The Application of Bilayer Artificial Dermis Combined with VSD Technology in Chronic Wounds

Background: Bilayer artificial dermis promotes wound healing and offers a treatment option for chronic wounds. Aim: Examine the clinical efficacy of bilayer artificial dermis combined with Vacuum Sealing Drainage (VSD) technology in the treatment of chronic wounds. Method: From June 2021 to December 2023, our hospital treated 24 patients with chronic skin tissue wounds on their limbs using a novel tissue engineering product, the bilayer artificial dermis, in combination with VSD technology to repair the wounds. The bilayer artificial dermis protects subcutaneous tissue, blood vessels, nerves, muscles, and tendons, and also promotes the growth of granulation tissue and blood vessels to aid in wound healing when used in conjunction with VSD technology for wound dressing changes in chronic wounds. Results: In this study, 24 cases of chronic wounds with exposed bone or tendon larger than 1.0 cm2 were treated with a bilayer artificial skin combined with VSD dressing after wound debridement. The wounds were not suitable for immediate skin grafting. At 2 - 3 weeks post-treatment, good granulation tissue growth was observed. Subsequent procedures included thick skin grafting or wound dressing changes until complete wound healing. Patients were followed up on average for 3 months (range: 1 - 12 months) post-surgery. Comparative analysis of the appearance, function, skin color, elasticity, and sensation of the healed chronic wounds revealed superior outcomes compared to traditional skin fl repairs, resulting in significantly higher satisfaction levels among patients and their families. Conclusion: The application of bilayer artificial dermis combined with VSD technology for the repair of chronic wounds proves to be a viable method, yielding satisfactory therapeutic effects compared to traditional skin flap procedures.

Study on the Application of Refined Nursing Care in The Care for Elderly Patients with Reflux Esophagitis

Objective: To investigate the application effect of refined nursing care in the care for elderly patients with reflux esophagitis. Methods: Following the difference in nursing style, 84 cases of elderly patients with reflux esophagitis admitted to our hospital from May 2022 to May 2023 were randomly grouped into a control group and a research group, with 42 cases each. The control group was given conventional nursing care and the research group was given refined nursing care. The psychological state and treatment adherence of the two groups of patients after the nursing intervention were compared. Results: After the nursing intervention, the self-rating anxiety scale (SAS) and self-rating depression scale (SDS) scores of the research group were lower than those of the control group (P < 0.05). The treatment compliance of the research group was better than the control group (P < 0.05). Conclusion: The implementation of refined nursing care for elderly patients with reflux esophagitis exhibited a significant effect on improving the patient’s psychological state, treatment compliance, and rehabilitation.

Enriching Iodine and Regulating Grain Aroma,Appearance Quality,and Yield in Aromatic Rice by Foliar Application of Sodium Iodide

Applying iodine fertilizers to cultivate iodine-rich crops for daily intake is an effective approach for iodine supplementation,especially for aromatic rice.Field experiments were conducted during the early growing seasons of 2021 and 2022 to evaluate the impacts of foliar application of iodine fertilizer on aromatic rice and to explore the optimal iodine fertilizer concentration.At the full heading stage,six different concentrations of sodium iodide solutions of 0%(CK),0.010%(T1),0.025%(T2),0.050%(T3),0.075%(T4),and 0.100%(T5)were applied to indica aromatic rice cultivars Meixiangzhan 2 and Xiangyaxiangzhan.The results showed that sodium iodide treatments significantly increased the iodine and sodium contents in both leaves and grains.Compared with the CK,the T1 and T2 treatments increased the 2-acetyl-1-pyrroline(2-AP)content in mature grains by 8.41%-101.66%and 13.58%-74.60%,respectively.Improvements in the contents of 1-pyrroline-5-carboxylic acid,proline,1-pyrroline,and methylglyoxal,as well as the activity of proline dehydrogenase were also detected.Additionally,sodium iodide treatments remarkably decreased the chalky grain rate,chalkiness area,and chalkiness degree of aromatic rice,with the T2 treatment exhibiting a 17.79%-47.42%decrease in chalkiness degree compared with the CK.Meanwhile,T1 and T2 treatments showed beneficial impacts on chlorophyll content,photosynthetic characteristics,and yield components,while T3,T4,and T5 treatments exhibited adverse effects on leaf and grain yields.The linear discriminant analysis revealed significant differences between treatments.The correlation analysis and piecewise structural equation modeling showed that the iodine and sodium influenced the photosynthetic characteristics and chlorophyll content of the leaves,thereby regulating the 2-AP biosynthesis and yield components,ultimately affecting the 2-AP content and yield.Overall,this study suggests that foliar application of 0.025%sodium iodide is an effective method to enrich the iodine content in rice grains,improve the grain aroma and appearance quality of aromatic rice,without detrimental effects on grain yield.

