Objective To investigate the clinical characteristics and treatment strategy of lower extremity arterial occlusive disease in patients with Crohn's disease (CD). Methods Clinical information of 9 cases suffering f...Objective To investigate the clinical characteristics and treatment strategy of lower extremity arterial occlusive disease in patients with Crohn's disease (CD). Methods Clinical information of 9 cases suffering from lower extremity arterial occlusion and CD was investigated retrospectively. Results All the cases were less than 50 years old and the most were females (8/9). Arterial occlusions occurred in either active (5/9) or inactive (4/9) stage of CD. Besides the arteries of lower extremities, other arteries could also be involved such as aorta, iliac artery, renal artery or mesentery artery. Seven cases had atherosclerotic imaging findings (4 had aortic plaques and 6 had iliac artery stenoses). Embolectomy or thromboendarterectomy were mostly performed. Four (44.4%) cases had recurrent lower limb ischemia. Conclusions Arterial occlusive disease is a rare extraintestinal manifestation of CD. A thorough inspection of aorta is necessary. Embolectomy is mostly preferred. Anticoagulation treatment is highly recommended after the operation.展开更多
Objective To investigate the effect of Furongtongmai capsule on the in-stent restenosis （ISR） of superficial femoral artery after interventional operation in lower extremity Arteriosclerosis Occlusion （ASO）....Objective To investigate the effect of Furongtongmai capsule on the in-stent restenosis （ISR） of superficial femoral artery after interventional operation in lower extremity Arteriosclerosis Occlusion （ASO）. Methods： A total of 110 inpatients with ASO who performed Superficial femoral artery stent implantation were randomly divided into observation group and control group, with 55 cases in each group.Both groups received Aspirin 100 mg/d and Clopidogrel 75 mg/d. The observation group was given Furongtongmai capsule on the basis of routine treatment. After continuous treatment for 6 months, the clinical efficacy, Ankle Brachial Index （ABI）, high-sensitivity C-reactive protein （Hs-CPR） and ISR were compared between the two groups. Results： At 6 months after operation, the plasma levels of Hs-CRP in the two groups were significantly lower than those in the control group （P 〈 0.05）. The ABI of treatment group was significantly higher than the control group （P 〈 0.05）. There was a statistically significant difference in ISR incidence between the treatment group and the control group 6 months after surgery （9.09% vs 27.78%, P 〈 0.05）. Conclusion： Furongtongmai Capsule can inhibit Hs-CRP in patients with ASO after femoral artery intervention, improve the ankle brachial index and reduce the incidence of ISR.展开更多
目的探讨下肢动脉硬化性疾病无症状高危人群的危险因素及踝肱指数(ankle-brachial index,ABI)的预测价值。方法选取2020年1月至2022年12月成武县人民医院110例无下肢动脉硬化性疾病症状的高危人群为研究对象,均接受ABI测量,根据ABI将其...目的探讨下肢动脉硬化性疾病无症状高危人群的危险因素及踝肱指数(ankle-brachial index,ABI)的预测价值。方法选取2020年1月至2022年12月成武县人民医院110例无下肢动脉硬化性疾病症状的高危人群为研究对象,均接受ABI测量,根据ABI将其分为异常组和正常组,对比两组基线资料,并分析影响下肢动脉硬化性疾病无症状高危人群的危险因素及ABI的预测价值。结果经ABI测量显示,ABI≤0.9共31例,占比28.18%。异常组年龄,有高血压史、糖尿病史、吸烟史占比,C反应蛋白及同型半胱高于正常组,总胆固醇及ABI低于正常组(P均<0.05)。年龄、高血压史、糖尿病史、吸烟史、同型半胱氨酸、ABI是下肢动脉硬化性疾病无症状高危人群的影响因素(P均<0.05)。年龄、同型半胱氨酸、ABI预测下肢动脉硬化性疾病无症状高危人群的曲线下面积(area under curve,AUC)分别为0.959、0.965、0.986,ABI预测的敏感度优于年龄和同型半胱氨酸预测(P均<0.05)。结论早期检测ABI对下肢动脉硬化性疾病无症状高危人群具有预测作用。展开更多
文摘Objective To investigate the clinical characteristics and treatment strategy of lower extremity arterial occlusive disease in patients with Crohn's disease (CD). Methods Clinical information of 9 cases suffering from lower extremity arterial occlusion and CD was investigated retrospectively. Results All the cases were less than 50 years old and the most were females (8/9). Arterial occlusions occurred in either active (5/9) or inactive (4/9) stage of CD. Besides the arteries of lower extremities, other arteries could also be involved such as aorta, iliac artery, renal artery or mesentery artery. Seven cases had atherosclerotic imaging findings (4 had aortic plaques and 6 had iliac artery stenoses). Embolectomy or thromboendarterectomy were mostly performed. Four (44.4%) cases had recurrent lower limb ischemia. Conclusions Arterial occlusive disease is a rare extraintestinal manifestation of CD. A thorough inspection of aorta is necessary. Embolectomy is mostly preferred. Anticoagulation treatment is highly recommended after the operation.
文摘Objective To investigate the effect of Furongtongmai capsule on the in-stent restenosis （ISR） of superficial femoral artery after interventional operation in lower extremity Arteriosclerosis Occlusion （ASO）. Methods： A total of 110 inpatients with ASO who performed Superficial femoral artery stent implantation were randomly divided into observation group and control group, with 55 cases in each group.Both groups received Aspirin 100 mg/d and Clopidogrel 75 mg/d. The observation group was given Furongtongmai capsule on the basis of routine treatment. After continuous treatment for 6 months, the clinical efficacy, Ankle Brachial Index （ABI）, high-sensitivity C-reactive protein （Hs-CPR） and ISR were compared between the two groups. Results： At 6 months after operation, the plasma levels of Hs-CRP in the two groups were significantly lower than those in the control group （P 〈 0.05）. The ABI of treatment group was significantly higher than the control group （P 〈 0.05）. There was a statistically significant difference in ISR incidence between the treatment group and the control group 6 months after surgery （9.09% vs 27.78%, P 〈 0.05）. Conclusion： Furongtongmai Capsule can inhibit Hs-CRP in patients with ASO after femoral artery intervention, improve the ankle brachial index and reduce the incidence of ISR.
文摘目的探讨下肢动脉硬化性疾病无症状高危人群的危险因素及踝肱指数(ankle-brachial index,ABI)的预测价值。方法选取2020年1月至2022年12月成武县人民医院110例无下肢动脉硬化性疾病症状的高危人群为研究对象,均接受ABI测量,根据ABI将其分为异常组和正常组,对比两组基线资料,并分析影响下肢动脉硬化性疾病无症状高危人群的危险因素及ABI的预测价值。结果经ABI测量显示,ABI≤0.9共31例,占比28.18%。异常组年龄,有高血压史、糖尿病史、吸烟史占比,C反应蛋白及同型半胱高于正常组,总胆固醇及ABI低于正常组(P均<0.05)。年龄、高血压史、糖尿病史、吸烟史、同型半胱氨酸、ABI是下肢动脉硬化性疾病无症状高危人群的影响因素(P均<0.05)。年龄、同型半胱氨酸、ABI预测下肢动脉硬化性疾病无症状高危人群的曲线下面积(area under curve,AUC)分别为0.959、0.965、0.986,ABI预测的敏感度优于年龄和同型半胱氨酸预测(P均<0.05)。结论早期检测ABI对下肢动脉硬化性疾病无症状高危人群具有预测作用。
