The Great Mosque of Tlemcen is a unique case,as it is one of the few mosques dating back to the Almoravid period that is almost intact.It has evolved in a constantly changing space and now has a conjoined public squar...The Great Mosque of Tlemcen is a unique case,as it is one of the few mosques dating back to the Almoravid period that is almost intact.It has evolved in a constantly changing space and now has a conjoined public square,following an occidental configuration,which is quite rare.The size of this square suggests that it could be put to use as an additional vector for the valorisation of the mosque,but the current situation is different.This added space,introduced by occidental culture,creates a dual architectural language with several other buildings that mark all the layers of evolution in the urban fabric.Apart from its religious function,this mosque used to play the role of a covered public square,a role that has eroded over time.The aim of this research is to analyse the relationship between the building and its surroundings,as well as the population’s perception of this relationship.Additionally,the research is intended to highlight changes in the perception of the Great Mosque of Tlemcen’s public square over time,depending on historical,political,and social contexts.This research relies on an approach that combines different methods,including a thorough analysis of historical,cartographic,and legislative documents.Through this approach,we were able to conduct a comparative analysis with other similar cases.Finally,field research allowed us to understand the relationship between space and society.Despite the legal recognition of the surroundings as a historical monument,this status is not widely perceived and integrated into the population’s sense of heritage space.This is reflected in private and even public actions,despite the instrumentalisation of this heritage status,with appropriations of protected space that occur outside of regulations and become part of the landscape expression of the building in its environment.展开更多
The paper addresses the issue of how residual spaces are intervened upon through formal and informal processes.It argues that a profound understanding for the dynamics of informal interventions,denoted by appropriatio...The paper addresses the issue of how residual spaces are intervened upon through formal and informal processes.It argues that a profound understanding for the dynamics of informal interventions,denoted by appropriation,could enhance the performance of their formal peers.Adopting a qualitative approach,the paper departs from Lefebvre's unitary theory of space and arrives at an analytical framework that helps to understand the appropriation processes in residual spaces.It,then,attempts to empirically challenge the applicability of this framework through analyzing a Cairene residual space that has undergone two cycles of intervention:a formal and informal one.展开更多
Background: Workers spend a significant amount of time in the workspace. Involvement of a spouse in a doctor’s workplace can take different forms and come with different intentions. Objectives: The survey aimed to de...Background: Workers spend a significant amount of time in the workspace. Involvement of a spouse in a doctor’s workplace can take different forms and come with different intentions. Objectives: The survey aimed to determine the prevalence and extent of spousal involvement in physicians’ workplaces as well as the outcome of such involvement on doctor’ swell-being, productivity, and relationship with colleagues. Methods: This cross-sectional online survey on spousal involvement in the workplace of doctors was conducted among 83 responding doctors from July to August 2023. Results: Among the respondents, 60 (72.3%) had witnessed a doctor’s spouse being involved in the workplace. The most common reason for spousal involvement in the workplace was to protect the spouse from what they perceived as a threat 34 (54.0%). Spouse’s ignorance of boundaries in the workplace (OR: 6.09 (95% CI: 1.70, 21.79) P: 0.003) and exertion of control by the spouse (OR: 11.2 (95% CI: 2.26, 56.41) P: 0.002) were significantly associated with higher odds of inappropriate spousal involvement in the workplace, while expression of love for spouse with acts of kindness was significantly associated with a lowered odd of inappropriate spousal involvement (OR: 0.11 (95% CI: 0.03, 0.36) P: 0.0001). Conclusion: Spousal involvement in the workplace is relatively common. Ignorance of the boundaries of the workplace and exertion of control by the spouse were significant enablers of inappropriate spousal involvement in the workplace of doctors. The establishment of workplace policies that define the limits of spousal involvement in the doctor’s workplace can foster a healthy workspace environment, enhance doctors’ well-being, and improve patient care.展开更多
