Hydrodynamic resistance of pore–throat structures and its effect on shale oil apparent permeability

Oil transport is greatly affected by heterogeneous pore–throat structures present in shale.It is therefore very important to accurately characterize pore–throat structures.Additionally,it remains unclear how pore–throat structures affect oil transport capacity.In this paper,using finite element(FE)simulation and mathematical modeling,we calculated the hydrodynamic resistance for four pore–throat structure.In addition,the influence of pore throat structure on shale oil permeability is analyzed.According to the results,the hydrodynamic resistance of different pore throat structures can vary by 300%.The contribution of additional resistance caused by streamline bending is also in excess of 40%,even without slip length.Fur-thermore,Pore–throat structures can affect apparent permeability by more than 60%on the REV scale,and this influence increases with heterogeneity of pore size distribution,organic matter content,and organic matter number.Clearly,modeling shale oil flow requires consideration of porous–throat structure and additional resistance,otherwise oil recovery and flow capacity may be overestimated.

Effects of uniconazole with or without micronutrient on the lignin biosynthesis,lodging resistance,and winter wheat production in semiarid regions

Lodging stress results in grain yield and quality reduction in wheat. Uniconazole, a potential plant growth regulator significantly enhances lignin biosynthesis and thus provides mechanical strength to plants in order to cope with lodging stress. A field study was conducted during the 2015–2016 and 2016–2017 growing seasons, to investigate the effects of uniconazole sole application or with micronutrient on the lignin biosynthesis, lodging resistance, and production of winter wheat. In the first experiment, uniconazole at concentrations of 0(CK), 15(US1), 30(US2), and 45(US3) mg L^-1 was applied as sole seed soaking, while in the second experiment with manganese(Mn) at concentration of 0.06 g L^-1 Mn, 0.06 g L^-1 Mn+ 15 mg L^-1 uniconazole(UMS1), 0.06 g L^-1 Mn+30 mg L^-1 uniconazole(UMS2), and 0.06 g L^-1 Mn+45 mg L^-1 uniconazole(UMS3), respectively. Uniconazole sole application or with micronutrient significantly increased the lignin content by improving the lignin-related enzyme activities of phenylalanine ammonia-lyase, cinnamyl alcohol dehydrogenase, tyrosine ammonialyase, and peroxidase, ameliorating basal internode characteristics, and breaking strength. The spike length, spike diameter, spikes/plant, weight/spike, yield/spike, and grain yield increased and then decreased with uniconazole application at a higher concentration, where their maximum values were recorded with UMS2 and US2 treatments. The lignin accumulation was positively correlated with lignin-related enzyme activities and breaking strength while, negatively correlated with lodging rate. Uniconazole significantly improved the lignin biosynthesis, lodging resistance, and grain yield of winter wheat and the treatments which showed the greatest effects were uniconazole seed soaking with micronutrient at a concentration of 30 mg L^-1 and 0.06 g L^-1 , and uniconazole sole seed soaking at a concentration of 30 mg L^-1 .

Experiments on the Resistance of a Large Transport Vessel Navigating in the Arctic Region in Pack Ice Conditions

In this study, we carried out model tests to investigate the ice failure process and the resistance experienced by a transport vessel navigating in the Arctic region in pack ice conditions. We tested different navigation velocities, ice plate sizes, and ice concentrations. During the tests, we closely observed several phenomena, including the modes of interaction of the ice ship and the moving and failure modes of ice. We also measured the vessel resistances under different conditions. The test results indicate that the navigation velocity is a significant determinant of the moving and failure modes of ice. Moreover, vessel resistance is remarkably dependent on the ice concentration and navigation velocity. The variances of the mean and maximum resistance are also compared and discussed in detail.

