Microglia lactylation in relation to central nervous system diseases

The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis.Microglia,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative diseases.Lactate has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of lactate.Lactylation is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various diseases.This review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting lactate.Finally,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

Practice and Exploration of Ideological and Political Education for Postgraduate Students Under the Mentor Responsibility System

This study aims to address the problems existing in the ideological and political education of postgraduate students,and combines the implementation of the mentor responsibility system to explore the role orientation,work content,and practical effects of mentors in the ideological and political education of postgraduate students.Through questionnaire surveys,interviews,and other research methods,the current situation of ideological and political education of postgraduate students under the mentor responsibility system is analyzed,and corresponding optimization strategies are proposed.

Dispatchable Capability of Aggregated Electric Vehicle Charging in Distribution Systems

This paper introduces a method for modeling the entire aggregated electric vehicle(EV)charging process and analyzing its dispatchable capabilities.The methodology involves developing a model for aggregated EV charging at the charging station level,estimating its physical dispatchable capability,determining its economic dispatchable capability under economic incentives,modeling its participation in the grid,and investigating the effects of different scenarios and EV penetration on the aggregated load dispatch and dispatchable capability.The results indicate that using economic dispatchable capability reduces charging prices by 9.7%compared to physical dispatchable capability and 9.3%compared to disorderly charging.Additionally,the peak-to-valley difference is reduced by 64.6%when applying economic dispatchable capability with 20%EV penetration and residential base load,compared to disorderly charging.

Comparison of biomechanical indices measured by ocular response analyzer between children and elderly:a systematic review

Biomechanical study of the visual system by ocular response analyzer investigates the inter-structural biological relationships,mechanics,and function of the visual system.This review aimed to investigate the changes in corneal biomechanical parameters with age and sex.The articles published in PubMed between 2000 and 2021 were investigated and critiqued,and valid scientific evidence was collected,reviewed and concluded according to the inclusion and exclusion criteria.Most studies showed that corneal biomechanical changes occur infrequently in children up to the age of 20y,and with increasing age and wider age range,there was a significant decrease in corneal biomechanical indices,especially corneal hysteresis.In children and adults,most studies have shown that these biomechanical indicators,especially corneal resistance factor,were higher in females.Although hormonal changes may contribute to this finding,the role of axial length and other biometric indicators should not be ignored.The axial length,the intraocular pressure,and the corneal thickness are other factors associated with biomechanical parameters that should be taken into account in clinical diagnosis and management especially for patients undergoing refractive surgery as well as keratoconus patients.

Study on Environmental Protection during Agricultural Eco-tourism Development in Guangzhou City——From the Perspective of Perfecting Environmental Responsibility System of Tourism Company

By taking Guangzhou City for example,a series of environmental problems brought by agricultural ecological tourism were analyzed from the perspective of environmental degradation caused by that tourism company failed to take environmental responsibility.Based on economic development and environmental protection,some suggestions on environmental protection were proposed from the perspective of perfecting environmental responsibility of tourism company in order to realize win-win of economic development and environmental protection.

Way to Push Ahead Corporate Social Responsibility Report System in China

According to the analysis and statistics of relevant institution, it is a prominent problem that CSR reports generally become a mere formality. Through the analysis on the causes, it finds that it is inevitable for the phenomenon. Thus, we proposed to improve the cultivation mechanism of corporate responsibility by ex- panding and advancing the subject and the object, as well as the contents, of fi- nancial analysis in order to push ahead with CSR report in China.

Systematic analysis of corporate environmental responsibility:elements,structure,function,and principles

Corporate Environmental Responsibility(CER) is the subsystem of Corporate Social Responsibility(CSR),which continues to increase prominence in the global economy.Nowadays,CER becomes more important in corporate sustainable development.Based on Carroll's pyramid mode of CSR,this article explores the systematic feature of CER.From a systematic perspective,it sorts out its elements,structure,function,and principles of CER.And the four levels of economic,legal,ethical,and charitable structure are emphasized.With these considerations interpreted into practice,success will be achieved in potential cost savings,technological innovation,increased public acceptance,and better relations with governments.