Background: Use of inappropriate amikacin dose is one of the most important factors in inducing toxicity, prolonged hospitalization as well as in increasing patient’s mortality. Objective: The aims of this study are ...Background: Use of inappropriate amikacin dose is one of the most important factors in inducing toxicity, prolonged hospitalization as well as in increasing patient’s mortality. Objective: The aims of this study are the analysis of amikacin dose, serum level and the examination of the effectiveness of the clinical pharmacologist (CP) therapeutic drug monitoring (TDM) intervention to guarantee the safety of amikacin use. Methods: This is a one-year retrospective observational chart review study, which evaluates amikacin dose, serum drug level, development of adverse effects in patients on amikacin with or without CP TDM consultation. Results: Amikacin was prescribed for 393 complex patients, with median age 83. Amikacin group (AG) included 140 (32%) courses with CP consultation (AG1) and 292 (68%) courses without CP consultation (AG2). The distribution of most study characteristics in both groups was similar including amikacin dose (9-10 mg/kg/day), renal failure (14%) and mortality (12%). Acceptance for CP consultation was in 46% of amikacin courses and dose changes were done in 63% after CP intervention. Prolonged antibiotic course (4.6 ± 1.5 vs 3.8 ± 1.6 days, p < 0.0001) and the patient’s hemodynamic instability (15% vs 7%, p = 0.01) were more frequent in the AG1 compared to the AG2. There was a strong association between CP consultation and prolonged hospitalization (p = 0.005), while no association between it and amikacin adverse effects, renal failure or mortality. Conclusions: There was no trend to reducing amikacin toxicity, days of hospitaliza tion or mortality in patients with CP consultation. CP TDM intervention was more in the management of complicated clinical situations. However, it is necessary to optimize it.展开更多
In the transition from "made in China" to "invented in China," what is the motivation of Chinese firms in applying for patents? Why do some firms bypass patents? How is patenting developing within Chinese firms...In the transition from "made in China" to "invented in China," what is the motivation of Chinese firms in applying for patents? Why do some firms bypass patents? How is patenting developing within Chinese firms? This paper attempts to answer these questions using data of Chinese firms in the Yangtze River Delta region. Results indicate that, for product innovation, obtaining the lead time for market entry is of top priority in innovation protection, followed by confidentiality and patent protection. As for process innovation, confidentiality ranks first, followed by patent protection and obtaining the lead time. There is a significant and positive relationship between prior experience of patent licensing and possibility of future patent licensing. Firms with painful patent litigation experience tend to avoid it in the future. It is also found that there are great differences in patent behaviors between Chinese enterprises and their foreign counterparts.展开更多
Purpose: This study aimed to develop teaching materials to prevent the dangers of ablution and bathing infants, based on the dangerous experiences of mothers and family members, and examine their appropriateness. Meth...Purpose: This study aimed to develop teaching materials to prevent the dangers of ablution and bathing infants, based on the dangerous experiences of mothers and family members, and examine their appropriateness. Methods: A total of 20 midwives and public health nurses were selected as participants. Teaching materials and anonymous self-administered questionnaires were distributed, and the participants were asked to view the teaching materials and fill in the questionnaires. Retrieval was done by mail. The teaching materials included digital content, such as videos, sounds, and characters, which incorporated dangerous situations, preventions, and innovations in ablution and bathing procedures. The analysis was conducted by simple tabulation for each survey item. The free description was coded to preserve anonymity. This study was conducted with the approval of the Research Ethics Review Board of the authors’ affiliated university. Results: The teaching materials were found to be appropriate in terms of suitability to purpose, degree of difficulty of content, ease of viewing the videos, validity of time, appropriateness of expression, and usability. Conclusions: Ablution teaching materials that are used at the present time do not focus on dangers, and to date, no resources on bathing have been used as teaching materials. The created teaching materials in this study can be viewed multiple times, and mothers and family members who are unfamiliar with ablution and bathing can acquire knowledge regarding dangers and danger prevention. The addition of specific preventive measures and countermeasures for the occurrence of danger, along with practice, would result in the development of further appropriate teaching materials to reduce danger and alleviate anxiety.展开更多
CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role...CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.展开更多
