ESMO2023:恩扎卢胺联合雄激素剥夺治疗对比安慰剂联合雄激素剥夺治疗在中国转移性激素敏感性前列腺癌患者中的疗效和安全性(中国ARCHES)

2019年发表的全球ARCHES试验(NCT02677896)结果显示,与安慰剂(placebo,PBO)+雄激素剥夺治疗(androgen deprivation therapy,ADT)相比,恩扎卢胺+ADT延长了转移性激素敏感性前列腺癌(metastatic hormone-sensitive prostate cancer,mHSPC)患者的总生存期和放射影像学无进展生存期(radiographic progression-free survival,rPFS)^([1])。然而,该试验无中国患者入组。欧洲肿瘤内科学会(European Society for Medical Oncology,ESMO)2023年会议报道了中国ARCHES研究(NCT04076059)的初步结果,这是一项评估恩扎卢胺+ADTvs.PBO+ADT在中国m HSPC患者中的疗效和安全性的多中心、随机、双盲、PBO对照的Ⅲ期试验^([2])。

Health diagnosis of ultrahigh arch dam performance using heterogeneous spatial panel vector model

Currently,more than ten ultrahigh arch dams have been constructed or are being constructed in China.Safety control is essential to long-term operation of these dams.This study employed the flexibility coefficient and plastic complementary energy norm to assess the structural safety of arch dams.A comprehensive analysis was conducted,focusing on differences among conventional methods in characterizing the structural behavior of the Xiaowan arch dam in China.Subsequently,the spatiotemporal characteristics of the measured performance of the Xiaowan dam were explored,including periodicity,convergence,and time-effect characteristics.These findings revealed the governing mechanism of main factors.Furthermore,a heterogeneous spatial panel vector model was developed,considering both common factors and specific factors affecting the safety and performance of arch dams.This model aims to comprehensively illustrate spatial heterogeneity between the entire structure and local regions,introducing a specific effect quantity to characterize local deformation differences.Ultimately,the proposed model was applied to the Xiaowan arch dam,accurately quantifying the spatiotemporal heterogeneity of dam performance.Additionally,the spatiotemporal distri-bution characteristics of environmental load effects on different parts of the dam were reasonably interpreted.Validation of the model prediction enhances its credibility,leading to the formulation of health diagnosis criteria for future long-term operation of the Xiaowan dam.The findings not only enhance the predictive ability and timely control of ultrahigh arch dams'performance but also provide a crucial basis for assessing the effectiveness of engineering treatment measures.

Numerical Simulation Analysis of Welded Joints in Arch Ribs of Large Span Steel Pipe Arch Bridges

In order to study the residual stress distribution law of welded joints of arch ribs of large-span steel pipe concrete arch bridges,numerical simulation of temperature,stress and strain fields based on ABAQUS for welded joints of arch-ribbed steel tubes using 7-,8-and 9-layer welds is carried out and its accuracy is demonstrated.The steel pipe welding temperature changes,residual stress distribution,different processes residual stress changes in the law,the prediction of post-weld residual stress distribution and deformation are studied in this paper.The results show that the temperature field values and test results are more consistent with the accuracy of numerical simulation of welding,the welding process is mainly in the form of heat transfer;Residual high stresses are predominantly distributed in the Fusion zone(FZ)and Heat-affected zone(HAZ),with residual stress levels tending to decrease from the center of the weld along the axial path,the maximum stress appears in the FZ and HAZ junction;The number of welding layers has an effect on the residual stress distribution,the number of welding layers increases,the residual stress tends to decrease,while the FZ and HAZ high stress area range shrinks;Increasing the number of plies will increase the amount of residual distortion.