Selection and application of four QTLs for grain protein content in modern wheat cultivars

The grain protein content(GPC)is the key parameter for wheat grain nutritional quality.This study conducted a resampling GWAS analysis using 406 wheat accessions across eight environments,and identified four previously reported GPC QTLs.An analysis of 87 landraces and 259 modern cultivars revealed the loss of superior GPC haplotypes,especially in Chinese cultivars.These haplotypes were preferentially adopted in different agroecological zones and had broad effects on wheat yield and agronomic traits.Most GPC QTLs did not significantly reduce yield,suggesting that high GPC can be achieved without a yield penalty.The results of this study provide a reference for future GPC breeding in wheat using the four identified QTLs.

Combined application of CIRCLE Software and Topo-LASIK for SMILE enhancement

Dear Editor,We present a case of combined application of CIRCLE software(Carl Zeiss Meditec AG,Germany)and topography-guided laser-assisted in situ keratomileusis(Topo-LASIK)for small-incision lenticule extraction(SMILE)enhancement.SMILE is a safe,minimally invasive corneal laser surgery using a femtosecond laser to create an extractable stromal lenticule.

Screening and field application of microbial-flooding activator systems

This study aims to further enhance the oil recovery of reservoirs in the Zhong-2 Block of the Gudao Oilfield by identifying the most effective microbial-flooding activator systems and applying them in the field.We began by analyzing the structure of the reservoirs'endogenous microbial communities to understand the potential impact of microbial flooding.This was followed by determining commonly used activator systems based on their abilities to stimulate oil-displacement functional bacteria.Through laboratory experiments on oil displacement efficiency and sweep characteristics,we determined the optimal activator injection method(injection ratio)and the requisite bacterial concentration for maximal microbial-flooding efficacy.Finally,we selected the optimal activator systems and applied them to field tests.Our findings suggest the target block is highly receptive to microbial-flooding.In terms of performance,the activator systems ranked as No.3>No.4>No.1>No.2.Interestingly,a deep activator system,when compared to the top-performing No.3 system,exhibited a higher bacterial concentration peak and longer peaking duration.Optimal oil displacement effects were observed at a 1:4 vol ratio between the No.3 activator and deep activator systems,with bacterial concentrations of up to 106 cells/mL or above.Field tests with the selected activator systems,following a specific injection protocol,demonstrated a notable increase in oil production and a reduction in water cut.

Prospects in the application of ultrasensitive chromosomal aneuploidy detection in precancerous lesions of gastric cancer

