Background: We investigated the differences between partial pressure of arterial carbon dioxide and end-tidal carbon dioxide (P(a-ET)CO2) with respect to the Broca-Katsura index (BKI), which is an obesity index, in ob...Background: We investigated the differences between partial pressure of arterial carbon dioxide and end-tidal carbon dioxide (P(a-ET)CO2) with respect to the Broca-Katsura index (BKI), which is an obesity index, in obese patients during general anesthesia. Materials and Methods: From January 2003 to December 2013, we studied 601 patients aged 16 years old or over undergoing general anesthesia. Patients had American Society of Anesthesiology physical status I and II and we reviewed their anesthetic charts. The P(a-ET)CO2 with respect to the BKI divided patients into two groups: 16 to 2 values between the two groups. Results: In patients aged 16 to 2 was 2.2 ± 3.1 mmHg at BKI 2 was 3.2 ± 4.1 mmHg at BKI 2 tends to increase in obese patients during general anesthesia with increasing BKI in patients aged 16 to < 65 years old.展开更多
In the east of China＇s seas, there is a wide range of the continental shelf. The nutrient cycle and the carbon cycle in the east of China＇s seas exhibit a strong variability on seasonal to decadal time scales. On th...In the east of China＇s seas, there is a wide range of the continental shelf. The nutrient cycle and the carbon cycle in the east of China＇s seas exhibit a strong variability on seasonal to decadal time scales. On the basis of a regional ocean modeling system（ROMS）, a three dimensional physical-biogeochemical model including the carbon cycle with the resolution（1/12）°×（1/12）° is established to investigate the physical variations, ecosystem responses and carbon cycle consequences in the east of China＇s seas. The ROMS-Nutrient Phytoplankton Zooplankton Detritus（NPZD） model is driven by daily air-sea fluxes（wind stress, long wave radiation, short wave radiation, sensible heat and latent heat, freshwater fluxes） that derived from the National Centers for Environmental Prediction（NCEP） reanalysis2 from 1982 to 2005. The coupled model is capable of reproducing the observed seasonal variation characteristics over the same period in the East China Sea. The integrated air-sea CO_2 flux over the entire east of China＇s seas reveals a strong seasonal cycle, functioning as a source of CO_2 to the atmosphere from June to October, while serving as a sink of CO_2 to the atmosphere in the other months. The 24 a mean value of airsea CO_2 flux over the entire east of China＇s seas is about 1.06 mol/（m^2·a）, which is equivalent to a regional total of3.22 Mt/a, indicating that in the east of China＇s seas there is a sink of CO_2 to the atmosphere. The partial pressure of carbon dioxide in sea water in the east of China＇s seas has an increasing rate of 1.15 μatm/a（1μtm/a=0.101 325Pa）, but p H in sea water has an opposite tendency, which decreases with a rate of 0.001 3 a^（–1） from 1982 to 2005.Biological activity is a dominant factor that controls the pCO_2 air in the east of China＇s seas, and followed by a temperature. The inverse relationship between the interannual variability of air-sea CO_2 flux averaged from the domain area and Ni？