Relation between the evolution of seismic apparent strain field and the region of strong earthquake occurrence

In this paper, according to the data on the middle and strong earthquakes in China, we have preliminary studied the relation between the characteristic of space-time evolution of the seismic apparent strain field and the regions of 31 macroseism events since 1955. The result shows that, there is a rather well correlation between the anomaly region of seismic apparent strain and the zone of macroseism event occurrence within the time range of one to about five years. The R value of the application of the abnormal region of seismic apparent strain to predicting the area of strong earthquake occurrence is 0.458, and the empirical possibility of forecasting the region of macroseism occurrence is 0.625, and so the forecasting effect is comparatively well. Finally, the main results obtained above are discussed preliminarily.

Molecular Detection of Mutations within the Quinolone Resistance-Determining Regions in Non Typhoidal Salmonella Isolates from Malaysia

Introduction: The efficacy of chemotherapy in bacteraemia caused by non-typhoidal Salmonella (NTS) is compromised by antibiotic resistance. Objective: This study was undertaken to describe the mechanism of resistance among clinical NTS isolates. Materials & Methodology: Thirty of NTS were isolated from blood (n = 19), stool (n = 10) and bronchioalveolar lavage (BAL;n = 1) respectively. These isolates were tested for susceptibility testing by disc diffusion method against ampicillin, gentamicin, tetracycline, co-trimoxazole, nalidixic acid, ciprofloxacin and ceftriaxone. Epsilometer tests (E-test) for nalidixic acid and ciprofloxacin were performed for nalidixic acid resistant isolates by disc diffusion method. DNA sequencing was carried out on six of the nalidixic acid resistant Salmonella Enteritidis isolates to identify mutations within quinolones resistance determining regions (QRDR) of gyrA, gyrB, parC and parE genes. Results: Resistance rates of NTS isolates from blood, stool, and BAL were respectively 37%, 20% and 0% for ampicillin, 79%, 40% and 0% for tetracycline, 32%, 40% and 0% for co-trimoxazole, 37%, 10% and 100% for nalidixic acid. Eight isolates were resistant to nalidixic acid and had exhibited reduced susceptibility towards ciprofloxacin by E-test. Mutation within QRDR was detected in gyrA gene (n = 6;Asp 47 → His [3], Asp 51 → Asn [1], Asp 73 → Gly [1], and Gly 48 → Asp [1]) and double mutation was detected in parE gene (n = 3;Gly 48 → Asp [3], Glu 82 → Ser [3]). Out of six isolates, three isolates were found to have both gyrA and parE gene mutations. Conclusions: There was no mutation observed in gyrB and parC gene. Mutation in gyrA gene was sufficient to induce decreased susceptibility to ciprofloxacin. Variation in amino acid sequences are novel, while detection of other gene mutation was uncommon.

Pharmacoepidemiologic study of association between apparent treatment resistant hypertension, cardiovascular disease and interaction effect by sex and age