Gastric cancer(GC)is a prevalent malignant tumor within the digestive system,with over 40%of new cases and deaths related to GC globally occurring in China.Despite advancements in treatment modalities,such as surgery supplemented by adjuvant radiotherapy or chemotherapeutic agents,the prognosis for GC remains poor.New targeted therapies and immunotherapies are currently under invest-igation,but no significant breakthroughs have been achieved.Studies have indicated that GC is a heterogeneous disease,encompassing multiple subtypes with distinct biological characteristics and roles.Consequently,personalized treatment based on clinical features,pathologic typing,and molecular typing is crucial for the diagnosis and management of precancerous lesions of gastric cancer(PLGC).Current research has categorized GC into four subtypes:Epstein-Barr virus-positive,microsatellite instability,genome stability,and chromosome instability(CIN).Technologies such as multi-omics analysis and gene sequencing are being employed to identify more suitable novel testing methods in these areas.Among these,ultrasensitive chromosomal aneuploidy detection(UCAD)can detect CIN at a genome-wide level in subjects using low-depth whole genome sequencing technology,in conjunction with bioinformatics analysis,to achieve qualitative and quantitative detection of chromosomal stability.This editorial reviews recent research advancements in UCAD technology for the diagnosis and management of PLGC.

Analysis on Demonstration Application of Silicon Fertilizer in Field Cultivation of Rice

[Objectives]This study was conducted to investigate the scientific application of silicon fertilizer in rice cultivation,one of the staple crops.[Methods]In 2022,Yandu District carried out a special experiment and field demonstration study on the effects of foliar application of Zhengda water-soluble silicon fertilizer on rice production.[Results]The preliminary results showed that①Zhengda water-soluble silicon fertilizer could effectively improve the growth and development of rice and improve the population quality.The peak number of tillers,productive tiller percentage,number of effective panicles and number of effective grains per panicle increased by 6.7%,5.8%,5.5%,and 1.2%,respectively.②The yield and processing quality were improved.After applying silicon fertilizer,the yield per unit area increased by about 6.8%,and the unpolished rice yield,milled rice yield and head rice yield increased by 0.7%,1.94%and 2.15%respectively.[Conclusions]The demonstration application of silicon fertilizer in field cultivation of rice in Yandu District further proves previous research conclusions and has important practical significance.

Diversity and Application of Herbaceous Flowers in Urban Road Greening in Hefei City

In urban road greening,the planting of ground cover flowers is essential,and herbaceous flowers are an important part.Through the investigation on the diversity of herbaceous flowers in urban road green spaces of Hefei City,the types,colors,application frequency and planting of herbaceous flowers in urban road green spaces were statistically analyzed,and the application forms of herbaceous flowers in the road greening of Hefei City were studied.The characteristics and problems of herbaceous flowers in the road greening of Hefei City were found,and some development suggestions were put forward.

Application of Flower Borders in Hefei City

The application value of 70 kinds of flowers in Hefei City was evaluated by analytic hierarchy process(AHP).From the three aspects of adaptability,ornamental value and economic traits,12 indicators were summarized to establish a comprehensive evaluation system.The results show that the application of grade-I plants(J≥3.6642)in flower borders is the most suitable,and they include 19 species of plants such as Osmanthus fragrans var.thunbergii,accounting for 27.14%.The application of grade-II plants(3.2319≤J≤3.6641)in flower borders is suitable,and 36 species of plants such as Jacobaea maritima are included,with the proportion of 51.42%.The application of grade-III plants(2.7935≤J≤3.2318)in flower borders is relatively suitable,and they contain 8 species of plants such as Acer palmatum’Atropurpureum’(Van Houtte)Schwerim,accounting for 11.42%.Grade-IV plants(J≤2.7934)can be applied in flower borders under special circumstances,and include 6 species of plants such as Muehlenbeckia complexa Meisn.,accounting for 8.57%.The results can provide reference for the selection of flower border plants in Hefei.The locations and types of 40 flower borders were summarized to provide a basis for the development direction and future planning of flower borders in Hefei.

