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Evaluation of macular choroidal and microvascular network changes by activity scores and serum antibodies in thyroid eye patients and healthy subjects
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作者 Mehmet Erkan Dogan Ibrahim Basol +2 位作者 Hatice Deniz Ilhan Yusuf Ayaz Olgar Ocal 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2023年第12期2089-2094,共6页
AIM:To investigate the choroidal thickness and the microvascular network changes around the macula in thyroid eye disease(TED)patients at different stages and the relationship of those changes with risk factors,serum ... AIM:To investigate the choroidal thickness and the microvascular network changes around the macula in thyroid eye disease(TED)patients at different stages and the relationship of those changes with risk factors,serum antibodies and the severity of TED.METHODS:A total of 85 participants were enrolled.All participants underwent ophthalmology and endocrinology examinations.Subfoveal choroidal thickness(SFCT),superficial(s)and deep(d)foveal avascular zone(FAZ)area,mean(m)and central(c)superficial vascular density(SVD),deep vascular density(DVD)measurements of the enrolled cases were performed with Topcon swept source optical coherence tomography(OCT)/OCT angiography(OCTA)DRI OCT Triton.Multiple linear regression analysis was used to explore the associations between SFCT,FAZ area,SVD,DVD and the relevant factors of TED.RESULTS:Those with active TED patients had higher c-DVD and m-DVD levels(P<0.05),however there is no statistically significant difference in SFCT between active and stable TED patients.Among the serum antibodies,it was observed that s-FAZ and d-FAZ increased,c-SVD and m-SVD decreased in patients with high thyroid stimulating hormone-receptor autoantibodies(TRAB)level,whereas SFCT thickened in patients with high levels of both TRAB and human thyroglobulin(hTG).There was no significant difference in SFCT,FAZ,SVD and DVD measurement at gender,between hyperthyroid and euthyroid patients and among those with or without thyroid papillary carcinoma.CONCLUSION:The results show that both disease activation and serum antibodies differentially affect both superficial and deep retinal vascular density.It has also been shown that high serum antibody levels affect choroidal thickness independent of clinical activity. 展开更多
关键词 thyroid eye disease optic coherence tomography angiography vascular density choroidal thickness foveal avascular zone area