Effects of comprehensive nursing with cognitive behavioral therapy in orthodontic osteodilated arch treatment

BACKGROUND This work explored the effects of cognitive behavior therapy(CBT)-based comprehensive nursing intervention(CNI)mode in arch expansion to treat patients with orthodontic osteodilated arch(OOA).AIM To explore the application effect of CBT-based CNI model in orthodontic expansion arch treatment.METHODS Using convenient sampling method,81 patients with OOA were selected and rolled into a control group(Ctrl group,40 cases)and an observation group(Obs group,41 cases).During the treatment,patients in the Ctrl group received routine nursing intervention mode,and the those in the Obs group received CBT mode on the basis of this.Before and after intervention,the incidence of oral mucositis,the mastery rate of correct arch expansion method,self-rating anxiety scale score,soft scale index,and plaque index were compared for patients in different groups.In addition,satisfaction and complications were comparatively analyzed.RESULTS Incidence of oral mucositis in the Obs group was lower(14.6%vs 38.5%),and the mastery rate of correct arch expansion method was obviously higher(90.2%vs 55.0%)was obviously higher(all P<0.05).Meanwhile,the soft scale index and plaque index in the Obs group were much lower(P<0.05).The compliance(90.24%)and satisfaction(95.12%)in the Obs group were greatly higher(P<0.05).CONCLUSION The CBT-based CNI mode greatly improved the mastery rate of correct arch expansion method during arch expansion in treating patients with OOA and enhanced the therapeutic effect of arch expansion and the oral health of patients,improving the patient compliance.

基于SARIMA-ARCH的电量预测模型

电量预测是供电单位购电的重要依据,是电力经济稳定运行的根本基础。提出采用SARIMA-ARCH融合模型对某地区售电量进行预测。首先,采用季节时间序列分析方法(SARIMA)对月度电量时间序列进行建模,通过ACF和PACF图筛选确定出最佳模型阶数,得到季节性时间序列模型(SARIMA)基础预测模型;提取模型残差的波动性,建立自回归条件异方差(ARCH)模型;最后,将SARIMA-ARCH模型与常规SRIAM和ARIMA的预测值进行对比分析。结果表明,SARIMAARCH混合模型的预测精度较高。

An analytical solution for evaluating the safety of an exposed face in a paste backfill stope incorporating the arching phenomenon

In current underground mining, the stability of the exposed backfill face is a basic issue associated with mining design and has been the subject of considerable research in mining safety and efficiency. In this study, an improved analytical solution for evaluating the safety of vertically exposed faces in backfilling was proposed. Based on a differential slice method, the proposed solution emphasizes the arching effect as having the advantages of more rigor and wider scalability. Feasibility of the proposed solution was validated with classic centrifuge results. Good agreement between compared results indicated that the proposed solution skillfully predicts the behavior of the paste centrifuge model. Additionally, calculation of exposed face safety in sequential filling was presented. The proposed solution has practical significance in mine backfill design.

Seismic behavior of concrete filled steel tubular arch structures

Shaking table tests of a 1:10 scale arch model performed to investigate the seismic behavior and resistance of concrete filled steel tubular (CFT) arch structures are described in this paper. The El-Centro record and Shanghai artificial wave were adopted as the input excitation. The entire test process can be divided into three stages depending on the lateral brace configurations, i.e., fully (five) braced, two braces removed, and all braces removed. A total of 46 tests, starting from the elastic state to failure condition, have been conducted. The natural vibration frequencies, responses of acceleration, displacement and strain were measured. From the test results, it is demonstrated that the CFT arch structures are capable of resisting severe ground motions and that CFT arches offer a credible alternative to reinforced concrete arches, especially in regions of high seismic intensity.

Mechanical properties and influence mechanism of confined concrete arches in high-stress tunnels