One of the practical approaches in identifying structures is the non-linear resonant decay method which identifies a non-linear dynamic system utilizing a model based on linear modal space containing the underlying li...One of the practical approaches in identifying structures is the non-linear resonant decay method which identifies a non-linear dynamic system utilizing a model based on linear modal space containing the underlying linear system and a small number of extra terms that exhibit the non-linear effects.In this paper,the method is illustrated in a simulated system and an experimental structure.The main objective of the non-linear resonant decay method is to identify the non-linear dynamic systems based on the use of a multi-shaker excitation using appropriated excitation which is obtained from the force appropriation approach.The experimental application of the method is indicated to provide suitable estimates of modal parameters for the identification of non-linear models of structures.展开更多
Creation of human landscape is the important component of highway landscape design,which has incomparable advantage in the aspects of transmitting cultural atmosphere and expressing regional features.It can not only b...Creation of human landscape is the important component of highway landscape design,which has incomparable advantage in the aspects of transmitting cultural atmosphere and expressing regional features.It can not only beautify highway environment,but also serve for traffic function.It is another effective approach to ensure traffic safety.The paper has analyzed existing problems and insufficiencies of modern highway human construction,and discussed the means and methods of expression of historical humanized landscape in highway landscape design.The paper has considered that during design of highway human landscape,it should fully explore historical and humanized background along the highway,extract cultural spirit,enrich cultural connotation,and oppose coarse and fictitious design on the basis of respecting culture and history.展开更多
This paper is on the Chinese-English advertisement translation. It gives people an orderly discussion with examples in three parts:the problems in current advertisement translation, the causes of these problems, essen...This paper is on the Chinese-English advertisement translation. It gives people an orderly discussion with examples in three parts:the problems in current advertisement translation, the causes of these problems, essential steps of making the Chinese-English translation of advertisement onto an appropriate way. This paper also suggests the principles of Chinese-English advertisement translation:natural, precise and understandable.展开更多
Krashen's affective filter theory drew researchers' attention to the fresh field of internal factors of learners.But researchers seem to pay too much attention to the other factors while tending to neglect a f...Krashen's affective filter theory drew researchers' attention to the fresh field of internal factors of learners.But researchers seem to pay too much attention to the other factors while tending to neglect a factor that we cannot afford to play down in language learning research-self-confidence.This paper is designed to discuss the close relationship between self-confidence and some of the other important affective factors,and furthermore raise appropriate concern over self-confidence.展开更多
Education is a complex system that has evolved over thousands of years to reach its current level.It has many objects and subjects.The education systems of the countries are very diverse.Almost every country has its o...Education is a complex system that has evolved over thousands of years to reach its current level.It has many objects and subjects.The education systems of the countries are very diverse.Almost every country has its own ranking approach,because there is no universally accepted scientific theory of education.The search for effective reform in education continues today,but any reform that is not based on scientific theory cannot solve the problem.There are many problems in the content and management of education.Knowledge assessment is also flawed.No country can build an ideal school.It can be considered that in the last hundred years,education has not developed conceptually in the desired direction.Thus,education aims to train strong personalities,not perfect(wise)people.Although individualistic education may seem beneficial locally,globally it divides humanity and prevents its sustainable and harmonious living.However,in societies made up of perfect people,in principle there will be no division,harmony will exist,because perfect people solve problems not by force,but by reason,prefer cooperation rather than conflict.This means protecting the planet.To make the world a gun-free society,the view of education must change conceptually.This article presents a new philosophical view of teaching knowledge and proposes a new model,criteria,and theory.展开更多
Appropriateness is very important in oral communication.By analyzing the problems in oral communication,this article puts forward some efficient ways to raise college students’awareness of appropriateness in oral com...Appropriateness is very important in oral communication.By analyzing the problems in oral communication,this article puts forward some efficient ways to raise college students’awareness of appropriateness in oral communication.展开更多