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Evaluation of childhood developing via optical coherence tomography-angiography in Qamdo,Tibet,China:A prospective cross-sectional,school-based study
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作者 Ke-Xin Sun Yong-Guo Xiang +7 位作者 Tong Zhang Sheng-Lan Yi Jiu-Yi Xia Xin Yang Shi-Jie Zheng Yan Ji Wen-Juan Wan Ke Hu 《World Journal of Clinical Cases》 SCIE 2023年第23期5479-5493,共15页
BACKGROUND Optical coherence tomography angiography(OCTA)is a new and reliable machine used to evaluate retinal structure and macular perfusion in children.The use of OCTA under bad condition such as high altitude,low... BACKGROUND Optical coherence tomography angiography(OCTA)is a new and reliable machine used to evaluate retinal structure and macular perfusion in children.The use of OCTA under bad condition such as high altitude,low atmospheric oxygen,and low humidity,in children is rarely.AIM To quantify the macular micro-vasculature in healthy children of various ages using OCTA in Qamdo.METHODS Design:Prospective cross-sectional,school-based study.Three hundred and fortyseven normal students from 9 schools in 4 different areas in Qamdo were included.OCTA was performed on a 3 mm×3 mm area centered on the macular region and macular cube 512×128 showed details in macular.Early treatment of diabetic retinopathy study Vessel Flow Density(VD)of the macular central vascular plexus density(CVD),inner vascular plexus density(IVD),full vascular plexus density(FVD),and the size of the foveal avascular zone(FAZ)were measured.All these results corrected by t/s=3.382×0.01306×(axial length-1.82).The differences were compared among various ages,sexes and living environments.RESULTS The mean FAZ area in all eyes was 0.27 mm^(2)±0.12 mm^(2).The mean foveal thickness(MFT)in the macular cube was 227.64μm±23.51μm.Compared with girls,boys had a lager FAZ(P=0.0029).Among the different age groups,MFT(P<0.001)and FVD(P<0.0001),IVD(P<0.0001),and CVD(P=0.0050)increased with age.FAZ areas were not correlated with age(P=0.8853)or others(MFT,area).CONCLUSION OCTA can use to evaluate macular perfusion in children.Our data bridge the gap between structural OCT and perfusion density in children in high altitude.Even though these were not a longitudinal study,it may provide us with hints about retina development during puberty and clinical implications of OCTA in children. 展开更多
关键词 Optical coherence tomography-angiography Qamdo foveal avascular zone area Vessel flow density TEENAGER
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糖尿病视网膜病变不同分期患者的HbAlc、FPG、FAZ、MVD水平变化及临床意义 被引量:1
