Study on The Current Status and Progress of Clinical Application of Ciprofol

Ciprofol,as a new type of short-acting intravenous anesthetic drug,belongs to the category of gamma-aminobutyric acid(GABA)receptor agonists.Its unique chemical structure,through the introduction of the cyclopropyl group in the isopropyl side chain of propofol,constructs a new type of chiral molecule,which significantly enhances the spatial effect,and improves the affinity for GABA receptors.Its pharmacological properties are characterized by high potency,rapid onset of action,rapid recovery,low accumulation,and minimal adverse reactions.Therefore,it has a wide range of applications in various endoscopic diagnostic and therapeutic operations,ICU sedation,and general anesthesia.In this paper,the related knowledge of ciprofol and the development of clinical application research are comprehensively sorted out and synthesized,to provide a solid theoretical basis for the rational application of ciprofol in clinical practice.At the same time,the future research direction of ciprofol will also be prospected to provide valuable references for research in related fields.

Association between glucose levels of children with type 1 diabetes and parental economic status in mobile health application

BACKGROUND The glycemic control of children with type 1 diabetes(T1D)may be influenced by the economic status of their parents.AIM To investigate the association between parental economic status and blood glucose levels of children with T1D using a mobile health application.METHODS Data from children with T1D in China's largest T1D online community,Tang-TangQuan■.Blood glucose levels were uploaded every three months and parental economic status was evaluated based on annual household income.Children were divided into three groups:Low-income(<30000 Yuan),middle-income(30000-100000 Yuan),and high-income(>100000 yuan)(1 Yuan=0.145 United States Dollar approximately).Blood glucose levels were compared among the groups and associations were explored using Spearman’s correlation analysis and multivariable logistic regression.RESULTS From September 2015 to August 2022,1406 eligible children with T1D were included(779 female,55.4%).Median age was 8.1 years(Q1-Q3:4.6-11.6)and duration of T1D was 0.06 years(0.02-0.44).Participants were divided into three groups:Low-income(n=320),middle-income(n=724),and high-income(n=362).Baseline hemoglobin A1c(HbA1c)levels were comparable among the three groups(P=0.072).However,at month 36,the low-income group had the highest HbA1c levels(P=0.036).Within three years after registration,glucose levels increased significantly in the low-income group but not in the middle-income and high-income groups.Parental economic status was negatively correlated with pre-dinner glucose(r=-0.272,P=0.012).After adjustment for confounders,parental economic status remained a significant factor related to pre-dinner glucose levels(odds ratio=13.02,95%CI:1.99 to 126.05,P=0.002).CONCLUSION The blood glucose levels of children with T1D were negatively associated with parental economic status.It is suggested that parental economic status should be taken into consideration in the management of T1D for children.

Status Quo Bias-A Research on Its Applications and the Correlating Mechanism

After several former studies on the cognitive heuristics and correlating economical influences,the explanatory effectiveness of Status Quo Bias perspective is explained by multiple empirical scenarios.Hence,this essay will focus on three applications in which the Status Quo Bias perspective,correlating models,and research methods would provide insightful opinions.After reviewing the former attempts on the original model and early researchers’empirical examination on the Status Quo Bias,this essay will concentrate on Status Quo Bias and technology resistance among the public sector employees,Status Quo Bias and medical insurance outcomes,Status Quo Bias and shoppers’mobile website purchasing resistance respectively.For each application,research methodology will be explained and be integrated into the Status Quo Bias perspective through the research question.Through researching on these applications’methodology and main studies,discussing cognitive biases existing in the empirical scenarios,the present study could approach to the efficiency of the explanation from Status Quo Bias perspective.