Establishment and Application of Prevention and Control Techniques of New Sugarcane White Leaf Disease

Aiming at the basic and key technical problems in prevention and control of sugarcane white leaf disease(SCWL),this study systematically overcame key technical bottleneck of prevention and control of new SCWL after 10 years of collaborative research,and achieved several innovative achievements.SCWL phytoplasmas newly recorded in China and the new subgroup of SCWL phytoplasmas(16SrXI-D)were discovered for the first time in Yunnan,and the whole genome analysis of the epidemic subgroup was completed.The main transmission source of SCWL pathogens has been identified as infected seed canes,and Tettigoniella viridis and Clovia conifer were newly discovered as vectors for virus transmission.The disease resistance of 25 main varieties was identified,and 10 control varieties were selected.The prevention and control strategy of"emphasizing early warning,strictly carrying out quarantine,blocking the vectors and controlling residual plants"was put forward,and a comprehensive prevention technique was established through integration of various techniques,and standardized technical regulations were formulated for demonstration application.The promotion and application of these achievements have realized scientific prevention and control of SCWL,effectively curbed the spread of SCWL,and ensured the safety of sugarcane producing areas in China,achieving great economic,social and ecological benefits and providing technical support for high-quality development,loss reduction and efficiency improvement of China's sugar industry.

Guidance and Application of Chinese Classical Gardens in Modern Gardens

As a representative of Eastern gardens,Chinese classical gardens have always held an extremely important position in world gardens.They not only carry the profound cultural and ideological connotations of China,but also have great aesthetic achievements that are worth exploring.In the process of urbanization,the construction of urban gardens is also progressing rapidly with the development of the city,and modern gardens are reflected more.Gradually,people began to realize that the aesthetics of Chinese classical gardens can collide with the design concepts of modern gardens,in order to conform to the current development trend of the new era.This paper compares and analyzes the differences and connections between Chinese classical gardens and modern gardens from three aspects:gardening concepts,gardening elements,and gardening techniques.Combined with relevant cases,it studies the practical application of Chinese classical garden design techniques in modern gardens,and explores and promotes the art of Chinese classical garden design.

Progress in the extraction and application of collagen peptides

Collagen peptide is the product of complete hydrolysis of collagen,which has a relatively small molecular weight and is more easily absorbed than proteins and amino acids.Collagen peptide not only has unique nutritional value,but also has certain physiological functions,which makes it has great potential value in various fields,so it has set off a wave of research on collagen peptide in the biological world.This paper describes the sources and extraction methods of collagen peptides,and describes the research progress and application of collagen peptides in the medical,food,material and skin care industries according to their physiological functions,which will provide new ideas for the future research of collagen peptides.

The Application of AI Big Model Will Usher in the“Wave Year”

2023 was known as the year of artificial intelligence,and the application of large models emerged one after another.From the beginning of the year,the cognitive intelligence model represented by ChatGPT was born,which quickly detonated the market.In the second half of the year,large-scale models quickly entered a new stage.Many large-scale models moved from technology to commercialization,and each family seized the high ground of data,computing power,scenarios and applications to compete for the right to speak in the large-scale model market.

Study on The Current Status and Progress of Clinical Application of Ciprofol

Ciprofol,as a new type of short-acting intravenous anesthetic drug,belongs to the category of gamma-aminobutyric acid(GABA)receptor agonists.Its unique chemical structure,through the introduction of the cyclopropyl group in the isopropyl side chain of propofol,constructs a new type of chiral molecule,which significantly enhances the spatial effect,and improves the affinity for GABA receptors.Its pharmacological properties are characterized by high potency,rapid onset of action,rapid recovery,low accumulation,and minimal adverse reactions.Therefore,it has a wide range of applications in various endoscopic diagnostic and therapeutic operations,ICU sedation,and general anesthesia.In this paper,the related knowledge of ciprofol and the development of clinical application research are comprehensively sorted out and synthesized,to provide a solid theoretical basis for the rational application of ciprofol in clinical practice.At the same time,the future research direction of ciprofol will also be prospected to provide valuable references for research in related fields.