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作者 陈彦霓 段娜 廖锐 《海南医学》 CAS 2022年第15期1946-1949,共4页
目的探讨糖尿病视网膜病变不同分期患者的糖化血红蛋白(HbAlc)、空腹血糖(FPG)、黄斑中心凹无血管区域(FAZ)、微血管密度(MVD)水平变化及临床意义。方法选择2018年7月至2020年12月惠州市第三人民医院收治的120例糖尿病患者为研究对象,... 目的探讨糖尿病视网膜病变不同分期患者的糖化血红蛋白(HbAlc)、空腹血糖(FPG)、黄斑中心凹无血管区域(FAZ)、微血管密度(MVD)水平变化及临床意义。方法选择2018年7月至2020年12月惠州市第三人民医院收治的120例糖尿病患者为研究对象,根据视网膜病变不同分期,将患者分为A组(无视网膜病变,41例)、B组(轻度非增殖性视网膜病变,23例)、C组(中度或重度非增殖性视网膜病变,20例)和D组(增殖性视网膜病变,36例),并选择同期在上述医院体检的50例健康者作为对照组。比较五组受检者的HbAlc、FPG、FAZ、MVD水平,并采用Spearman秩相关分析法分析HbAlc、FPG、FAZ、MVD水平与糖尿病视网膜病变不同分期的相关性。结果对照组受检者的HbAlc、FPG水平分别为(5.48±0.50)mmol/L、(5.77±0.56)mmol/L,均明显低于B组的(10.25±1.01)mmol/L、(10.08±1.00)mmol/L、C组的(10.79±1.06)mmol/L、(10.59±1.04)mmol/L和D组的(11.02±1.09)mmol/L、(10.87±1.07)mmol/L,且A组患者的HbAlc、FPG水平分别为(8.27±0.82)mmol/L、(8.32±0.84)mmol/L,均明显低于B组、C组和D组,差异均有统计学意义(P<0.05),而对照组受检者的HbAlc、FPG水平与A组比较差异均无统计学意义(P>0.05);对照组受检者的FAZ面积为(0.278±0.02)mm^(2),明显小于B组的(0.408±0.04)mm^(2)、C组的(0.420±0.04)mm^(2)和D组的(0.606±0.06)mm^(2),且A组患者的FAZ面积为(0.372±0.03)mm^(2),明显小于D组,差异均有统计学意义(P<0.05),而对照组受检者的FAZ面积与A组比较差异无统计学意义(P>0.05);五组受检者外层视网膜的MVD比较差异无统计学意义(P>0.05);对照组受检者表层视网膜、深层视网膜及脉络膜毛细血管层的MVD分别为(0.527±0.05)%、(0.574±0.06)%、(0.667±0.07)%,均明显高于A组[(0.506±0.05)%、(0.551±0.05)%、(0.639±0.06)%]、B组[(0.485±0.04)%、(0.520±0.05)%、(0.623±0.06)%]、C组[(0.481±0.04)%、(0.516±0.05)%、(0.620±0.06)%]和D组[(0.475±0.04)%、(0.503±0.05)%、(0.611±0.06)%],且A组患者表层视网膜、深层视网膜的MVD均明显高于B组、C组,脉络膜毛细血管层的MVD明显高于D组,差异均有统计学意义(P<0.05);经Spearman秩相关分析结果显示,HbAlc、FPG水平及FAZ面积与糖尿病视网膜病变不同分期呈正相关(r=0.568、0.447、0.326,P<0.05),MVD与糖尿病视网膜病变不同分期呈负相关(r=-0.282,P<0.05)。结论糖尿病视网膜病变不同分期患者的HbAlc、FPG、FAZ、MVD水平明显异于健康者,且HbAlc、FPG、FAZ、MVD水平与糖尿病视网膜病变不同分期有一定相关性。 展开更多
关键词 糖尿病 视网膜病变 分期 糖化血红蛋白 空腹血糖 黄斑中心凹无血管区域 微血管密度 相关性
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全视网膜激光光凝术后糖尿病视网膜病变患者FAZ特征指标和脉络膜血流量及黄斑厚度的变化特征 被引量:7
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作者 孙璐 岳钟 宋森 《贵州医科大学学报》 CAS 2022年第7期863-868,共6页
目的探讨全视网膜激光光凝术(PRP)后糖尿病视网膜病变(DR)患者中心凹无血管区(FAZ)特征指标、脉络膜血流量及黄斑厚度的变化特征。方法DR患者72例(124眼)据DR分级标准分为增生型组[30例(45眼)]和非增生型组[42例(79眼)],分别于术前、术... 目的探讨全视网膜激光光凝术(PRP)后糖尿病视网膜病变(DR)患者中心凹无血管区(FAZ)特征指标、脉络膜血流量及黄斑厚度的变化特征。方法DR患者72例(124眼)据DR分级标准分为增生型组[30例(45眼)]和非增生型组[42例(79眼)],分别于术前、术后1个月及术后6个月,采用国际标准视力表和球后血管血流状态彩色多普勒检测2组DR患者的最佳矫正视力(BCVA)和脉络膜血流量指标[睫状后动脉收缩期峰值血流速度(PSV)、阻力指数(RI)、舒张末期血流速度(EDV)],采用美国Bayspec光学相干断层扫描血管成像(OCTA)检查FAZ特征指标(FAZ面积、FAZ形态指数及FAZ周长)和黄斑中心凹厚度(CMT)值。结果DR患者术后6个月BCVA、FAZ形态指数、PSV及EDV分别高于术前和术后1个月,RI、CMT分别低于术前和术后1个月,差异均有统计学意义(P<0.05);非增生型组、增生型组术后6个月的BCVA高于术前,其中非增生型组术后6个月的BCVA、FAZ形态指数高于术前、术后1个月与增生型组(P<0.05);非增生型组DR患者术后6个月PSV、EDV分别高于增生型组,RI、CMT分别低于增生型组(P<0.05)。结论与术前及术后1个月比较,DR患者术后6个月BCVA、FAZ形态指数增高,脉络膜血流量改善,CMT降低,但FAZ面积和周长无明显变化;与增生型相比,非增生型DR患者术后6个月的BCVA、FAZ形态指数、脉络膜血流量及CMT的改善更为明显。 展开更多