Current Status of Clinical Application and Basic Research on Draba nemerosa Hebecarpa Jujube Lung-Diarrhoea Soup

The clinical application and basic research of Draba nemerosa Hebecarpa jujube diarrhoea lung soup focus on respiratory diseases and circulatory diseases, and its clinical application is more compared with the basic research, and Draba nemerosa Hebecarpa jujube diarrhoea lung soup is mostly used in the form of “Draba nemerosa Hebecarpa Hebecarpa jujube diarrhoea lung soup with additional subtractions or other formulas combining Draba nemerosa Hebecarpa Hebecarpa Hebecarpa jujube diarrhoea lung soup” in the clinical application. This article will focus on the main mechanisms of Draba nemerosa Hebecarpa jujube diarrhoea lung soup and its main components in the treatment of respiratory and circulatory diseases, and will give a review of the basic research on Draba nemerosa Hebecarpa Hebecarpa jujube diarrhoea lung soup as follows.

Gut microbiome and metabolic-associated fatty liver disease:Current status and potential applications

Metabolic-associated fatty liver disease(MAFLD)is one of the most common chronic liver diseases worldwide.In recent years,the occurrence rate of MAFLD has been on the rise,mainly due to lifestyle changes,high-calorie diets,and imbalanced dietary structures,thereby posing a threat to human health and creating heavy social and economic burdens.With the development of 16S sequencing and integrated multi-omics analysis,the role of the gut microbiota(GM)and its metabolites in MAFLD has been further recognized.The GM plays a role in digestion,energy metabolism,vitamin synthesis,the prevention of pathogenic bacteria colonisation,and immunoregulation.The gut-liver axis is one of the vital links between the GM and the liver.Toxic substances in the intestine can enter the liver through the portal vascular system when the intestinal barrier is severely damaged.The liver also influences the GM in various ways,such as bile acid circulation.The gut-liver axis is essential in maintaining the body’s normal physiological state and plays a role in the onset and prognosis of many diseases,including MAFLD.This article reviews the status of the GM and MAFLD and summarizes the GM characteristics in MAFLD.The relationship between the GM and MAFLD is discussed in terms of bile acid circulation,energy metabolism,micronutrients,and signalling pathways.Current MAFLD treat ments targeting the GM are also listed.

Status Quo and Application of North American Wisteria in Shijiazhuang

The introduction and planting of three cultivars of North American wisteria in Shijiazhuang were observed.By comparing the inflorescences of Chinese wisteria,Japanese wisteria and North American wisteria,it is concluded that North American wisteria has compact inflorescence,rich color and late flowering period,and can prolong the ornamental time of wisteria when collocating with Chinese wisteria and Japanese wisteria in landscape application.The application of North American wisteria in Chinese gardens can not only enrich the species diversity of the region,but also have positive significance for improving the landscape effect of the whole city.

Ferroelectricity of hafnium oxide-based materials:Current status and future prospects from physical mechanisms to device applications

The finding of the robust ferroelectricity in HfO_(2)-based thin films is fantastic from the view point of both the fundamentals and the applications.In this review article,the current research status of the future prospects for the ferroelectric HfO_(2)-based thin films and devices are presented from fundamentals to applications.The related issues are discussed,which include:1)The ferroelectric characteristics observed in HfO_(2)-based films and devices associated with the factors of dopant,strain,interface,thickness,defect,fabrication condition,and more;2)physical understanding on the observed ferroelectric behaviors by the density functional theory(DFT)-based theory calculations;3)the characterizations of microscopic and macroscopic features by transmission electron microscopes-based and electrical properties-based techniques;4)modeling and simulations,5)the performance optimizations,and 6)the applications of some ferroelectric-based devices such as ferroelectric random access memory,ferroelectric-based field effect transistors,and the ferroelectric tunnel junction for the novel information processing systems.

Analysis of Application Status and Recommendations for Shade-Tolerant Lawns and Ground Cover Plants in the West Lake Scenic Area

Taking 8 parks in Xihu Scenic Area as the survey objects, this study found that there are 77 kinds of shade-tolerant lawns and ground cover plants under the forest in good growth condition, and there are 3 types of application forms: dense forest, sparse forest and forest edge. In response to the existing problems, it is proposed that it is necessary to adhere to principles of ecology, adapt to local conditions and plant suitable varieties in accordance with local conditions, develop and use new varieties of wild shade-tolerant lawns and ground cover plants, and strengthen the promotion of the mixed planting model of shade-tolerant lawns and ground cover plants, so as to provide guidance for the better use of shade-tolerant lawns and ground cover under the forest in the West Lake Scenic Area in the future.

