The use of bone marrow concentrate in the treatment of degenerative joint disese(DJD)in dogs represents an innovative approach,minim invasive,that already has been used with increasing success in the veterinary field....The use of bone marrow concentrate in the treatment of degenerative joint disese(DJD)in dogs represents an innovative approach,minim invasive,that already has been used with increasing success in the veterinary field.The technique,adapted from human medicine for the quadruped patients is based on the principle of the autologous transplant of mesenchymal stem cells that are included in the bone marrow concentrate.The intervention involves a short anesthesia of the animal for harvesting the marrow.The processing of the marrow is realised in strict aseptic conditions in a laboratory and the inoculation is done in the same day.The results are clinically visible after 2-4 weeks.For an enhanced effect,a part of the concentrate is grown on a flask in specific conditions in order to expand autologous bone marrow stem cells and is inoculated after a sufficient number of cells are achieved,usually 3-4 weeks.展开更多
Introduction: Currently, the therapeutic arsenal of osteoarthritis includes several extracts of Curcuma including Flexofytol®, a bio-optimized extract of Curcuma longa. However, in older patients, indications ...Introduction: Currently, the therapeutic arsenal of osteoarthritis includes several extracts of Curcuma including Flexofytol®, a bio-optimized extract of Curcuma longa. However, in older patients, indications for treatment might be limited by comorbidity and polymedication. Therefore, we aimed to assess the benefits and risks of Flexofytol®, in an older population with comorbidities. Patients and Methods: This retrospective observational study included 31 patients over age 70 years (medianage: 77 years, range 71 - 81) that were treated with Flexofytol for painful osteoarthritis of the knee or lumbar spine. These patients were initially weakened by diabetes (48%) and/or renal insufficiency (71%), or they were taking anticoagulants (35%). The effects of Flexofytol®, were evaluated at 0, 6 and 12 weeks with visual analog scales for pain and disability and the SF-12 Quality of Life questionnaire. Adverse effects and drug interactions of Flexofytol®, were evaluated. In particular, we evaluated renal function, diabetes parameters and coagulation tests. The data were analyzed with Kruskal-Wallis and Wilcoxon-Mann-Withney non-parametric tests. Results: Patients with Flexofytol®, showed significant improvement: pain improved by 50% (p = 0.0002) and functional disability improved by 33% (p = 0.0075). A series of quality of life parameters improved within the first 6 weeks of treatment and up to 3 months of treatment without impacting renal function, metabolic parameters or coagulation tests. We observed no significant adverse effects. Conclusion: In conclusion, our results suggested that Flexofytol®, may be useful in the management of painful osteoarthritis, particularly in older patients that are fragile due to comorbidity and polymedication. These initial results must be confirmed in future studies.展开更多
Artificial bone powder is satisfactorily deposited onto the surface of synthetic metal arthrosis(Co-Cr-Mo) with plasma spraying process. Factors influencing the quality of coating are investigated. Bond of artificial ...Artificial bone powder is satisfactorily deposited onto the surface of synthetic metal arthrosis(Co-Cr-Mo) with plasma spraying process. Factors influencing the quality of coating are investigated. Bond of artificial bone powder coating sprayed with different parameters is measured. and the coatings are anlyzed with metallographic examination and electron probe analysis. Experiments show that artificial bone powder coating sprayed onto synthetic metal arthrosis with satisfactory bond strength can be obtained by manipulating plasma spraying.展开更多
文摘The use of bone marrow concentrate in the treatment of degenerative joint disese(DJD)in dogs represents an innovative approach,minim invasive,that already has been used with increasing success in the veterinary field.The technique,adapted from human medicine for the quadruped patients is based on the principle of the autologous transplant of mesenchymal stem cells that are included in the bone marrow concentrate.The intervention involves a short anesthesia of the animal for harvesting the marrow.The processing of the marrow is realised in strict aseptic conditions in a laboratory and the inoculation is done in the same day.The results are clinically visible after 2-4 weeks.For an enhanced effect,a part of the concentrate is grown on a flask in specific conditions in order to expand autologous bone marrow stem cells and is inoculated after a sufficient number of cells are achieved,usually 3-4 weeks.
文摘Introduction: Currently, the therapeutic arsenal of osteoarthritis includes several extracts of Curcuma including Flexofytol®, a bio-optimized extract of Curcuma longa. However, in older patients, indications for treatment might be limited by comorbidity and polymedication. Therefore, we aimed to assess the benefits and risks of Flexofytol®, in an older population with comorbidities. Patients and Methods: This retrospective observational study included 31 patients over age 70 years (medianage: 77 years, range 71 - 81) that were treated with Flexofytol for painful osteoarthritis of the knee or lumbar spine. These patients were initially weakened by diabetes (48%) and/or renal insufficiency (71%), or they were taking anticoagulants (35%). The effects of Flexofytol®, were evaluated at 0, 6 and 12 weeks with visual analog scales for pain and disability and the SF-12 Quality of Life questionnaire. Adverse effects and drug interactions of Flexofytol®, were evaluated. In particular, we evaluated renal function, diabetes parameters and coagulation tests. The data were analyzed with Kruskal-Wallis and Wilcoxon-Mann-Withney non-parametric tests. Results: Patients with Flexofytol®, showed significant improvement: pain improved by 50% (p = 0.0002) and functional disability improved by 33% (p = 0.0075). A series of quality of life parameters improved within the first 6 weeks of treatment and up to 3 months of treatment without impacting renal function, metabolic parameters or coagulation tests. We observed no significant adverse effects. Conclusion: In conclusion, our results suggested that Flexofytol®, may be useful in the management of painful osteoarthritis, particularly in older patients that are fragile due to comorbidity and polymedication. These initial results must be confirmed in future studies.
文摘Artificial bone powder is satisfactorily deposited onto the surface of synthetic metal arthrosis(Co-Cr-Mo) with plasma spraying process. Factors influencing the quality of coating are investigated. Bond of artificial bone powder coating sprayed with different parameters is measured. and the coatings are anlyzed with metallographic examination and electron probe analysis. Experiments show that artificial bone powder coating sprayed onto synthetic metal arthrosis with satisfactory bond strength can be obtained by manipulating plasma spraying.