关键词 糖尿病视网膜病变 全视网膜激光光凝术 中心凹无血管区 脉络膜血流量 黄斑中心凹厚度 舒张末期血流速
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Long-Term Postoperative Perfusion Indices in Surgically Resolved Myopic Traction Maculopathy
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作者 Miguel A. Quiroz-Reyes Erick A. Quiroz-Gonzalez +1 位作者 Miguel A. Quiroz-Gonzalez Virgilio Lima-Gomez 《Open Journal of Ophthalmology》 2023年第1期143-171,共29页
Background: Pathological myopia can be complicated by the presence of posterior staphyloma, macular atrophy, ruptures in Bruch’s membrane, pathologic choroidal neovascularization, and different degrees of myopic trac... Background: Pathological myopia can be complicated by the presence of posterior staphyloma, macular atrophy, ruptures in Bruch’s membrane, pathologic choroidal neovascularization, and different degrees of myopic traction maculopathy. Purpose: To report the structural, functional and perfusional outcomes in patients underwent surgery for different stages of myopic traction maculopathy (MTM). Methods: A retrospective, consecutive, comparative, interventional, one-surgeon, case-control study was conducted in 46 eyes of 34 individuals between April 2015 and May 2021. Participants included normal emmetropic eyes (Control emmetropia, n = 25), healthy myopic eyes (Control high myopia, n = 20), and operated and structurally fully resolved myopic eyes with different stages of MTM (Surgically treated group, n = 46). Long-term postoperative functional and perfusional follow-up evaluations were performed with spectral domain-optical coherence tomography (SD-OCT) and OCT angiography. The primary outcome measure included long-term functional, structural and perfusion macular status across groups. Results: Forty-six eyes in 34 patients were included in the study group, with both eyes affected in 12 (26.3%) patients. The mean axial length was 29.89 ± 1.67 mm. The preoperative logMAR was 1.29 ± 0.54 and the postoperative logMAR was 0.60 ± 0.52 (P Conclusion: Compared to emmetropic and healthy myopic eyes, surgically-resolved MTM eyes generally have larger superficial foveal avascular zone area, lower vessel density, smaller choriocapillaris flow area, thinner central subfoveal thickness, and more macular defects. Eyes with stage III or IV MTM had larger deviation compared to eyes at earlier stages. Visual function change after surgery was associated with superficial foveal avascular zone area. Better functional, structural and perfusion index outcomes were observed when highly myopic eyes underwent early surgery. 展开更多