Development Status and Application Analysis of Vehicle to Grid (V2G)

With the shortages of resources,environmental pollution,climate change,and other issues becoming more and more serious,it is extremely urgent to vigorously develop new energy vehicles.As the cost of batteries decrease year by year,the production and quantity of sales of electric vehicles(EVs)in the world,especially in China,increased substantially.In order to make vehicles to grid(V2G)technology better developed and applied in China.The brief introduction to V2G is given at first.Then the development status and specific cases of V2G at home and abroad are summarized.Finally,the problems that V2G may encounter during promotion and application in China are analyzed.Based on the development of the United States and Japan,specific policy recommendations are given in line with the basic national conditions of China.

Application Status and Development Measures of Biogas Fertilizer in Agricultural Production

Biogas fertilizer is widely used in agricultural production,and it can be used in a variety of ways,including liquid spraying,root fertilization,presoaking and biological pesticides,etc.It can improve soil structure,increase the content of soil organic matter and available nutrients,and increase crop yield.In addition,there are some problems in the utilization of biogas fertilizer.Some details that need to be paid attention to and can not be ignored should be further studied and discussed to achieve a final principle of harmonious,safe and efficient use,so as to ensure the benefit maximization of biogas fertilizer as an economic fertilizer source.Therefore,this paper summarizes the main ways and methods,existing problems and corresponding development measures concerning the application of biogas fertilizer in agriculture,in order to provide some reference for the utilization of biogas fertilizer in the field of agriculture and make it universal,safe and stable.

Research Status and Application Prospect of Aluminum Matrix Composites

Aluminum matrix composite is one of the most attractive metal matrix composites.It is a kind of material with strong vitality emerging in response to the needs of modern scientific development.Compared with traditional materials,aluminum matrix composites have the advantages of low density,good electric conductivity and heat conductivity,good wear resistance and oxidation resistance,high specific strength and stiffness,high temperature resistance,good heat treatment performance and flexible preparation process,which make them widely used in the fields of aviation,aerospace,and automobile.In this paper,the factors affecting the properties of aluminum matrix composites,the strengthening mechanism,classification and preparation methods of aluminum matrix composites are summarized.The research status,development direction and application prospect of aluminum matrix composites are briefly introduced.

Application Status and Prospect of Three-Dimensional Printing Technology in the Field of Medical Devices

Three-dimensional(3D)printing technology belongs to a new manufacturing science and has been widely used in various fields of industry.This article will apply 3D printing technology as its main research topic,with emphasis on its application in the field of medical devices and prospects for contribution.

The Status and Future of Titanium Application in China

Through 40 years development Ti hasbecame an important military and civil in-dustry material called "Air"—"Land"—"Ocean"metal.Ti is an ideal structurematerial and corrosion resistant material,which has bright future in the developmentof modern technology.

Analysis and results to the status of BIM technology application in China

Information age and the rapid development of information technology has brought the infinite creativity and possibility for all works in modem society. If CAD technology is first innovation of information technology in construction industry, then the emergence of the BIM technology shall fully deserved to be treated as a second innovation in construction industry. As a new technology which have been introduced to China in recent years, BIM technology already had its major application in foreigner countries .This paper focuses on the current status of BIM technology application in our country, especially on some small and medium enterprises using the traditional BIM technology to handle the project which have complex usage,creative deign and cost limitation. Firstly,we take a deep analysis on the initial application situation. Then we go through the practical application and analyse what benefit can be given to a project from BIM technology. Finally, analyse the problems and solutions in BIM application with consideration of Chinese building engineering development. Only after a careful analysis, a deep understanding of BIM, we can fully understand this new technology and make BIM to give its value to construction project.

Influence on Sport Industry from Traditional Chinese sport＇s Application for the Status of National Intangible Cultural Heritage

Traditional Chinese sport conveys China＇s millenniums＇ culture, which can be taken as symbol of China＇s culture. Therefore, the application for the status of national intangible cultural heritage becomes unavoidable. No matter it will be successful or not, the process will boost its industry. This paper argued its push to traditional Chinese sport industry from the point of traveling, sporting goods, culture industry and entertainment and relaxation.

