Eisai Medical Research公司已在美国获得其治疗阿尔茨海默氏病的Aricept(donepezil，多奈哌齐)的新型口腔崩解片剂及液体配方的批准。该乙酰胆碱酯酶抑制剂的新配方被设计成使吞咽困难的患者易于接受。这种口腔崩解片剂是7月份在日本...Eisai Medical Research公司已在美国获得其治疗阿尔茨海默氏病的Aricept(donepezil，多奈哌齐)的新型口腔崩解片剂及液体配方的批准。该乙酰胆碱酯酶抑制剂的新配方被设计成使吞咽困难的患者易于接受。这种口腔崩解片剂是7月份在日本上市的，两种新增加的剂型都正在等待欧洲的批准。展开更多
A novel soft-sensor model which incorporates PCA （principal component analysis）, RBF （Radial Basis Function） networks, and MSA （Multi-scale analysis）, is proposed to infer the properties of manufactured products...A novel soft-sensor model which incorporates PCA （principal component analysis）, RBF （Radial Basis Function） networks, and MSA （Multi-scale analysis）, is proposed to infer the properties of manufactured products from real process variables. PCA is carried out to select the most relevant process features and to eliminate the correlations of input variables; multi-scale analysis is introduced to acquire much more information and to reduce uncertainty in the system; and RBF networks are used to characterize the nonlinearity of the process. A prediction of the melt index （MI）, or quality of polypropylene produced in an actual industrial process, is taken as a case study. Research results show that the proposed method provides promising prediction reliability and accuracy.展开更多
The MSA and nssSO 2- 4 concentration data from the ice cores and from atmospheric aerosols of the regions surrounding Weddell Sea have been analyzed in the present paper. The results suggest that the high concen...The MSA and nssSO 2- 4 concentration data from the ice cores and from atmospheric aerosols of the regions surrounding Weddell Sea have been analyzed in the present paper. The results suggest that the high concentration of biogenic sulphur in the snow and ice as well as in the atmospheric aerosols reflects the proximity of the Weddell Sea even though a distinct strength discrepancy exists in the productivity among the areas. The snow/ice shows that the production seems to be higher in the middle of the Antarctic Peninsula than near the Filchner Ronne ice shelf. Despite the factors impacting on the transportation and deposition processes of biogenic surlphur, the concentration of MSA and nssSO 2- 4 in snow and ice shows a regular spatial distribution: decreasing with the distance from the open sea and the altitude above sea level. Nevertheless, below a certain height, the “altitude effect” is no longer significant. The “displacement” of seasonality for MSA concentration observed in ice cores of the regions has been discussed. The “out of phase” pattern in surface layer is attributed to the modification by prevailing meteorological condition to the transport and deposition process; while “relocation” in the deep layers may be caused by migration, a mechanism for which is to be further investigated.The comparative study of the atmospheric and snow/ice samples implies that at the high altitude like the Weddell Sea the atmospheric signal of SO 2- 4 and MSA could be somewhat muted in the snow samples. But the seasonal variations in the airborn sulphate and MSA are reasonably well reproduced in the surface snow, for temporal and spacial distribution. The very close ratio of MSA to nssSO 2- 4 (or to SO 2- 4) of atmospheric aerosol and snow/ice sample is indicative of weak, if any, fraction between the two species during the scavenging and deposition processes. This could serve as the internal cause to explain the relative stable MSA/nssSO 2- 4 ratio, both for atmosphere and snow, an important regional specificity for the study of marine biogenic sulphur.展开更多
文摘Eisai Medical Research公司已在美国获得其治疗阿尔茨海默氏病的Aricept(donepezil，多奈哌齐)的新型口腔崩解片剂及液体配方的批准。该乙酰胆碱酯酶抑制剂的新配方被设计成使吞咽困难的患者易于接受。这种口腔崩解片剂是7月份在日本上市的，两种新增加的剂型都正在等待欧洲的批准。
基金This work is supported by the National Natural Science Foundation of China (No.20106008) the National Development and Reform Commission of China (No.Fagai Gaoji-2004-2080) and the science fund for distinguished young scholars of Zhejiang University (No.111000-581645).
文摘A novel soft-sensor model which incorporates PCA （principal component analysis）, RBF （Radial Basis Function） networks, and MSA （Multi-scale analysis）, is proposed to infer the properties of manufactured products from real process variables. PCA is carried out to select the most relevant process features and to eliminate the correlations of input variables; multi-scale analysis is introduced to acquire much more information and to reduce uncertainty in the system; and RBF networks are used to characterize the nonlinearity of the process. A prediction of the melt index （MI）, or quality of polypropylene produced in an actual industrial process, is taken as a case study. Research results show that the proposed method provides promising prediction reliability and accuracy.
文摘The MSA and nssSO 2- 4 concentration data from the ice cores and from atmospheric aerosols of the regions surrounding Weddell Sea have been analyzed in the present paper. The results suggest that the high concentration of biogenic sulphur in the snow and ice as well as in the atmospheric aerosols reflects the proximity of the Weddell Sea even though a distinct strength discrepancy exists in the productivity among the areas. The snow/ice shows that the production seems to be higher in the middle of the Antarctic Peninsula than near the Filchner Ronne ice shelf. Despite the factors impacting on the transportation and deposition processes of biogenic surlphur, the concentration of MSA and nssSO 2- 4 in snow and ice shows a regular spatial distribution: decreasing with the distance from the open sea and the altitude above sea level. Nevertheless, below a certain height, the “altitude effect” is no longer significant. The “displacement” of seasonality for MSA concentration observed in ice cores of the regions has been discussed. The “out of phase” pattern in surface layer is attributed to the modification by prevailing meteorological condition to the transport and deposition process; while “relocation” in the deep layers may be caused by migration, a mechanism for which is to be further investigated.The comparative study of the atmospheric and snow/ice samples implies that at the high altitude like the Weddell Sea the atmospheric signal of SO 2- 4 and MSA could be somewhat muted in the snow samples. But the seasonal variations in the airborn sulphate and MSA are reasonably well reproduced in the surface snow, for temporal and spacial distribution. The very close ratio of MSA to nssSO 2- 4 (or to SO 2- 4) of atmospheric aerosol and snow/ice sample is indicative of weak, if any, fraction between the two species during the scavenging and deposition processes. This could serve as the internal cause to explain the relative stable MSA/nssSO 2- 4 ratio, both for atmosphere and snow, an important regional specificity for the study of marine biogenic sulphur.
