Objective:To explore the best time for progesterone supplementation in AID ovulation induction cycles by Letrozole.Methods: The data analysed in this study were collected from 509 patients who were performed AID (Arti...Objective:To explore the best time for progesterone supplementation in AID ovulation induction cycles by Letrozole.Methods: The data analysed in this study were collected from 509 patients who were performed AID (Artificial Insemination by Donor) administrated letrozole (LE) between 2014.8-2015.7. All patients were randomly divided into 4 groups by the time of progesterone administrated, including experimental group and the control group. The experimental group was divided into group 1-72 h after ovulation, group 2-48 h after ovulation, group 3-24 h after ovulation and control group—without administrated LE. The gestation and live birth rate were evaluated by monitoring vaginal ultrasound and HCG blood value 14 d after AID.Results: The pregnancy rate with administrated progesterone added 72 h after ovulation was 31.9%, which was significantly higher than those of other groups, the same situation as groups added progesterone was significantly higher than the control group. However, there was no significant difference in the numbers of abortions among the four groups. The LBR of group 4 was significantly lower than that of group 1.Conclutions: Progesterone administrated 72 h after ovulation can promoted the gestation rate, but did not affect the rate of miscarrage .展开更多
供精人工授精(artificial insemination by donor,AID)是人类辅助生殖技术之一,对于少、弱、畸形精子症,严重遗传病等男性患者,通过非性交方式将供精者的精液放入女性生殖道内,达到生育目的,AID是目前世界各国广为采用的治疗男性不育的...供精人工授精(artificial insemination by donor,AID)是人类辅助生殖技术之一,对于少、弱、畸形精子症,严重遗传病等男性患者,通过非性交方式将供精者的精液放入女性生殖道内,达到生育目的,AID是目前世界各国广为采用的治疗男性不育的技术。这种生育方式使以血缘为基础和纽带的传统亲子关系受到根本性的冲击,从而引起一系列伦理和法律问题等方面的社会问题。本文就亲子关系的复杂化和AID子女的法律地位、单身妇女可否接受AID、孩子的知情权、精子库管理及近亲繁殖的问题进行探讨。展开更多
目的分析探讨多种因素对供精人工授精(AID)妊娠结局的影响。方法回顾性分析2013年1月-2015年12月期间在本中心治疗的10 690个AID周期,对女方年龄、不孕年限、治疗方案、输卵管通畅程度、子宫内膜厚度、每周期排卵数、每周期A I D授精次...目的分析探讨多种因素对供精人工授精(AID)妊娠结局的影响。方法回顾性分析2013年1月-2015年12月期间在本中心治疗的10 690个AID周期,对女方年龄、不孕年限、治疗方案、输卵管通畅程度、子宫内膜厚度、每周期排卵数、每周期A I D授精次数、精子冻融复苏后浓度、精子冻融复苏后活动率、精子冻融复苏后前向运动精子总数与术后妊娠结局进行χ~2和多因素Logistic回归分析。结果年龄≤30岁妇女的妊娠机会是年龄>35岁者的1.934倍(OR=1.934,P<0.001)、年龄31~35岁妇女的妊娠机会是>35岁者的1.511倍(OR=1.511,P<0.001),自然周期妇女妊娠机会是促排卵周期者的1.307倍(OR=1.307,P<0.001),每周期AID授精2次的妇女妊娠机会是1次组的1.486倍(OR=1.486,P=0.001),每周期AID授精3次的妇女妊娠机会是1次组的1.338倍(OR=1.338,P=0.020),每周期排卵2个的妇女妊娠机会是排1个卵组的1.362倍(OR=1.362,P=0.001),每周期排卵3个的妇女妊娠机会是排卵1个组的1.499倍(OR=1.499,P=0.004),精子冻融复苏后活动率>60%的妇女妊娠机会是≤60%组的1.211倍(OR=1.211,P=0.038),精子冻融复苏后前向运动精子总数≥35×10~6的妇女妊娠机会是≤25×10~6组的1.319倍(OR=1.319,P=0.011)。结论女方年龄≤35岁、每周期排卵2~3个、每周期AID授精2~3次、精子冻融复苏后活动率>60%和精子冻融复苏后前向运动精子总数≥35×10~6能提高授精妇女的妊娠几率;在患者无明显排卵障碍的情况下,应首选自然周期。展开更多
基金National Natural Science Foundation project(81260124)Henan Province Department of Education Science and Technology Project(14B310019).