关键词 Choriocapillaris Flow area Deep Vascular Plexus Foveoretinal Detachment Myopic Foveoschisis foveal avascular zone Myopic Macular Hole
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基于OCTA观察益气活血法对NPDR的临床特征
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作者 金梅 罗晓燕 《长春中医药大学学报》 2023年第11期1271-1274,共4页
目的探究益气活血法治疗下光学相干断层扫描血管成像技术(OCTA)对非增生性糖尿病视网膜病变(NPDR)的临床特征。方法选取2020年1月-2021年12月期间广东省中西医结合医院收治的非增生性糖尿病视网膜病变患者60例,按随机数字表法分为观察... 目的探究益气活血法治疗下光学相干断层扫描血管成像技术(OCTA)对非增生性糖尿病视网膜病变(NPDR)的临床特征。方法选取2020年1月-2021年12月期间广东省中西医结合医院收治的非增生性糖尿病视网膜病变患者60例,按随机数字表法分为观察组和对照组,各30例。对照组给予常规西药治疗,观察组在对照组的基础上给予益气活血法方剂治疗。比较2组的临床疗效、治疗前后的中医证候积分、最佳矫正视力、黄斑中心凹血流密度、黄斑中心凹无血管区面积以及不良反应的发生情况。结果观察组的临床疗效(96.67%)高于对照组(76.67%)(P<0.05);治疗后,2组的中医证候积分、最佳矫正视力下降,且观察组低于对照组(P<0.05);治疗后,2组的黄斑中心凹血流密度均上升,且观察组高于对照组(P<0.05)。结论益气活血法能够提高非增生性糖尿病视网膜病变患者的临床疗效,改善其视力和临床症状,并且在光学相干断层扫描血管成像技术的辅助下,能观察到患者的黄斑区血流密度得到明显改善。 展开更多
关键词 光学相干断层扫描血管成像技术 非增生性糖尿病视网膜病变 益气活血法 黄斑血流密度 黄斑中心凹无血管区面积
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两种OCTA设备测量正常人黄斑中心凹无血管区的比较 被引量:1
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作者 程建宏 李璟 +1 位作者 江柯 潘超 《临床眼科杂志》 2020年第3期197-201,共5页
目的评估两种相干光层析血管成像术(OCTA)设备测量正常人黄斑中心凹无血管区(FAZ)面积的差异性和一致性,为临床应用提供指导。方法27名前瞻性纳入的健康志愿者(27只眼)接受两种OCTA检查:Triton(Topcon)和RTVue XR Avanti(Optovue)。浅... 目的评估两种相干光层析血管成像术(OCTA)设备测量正常人黄斑中心凹无血管区(FAZ)面积的差异性和一致性,为临床应用提供指导。方法27名前瞻性纳入的健康志愿者(27只眼)接受两种OCTA检查:Triton(Topcon)和RTVue XR Avanti(Optovue)。浅层毛细血管层和深层毛细血管层FAZ面积由同一名测量者利用Image J软件手动测量3次,取其平均值进行分析。采用配对t检验评估两种OCTA设备测量FAZ面积的差异性,采用Bland-Altman分析两种OCTA设备测量FAZ面积的一致性。结果27名受试者平均年龄为(32.07±0.95)岁。两种OCTA测量的浅层毛细血管层FAZ面积分别为(0.468±0.086)mm^2、(0.405±0.088)mm^2,差异具有统计学意义(t=4.28,P<0.001);深层毛细血管层FAZ面积分别为(0.354±0.085)mm^2、(0.659±0.096)mm^2,差异具有统计学意义(t=-15.73,P<0.001)。Bland-Altman分析显示两种OCTA测量浅层、深层毛细血管层FAZ面积的一致性区间分别为(-0.09 mm^2,0.21 mm^2)、(-0.50 mm^2,-0.11 mm^2)。RTVue-XR Avanti OCTA设备自动测量的视网膜全层FAZ面积为(0.322±0.08)mm^2。结论两种OCTA设备测量的浅层、深层毛细血管层FAZ面积均有显著的差异性,一致性差,提示临床运用中不可相互替代使用。 展开更多
关键词 相干光层析血管成像术 中央凹 黄斑 无血管区 一致性
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Microvascular changes after conbercept therapy in central retinal vein occlusion analyzed by optical coherence tomography angiography 被引量:21
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作者 Yang Deng Qi-Wen Zhong +11 位作者 Ai-Qi Zhang Xiao-Juan Cai Ming-Zhi Lu Shao-Chong Zhang Li-Shi Su Hui Chen Ying Lin Li-Mei Sun Guan-Di Chen Li-Ting Zhong Chen-Jin Jin Wei Chi 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2019年第5期802-808,共7页
