NEW HYBRID AI-SVM ALGORITHM: COMBINATION OF SUPPORT VECTOR MACHINES AND ARTIFICIAL IMMUNE NETWORKS

Support vector machines （SVMs） are combined with the artificial immune network （aiNet）, thus forming a new hybrid ai-SVM algorithm. The algorithm is used to reduce the number of samples and the training time of SVM on large datasets, aiNet is an artificial immune system （AIS） inspired method to perform the automatic data compression, extract the relevant information and retain the topology of the original sample distribution. The output of aiNet is a set of antibodies for representing the input dataset in a simplified way. Then the SVM model is built in the compressed antibody network instead of the original input data. Experimental results show that the ai-SVM algorithm is effective to reduce the computing time and simplify the SVM model, and the accuracy is not decreased.

Parameter optimization of pharmacokinetics based on artificial immune network

A new method for parameter optimization of pharmacokinetics based on an artificial immune network named PKAIN is proposed. To improve local searching ability of the artificial immune network, a partition-based concurrent simplex mutation is developed. By means of evolution of network cells in the PKAIN artificial immune network, an optimal set of parameters of a given pharmacokinetic model is obtained. The Laplace transform is applied to the pharmacokinetic differential equations of remifentanil and its major metabolite, remifentanil acid. The PKAIN method is used to optimize parameters of the derived compartment models. Experimental results show that the twocompartment model is sufficient for the pharmacokinetic study of remifentanil acid for patients with mild degree of renal impairment.

Anomaly Detection with Artificial Immune Network

Inspired by the immune network theory, an adaptive anomaly detection paradigm based on artificial immune network, referred as APAI, is proposed. The implementation of the paradigm includes： initially, the first is to create the initial antibody network; then, through the learning of each training antigen, the antibody network is evolved and updated by the optimal antibodies. Finally, anomaly detection process is accomplished by majority vote of the k nearest neighbor antibodies in the network. The experiments used the famous Sonar Benchmark dataset in our study, which is taken from the UCI machine learning database. The obtained detection accuracy of APAI was 97.7%, which was very promising with regard to the other classification applications in the literature for this problem. In addition to its nonlinear classification properties, APAI possesses biological immune network properties such as clonal selection, immune network, and immune memory, which can be applied to pattern recognition, classification, and etc.

A decision hyper plane heuristic based artificial immune network classification algorithm

Most of the developed immune based classifiers generate antibodies randomly, which has negative effect on the classification performance. In order to guide the antibody generation effectively, a decision hyper plane heuristic based artificial immune network classification algorithm （DHPA1NC） is proposed. DHPAINC taboos the inner regions of the class domain, thus, the antibody generation is limited near the class domain boundary. Then, the antibodies are evaluated by their recognition abilities, and the antibodies of low recognition abilities are removed to avoid over-fitting. Finally, the high quality antibodies tend to be stable in the immune network. The algorithm was applied to two simulated datasets classification, and the results show that the decision hyper planes determined by the antibodies fit the class domain boundaries well. Moreover, the algorithm was applied to UCI datasets classification and emotional speech recognition, and the results show that the algorithm has good performance, which means that DHPAINC is a promising classifier.

A new artificial immune algorithm and its application for optimization problems

A new artificial immune algorithm （AIA） simulating the biological immune network system with selfadjustment function is proposed in this paper. AIA is based on the modified immune network model in which two methods of affinity measure evaluated are used, controlling the antibody diversity and the speed of convergence separately. The model proposed focuses on a systemic view of the immune system and takes into account cell-cell interactions denoted by antibody affinity. The antibody concentration defined in the immune network model is responsible directly for its activity in the immune system. The model introduces not only a term describing the network dynamics, but also proposes an independent term to simulate the dynamics of the antigen population. The antibodies＇ evolutionary processes are controlled in the algorithms by utilizing the basic properties of the immune network. Computational amount and effect is a pair of contradictions. In terms of this problem, the AIA regulating the parameters easily attains a compromise between them. At the same time, AIA can prevent premature convergence at the cost of a heavy computational amount （the iterative times）. Simulation illustrates that AIA is adapted to solve optimization problems, emphasizing muhimodal optimization.

Real-time immune-inspired optimum state-of-charge trajectory estimation using upcoming route information preview and neural networks for plug-in hybrid electric vehicles fuel economy

The main proposition of the current investigation is to develop a computational intelligence-based framework which can be used for the real-time estimation of optimum battery state-of-charge （SOC） trajectory in plug-in hybrid electric vehicles （PHEVs）. The estimated SOC trajectory can be then employed for an intelligent power management to significantly improve the fuel economy of the vehicle. The devised intelligent SOC trajectory builder takes advantage of the upcoming route information preview to achieve the lowest possible total cost of electricity and fossil fuel. To reduce the complexity of real-time optimization, the authors propose an immune system-based clustering approach which allows categoriz- ing the route information into a predefined number of segments. The intelligent real-time optimizer is also inspired on the basis of interactions in biological immune systems, and is called artificial immune algorithm （AIA）. The objective function of the optimizer is derived from a computationally efficient artificial neural network （ANN） which is trained by a database obtained from a high-fidelity model of the vehicle built in the Autonomic software. The simulation results demonstrate that the integration of immune inspired clustering tool, AIA and ANN, will result in a powerful framework which can generate a near global optimum SOC trajectory for the baseline vehicle, that is, the Toyota Prius PHEV. The outcomes of the current investigation prove that by taking advantage of intelligent approaches, it is possible to design a computationally efficient and powerful SOC trajectory builder for the intelligent power management of PHEVs.