Relationships of Corporate Social Responsibility （CSR） With Accounting Information Systems A Study

The objectives of the present study are to put forth the concept of corporate social responsibility （CSR） in Turkey （Kayseri） and to examine research on this concept and the relationships between CSR and accounting information systems. Research data were gathered from 100 accounting managers who work in businesses with 250 or more employees in Kayseri. The dimensions of CSR were considered as business policies, environmental policies, market policies, and social policies, and the effects of these factors on accounting information systems were tested. Market policies and social policies dimensions of CSR had no significant impact on accounting information systems. Business policies and environmental policies dimensions of CSR had significant impacts on accounting information systems. Two basic conclusions were drawn from the current study： The business policy dimension of CSR had significant impacts on accounting information systems; the business policy and environmental policy dimensions of CSR together had significant impacts on accounting intbrmation systems.

The Evaluation Indicator System for the Audit of Township Leading Cadres' Economic Responsibility: Based on the Survey of One County in Chongqing

Economic responsibility audit evaluation of township cadres is important and difficult. According to the evaluation content and principles,the paper constructs the evaluation indicator of five subsystems: " economic management", " economic decision-making", " implementation of economic policy", " economic development",and " honest and upright administration". Through the field survey of some county in Chongqing,evaluation indicator is screened. According to the expert questionnaire,it uses the Hierarchy Analysis Process method to construct the judgment matrix and calculate the indicator weight and thereby build evaluation indicator system. It focuses on traditional indicators and evaluation indicator of sustainable development to construct a new,more complete evaluation indicator system.

Unit Environmental Property Rights: Efficiency, Responsibility and System

The inexplicit efficiency of environmental property rights lies in its fuzziness. Based on the character of environmental property rights discussed, unit environment shows intra relationship between efficiency and duty of environmental property rights, and constructs a symmetrical system arrangement. Through analyzing the possibility and feasibility of unit environmental property rights, the significance of symmetrical system arrangement to avoid the inexplicit efficiency of environmental property rights is discussed in this dissertation from the aspect of the validity of offering and implementing system.

Research on the Relationship Between Environmental and Economic Coupling Systems in Bohai Bay Area Based on a Vector Autoregression(VAR)Model

This study analyzed the impact of land-based contaminants and tertiary industrial structure on economic development in the selected Bohai Bay area,China.Based on panel data spanning 2011-2020,a vector autoregressive(VAR)model is used to analyze and forecast the short-run and long-run relationships between three industrial structures,pollutant discharge,and economic development.The results showed that the environmental index had a long-term cointegration relationship with the industrial structure economic index.Per capital chemical oxygen demand(PCOD)and per capita ammonia nitrogen(PNH_(3)N)had a positive impact on delta per capita GDP(dPGDP),while per capita solid waste(PSW),the secondary industry rate(SIR)and delta tertiary industry(dTIR)had a negative impact on dPGDP.The VAR model under this coupling system had stability and credibility.The impulse response results showed that the short-term effect of the coupling system on dPGDP was basically consistent with the Granger causality test results.In addition,variance decomposition was used in this study to predict the long-term impact of the coupling system in the next ten periods(i.e.,ten years).It was found that dTIR had a great impact on dPGDP,with a contribution rate as high as 74.35%in the tenth period,followed by the contribution rate of PCOD up to 3.94%,while the long-term contribution rates of PSW,SIR and PNH3N were all less than 1%.The results show that the government should support the development of the tertiary industry to maintain the vitality of economic development and prevent environmental deterioration.