文摘Objective:To explore the best time for progesterone supplementation in AID ovulation induction cycles by Letrozole.Methods: The data analysed in this study were collected from 509 patients who were performed AID (Artificial Insemination by Donor) administrated letrozole (LE) between 2014.8-2015.7. All patients were randomly divided into 4 groups by the time of progesterone administrated, including experimental group and the control group. The experimental group was divided into group 1-72 h after ovulation, group 2-48 h after ovulation, group 3-24 h after ovulation and control group—without administrated LE. The gestation and live birth rate were evaluated by monitoring vaginal ultrasound and HCG blood value 14 d after AID.Results: The pregnancy rate with administrated progesterone added 72 h after ovulation was 31.9%, which was significantly higher than those of other groups, the same situation as groups added progesterone was significantly higher than the control group. However, there was no significant difference in the numbers of abortions among the four groups. The LBR of group 4 was significantly lower than that of group 1.Conclutions: Progesterone administrated 72 h after ovulation can promoted the gestation rate, but did not affect the rate of miscarrage .
文摘供精人工授精(artificial insemination by donor,AID)是人类辅助生殖技术之一,对于少、弱、畸形精子症,严重遗传病等男性患者,通过非性交方式将供精者的精液放入女性生殖道内,达到生育目的,AID是目前世界各国广为采用的治疗男性不育的技术。这种生育方式使以血缘为基础和纽带的传统亲子关系受到根本性的冲击,从而引起一系列伦理和法律问题等方面的社会问题。本文就亲子关系的复杂化和AID子女的法律地位、单身妇女可否接受AID、孩子的知情权、精子库管理及近亲繁殖的问题进行探讨。
文摘目的分析探讨多种因素对供精人工授精(AID)妊娠结局的影响。方法回顾性分析2013年1月-2015年12月期间在本中心治疗的10 690个AID周期,对女方年龄、不孕年限、治疗方案、输卵管通畅程度、子宫内膜厚度、每周期排卵数、每周期A I D授精次数、精子冻融复苏后浓度、精子冻融复苏后活动率、精子冻融复苏后前向运动精子总数与术后妊娠结局进行χ~2和多因素Logistic回归分析。结果年龄≤30岁妇女的妊娠机会是年龄>35岁者的1.934倍(OR=1.934,P<0.001)、年龄31~35岁妇女的妊娠机会是>35岁者的1.511倍(OR=1.511,P<0.001),自然周期妇女妊娠机会是促排卵周期者的1.307倍(OR=1.307,P<0.001),每周期AID授精2次的妇女妊娠机会是1次组的1.486倍(OR=1.486,P=0.001),每周期AID授精3次的妇女妊娠机会是1次组的1.338倍(OR=1.338,P=0.020),每周期排卵2个的妇女妊娠机会是排1个卵组的1.362倍(OR=1.362,P=0.001),每周期排卵3个的妇女妊娠机会是排卵1个组的1.499倍(OR=1.499,P=0.004),精子冻融复苏后活动率>60%的妇女妊娠机会是≤60%组的1.211倍(OR=1.211,P=0.038),精子冻融复苏后前向运动精子总数≥35×10~6的妇女妊娠机会是≤25×10~6组的1.319倍(OR=1.319,P=0.011)。结论女方年龄≤35岁、每周期排卵2~3个、每周期AID授精2~3次、精子冻融复苏后活动率>60%和精子冻融复苏后前向运动精子总数≥35×10~6能提高授精妇女的妊娠几率;在患者无明显排卵障碍的情况下,应首选自然周期。