AIM: To investigate microvascular changes in eyes with central retinal vein occlusion(CRVO) complicated by macular edema before and after intravitreal conbercept injection and evaluate correlations between these chang... AIM: To investigate microvascular changes in eyes with central retinal vein occlusion(CRVO) complicated by macular edema before and after intravitreal conbercept injection and evaluate correlations between these changes and best-corrected visual acuity(BCVA) and retinal thickness. METHODS: Twenty-eight eyes of 28 patients with macular edema caused by CRVO were included in this retrospective study. All patients received a single intravitreal conbercept injection to treat macular edema. BCVA and the results of optical coherence tomography angiography(OCTA) automatic measurements of the vessel density in the superficial(SCP) and deep retinal capillary plexus(DCP), the foveal avascular zone(FAZ) area, the FAZ perimeter(PERIM), the vessel density within a 300-μm wide ring surrounding the FAZ(FD-300), the acircularity index(AI), the choriocapillaris flow area, and retinal thickness were recorded before and at one month after treatment and compared with the results observed in age-and sexmatched healthy subjects. RESULTS: The vessel density in the SCP and DCP, the FD-300, and the flow area of the choriocapillaris were allsignificantly lower in CRVO eyes than in healthy eyes, while the AI and retinal thickness were significantly higher(all P<0.05). After treatment, retinal thickness was significantly decreased, and the mean BCVA had markedly improved from 20/167 to 20/65(P=0.0092). The flow area of the choriocapillaris was also significantly improved, which may result from the reduction of shadowing effect caused by the attenuation of macular edema. However, there were no significant changes in SCP and DCP vessel density after treatment. The flow area of the choriocapillaris at baseline was negatively correlated with retinal thickness.CONCLUSION: OCTA enables the non-invasive, layerspecific and quantitative assessment of microvascular changes both before and after treatment, and can therefore be used as a valuable imaging tool for the evaluation of the follow-up in CRVO patients. 展开更多
关键词 central retinal VEIN OCCLUSION optical coherence tomography ANGIOGRAPHY MACULAR EDEMA conbercept vessel density flow area foveal avascular zone
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雷珠单抗与傲迪适注射治疗对伴ME的RVO患者黄斑区血流的影响 被引量:3
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作者 周冠芳 蒋劲 +2 位作者 郑青青 沈婷 洪朝阳 《浙江临床医学》 2021年第4期486-489,共4页
