The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect...The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.展开更多
In data centers, the transmission control protocol(TCP) incast causes catastrophic goodput degradation to applications with a many-to-one traffic pattern. In this paper, we intend to tame incast at the receiver-side a...In data centers, the transmission control protocol(TCP) incast causes catastrophic goodput degradation to applications with a many-to-one traffic pattern. In this paper, we intend to tame incast at the receiver-side application. Towards this goal, we first develop an analytical model that formulates the incast probability as a function of connection variables and network environment settings. We combine the model with the optimization theory and derive some insights into minimizing the incast probability through tuning connection variables related to applications. Then,enlightened by the analytical results, we propose an adaptive application-layer solution to the TCP incast.The solution equally allocates advertised windows to concurrent connections, and dynamically adapts the number of concurrent connections to the varying conditions. Simulation results show that our solution consistently eludes incast and achieves high goodput in various scenarios including the ones with multiple bottleneck links and background TCP traffic.展开更多
This ancient city has a history going back over 2,000 years.It has witnessed the fusion of multiple ethnic cultures including the Miao,Dong,and Han,and hosts a number of cultural heritage sites.THE old town of Zhenyua...This ancient city has a history going back over 2,000 years.It has witnessed the fusion of multiple ethnic cultures including the Miao,Dong,and Han,and hosts a number of cultural heritage sites.THE old town of Zhenyuan is located in Zhenyuan County,Qiandongnan Miao and Dong Autonomous Prefecture in southwest China’s Guizhou Province.Covering an area of just around three square kilometers,it sits on the banks of the Wuyang River and is surrounded by mountains.Zhenyuan has been a county for more than 2,281 years and was the prefectural capital during the Yuan(1271-1368)and Qing(1644-1911)dynasties.It is a multicultural region,with Miao,Dong,and other ethnic minorities making up nearly half of the population.展开更多
With the vigorous development of Internet of Things(IoT)technology,the demand for communication and data exchange between different types of IoT devices is increasing day by day.To solve the problems of diversity and ...With the vigorous development of Internet of Things(IoT)technology,the demand for communication and data exchange between different types of IoT devices is increasing day by day.To solve the problems of diversity and complexity of communication protocols between devices,this paper proposes a design scheme of a multi-connector IoT central gateway based on Raspberry Pi and Docker.Through the research and application of related technologies,by integrating multiple communication interfaces and utilizing containerization technology,an efficient,flexible,and scalable IoT central gateway has been realized,which can support the connection and data interaction of multiple communication protocols and provide strong support for the stable operation and development of the IoT system.展开更多
文摘The umbrella term"neurodege ne rative disorders"(NDDs) refers to several conditions characterized by a progressive loss of structure and function of cells belonging to the nervous system.Such diseases affect more than 50million people worldwide.Neurodegenerative disorders are characterized by sundry factors and pathophysiological mechanisms that a re challenging to be fully profiled.Many of these rely on cell signaling pathways to preserve homeostasis,involving second messengers such as cyclic adenosine monophosphate (cAMP)and cyclic guanosine 3',5'-monophosphate(cGMP).Their ability to control the duration and amplitude of the signaling cascade is given by the presence of several common and uncommon effectors.Protein kinases A and G (PKA and PKG),phosphodiesterases (PDEs),and scaffold proteins are among them.
基金supported by the Fundamental Research Fundsfor the Central Universities under Grant No.ZYGX2015J009the Sichuan Province Scientific and Technological Support Project under Grants No.2014GZ0017 and No.2016GZ0093
文摘In data centers, the transmission control protocol(TCP) incast causes catastrophic goodput degradation to applications with a many-to-one traffic pattern. In this paper, we intend to tame incast at the receiver-side application. Towards this goal, we first develop an analytical model that formulates the incast probability as a function of connection variables and network environment settings. We combine the model with the optimization theory and derive some insights into minimizing the incast probability through tuning connection variables related to applications. Then,enlightened by the analytical results, we propose an adaptive application-layer solution to the TCP incast.The solution equally allocates advertised windows to concurrent connections, and dynamically adapts the number of concurrent connections to the varying conditions. Simulation results show that our solution consistently eludes incast and achieves high goodput in various scenarios including the ones with multiple bottleneck links and background TCP traffic.
文摘This ancient city has a history going back over 2,000 years.It has witnessed the fusion of multiple ethnic cultures including the Miao,Dong,and Han,and hosts a number of cultural heritage sites.THE old town of Zhenyuan is located in Zhenyuan County,Qiandongnan Miao and Dong Autonomous Prefecture in southwest China’s Guizhou Province.Covering an area of just around three square kilometers,it sits on the banks of the Wuyang River and is surrounded by mountains.Zhenyuan has been a county for more than 2,281 years and was the prefectural capital during the Yuan(1271-1368)and Qing(1644-1911)dynasties.It is a multicultural region,with Miao,Dong,and other ethnic minorities making up nearly half of the population.
文摘With the vigorous development of Internet of Things(IoT)technology,the demand for communication and data exchange between different types of IoT devices is increasing day by day.To solve the problems of diversity and complexity of communication protocols between devices,this paper proposes a design scheme of a multi-connector IoT central gateway based on Raspberry Pi and Docker.Through the research and application of related technologies,by integrating multiple communication interfaces and utilizing containerization technology,an efficient,flexible,and scalable IoT central gateway has been realized,which can support the connection and data interaction of multiple communication protocols and provide strong support for the stable operation and development of the IoT system.