Business English is a branch of ESP(English for specific Purpose),which determines its vocational and professional orient and its focus on learning for reality,work and professions,so applying real and authentic conte...Business English is a branch of ESP(English for specific Purpose),which determines its vocational and professional orient and its focus on learning for reality,work and professions,so applying real and authentic content in Business English teaching is suggested to be helpful both in theory and in practice.However,compared with other L2 skills teaching,to some points,listening input turns out to be problematic and uncertain in terms of utilization and selection of authentic listening materials currently.This article tries to present the problems and analyze to what extent these problems can be tackled by suggesting some appropriate listening materials.展开更多
文摘The Great Mosque of Tlemcen is a unique case,as it is one of the few mosques dating back to the Almoravid period that is almost intact.It has evolved in a constantly changing space and now has a conjoined public square,following an occidental configuration,which is quite rare.The size of this square suggests that it could be put to use as an additional vector for the valorisation of the mosque,but the current situation is different.This added space,introduced by occidental culture,creates a dual architectural language with several other buildings that mark all the layers of evolution in the urban fabric.Apart from its religious function,this mosque used to play the role of a covered public square,a role that has eroded over time.The aim of this research is to analyse the relationship between the building and its surroundings,as well as the population’s perception of this relationship.Additionally,the research is intended to highlight changes in the perception of the Great Mosque of Tlemcen’s public square over time,depending on historical,political,and social contexts.This research relies on an approach that combines different methods,including a thorough analysis of historical,cartographic,and legislative documents.Through this approach,we were able to conduct a comparative analysis with other similar cases.Finally,field research allowed us to understand the relationship between space and society.Despite the legal recognition of the surroundings as a historical monument,this status is not widely perceived and integrated into the population’s sense of heritage space.This is reflected in private and even public actions,despite the instrumentalisation of this heritage status,with appropriations of protected space that occur outside of regulations and become part of the landscape expression of the building in its environment.
文摘The paper addresses the issue of how residual spaces are intervened upon through formal and informal processes.It argues that a profound understanding for the dynamics of informal interventions,denoted by appropriation,could enhance the performance of their formal peers.Adopting a qualitative approach,the paper departs from Lefebvre's unitary theory of space and arrives at an analytical framework that helps to understand the appropriation processes in residual spaces.It,then,attempts to empirically challenge the applicability of this framework through analyzing a Cairene residual space that has undergone two cycles of intervention:a formal and informal one.
文摘Background: Workers spend a significant amount of time in the workspace. Involvement of a spouse in a doctor’s workplace can take different forms and come with different intentions. Objectives: The survey aimed to determine the prevalence and extent of spousal involvement in physicians’ workplaces as well as the outcome of such involvement on doctor’ swell-being, productivity, and relationship with colleagues. Methods: This cross-sectional online survey on spousal involvement in the workplace of doctors was conducted among 83 responding doctors from July to August 2023. Results: Among the respondents, 60 (72.3%) had witnessed a doctor’s spouse being involved in the workplace. The most common reason for spousal involvement in the workplace was to protect the spouse from what they perceived as a threat 34 (54.0%). Spouse’s ignorance of boundaries in the workplace (OR: 6.09 (95% CI: 1.70, 21.79) P: 0.003) and exertion of control by the spouse (OR: 11.2 (95% CI: 2.26, 56.41) P: 0.002) were significantly associated with higher odds of inappropriate spousal involvement in the workplace, while expression of love for spouse with acts of kindness was significantly associated with a lowered odd of inappropriate spousal involvement (OR: 0.11 (95% CI: 0.03, 0.36) P: 0.0001). Conclusion: Spousal involvement in the workplace is relatively common. Ignorance of the boundaries of the workplace and exertion of control by the spouse were significant enablers of inappropriate spousal involvement in the workplace of doctors. The establishment of workplace policies that define the limits of spousal involvement in the doctor’s workplace can foster a healthy workspace environment, enhance doctors’ well-being, and improve patient care.