o3 SST Index indicates that the carbon cycle in the east of China＇s seas has a high correlation with El Ni？o-Southern Oscillation（ENSO）.展开更多
目的:分析不同血循环状态下经皮氧分压(transcutaneous oxygen pressure,PctO_2)与血氧分压(partial pressure of oxygen in arterial blood,PaO_2)、经皮二氧化碳分压(transcutaneous carbon dioxide pressure,PctCO_2)与血二氧化碳分...目的:分析不同血循环状态下经皮氧分压(transcutaneous oxygen pressure,PctO_2)与血氧分压(partial pressure of oxygen in arterial blood,PaO_2)、经皮二氧化碳分压(transcutaneous carbon dioxide pressure,PctCO_2)与血二氧化碳分压(partial pressure of oxygen in arterial blood,PaCO_2)的相关性及差异性,从而了解PctO_2及PctCO_2在微循环障碍时的监测意义。方法:对2014年11月至2015年3月在重庆医科大学附属儿童医院重症医学科住院的56例患儿进行PctO_2/PctCO_2监测,因病情需要,部分患儿不同时段予动态监测,共采集110份数据。分析微循环正常组(n=75)、轻度障碍组(n=20)及重度障碍组(n=15)间PctO_2与PaO_2及PctCO_2与PaCO_2的相关性及差异性。用受试者工作特征曲线(receiver operating characteristics curve,ROC curve)评价PctO_2、PctCO_2诊断低氧血症及二氧化碳潴留的敏感度及特异度。结果:相关性分析:在微循环正常组(n=75),PctO_2与PaO_2、PctCO_2与PaCO_2均有良好相关性(r=0.937、0.569,均P<0.05);在微循环轻度障碍组(n=20)及重度障碍组(n=15),患儿PctCO_2与PaCO_2均具有良好的相关性(r=0.718、0.679,均P<0.05),而PctO_2与PaO_2无相关性(P=0.175、0.074)。氧分压差(△PO2):微循环正常组(n=75)、轻度障碍组(n=20)和重度障碍组(n=15)的△PO2分别为:(0.24±1.08)、(7.99±7.99)和(9.71±5.15)k Pa。ROC曲线分析:微循环正常组(n=75)中,PctO_2在ROC曲线下面积(area under the ROC curve,AUC)为0.89(95%CI=0.82~0.96,P=0.036),PctO_2=10.25 k Pa时诊断缺氧的敏感度是81.5%,特异度是83.3%。PctCO_2的AUC为0.77(95%CI=0.65~0.88,P=0.000),PctCO_2=5.45 k Pa时诊断二氧化碳潴留的敏感度是81.5%,特异度是66.7%。结论:在微循环正常时,PctO_2/PctCO_2监测在一定程度上可预测PaO_2/PaCO_2。在微循环轻度障碍及重度障碍时,PctCO_2监测可预测PaCO_2。PctO_2与PaO_2差别明显时往往提示微循环灌注不良,对于此类危重症患者,可结合PctO_2/PctCO_2监测与血气分析中PaO_2/PaCO_2综合判断。展开更多
文摘Background: We investigated the differences between partial pressure of arterial carbon dioxide and end-tidal carbon dioxide (P(a-ET)CO2) with respect to the Broca-Katsura index (BKI), which is an obesity index, in obese patients during general anesthesia. Materials and Methods: From January 2003 to December 2013, we studied 601 patients aged 16 years old or over undergoing general anesthesia. Patients had American Society of Anesthesiology physical status I and II and we reviewed their anesthetic charts. The P(a-ET)CO2 with respect to the BKI divided patients into two groups: 16 to 2 values between the two groups. Results: In patients aged 16 to 2 was 2.2 ± 3.1 mmHg at BKI 2 was 3.2 ± 4.1 mmHg at BKI 2 tends to increase in obese patients during general anesthesia with increasing BKI in patients aged 16 to < 65 years old.
