各量表的评分值,并分析差异性及相关性等。结果:中-重度OSA组的颈围、BMI、SCWT-A、B、C耗时数、SIE、SAS、SDS显著高于无-轻度OSA组,MoCA视空间与执行能力、记忆、语言、抽象、延迟回忆、定向及MoCA总分、最低血氧饱和度(LSaO_(2))、平均血氧饱和度、DST-b、DST-f得分显著低于无-轻度OSA组(P均<0.05)。颈围、AHI、SAS与MoCA评分相关(OR=1.401,95%CI:1.702~1.803;OR=1.028,95%CI:1.007~1.050;OR=1.070,95%CI:0.991~1.155,P均<0.05),AHI与SDS、SAS评分相关(OR=1.001,95%CI:0.979~.025,P=0.003)。结论:中-重度OSA患者常合并认知功能障碍及抑郁、焦虑相关情绪问题,与AHI、LSaO_(2)、平均血氧饱和度指标密切相关,OSA合并焦虑与认知功能障碍具有显著相关性。
基金Supported by Planned Science and Technology Project of Xi’an City, China [No.2017116SF/YX010(9)]
文摘To investigate the possible correlation between obstructive sleep apnea(OSA) and central retinal vein occlusion(CRVO). Thirty consecutive patients with a recent(<3 mo)CRVO and an age-and sex-matched group of 30 control subjects were recruited. All subjects underwent full-night polysomnography to measure apnea-hypopnea index(AHI)and oxygen desaturation index(ODI). The average AHI and ODI were significantly higher in CRVO patients(AHI:13.86±8.63, ODI: 9.21±4.47) than in control subjects(AHI:8.51±6.36, ODI: 5.87±3.18;P=0.008 and 0.001 respectively).Additionally, the AHI was positively correlated with body mass index(BMI;r=0.476, P=0.017) and ODI(r=0.921,P<0.01) in both CRVO and control subjects. According to AHI scores, twenty-two(73.33%) CRVO patients had OSA and 12(40.00%) control subjects had OSA, a difference that was statistically significant(P=0.019). OSA may be a risk factor for or a trigger of CRVO development.
文摘Summary： Obstructive sleep apnea-hypopnea syndrome （OSAHS） is a serious health issue, which can impact the hormone secretion. The aim of this study is to analyze the relationship between serum sex hormone concentrations and different severity degree of OSAHS, and to evaluate the influence of OSAHS on sex hormone levels. We enrolled 116 subjects who were subjected to polysomnography （PSG）. They were divided into three groups： control group （n=10） [apnea hypopnea index （AHI） 〈5/h], mild-moderate OSAHS group ,（n=15） （5〈AHI〈30/h）, and severe OSAHS group （n=91） （AHI〉30/h）. The patients in OSAHS group were subdivided into obesity and non-obesity subgroups. The parameters such as AHI, body mass index （BMI）, lowest oxygen saturation （LSaO2）, and mean oxygen saturation （MSaO2） were recorded. Serum levels of testosterone, polactin, estradiol, follicle stimulating hormone （FSH） and luteinizing hormone （LH） were determined in the morning immediately after waking up. Mean levels of hormones were compared among groups. The correlation between hormone levels and sleep-breathing parameters was analyzed. No significant differences in serum sex hormone levels were found among control, mild-moderate OSAHS, and severe OSAHS groups （P〉0.05）. There was no cor- relation between AHI and sex hormone levels （P〉0.05）. Testosterone was significantly negatively cor- related with BMI （P〈0.05）. These results suggested that BMI might have a direct effect on testosterone level, and it might be an important factor affecting testosterone level in male OSAHS patients, and there may be no correlation between severity of OSAHS and sex hormones levels.