文摘Background: Use of inappropriate amikacin dose is one of the most important factors in inducing toxicity, prolonged hospitalization as well as in increasing patient’s mortality. Objective: The aims of this study are the analysis of amikacin dose, serum level and the examination of the effectiveness of the clinical pharmacologist (CP) therapeutic drug monitoring (TDM) intervention to guarantee the safety of amikacin use. Methods: This is a one-year retrospective observational chart review study, which evaluates amikacin dose, serum drug level, development of adverse effects in patients on amikacin with or without CP TDM consultation. Results: Amikacin was prescribed for 393 complex patients, with median age 83. Amikacin group (AG) included 140 (32%) courses with CP consultation (AG1) and 292 (68%) courses without CP consultation (AG2). The distribution of most study characteristics in both groups was similar including amikacin dose (9-10 mg/kg/day), renal failure (14%) and mortality (12%). Acceptance for CP consultation was in 46% of amikacin courses and dose changes were done in 63% after CP intervention. Prolonged antibiotic course (4.6 ± 1.5 vs 3.8 ± 1.6 days, p < 0.0001) and the patient’s hemodynamic instability (15% vs 7%, p = 0.01) were more frequent in the AG1 compared to the AG2. There was a strong association between CP consultation and prolonged hospitalization (p = 0.005), while no association between it and amikacin adverse effects, renal failure or mortality. Conclusions: There was no trend to reducing amikacin toxicity, days of hospitaliza tion or mortality in patients with CP consultation. CP TDM intervention was more in the management of complicated clinical situations. However, it is necessary to optimize it.
文摘In the transition from "made in China" to "invented in China," what is the motivation of Chinese firms in applying for patents? Why do some firms bypass patents? How is patenting developing within Chinese firms? This paper attempts to answer these questions using data of Chinese firms in the Yangtze River Delta region. Results indicate that, for product innovation, obtaining the lead time for market entry is of top priority in innovation protection, followed by confidentiality and patent protection. As for process innovation, confidentiality ranks first, followed by patent protection and obtaining the lead time. There is a significant and positive relationship between prior experience of patent licensing and possibility of future patent licensing. Firms with painful patent litigation experience tend to avoid it in the future. It is also found that there are great differences in patent behaviors between Chinese enterprises and their foreign counterparts.
文摘Purpose: This study aimed to develop teaching materials to prevent the dangers of ablution and bathing infants, based on the dangerous experiences of mothers and family members, and examine their appropriateness. Methods: A total of 20 midwives and public health nurses were selected as participants. Teaching materials and anonymous self-administered questionnaires were distributed, and the participants were asked to view the teaching materials and fill in the questionnaires. Retrieval was done by mail. The teaching materials included digital content, such as videos, sounds, and characters, which incorporated dangerous situations, preventions, and innovations in ablution and bathing procedures. The analysis was conducted by simple tabulation for each survey item. The free description was coded to preserve anonymity. This study was conducted with the approval of the Research Ethics Review Board of the authors’ affiliated university. Results: The teaching materials were found to be appropriate in terms of suitability to purpose, degree of difficulty of content, ease of viewing the videos, validity of time, appropriateness of expression, and usability. Conclusions: Ablution teaching materials that are used at the present time do not focus on dangers, and to date, no resources on bathing have been used as teaching materials. The created teaching materials in this study can be viewed multiple times, and mothers and family members who are unfamiliar with ablution and bathing can acquire knowledge regarding dangers and danger prevention. The addition of specific preventive measures and countermeasures for the occurrence of danger, along with practice, would result in the development of further appropriate teaching materials to reduce danger and alleviate anxiety.
文摘CDMOs are emerging as critical drivers of innovation within the pharmaceutical and biotech industries. As the pharmaceutical industry continues to evolve, we can expect to see CDMOs play an increasingly important role in drug development and manufacturing. Many companies within these sectors are now leveraging the expertise of CDMOs through technology transfers to foster innovation and enhance the development of new drug products. In the extensive field of drug development, technology transfer plays a crucial role at multiple stages, ranging from preclinical phases to commercialization. By working closely with drug developers, CDMOs can ensure that technologies are transferred seamlessly between phases of drug development, allowing for a more efficient and cost-effective development process. CDMOs also bring a wealth of experience in various areas of drug development, including process development, analytical testing, quality control, and manufacturing. This expertise, combined with a focus on innovation, can help drug developers to overcome technical challenges and optimize their drug development programs. CDMOs can provide drug developers with various manufacturing capabilities, from small-scale clinical trials to large-scale commercial production. This flexibility allows drug developers to focus on their core competencies while relying on CDMOs to provide the necessary infrastructure and support for drug manufacturing. The critical role of CDMOs in advancing pharmaceutical innovation in phase-appropriate technology transfer where there will be a lot of effort and patience with strong technical expertise is required. This article explores the various types of Technology transfer from preclinical to commercial stages and successful strategies to foster innovation.