目的观察视网膜静脉阻塞(RVO)伴黄斑水肿(ME)患者玻璃体腔注射雷珠单抗或傲迪适治疗前后,黄斑区视网膜、脉络膜血流变化情况,以评估两种药物临床治疗效果.方法纳入2019年11月至2020年12月在浙江省人民医院就诊的RVO伴发ME患者110例.随... 目的观察视网膜静脉阻塞(RVO)伴黄斑水肿(ME)患者玻璃体腔注射雷珠单抗或傲迪适治疗前后,黄斑区视网膜、脉络膜血流变化情况,以评估两种药物临床治疗效果.方法纳入2019年11月至2020年12月在浙江省人民医院就诊的RVO伴发ME患者110例.随机分为雷珠单抗组和傲迪适组,雷珠单抗组60例,玻璃体腔注射雷珠单抗;傲迪适组50例,玻璃体腔注射傲迪适;另同期选取眼部屈光介质清且无其他眼部疾病(轻度白内障除外)的正常人40例,作为对照组.于玻璃体腔内注射药物治疗前后行OCTA血流成像技术测量患者视网膜、脉络膜MVD以及FAZ面积.结果RVO患者玻璃体腔注射雷珠单抗或傲迪适后,黄斑区各层MVD较治疗前均有增加,且有统计学差异(P<0.05);浅层FAZ面积较治疗前减小且有差异(P<0.05).两种药物治疗后比较,雷珠单抗组、傲迪适组DVC层MVD分别为36.08%±1.04%、38.63%±1.63%,只有DVC层MVD增加有统计学差异(P<0.05).结论RVO伴黄斑水肿患者相比正常人,黄斑区视网膜脉络膜各层的MVD偏低;RVO伴ME患者注射雷珠单抗与注射傲迪适对比,只有DVC层MVD增加是有差异的,且傲迪适组增加幅度更大. 展开更多
关键词 视网膜静脉阻塞 黄斑水肿 中心凹无血管区面积 黄斑区血管密度
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OCTA在NPDR患者黄斑区微循环改变中的临床效果及应用价值
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作者 刘晓辉 秦程 +2 位作者 康桂红 崔鲲龙 王海燕 《华夏医学》 CAS 2021年第5期9-13,共5页
目的:利用光学相干断层扫描血管成像(OCTA)观察非增殖型糖尿病视网膜病变(NPDR)患者黄斑区微循环改变情况,探讨OCTA的临床应用价值。方法:选择经FFA检查确诊为NPDR的患者70例118只眼为实验组,同期年龄、性别与患者相匹配、眼底无其他异... 目的:利用光学相干断层扫描血管成像(OCTA)观察非增殖型糖尿病视网膜病变(NPDR)患者黄斑区微循环改变情况,探讨OCTA的临床应用价值。方法:选择经FFA检查确诊为NPDR的患者70例118只眼为实验组,同期年龄、性别与患者相匹配、眼底无其他异常的健康人70例98只眼为对照组。实验组分为轻、中、重度NPDR,分别为19例26只眼、23例39只眼、28例53只眼。利用OCTA测量黄斑中心凹无血管区(FAZ)面积、黄斑区3 mm×3 mm血流密度,选用视网膜浅层(SRL)和视网膜深层(DRL)血流图像进行分析。结果:实验组中、重度NPDR组黄斑区视网膜毛细血管较正常对照组改变明显;无论是SRL还是DRL,4组的FAZ面积依次增大,血流密度依次减小,差异均有统计学意义(P<0.05)。结论:FAZ面积、黄斑区血流密度可作为检测NPDR病变程度的敏感指标,OCTA在诊断糖尿病视病变患者黄斑区微循环改变中具有重要临床应用价值,值得推广。 展开更多
关键词 光学相干断层扫描血管成像 视网膜病变 黄斑中心凹无血管区面积 黄斑区血流密度
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不同类型糖尿病性黄斑水肿患者血管及病变区域变化差异的研究 被引量:1
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作者 巨朝娟 梁晓丽 +3 位作者 赵丽娜 石笑楠 王丽娜 张新 《中华糖尿病杂志》 CAS CSCD 北大核心 2023年第7期630-634,共5页
目的分析不同类型糖尿病性黄斑水肿(DME)患者血管及病变区域变化的差异。方法选取2018年1月至2021年1月于河北医科大学第一医院就诊的DME患者196例为研究对象,根据是否存在黄斑区浆液性视网膜脱离(SRD)分为单纯弥漫性DME组(76例)及SRD型... 目的分析不同类型糖尿病性黄斑水肿(DME)患者血管及病变区域变化的差异。方法选取2018年1月至2021年1月于河北医科大学第一医院就诊的DME患者196例为研究对象,根据是否存在黄斑区浆液性视网膜脱离(SRD)分为单纯弥漫性DME组(76例)及SRD型DME组(120例)。收集两组患者的年龄、性别、糖尿病病程等一般资料及血肌酐等实验室指标。对两组患者进行眼部常规检查及光学相干断层扫描血管成像检查,检测黄斑中心凹视网膜厚度(CST)、黄斑中心凹下方脉络膜厚度(SFCT)、黄斑中心凹无血管区(FAZ)面积及视网膜深浅层血流比(DSFR)。两组间比较采用独立样本t检验,采用多因素logistic回归分析法分析DME患者合并SRD的影响因素。结果与单纯弥漫性DME组相比,SRD型DME组患者的CST[分别为(485.63±18.63)和(405.61±25.36)μm,t=32.395,P<0.001]、SFCT水平[分别为(295.46±51.16)和(274.16±52.98)μm,t=3.581,P<0.001]升高,DSFR水平(分别为1.10±0.05和1.16±0.12,t=6.164,P<0.001)和FAZ面积[分别为(0.31±0.16)和(0.38±0.12)mm^(2),t=4.196,P<0.001]降低,差异均具有统计学意义。多因素logistic回归分析结果显示,SFCT、DSFR、FAZ面积均为DME患者合并SRD的影响因素(OR=1.905,P=0.005;OR=0.452,P=0.001;OR=0.658,P=0.012)。结论不同类型DME患者SFCT、DSFR、FAZ面积存在差异,上述3个指标均为DME患者发生SRD的影响因素。 展开更多
关键词 糖尿病 黄斑水肿 血流密度 视网膜深浅层血流比 黄斑中心凹无血管区面积
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