肿瘤分期和淋巴结受累是局部晚期宫颈癌最重要的预后因素。对于宫颈癌,妇科肿瘤医师普遍应用国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)标准。然而目前FIGO 2018分期标准中,ⅢC期仅基于转移淋巴结的...肿瘤分期和淋巴结受累是局部晚期宫颈癌最重要的预后因素。对于宫颈癌,妇科肿瘤医师普遍应用国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)标准。然而目前FIGO 2018分期标准中,ⅢC期仅基于转移淋巴结的解剖位置,并未考虑局部肿瘤因素及其他淋巴状态参数,一定程度上限制了其预后意义。本文旨在总结ⅢC期宫颈癌局部肿瘤因素及不同淋巴状态参数对预后的影响以及治疗选择。展开更多
Objectives Both apolipoprotein(Apo)C-Ⅲgene polymorphism and alcohol consumption have been associated with increased serum triglyceride(TG) levels,but their interactions on serum TG levels are not well known.The prese...Objectives Both apolipoprotein(Apo)C-Ⅲgene polymorphism and alcohol consumption have been associated with increased serum triglyceride(TG) levels,but their interactions on serum TG levels are not well known.The present study was undertaken to detect the interactions of the ApoC-Ⅲ3238C】G(rs5128) polymorphism and alcohol consumption on serum TG levels.Methods A total of 516 unrelated nondrinkers and 514 drinkers aged 15-89 were randomly selected from our previous stratified randomized cluster samples. Genotyping of the ApoC-Ⅲ3238C】G was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis,and then confirmed by direct sequencing.Interactions of the ApoC-Ⅲ3238C】G genotype and alcohol consumption was assessed by using a cross-product term between genotypes and the afore-mentioned factor.Results Serum total cholesterol(TC), TG,high-density lipoprotein cholesterol(HDL-C),ApoA-I and ApoB levels were higher in drinkers than in nondrinkers (P【0.05-0.001).There was no significant difference in the genotypic and allelic frequencies between the two groups. Serum TG levels in nondrinkers were higher in CG genotype than in CC genotype(P【0,01).Serum TC,TG,low-density lipoprotein cholesterol(LDL-C) and ApoB levels in drinkers were higher in GG genotype than in CC or CG genotype(P【0.01 for all).Serum HDL-C levels in drinkers were higher in CG genotype than in CC genotype(P【0.01).Serum TC, TG,HDL-C and ApoA-I levels in CC genotype,TC,HDL-C, ApoA-I levels and the ratio of ApoA-I to ApoB in CG genotype, and TC,TG,LDL-C,ApoA-I and ApoB levels in GG genotype were higher in drinkers than in nondrinkers(P【0.05-0.01).But the ratio of ApoA-I to ApoB in GG genotype was lower in drinkers than in nondrinkers(P【0.01). Multivariate logistic regression analysis showed that the levels of TC,TG and ApoB were correlated with genotype in non drinkers(P【0.05 for all).The levels of TC,LDL-C and ApoB were associated with genotype in drinkers(P【0.01 for all). Serum lipid parameters were also correlated with age,sex,alcohol consumption,cigarette smoking,blood pressure,body weight,and body mass index in both groups.Conclusions This study suggests that the ApoC-Ⅲ3238CG heterozygotes benefited more from alcohol consumption than CC and GG homozygotes in increasing serum levels of HDL-C,ApoA-I, and the ratio of ApoA-I to ApoB,and lowering serum levels of TC and TG.展开更多
文摘肿瘤分期和淋巴结受累是局部晚期宫颈癌最重要的预后因素。对于宫颈癌,妇科肿瘤医师普遍应用国际妇产科联盟(International Federation of Gynecology and Obstetrics,FIGO)标准。然而目前FIGO 2018分期标准中,ⅢC期仅基于转移淋巴结的解剖位置,并未考虑局部肿瘤因素及其他淋巴状态参数,一定程度上限制了其预后意义。本文旨在总结ⅢC期宫颈癌局部肿瘤因素及不同淋巴状态参数对预后的影响以及治疗选择。
文摘Objectives Both apolipoprotein(Apo)C-Ⅲgene polymorphism and alcohol consumption have been associated with increased serum triglyceride(TG) levels,but their interactions on serum TG levels are not well known.The present study was undertaken to detect the interactions of the ApoC-Ⅲ3238C】G(rs5128) polymorphism and alcohol consumption on serum TG levels.Methods A total of 516 unrelated nondrinkers and 514 drinkers aged 15-89 were randomly selected from our previous stratified randomized cluster samples. Genotyping of the ApoC-Ⅲ3238C】G was performed by polymerase chain reaction and restriction fragment length polymorphism combined with gel electrophoresis,and then confirmed by direct sequencing.Interactions of the ApoC-Ⅲ3238C】G genotype and alcohol consumption was assessed by using a cross-product term between genotypes and the afore-mentioned factor.Results Serum total cholesterol(TC), TG,high-density lipoprotein cholesterol(HDL-C),ApoA-I and ApoB levels were higher in drinkers than in nondrinkers (P【0.05-0.001).There was no significant difference in the genotypic and allelic frequencies between the two groups. Serum TG levels in nondrinkers were higher in CG genotype than in CC genotype(P【0,01).Serum TC,TG,low-density lipoprotein cholesterol(LDL-C) and ApoB levels in drinkers were higher in GG genotype than in CC or CG genotype(P【0.01 for all).Serum HDL-C levels in drinkers were higher in CG genotype than in CC genotype(P【0.01).Serum TC, TG,HDL-C and ApoA-I levels in CC genotype,TC,HDL-C, ApoA-I levels and the ratio of ApoA-I to ApoB in CG genotype, and TC,TG,LDL-C,ApoA-I and ApoB levels in GG genotype were higher in drinkers than in nondrinkers(P【0.05-0.01).But the ratio of ApoA-I to ApoB in GG genotype was lower in drinkers than in nondrinkers(P【0.01). Multivariate logistic regression analysis showed that the levels of TC,TG and ApoB were correlated with genotype in non drinkers(P【0.05 for all).The levels of TC,LDL-C and ApoB were associated with genotype in drinkers(P【0.01 for all). Serum lipid parameters were also correlated with age,sex,alcohol consumption,cigarette smoking,blood pressure,body weight,and body mass index in both groups.Conclusions This study suggests that the ApoC-Ⅲ3238CG heterozygotes benefited more from alcohol consumption than CC and GG homozygotes in increasing serum levels of HDL-C,ApoA-I, and the ratio of ApoA-I to ApoB,and lowering serum levels of TC and TG.