文摘One of the practical approaches in identifying structures is the non-linear resonant decay method which identifies a non-linear dynamic system utilizing a model based on linear modal space containing the underlying linear system and a small number of extra terms that exhibit the non-linear effects.In this paper,the method is illustrated in a simulated system and an experimental structure.The main objective of the non-linear resonant decay method is to identify the non-linear dynamic systems based on the use of a multi-shaker excitation using appropriated excitation which is obtained from the force appropriation approach.The experimental application of the method is indicated to provide suitable estimates of modal parameters for the identification of non-linear models of structures.
文摘Creation of human landscape is the important component of highway landscape design,which has incomparable advantage in the aspects of transmitting cultural atmosphere and expressing regional features.It can not only beautify highway environment,but also serve for traffic function.It is another effective approach to ensure traffic safety.The paper has analyzed existing problems and insufficiencies of modern highway human construction,and discussed the means and methods of expression of historical humanized landscape in highway landscape design.The paper has considered that during design of highway human landscape,it should fully explore historical and humanized background along the highway,extract cultural spirit,enrich cultural connotation,and oppose coarse and fictitious design on the basis of respecting culture and history.
文摘This paper is on the Chinese-English advertisement translation. It gives people an orderly discussion with examples in three parts:the problems in current advertisement translation, the causes of these problems, essential steps of making the Chinese-English translation of advertisement onto an appropriate way. This paper also suggests the principles of Chinese-English advertisement translation:natural, precise and understandable.
文摘Krashen's affective filter theory drew researchers' attention to the fresh field of internal factors of learners.But researchers seem to pay too much attention to the other factors while tending to neglect a factor that we cannot afford to play down in language learning research-self-confidence.This paper is designed to discuss the close relationship between self-confidence and some of the other important affective factors,and furthermore raise appropriate concern over self-confidence.
文摘Education is a complex system that has evolved over thousands of years to reach its current level.It has many objects and subjects.The education systems of the countries are very diverse.Almost every country has its own ranking approach,because there is no universally accepted scientific theory of education.The search for effective reform in education continues today,but any reform that is not based on scientific theory cannot solve the problem.There are many problems in the content and management of education.Knowledge assessment is also flawed.No country can build an ideal school.It can be considered that in the last hundred years,education has not developed conceptually in the desired direction.Thus,education aims to train strong personalities,not perfect(wise)people.Although individualistic education may seem beneficial locally,globally it divides humanity and prevents its sustainable and harmonious living.However,in societies made up of perfect people,in principle there will be no division,harmony will exist,because perfect people solve problems not by force,but by reason,prefer cooperation rather than conflict.This means protecting the planet.To make the world a gun-free society,the view of education must change conceptually.This article presents a new philosophical view of teaching knowledge and proposes a new model,criteria,and theory.
文摘Appropriateness is very important in oral communication.By analyzing the problems in oral communication,this article puts forward some efficient ways to raise college students’awareness of appropriateness in oral communication.
文摘Business English is a branch of ESP(English for specific Purpose),which determines its vocational and professional orient and its focus on learning for reality,work and professions,so applying real and authentic content in Business English teaching is suggested to be helpful both in theory and in practice.However,compared with other L2 skills teaching,to some points,listening input turns out to be problematic and uncertain in terms of utilization and selection of authentic listening materials currently.This article tries to present the problems and analyze to what extent these problems can be tackled by suggesting some appropriate listening materials.