Deep underground projects(e.g., coal mines), are often faced with complex conditions such as high stress and extremely soft rock. The strength and rigidity of the traditional support system are often insufficient,which makes it difficult to meet the requirements of ground control under complex conditions. As a new support form with high strength and rigidity, the confined concrete arch plays an important role in controlling the rock deformation under complex conditions. The section shape of the tunnel has an important impact on the mechanical properties and design of the support system. However, studies on the mechanical properties and influence mechanism of the new confined concrete arch are rarely reported. To this end, the mechanical properties of traditional U-shaped steel and new confined concrete arches are compared and comparative tests on arches of circular and straight-leg semicircular shapes in deep tunnels are conducted. A large mechanical testing system for underground engineering support structure is developed. The mechanical properties and influence mechanism of confined concrete arches with different section shapes under different loading modes and cross-section parameters are systematically studied. Test results show that the bearing capacity of the confined concrete arch is 2.10 times that of the U-shaped steel arch, and the bearing capacity of the circular confined concrete arch is 2.27 times that of the straight-leg semicircular arch. Among the various influencing factors and their engineering parameters,the lateral stress coefficient has the greatest impact on the bearing capacity of the confined concrete arch,followed by the steel pipe wall thickness, steel strength, and core concrete strength. Subsequently, the economic index of bearing capacity and cost is established, and the optimization design method for the confined concrete arch is proposed. Finally, this design method is applied to a high-stress tunnel under complex conditions, and the deformation of the surrounding rock is effectively controlled.

Deformation critical threshold estimation of Xiaowan ultrahigh arch dam with time-varying grey model

The structural behavior of the Xiaowan ultrahigh arch dam is primarily influenced by external loads and time-varying characteristics of dam concrete and foundation rock mass during long-term operation. According to overload testing with a geological model and the measured time series of installed perpendicular lines, the space and time evolution characteristics of the arch dam structure were analyzed, and its mechanical performance was evaluated. Subsequently, the deformation centroid of the deflective curve was suggested to indicate the magnitude and unique distribution rules for a typical dam section using the measured deformation values at multi-monitoring points. The ellipse equations of the critical ellipsoid for the centroid were derived from the historical measured time series. Hydrostatic and seasonal components were extracted from the measured deformation values with a traditional statistical model, and residuals were adopted as a grey component. A time-varying grey model was developed to accurately predict the evolution of the deformation behavior of the ultrahigh arch dam during future operation. In the developed model, constant coefficients were modified so as to be time-dependent functions, and the prediction accuracy was significantly improved through introduction of a forgetting factor. Finally, the critical threshold was estimated, and predicted ellipsoids were derived for the Xiaowan arch dam. The findings of this study can provide technical support for safety evaluation of the actual operation of ultrahigh arch dams and help to provide early warning of abnormal changes.

Structural Damage Identification System Suitable for Old Arch Bridge in Rural Regions: Random Forest Approach

A huge number of old arch bridges located in rural regions are at the peak of maintenance.The health monitoring technology of the long-span bridge is hardly applicable to the small-span bridge,owing to the absence of technical resources and sufficient funds in rural regions.There is an urgent need for an economical,fast,and accurate damage identification solution.The authors proposed a damage identification system of an old arch bridge implemented with amachine learning algorithm,which took the vehicle-induced response as the excitation.A damage index was defined based on wavelet packet theory,and a machine learning sample database collecting the denoised response was constructed.Through comparing three machine learning algorithms:Back-Propagation Neural Network(BPNN),Support Vector Machine(SVM),and Random Forest(R.F.),the R.F.damage identification model were found to have a better recognition ability.Finally,the Particle Swarm Optimization(PSO)algorithm was used to optimize the number of subtrees and split features of the R.F.model.The PSO optimized R.F.model was capable of the identification of different damage levels of old arch bridges with sensitive damage index.The proposed framework is practical and promising for the old bridge’s structural damage identification in rural regions.

Improved super-elastic Ti–Ni alloy wire intrusion arch for skeletal class Ⅱ malocclusion combined with deep overbite:A case report

BACKGROUND Treatment for deep overbite cases can be difficult. This case report presents some techniques with improved super-elastic Ti–Ni alloy wire(ISW) for deep overbite correction.CASE SUMMARY A 21-year-old woman had a chief complaint of flaring maxillary teeth. Orthodontic evaluation revealed a skeletal class Ⅱ malocclusion and a convex profile appearance. A deep overbite with palatal impingement and large overjet were also noted. Bilateral maxillary first premolars were extracted, and spaces were closed using a closed-coil spring and elastic chain. The deep overbite was corrected by applying the ISW curve and ISW intrusion arch. Intermaxillary elastics was used to adjust the intermaxillary relationship. Active treatment took approximately 3 years, and the appearance and dentition alignment noticeably improved.CONCLUSION The use of the ISW technique in a case of skeletal class Ⅱ malocclusion with deep overbite achieved a desirable result, and the patient was satisfied with the treatment outcome.