Analysis of the Design and Application of a Novel CT Secondary Cable Line Calibrator

With the rapid development of electrical power systems,ensuring the accuracy and reliability of power transmis-sion has become particularly crucial.The secondary cable line calibrator for current transformers(CT)plays an essential role in calibrating electrical power systems.It is not only related to the safe operation of the system but also directly im-pacts the accuracy of energy metering.This study aims to design and analyze an efficient CT secondary cable line calibra-tor to explore its application effects in the power system.By thoroughly analyzing the characteristics of CT secondary ca-ble lines and the design requirements of the calibrator,this paper proposes an innovative design scheme for the calibrator.This device demonstrates significant effects in enhancing the accuracy and stability of power system calibration,providing robust technical support for the optimization and upgrade of the power system.This research not only offers a theoretical basis and practical guidance for the design and application of CT secondary cable line calibrators but also contributes new ideas and methods for the precise calibration and efficient management of the power system.

Research Progress on the Application of Nanomaterials in the Treatment of Oral Cancer

Oral cancer is a complex pathological process caused by a combination of exogenous factors represented by oncoviruses and endogenous factors represented by immune damage,individual DNA damage,and repair.Targeted treatment for oral cancer is based on the perspective of molecular genetics,which can not only reduce toxicity and increase efficacy,but also improve the quality of life of patients.This is the bottleneck that clinical oral cancer treatment needs to break through the most.Nanomaterials can exhibit a unique large molecular surface area,with relatively high surface reactivity and multiple surface active centers,resulting in strong adsorption capacity in molecular metabolism.There is a certain foundation in its application in the field of biology,but it has good tumor cytotoxicity and inhibition of proliferation in the treatment of oral cancer.This study reviews the application of nanomaterials in tumor prevention,treatment,and other fields,providing new ideas for the future treatment of this disease.

The Application of Psychological Nursing in Pediatric Clinical Nursing

Objective:To study the application effect of psychological nursing in pediatric clinical nursing.Method:100 pediatric patients who underwent treatment in our hospital from January 2019 to December 2020 were selected as the research subjects.They were randomly divided into a control group and an observation group,with 50 cases in each group.The control group received routine nursing care,while the observation group received psychological care based on routine nursing care.The nursing compliance,incidence of adverse events,and parental satisfaction of the two groups of pediatric patients were compared and analyzed.Result:Through psychological nursing intervention,it was found that the observation group had better nursing compliance,incidence of adverse events,and parental satisfaction than the control group,P<0.05,the differences are statistically significant.Conclusion:The application of psychological nursing in pediatric clinical nursing can improve the compliance of pediatric care,reduce the incidence of adverse events,enhance parental satisfaction,and have clinical promotion and application value.

Localized Application of Chinese Standards in Jakarta-Bandung HSR Project

Jakarta-Bandung HSR in Indonesia is the first“go global”project of China's high speed railway with a whole system,all elements and a whole industry chain,as well as the first overseas project adopting a complete set of Chinese standards.This paper sorts out the differences between relevant standards in China and Indonesia,including those in concrete raw materials,rebar standards and other main material standards,and those in external interface standards,train operation direction requirements,project approval requirements,special acceptance requirements,etc.,and summarizes the realization methods and specific achievements of localized application of Chinese standards during the implementation of Jakarta-Bandung HSR Project,to provide reference for localized application of Chinese standards in overseas projects in the future.

The Application of China's High Speed Railway Earthquake Early Warning System in Jakarta-Bandung HSR

Earthquake has a significant impact on operation safety of the high speed railway,and for Jakarta-Bandung High Speed Railway(HSR)in Indonesia where it is earthquake-prone,it is necessary to establish an earthquake early warning system to strengthen its earthquake resistance.Based on the principle and technical characteristics of China's high speed railway earthquake early warning system and combining the actual situations of Jakarta-Bandung HSR in Indonesia,this paper describes how to implement China's high speed railway earthquake early warning system in Jakarta-Bandung HSR.It focuses on optimizations in environmental adaptation design and seismic network interface design,earthquake attenuation model parameter adjustment and terminal software interface adjustment,so as to make the system better suit the local situations,and meet operation requirements and guarantee safe operation of Jakarta-Bandung HSR.