BACKGROUND A limited number of studies have been conducted to test the magnitudes of the association between apparent treatment resistant hypertension(aTRH)and risk of cardiovascular disease(CVD).AIM To investigate the association between aTRH and risk of CVD and examine whether sex and age modify this association.METHODS We applied an observational analysis study design using data from the United States Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial(ALLHAT).ALLHAT recruited participants(n=25516)from 625 primary care settings throughout the United States,Canada,Puerto Rico,and United States Virgin Islands,aged 55 and older with hypertension and at least one additional risk factor for heart disease.aTRH was assessed from the year 2 visit.CVD event was defined as one of the following from the year 2 follow-up visit:Fatal or non-fatal myocardial infarction,coronary revascularization,angina,stroke,heart failure,or peripheral artery disease.Cox proportional hazards regression was used to examine the effect of aTRH on CVD risk.Potential modifications of sex and age on this association were examined on the multiplicative scale by interaction term and additive scale by joint effects and relative excess risk for interaction.RESULTS Of the total study participants(n=25516),5030 experienced a CVD event during a mean of 4.7 years follow-up.aTRH was associated with a 30%increase in risk of CVD compared to non-aTRH[hazards ratio(HR)=1.3,95%CI:1.19-1.42].Sex and age modified this relationship on both multiplicative and additive scales independently.Stratified by sex,aTRH was associated with a 64%increase in risk of CVD(HR=1.64,95%CI:1.43–1.88)in women,and a 13%increase in risk of CVD(HR=1.13,95%CI:1.01–1.27)in men.Stratified by age,aTRH had a stronger impact on the risk of CVD in participants aged<65(HR=1.53,95%CI:1.32–1.77)than it did in those aged≥65(HR=1.18,95%CI:1.05–1.32).Significant two-way interactions of sex and aTRH,and age and aTRH on risk of CVD were observed(P<0.05).The observed joint effect of aTRH and ages≥65 years(HR=1.85,95%CI:1.22–2.48)in males was less than what was expected for both additive and multiplicative models(HR=4.10,95%CI:3.63–4.57 and 4.88,95%CI:3.66–6.31),although three-way interaction of sex,age,and aTRH on the risk of CVD and coronary heart disease did not reach a statistical significance(P>0.05).CONCLUSION aTRH was significantly associated with an increased risk of CVD and this association was modified by both sex and age.Further studies are warranted to test these mechanisms.

Crust and Upper Mantle Electrical Resistivity Structure in the Panxi Region of the Eastern Tibetan Plateau and Its Significance

The Panxi region is located in the frontal zone of positive squeezing subduction and side squeezing shearing between the Indian plate and the Eurasian plate. The long-period magnetotelluric （LMT） and broadband magnetotelluric （MT） techniques are both used to study the deep electrical conductivity structure in this region; magnetic and gravity surveys are also performed along the profile. According to the 2-D resistivity model along the Yanyuan-Yongshan profile, a high- conductivity layer （HCL） exists widely in the crust, and a high-resistivity block （HRB） exists widely in the upper mantle in general, as seen by the fact that a large HCL exists from the western Jinpingshan tectonic zone to the eastern Mabian tectonic zone in the crust, while the HRB found in the Panxi tectonic zone is of abnormally high resistivity in that background compared to both sides of Panxi tectonic zone. In addition, the gravity and magnetic field anomalies are of high value. Combined with geological data, the results indicate that there probably exists basic or ultrabasic rock with a large thickness in the lithosphere in the Panxi axial region, which indicates that fracture activity once occurred in the lithosphere. As a result, we can infer that the high-resistivity zone in the Panxi lithosphere is the eruption channel for Permian Emeishan basalt and the accumulation channel for basic and ultrabasic rock. The seismic sources along the profile are counted according to seismic record data. The results indicate that the most violent earthquake sources are located at the binding site of the HRB and the HCL, where the tectonic activity zone is generally acknowledged to be; however, the earthquakes occurring in the HCL are not so violent, which reflects the fact that the HCL is a plastic layer, and the fracture threshold of a plastic layer is low generally, making high stress difficult to accumulate but easy to release in the layer. As a result, a higher number of smaller earthquakes occurred in the HCL at Daliangshan tectonic zone, and violent earthquakes occurred at the binding site of high- and low-resistivity blocks at the Panxi tectonic zone.

Apparent diffusion coefficient evaluation for secondary changes in the cerebellum of rats after middle cerebral artery occlusion

Supratentorial cerebral infarction can cause functional inhibition of remote regions such as the cerebellum, which may be relevant to diaschisis. This phenomenon is often analyzed using positron emission tomography and single photon emission CT. However, these methods are expensive and radioactive. Thus, the present study quantified the changes of infarction core and remote regions after unilateral middle cerebral artery occlusion using apparent diffusion coefficient values. Diffu- sion-weighted imaging showed that the area of infarction core gradually increased to involve the cerebral cortex with increasing infarction time. Diffusion weighted imaging signals were initially in- creased and then stabilized by 24 hours. With increasing infarction time, the apparent diffusion co- efficient value in the infarction core and remote bilateral cerebellum both gradually decreased, and then slightly increased 3-24 hours after infarction. Apparent diffusion coefficient values at remote regions （cerebellum） varied along with the change of supratentorial infarction core, suggesting that the phenomenon of diaschisis existed at the remote regions. Thus, apparent diffusion coefficient values and diffusion weighted imaging can be used to detect early diaschisis.