基于ARCH族模型的石油价格波动性分析

随着中国成为世界第二大经济实体,能源在经济发展方面的重要地位也与日俱增,石油价格的波动牵动着全球经济的“神经”,会对经济发展产生极大的影响,因此降低石油价格波动所产生风险非常必要。本文以1987~2021年WTI原油价格为原始数据,利用ARCH族模型对油价波动进行实证分析,研究表明石油价格波动具有肥尾分布和波动率聚类的特征且具有均值回归的倾向,当面对“黑天鹅事件”时能够以较快的速度减小危机带来的冲击,从而得出石油价格波动在突发情形下具有较大弹性的一般结论,并基于此提出完善市场机制作为主要政策实施方向和发展石油期货期权等衍生产品的政策建议,从而减小经济发展的不确定性风险。

基于ARCH类模型的农产品价格波动特征研究

基于2011年1月至2022年8月的月度价格指数,运用自回归条件异方差ARCH类模型对猪肉、牛肉、棉花、大豆、稻谷、羊肉六种农产品进行价格波动特征分析研究。结果表明:具有较为显著的ARCH效应是牛肉、大豆、猪肉、棉花这四种农产品;其中农产品价格具有波动集聚性特征的是牛肉、大豆、猪肉、棉花;牛肉、大豆、猪肉、棉花价格不具备高风险和高报酬的特征;农产品价格均具有非对称性是棉花、大豆、猪肉。基于研究分析结果,本文提出相关政策建议,为农产品市场价格调控提供参考。

Approach for analyzing the ultimate strength of concrete filled steel tubular arch bridges with stiffening girder

A convenient approach is proposed for analyzing the ultimate load carrying capacity of concrete filled steel tubular (CFST) arch bridge with stiffening girders. A fiber model beam element is specially used to simulate the stiffening girder and CFST arch rib. The geometric nonlinearity, material nonlinearity, influence of the construction process and the contribution of prestressing reinforcement are all taken into consideration. The accuracy of this method is validated by comparing its results with experimental results. Finally, the ultimate strength of an abnormal CFST arch bridge with stiffening girders is investigated and the effect of construction method is discussed. It is concluded that the construction process has little effect on the ultimate strength of the bridge.

In-Plane Creep Buckling of Concrete-Filled Steel Tubular Arches

The creep-induced deformation of the arch rib of concrete-filled steel tubular(CFST) arches under a sustained load can increase the bending moment, which may lead to earlier stability failure called creep buckling. To investigate the influences of concrete creep on the buckling strength of arches, a theoretical analysis for the creep buckling of CFST circular arches under distributed radial load is performed. The simplified Arutyunyan-Maslov(AM)creep law is used to model the creep behavior of concrete core, and the creep integral operator is introduced. The analytical solutions of the time-dependent buckling strength under the sustained load are achieved and compared with the existing formula based on the age-adjusted effective modulus method(AEMM). Then the solutions are used to determine the influences of the steel ratio and the first loading age on the creep buckling of CFST arches. The results show that the analytical solutions are of good accuracy and applicability. For CFST arches, the steel ratio and the first loading age have significant influences on creep buckling. An approximate log-linear relationship between the decreased degrees of the creep buckling strength and the first loading age is found. For the commonly used parameters, the maximum loss of the buckling strength induced by concrete creep is close to 40%.