An innovative classification system for ranking the biological effects of marine aromatic hydrocarbons based on fish embryotoxicity

Petroleum hydrocarbon pollution is a global concern,particularly in coastal environments.Polycyclic aromatic hydrocarbons(PAHs) are regarded as the most toxic components of petroleum hydrocarbons.In this study,the biomonitoring and ranking effects of petroleum hydrocarbons and PAHs on the marine fish model Oryzias melastigma embryos were determined in the Jiulong River Estuary(JRE) and its adjacent waters in China.The results showed that the levels of petroleum hydrocarbons from almost all sites met the primary standard for marine seawater quality,and the concentrations of the 16 priority PAHs in the surface seawater were lower compared with those in other coastal areas worldwide.A new fish expert system based on the embryotoxicity of O.melastigma(OME-FES) was developed and applied in the field to evaluate the biological effects of petroleum hydrocarbons and PAHs.The selected physiological index and molecular indicators in OME-FES were appropriate biomarkers for indicating the harmful effects of petroleum hydrocarbons and PAHs.The outcome of OME-FES revealed that the biological effect levels of the sampling sites ranged from level Ⅰ(no stress) to level Ⅲ(medium stress),which is further corroborated by the findings of nested analysis of variance(ANOVA) models.Our results suggest that the OME-FES is an effective tool for evaluating and ranking the biological effects of marine petroleum hydrocarbons and PAHs.This method may also be applied to evaluate other marine pollutants based on its framework.

The Role of Accounting Information Systems in Activating the Role of the Responsibility in the Jordanian Industrial Companies

The study aims at examining the role of accounting information systems in activating the role of the responsibility accounting in the Jordanian industrial companies. The study population has consisted of accounting managers working in the Jordanian industrial companies, where a convenience sample of 50 managers has been taken and questionnaires have been distributed for them and then these questionnaires have been collected. The study has found that the attitudes of study sample have been positive toward the role of accounting information systems in activating the role of the responsibility accounting in the Jordanian industrial companies. The study has also found that there is a role for accounting information systems in activating the role of the responsibility accounting in the Jordanian industrial companies. The study also found that the role of accounting information systems in activating the role of the responsibility accounting in the Jordanian industrial companies does not vary depending on the educational qualification of employees. In addition, the role of accounting information systems in activating the role of responsibility accounting in the Jordanian industrial companies varies depending on the practical experience of the employee. The study has made several recommendations, including： focusing attention on the disclosure of social activities in industrial companies, in addition to focusing on the development of equipment used in information systems at the company.

Lethal Autonomous Weapon Systems and Responsibility Gaps

This paper argues that delegation of lethal decisions to autonomous weapon systems opens an unacceptable responsibility gap, which cannot be effectively countered unless we enforce a preemptive ban on lethal autonomous weapon systems （LAWS）. Initially, the promises and perils of artificial intelligence are brought forward in pointing out （1） that it remains an open question whether moral decision making, understood as situated ethical judgement, is computationally tractable, and （2） that the kind of artificial intelligence, which would be required to cause ethical reasoning, would imply a system capable of operating as an independent reasoner in novel contexts （sec. 2）. In continuation thereof, issues of responsibility are discussed （sec. 3 and 3.1） and it is claimed that unacceptable responsibility gaps may occur since unpredictability would presumably follow full system autonomy. These circumstances call for a strong precautionary principle, in the form of a preemptive ban.

Plant Protection： The Risk Mitigation of Endocrine Disrupting Pesticides Use Demands the Shared Responsibility of All within the Agricultural System

The widespread use of agrochemicals and its possible negative impacts on humans and the environment remains a highly topical and controversial issue. Of particular concern here are chemicals that can disturb an organism＇s endocrine system. Referring to the precautionary principle, the objective of the research project start2 is to develop management strategies that help reduce possible risks for httmans and the environment of endocrine active agrochemicals. As an empirical basis we combined qualitative and quantitative methods and initiated two expert dialogues. Our findings underpin the well known fact that the use of agrochemicals is complex and dependent on more than the individual attitudes of farmers. Agricultural plant protection management is the collective product of a complex agricultural system, which encompasses treatment, marketing, industry and agricultural consultation as well as agricultural teaching institutions and relevant scientific disciplines. Successful management strategies for risk reduction in the context of hormonally active agrochemicals thus need to involve all actors within this system. The paper proposes a strategy that promotes participation by enabling learning processes among these actors.