Mutations around interferon sensitivity-determining region:A pilot resistance report of hepatitis C virus 1b in a Hong Kong population

AIM： To explore mutations around the interferon sensitivity-determining region （ISDR） which are associated with the resistance of hepatitis C virus lb （HCV-lb） to interferon-α treatment. METHODS： Thirty-seven HCV-lb samples were obtained from Hong Kong patients who had completed the combined interferon-α/ribavirin treatment for more than one year with available response data. Nineteen of them were sustained virological responders, while 18 were non-responders. The amino acid sequences of the extended ISDR （eISDR） covering 64 amino acids upstream and 67 amino acids downstream from the previously reported ISDR were analyzed. RESULTS： One amino acid variation （I2268V, P = 0.023） was significantly correlated with treatment outcome in this pilot study with a limited number of patients, while two amino acid variations （R2260H, P = 0.05 and $2278T, P = 0.05） were weakly associated with treat- ment outcome. The extent of amino acid variations within the ISDR or eISDR was not correlated with treat- ment outcome as previously reported. CONCLUSION： Three amino acid mutations near but outside of ISDR may associate with interferon treatment resistance of HCV-lb patients in Hong Kong.

Study on System of Faults in the Gulf of Mexico and Adjacent Region based on Gravity Data

In the Gulf of Mexico and adjacent landmasses,faults are very complex,and their distribution is closely related to plate tectonics,ocean-land boundary,and former structure.The plane position of the faults can be identified by the maximum characteristic of the vertical derivative of the normalized vertical derivative of the total horizontal derivative(NVDR-THDR)of the Bouguer gravity anomaly.The apparent depth of the faults is inverted by the Bouguer gravity anomaly curvature property.Based on tectonic evolutionary processes and the plane distribution and apparent depth characteristics of the faults,a complete fault system for the Gulf of Mexico and adjacent areas has been established,including 102 faults.The apparent depths of 33 first-class faults are 16-20 km and for 69 second-class faults are 12-16 km.The F_(1-2)and F_(1-3)subduction fault zones are two caused by the subduction of the Cocos Plate into the old Yucatan and Chorti landmasses;F_(1-11)and F_(1-12)fault zones extend westward to the coast of Guatemala and do not extend into the continent;F_(1-17)and F_(1-20)faults,which control the boundary of the oceanic crust,do not extend southward into the continent.The fault system,which radiates in a"fan-shaped"structure as a whole,unfolds to the northeast.Faults of different nature and sizes are distributed in the Cocos Plate subduction zone,Continental,Gulf of Mexico,Yucatan old landmass and Caribbean Plate in NW,NNW,NS,NE and NEE directions.In the Gulf of Mexico region,the fault system is a comprehensive reflection of former tectonic movements,such as plate movement,drift of old landmasses and expansion of oceanic crusts.The first-class faults control the plate and ocean-continental boundaries.The second-class faults are subordinate to the first-class faults or related to the distribution of different sedimentary layers.