基金The National Key Research and Development Program of China under contract No.2016YFC1401605the National Key Research and Development Program of China under contract No.2016YFC1401605+3 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences under contract No.XDA 1102010403the National Natural Science Foundation of China under contract Nos 41222038,41206023 and 41076011the Public Science and Technology Research Funds projects of Ocean of China under contract No.201205018the Guangdong Provincial Key Laboratory of Fishery Ecology and Environment under contract No.LFE-2015-3
文摘In the east of China＇s seas, there is a wide range of the continental shelf. The nutrient cycle and the carbon cycle in the east of China＇s seas exhibit a strong variability on seasonal to decadal time scales. On the basis of a regional ocean modeling system（ROMS）, a three dimensional physical-biogeochemical model including the carbon cycle with the resolution（1/12）°×（1/12）° is established to investigate the physical variations, ecosystem responses and carbon cycle consequences in the east of China＇s seas. The ROMS-Nutrient Phytoplankton Zooplankton Detritus（NPZD） model is driven by daily air-sea fluxes（wind stress, long wave radiation, short wave radiation, sensible heat and latent heat, freshwater fluxes） that derived from the National Centers for Environmental Prediction（NCEP） reanalysis2 from 1982 to 2005. The coupled model is capable of reproducing the observed seasonal variation characteristics over the same period in the East China Sea. The integrated air-sea CO_2 flux over the entire east of China＇s seas reveals a strong seasonal cycle, functioning as a source of CO_2 to the atmosphere from June to October, while serving as a sink of CO_2 to the atmosphere in the other months. The 24 a mean value of airsea CO_2 flux over the entire east of China＇s seas is about 1.06 mol/（m^2·a）, which is equivalent to a regional total of3.22 Mt/a, indicating that in the east of China＇s seas there is a sink of CO_2 to the atmosphere. The partial pressure of carbon dioxide in sea water in the east of China＇s seas has an increasing rate of 1.15 μatm/a（1μtm/a=0.101 325Pa）, but p H in sea water has an opposite tendency, which decreases with a rate of 0.001 3 a^（–1） from 1982 to 2005.Biological activity is a dominant factor that controls the pCO_2 air in the east of China＇s seas, and followed by a temperature. The inverse relationship between the interannual variability of air-sea CO_2 flux averaged from the domain area and Ni？o3 SST Index indicates that the carbon cycle in the east of China＇s seas has a high correlation with El Ni？o-Southern Oscillation（ENSO）.
文摘目的:分析不同血循环状态下经皮氧分压(transcutaneous oxygen pressure,PctO_2)与血氧分压(partial pressure of oxygen in arterial blood,PaO_2)、经皮二氧化碳分压(transcutaneous carbon dioxide pressure,PctCO_2)与血二氧化碳分压(partial pressure of oxygen in arterial blood,PaCO_2)的相关性及差异性,从而了解PctO_2及PctCO_2在微循环障碍时的监测意义。方法:对2014年11月至2015年3月在重庆医科大学附属儿童医院重症医学科住院的56例患儿进行PctO_2/PctCO_2监测,因病情需要,部分患儿不同时段予动态监测,共采集110份数据。分析微循环正常组(n=75)、轻度障碍组(n=20)及重度障碍组(n=15)间PctO_2与PaO_2及PctCO_2与PaCO_2的相关性及差异性。用受试者工作特征曲线(receiver operating characteristics curve,ROC curve)评价PctO_2、PctCO_2诊断低氧血症及二氧化碳潴留的敏感度及特异度。结果:相关性分析:在微循环正常组(n=75),PctO_2与PaO_2、PctCO_2与PaCO_2均有良好相关性(r=0.937、0.569,均P<0.05);在微循环轻度障碍组(n=20)及重度障碍组(n=15),患儿PctCO_2与PaCO_2均具有良好的相关性(r=0.718、0.679,均P<0.05),而PctO_2与PaO_2无相关性(P=0.175、0.074)。氧分压差(△PO2):微循环正常组(n=75)、轻度障碍组(n=20)和重度障碍组(n=15)的△PO2分别为:(0.24±1.08)、(7.99±7.99)和(9.71±5.15)k Pa。ROC曲线分析:微循环正常组(n=75)中,PctO_2在ROC曲线下面积(area under the ROC curve,AUC)为0.89(95%CI=0.82~0.96,P=0.036),PctO_2=10.25 k Pa时诊断缺氧的敏感度是81.5%,特异度是83.3%。PctCO_2的AUC为0.77(95%CI=0.65~0.88,P=0.000),PctCO_2=5.45 k Pa时诊断二氧化碳潴留的敏感度是81.5%,特异度是66.7%。结论:在微循环正常时,PctO_2/PctCO_2监测在一定程度上可预测PaO_2/PaCO_2。在微循环轻度障碍及重度障碍时,PctCO_2监测可预测PaCO_2。PctO_2与PaO_2差别明显时往往提示微循环灌注不良,对于此类危重症患者,可结合PctO_2/PctCO_2监测与血气分析中PaO_2/PaCO_2综合判断。