An Empirical Study on the Cadre Responsibility System of Local Government in China

Based on nationally representative panel data, this paper examines the content and evolution of China＇s cadre responsibility system at county-township and township- village levels. Our findings suggest that, with abolition of agricultural tax, there has been a series of changes in the focus of evaluation both at county-township and township-village levels. In county-township evaluation system, importance of economic development and social stability grew but fiscal pressure did not weaken; while in township-village system, original indicator of fiscal pressure became less important. Meanwhile, by enhancing ＂veto＂ indicator of evaluation on village cadres, township government attempted to cascade the pressure of social stability to village administration. Although central government has initiated a series of reforms on agriculture, countryside and farmers, county and township governments did not pay more attention to rural infrastructure. In addition, county government paid less and less attention to farmers＇ income growth.

Behavior configuration of tea farmers’ participation in ecotourism environmental responsibility from the perspective of system theory

The coordination and optimization of eco-tourism development and world heritage protection are related to the sustainable development of the two,and the behavior of tea farmers is affected by the multiple subjects of rural production and living system,which has nonlinear and complex characteristics.In view of this,based on the theory of human-land system,this study is using system theory and fuzzy set qualitative comparative analysis(fsQCA)to explore the internal mechanism of tea farmers‘environmental responsibility behavior.The results show that:(1)single factor,infrastructure environment perception constitutes a necessary condition for environmental responsibility behavior,and there is equivalence between infrastructure environment perception,Cultural environment perception,external intervention perception and environmental supervision perception.(2)Infrastructure environment perception and cultural environment perception are important internal driving forces for high environmental responsibility behavior,while external intervention perception and environmental supervision perception constitute external traction.(3)Infrastructure environment perception and cultural environment perception exist in all configurations in a single or common form.This provides enlightenment for changing the governance logic of ecotourism and improving the governance performance of ecotourism.

The Transition of the International System: From the Perspective of the Theory of Responsibility

The international system refers to the whole of the interacting and stable relationship formed by actors of

Modern technologies and solutions to enhance surveillance and response systems for emerging zoonotic diseases

Background:Zoonotic diseases originating in animals pose a significant threat to global public health.Recent outbreaks,such as coronavirus disease 2019(COVID-19),have caused widespread illness,death,and socioeconomic disruptions worldwide.To cope with these diseases effectively,it is crucial to strengthen surveillance capabilities and establish rapid response systems.Aim:The aim of this review is to examine the modern technologies and solutions that have the potential to enhance zoonotic disease surveillance and outbreak responses and provide valuable insights into how cuttingedge innovations could be leveraged to prevent,detect,and control emerging zoonotic disease outbreaks.Herein,we discuss advanced tools including big data analytics,artificial intelligence,the Internet of Things,geographic information systems,remote sensing,molecular diagnostics,point-of-care testing,telemedicine,digital contact tracing,and early warning systems.Results:These technologies enable real-time monitoring,the prediction of outbreak risks,early anomaly detection,rapid diagnosis,and targeted interventions during outbreaks.When integrated through collaborative partnerships,these strategies can significantly improve the speed and effectiveness of zoonotic disease control.However,several challenges persist,particularly in resource-limited settings,such as infrastructure limitations,costs,data integration and training requirements,and ethical implementation.Conclusion:With strategic planning and coordinated efforts,modern technologies and solutions offer immense potential to bolster surveillance and outbreak responses,and serve as a critical resource against emerging zoonotic disease threats worldwide.

Identification of Systems Containing Nonlinear Element Using Constant Response Vibration Tests

Nonlinear behavior is important in the vibration test of engineering structures. In this study, a constant response vibration test is proposed for nonlinear element extraction. The method is based on the principle of Harmonic Balance Method (HBM). The stiffness or damping can be regarded as constant for particular steady displacement or velocity response. The displacement or velocity is controlled as a constant in the test. Then the measured Frequency Response Function(FRF) is obtained. The equivalent stiffness or damping is estimated using FRFs for a particular vibration response level. The displacement-dependent stiffness and velocity-dependent damping are fitted to describe the unknown non-linearity. The nonlinear spring and damping force can be obtained by combining the fitting results with HBM using first-order expansion. Constant response vibration test is illustrated through experimental setup to verify its effectiveness. Experimental results show that the procedure is capable of achieving an accurate parameter identification of nonlinear damping and stiffness, which is hopeful for industrial application.