Research on the Dynamic Change of Regional Stress Fields before the M_S8.0 Wenchuan Earthquake

Using the digital telemetric seismic waveform data of Chengdu and Kunming, this article studies the focal mechanism solutions and the apparent stress values of a large number of small earthquakes, and then analyzes the dynamic variation of regional stress fields and the spatio- temporal distribution of apparent stress values. The annual variation values of the azimuth of average principal stress field before the May 12, 2008 Ms8.0 Wenchuan earthquake in the Sichuan-Yunnan region were 58° from 2003 to 2004, 85° from 2003 to 2005,61° from 2006 to 2007 and 90° from 2006 to April 2008 respectively. In recent years, deflection or disturbances occurred in the azimuth of the average principal stress field in the Sichuan-Yunnan region. Analysis shows that this may be related to the change of stress field states of crustal blocks before and after the December 26, 2004 Ms9.0 Sumatra earthquake and the 2008 Ms8.0 Wenchuan earthquake. The ratio of thrust-type earthquakes in the Sichnan-Qinghai block was on the higher side in the period from 2006 to 2007, and the source faulting type of the regional moderate and small earthquakes had changed before the Ms8.0 Wenchnan earthquake. The change of state of the stress field is consistent with the changes in block displacement fields revealed by GPS data and the crustal shortening velocity vertical to the Longmenshan fault zone. Based on the radiation energy calculated from all bands of the seismic waveform, the value of apparent stress σapp is obtained. The fluctuation shape of the fitting trend of the apparent stress is related to the intensity of regional seismicity. It reveals that the micro- dynamic fluctuation process of the regional stress value is similar to the azimuth transition of the regional principal compressive stress field, which can be used to probe for pregnant physical processes. Areas with a higher value of apparent stress σapp are possible areas of potential seismic risk. It can be seen from the spatial distribution of the medium and shortterm apparent stress σapp before the Ms8.0 Wenchuan earthquake, the Longmenshan fault zone is in a low stress distribution area, and the relatively high apparent stress is in the peripheral area. These images may show medium and short-term locking phenomena near the seismogenic tectonics of the Ms8.0 Wenchuan earthquake. For example, changes with time of the focal parameter consistency of the sub-blocks in Sichuan and Yunnan Provinces, continual increase of thrust-type earthquakes in the Sichuan-Qinghai block and the appearance of spatial distribution areas of high apparent σapp stress. The work on this aspect was continued after the Ms8.0 Wenchuan earthquake, and the results seem to be shown a clearer relationship between these phenomena and future great earthquakes.

The Effects of Negative Values of Apparent Resistivity in TEM Surveys

The calculation of apparent resistivity in electrical methods is relatively simple and consolidated in the literature. Furthermore, in the case of DC methods, the apparent resistivity values are for the most part, intuitive and enable an initial interpretation of the results. On the other hand, in TEM method the apparent resistivity values are not very intuitive and interpretation based only on the apparent resistivity values cannot be done reasonably. In this way, this paper presents a discussion about the reasons and effects of the negatives values of apparent resistivity in TEM soundings. The main objective of this paper is to clarify the meanings of these negatives values and the possible effects in TEM inversion.

Biomechanical forces in atherosclerosis-susceptible and -resistant regions of human vasculature differentially regulate endothelial vaso-protective phenotypes

Introduction Atherosclerosis is a potentially life-threatening disease of large arteries that is strongly associated with systemic risk factors such as hypercholesterolemia,hypertension,smoking,and diabetes. However,atherosclerosis develops as a

Analysis on Apparent Resistivity Variations of Garzê Station before the 2013 Lushan M_S 7. 0 Earthquake