基于马尔科夫转换ARCH模型的房地产市场波动研究——以房地产市场景气指数为例

近年来,我国房价波动较大,房地产投机现象时有发生。因此,研究房地产市场的运行规律,对于预测房价、防范房地产泡沫具有重要意义。本文研究了中国住房市场的波动状态。使用ARCH和GARCH模型来寻找房地产市场景气指数随时间变化的证据。然后利用马尔科夫转移模型(MS模型)连续分析2000年~2021年中国住房市场波动状态的动态。结果表明,中国住房市场存在低波动性、中波动性和高波动性三种状态。实证分析发现,2002年之前,房地产市场一直处于低波动状态,2002年以后,房地产市场在中波动状态和高波动状态来回转换,针对每一个波动拐点,也可以找到当年政府发布的与房地产市场相关的政策,这在一定程度也说明政府行为对房地产市场常起导向作用。本文以房地产市场景气指数为数据,运用EViews和MATLAB进行实践操作,对研究问题进行求解,目的是了解中国房地产市场的波动情况,判断房地产市场的稳定性,为相关房地产企业经营决策和政府部门的规范管理提供参考。

Dynamic soil arching in piled embankment under train load of high-speed railways

Piled embankments have many advantages that have been applied in high-speed railway construction engineering.However,the load transfer mechanism of piled embankments,such as soil arching and tension membranes,is still unclear,especially under dynamic loads.To investigate the soil arching and tension membrane under dynamic train loads on high-speed railways,a large-scale piled embankment model test with X-shaped piles as vertical reinforcement was performed,in which twenty-eight earth pressure cells were installed in the piled embankment and an M-shaped wave was adopted to simulate the high-speed railway train load.The results show that dynamic soil arching only occurs when two bogies of a carriage pass by and disappears at other times.The dynamic soil arching and membrane effect are the most significant under the concrete base.The arching height,stress concentration ratio and pile-soil load sharing ratio have a minimal value at 25 Hz.The dynamic soil arching degrades severely at 25 Hz,whose height at 25 Hz is only 0.35 times that at 5 Hz.The arching height fluctuates over a narrow range with increasing loading amplitude.The stress concentration ratio and the pile-soil load sharing ratio increase monotonically as the loading amplitude increases.

Comparison of seismic fragility analysis methods for arch dams

This study focuses on the seismic fragility analysis of arch dams.The multiple stripe analysis(MSA),cloud analysis(CLA),and incremental dynamic analysis(IDA)methods are compared.A comprehensive dam-reservoir-foundation rock system,which considers the opening of contraction joints,the nonlinearity of dam concrete and foundation rock,the radiation damping effect of semi-unbounded foundation,and the compressibility of reservoir water,is used as a numerical example.225,80,and 15 earthquake records are selected for MSA,CLA,and IDA,respectively.The results show that MSA provides satisfactory fragility analysis,while both CLA and IDA have assumptions that may lead to deviations.Therefore,MSA is the most reliable method among the three methods and is recommended for the fragility analysis of arch dams.It is also shown that the choice of demand level affects the reliability of fragility curves and the effect of the material uncertainty on the fragility of the dam is not significant.

Predictive value of the trans-perineal three-dimensional ultrasound measurement of the pubic arch angle for vaginal delivery

BACKGROUND Numerous variables are linked to the success of vaginal delivery,including the subpubic arch angle(SPAA)during labor,the importance of which has not yet been fully elucidated.AIM To examine the SPAA distributional characteristics and to ascertain SPAA’s ability to predict the type and duration of labor.METHODS We determined the SPAA and analyzed the corresponding data.We also evaluated the relationship between the SPAA and the mode of delivery and the duration of labor by regression.The present study comprised a total of 301 pregnant women who had given birth at Beijing Tiantan Hospital of the Capital Medical University between January and December of 2021.RESULTS Our analysis of 301 pregnant women revealed that the SPAA measured using three-dimensional trans-perineal ultrasound had a minimum angle of 81°and a maximum angle of 122.2°.The angle in the normal vaginal delivery group was greater than that in the labor cesarean group(P=0.000).The SPAA was a highly significant positive predictor of normal vaginal delivery(P=0.000)with an area under the curve of 0.782(P=0.000;95%CI:0.717-0.848).We found the length of the second stage of labor to be positively influenced by the SPAA using linear regression analysis(P=0.045).CONCLUSION The SPAA was a highly significant positive predictor of normal vaginal delivery.The length of the second stage of labor and normal vaginal birth were predicted by SPAA.