Application Status of Enhanced Recovery After Surgery in Perioperative Nursing of Neurosurgery

Enhanced recovery after surgery(ERAS)is a strategy of perioperative management aimed to accelerate the rehabilitation of patients through various optimized perioperative managements as well as ongoing adherence to a patient-focused,multidisciplinary,and multimodal approach.ERAS is a good reflection of the perioperative value-based care,which has been widely applied in many surgical fields and shown quick recovery and low morbidity when applied on patients.However,there is a lack of attention on ERAS in neurosurgery.This review aims to describe the current application status of ERAS in neurosurgery and to provide readers with the commonly accepted principles in the perioperative nursing of neurosurgery.

Application of extension neural network to safety status pattern recognition of coalmines

In order to accurately and quickly identify the safety status pattern of coalmines,a new safety status pattern recognition method based on the extension neural network (ENN) was proposed,and the design of structure of network,the rationale of recognition algorithm and the performance of proposed method were discussed in detail.The safety status pattern recognition problem of coalmines can be regard as a classification problem whose features are defined in a range,so using the ENN is most appropriate for this problem.The ENN-based recognition method can use a novel extension distance to measure the similarity between the object to be recognized and the class centers.To demonstrate the effectiveness of the proposed method,a real-world application on the geological safety status pattern recognition of coalmines was tested.Comparative experiments with existing method and other traditional ANN-based methods were conducted.The experimental results show that the proposed ENN-based recognition method can identify the safety status pattern of coalmines accurately with shorter learning time and simpler structure.The experimental results also confirm that the proposed method has a better performance in recognition accuracy,generalization ability and fault-tolerant ability,which are very useful in recognizing the safety status pattern in the process of coal production.

Application Research Status and Development Prospect of Microbial Flocculant

Microbial flocculant （MBF） is a kind of novel flocculant, which is widely used for the food industry, highly concentrated organic waste water treatment and the urban water supply technology. Due to its characteristics of superior flocculation effect, without secondary pollution to the environment and being easily degraded, MBF has been emerging as a hotspot of water treatment research in recent years. In this paper, the latest progress of the preparation of MBFs and the flocculating mechanism were presented. The practical application research of MBFs for water treatment was reviewed. Finally, suggestions and development prospect of research on MBFs were discussed.

STATUS UP DATE ON USE OF INTERMETALLICS FOR STRUCTURAL APPLICATIONS

Several key issues related to ductility and fracture toughness limiting the application of intermetallics were discussed. Progress made in resolving some of the issues was discussed. The paper addresses design methodology for low defect tolerant materials. Impact resistance of NiAl under engine simulative conditions has been studied. The impact test results demonstrated a need for materials possessing improved impact resistance for turbine blade and vane applications. Some of the production implementation issues were also discussed.

Application Status and Prospect of <i>Pinus massoniana</i>Sawdust as the Substrate for the Cultivation of Edible Fungi

In this paper, the research status of using Pinus massoniana sawdust for the cultivation of edible fungi was analyzed and discussed. It was found that Pinus massoniana sawdust contained the material base of edible fungi with sufficient cellulose, hemicellulose and lignin and a small amount of nitrogen, phosphorus, potassium, calcium, magnesium, other mineral salts, and some vitamins for the growth of edible fungi. However, the Pinus massoniana wood contained a significant amount of terpenoids, which are detrimental to the growth of edible fungus and mycelial. The major and current detoxification methods for Pinus massoniana sawdust were analyzed, such as steaming method, distillation method, lime water immersion method, outdoor piling fermentation method, and chemical method. Their advantages and disadvantages were discussed and reviewed. Finally, the major issues in the application of Pinus massoniana sawdust as the cultivation substrate of edible fungi were analyzed, and the application prospect of Pinus massoniana sawdust as the substrate for the cultivation of edible fungi was also reviewed.