A trend increase in apparent resistivity has been observed in the N30°E monitoring direction at Garze Seismic Station since July 2011. This increase trend in geo-electric resistivity has been observed in the N60°W direction since 2012. During the period of the increase, the national highway No.317 was expanded in the monitoring area, so the potential electrodes in the N30°E direction had to be moved 10m towards the current electrodes. We interpreted the electric sounding data of Garz6 Seismic Station with a horizontally layered model. Analysis based on this model showed that the shift of potential electrodes can cause a 4 l-l.m rise to the measurements in the N30°E direction. Therefore, apparent resistivity of the two directions increased in the same time in 2012 after offsetting the effects from electrodes shift. Sensitivity coefficients of the two observation directions were also obtained using the model. Sensitivity coefficients of both directions were negative for the shallow layers, which can well explain the unexpected annual variations of Garze Seismic Station. In order to quantitatively analyze the effects from the expansion of the national highway on the observation, we constructed a finite element model based on the electrical structure. Analysis results also suggested that the expansion of the national highway could only cause a 0. 15 Ω·m decrease in the N60°W monitoring direction and 0. 1 Ω· m increase in the N30°E direction. Additionally, the valley values of annual variation of 2013 were distinctively higher than that of other years since 2008, meaning that there was an abnormal rise in apparent resistivity in the two observation directions at Garz~ Seismic Station before the Lushan earthquake. However, the rise was contrary to the decline variation before the Wenchuan earthquake. Therefore, it is still unsure whether or not the rise variation is related to the Lushan earthquake.

Flow resistance in the channel-bar landscape of large alluvial rivers

Accurate approaches for estimating flow resistance in large alluvial rivers are fundamental for simulating discharge,sediment transport,and flood routing.However,methods for estimating riverbed resistance and additional resistance in the channel-bar landscapes remain poorly investigated.In this study,we used in situ river bathymetry,sediment,and hydraulic data from the Shashi Reach in the Yangtze River to develop a semi-empirical approach for calculating flow resistance.Our method quantitatively separates flow resistance into riverbed resistance and additional resistance and shows high accuracy in terms of deviation ratio(~20%),root-mean-square error(~0.008),and geometric standard deviation(~3).Additional resistance plays a dominant role under low-flow conditions but a secondary role under high flows,primarily due to the reduction in momentum exchange in channel-bar regions as discharge increases.Riverbed resistance first decreases and then increases,which might be attributed to bedform changes in the lower and transitional flow regimes as flow velocity increases.Overall,our findings further the understanding of dynamic changes in flow resistance in the channel-bar landscapes of large river systems and have important implications for riverine ecology and flood management.

Calculation of all-time apparent resistivity of large loop transient electromagnetic method with very fast simulated annealing

In large loop transient electromagnetic method(TEM),the late time apparent resistivity formula cannot truly reflect the geoelectric model,thus it needs to define the all-time apparent resistivity with the position information of measuring point.Utilizing very fast simulated annealing(VFSA) to fit the theoretical electromagnetic force(EMF) and measured EMF could obtain the all-time apparent resistivity of the measuring points in rectangular transmitting loop.The selective cope of initial model of VFSA could be confirmed by taking the late time apparent resistivity of transient electromagnetic method as the prior information.For verifying the correctness,the all-time apparent resistivities of the geoelectric models were calculated by VFSA and dichotomy,respectively.The results indicate that the relative differences of apparent resistivities calculated by these two methods are within 3%.The change of measuring point position has little influence on the tracing pattern of all-time apparent resistivity.The first branch of the curve of all-time apparent resistivity is close to the resistivity of the first layer medium and the last branch is close to the resistivity of the last layer medium,which proves the correctness of the arithmetics proposed.

AN EFFICIENT NUMERICAL MODELING OF THE DC RESISTIVITY LOGGING: THEORY AND APPLICATIONS

The numerical solution of Green’s function for the potential in 2-D arbitrary in-homogeneous media with axial symmetry has been given by use of efficient half-analytical, half-numerical hybrid method. Then the logging responses of various kinds of the DC resistivity log with axisymmetric excitation have been obtained by using surface integral equation method to match the boundary conditions on the electrodes of the logging sonde. Comparing the results with that obtained by other methods, one can see good precision and efficiency of the given method. Some applications of the numerical modeling have been also discussed.

Wavelet analysis and interpretation of gravity data in Sichuan-Yunnan region, China

The Bouguer gravity anomaly data of Sichuan-Yunnan region and its vicinity were analyzed with wavelet trans- formation method. In the process, complete orthogonal wavelet function system with good symmetry and higher vanishing moment was selected to decompose the gravity anomaly into two parts. With the power spectral analysis on the decomposed anomalies, we interpreted that the two parts of anomalies represent the density variation in upper and middle crust, and in deep crust and uppermost mantle, respectively. The two parts of anomalies indicate the difference between shallow and deep tectonics. The results of shallow-layer apparent density mapping reveal that: a) the crustal density in Sichuan basin is higher than that in Songpan-Garze orogenic zone; b) the density of Kangdian rhombic block is heterogeneous; c) the boundary faults of Kangdian block are of different density fea- tures, suggesting different tectonic signification. The results of deep-layer apparent density mapping show a similar, but not the same, density distribution pattern as the shallow results, and indicate that the tectonics of shallow and deep crust are different, they may be in a status of incomplete coupling. Our results also show that the earthquakes in this area are controlled not only by the fracture zones but also by the deep density distribution.

Ecological Land Suitability for Arid Region at River Basin Scale:Framework and Application Based on Minmum Cumulative Resistance(MCR) Model

As an important and typical arid inland region in China,Shiyang River Basin plays an important role in maintaining the sustainable development of eco-environment,whose ecological land suitability restricts the development of the local human activities.Therefore,Shiyang River Basin was selected as the case study,the minimum cumulative resistance(MCR)model and GIS technique were integrated to create land suitability evaluation map.We calculated the MCR value of ecological source and living source,and divided the whole basin into five partitions according to the difference between ecological source and living source,and analyzed the patterns and characteristics of the ecological land suitability evaluation(ELSE)regions,respectively.The results showed that:1)The suitable ecological land includes prohibited development region and restricted development region,which accounts for 15.45%and 23.35%of the total land area of the Shiyang River Basin,respectively.These two regions mainly distributed high altitude region in the southern Qilian Mountain and low altitude region where had high density of rivers.2)The protection of ecological land requires not only conserving existing ecological land but also focusing on ecological buffer belts around ecological sources and improving ecological land service ability.3)Ecological networks should be constructed through artificial planting trees around the boundary of oasis and ecological restoration region.Buffer greenbelts should also be established between optimized development region and ecological restoration region.

Molecular characterization of antimicrobial multi-drug resistance in non-typhoidal Salmonellae from chicken and clam in Mangalore, India

Salmonella enterica has been documented as one of the leading causes of salmonellosis throughout the world and is most commonly associated with the consumption of contaminated food products. Thus, this research was aimed at studying the antimicrobial susceptibility pattern and detection of quinolone resistance in Salmonella spp isolated from food of animal origin. Thirty-six Salmonella isolates comprising 8 from poultry and 28 from seafood（clams） were identified, serotyped and characterized for their antimicrobial susceptibility against 10 different antibiotics. Plasmid DNA was isolated from all the isolates by alkaline lysis, quinolone resistant non-typhoidal S. Weltevreden were examined for mutation in the DNA gyrase coding gene. Among the 36 Salmonella isolates, 20 were S. weltevreden（8 from poultry and 12 from seafood） and 16 were S. Typhimurium（from seafood）. All the isolates showed multiple resistance to nalidixic acid, tetracycline, co-trimoxazole and nitrofurantoin, but, interestingly, the isolates were 100% susceptible to ampicillin, chloramphenicol and gentamicin. Resistant isolates from the study carried the genes responsible for resistance to respective antibiotics. The strain S130 isolated in the study showed single point mutation,Asp87Gly, at position 87 in quinolone resistance determining region. It revealed mutation in quinolone resistance determining region as a cause for quinolone resistance in non-typhoidal Salmonellae. The occurrence of genes accountable for plasmid mediated resistance to quinolones（viz., qnrA, qnrB and qnrS） in plasmid of non-typhoidal Salmonellae isolates provides evidence for plasmid mediated quinolone resistance.