Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility.However,distinct groups of infertile patients with unexplained infertility,congenital disorders,and other complex case...Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility.However,distinct groups of infertile patients with unexplained infertility,congenital disorders,and other complex cases pose a challenge in in vitro fertilization(IVF)practices.This special cohort of patients is associated with futile attempts,IVF overuse,and dead ends in management.Cutting edge research on animal models introduced this concept,along with the development of artificial organs with the aim to mimic the respective physiological functions in reproduction.Extrapolation on clinical application leads to the future use of infertility management in humans.To date,the successful clinical application of artificial reproductive organs in humans is not feasible because further animal model studies are required prior to clinical trials.The application of these artificial organs could provide a solution to infertility cases with no other options.This manuscript presents an overview on the current status,future prospects,and considerations on the potential clinical application of artificial ovary,uterus,and gametes in humans.This paper presents how the IVF practice landscape may be shaped and challenged in the future,along with the subsequent concerns in assisted reproductive treatments.展开更多
Reproduction is the most important event for the continuation of life.Unfortunately,infertility is a widespread problem.Recently,biomaterials have been widely used in reproductive biology,including tissue engineering,...Reproduction is the most important event for the continuation of life.Unfortunately,infertility is a widespread problem.Recently,biomaterials have been widely used in reproductive biology,including tissue engineering,regenerative medicine and contraception.In this review,we summarize the research progress of biomaterials applied in follicle culture,artificial ovary,tissue engineering,and contraception.We first introduce the applications and advantages of different biomaterials in follicle culture and artificial ovary.Then,we summarize the biomaterials for tissue engineering in reproductive biology.Also,we introduce the applications of biomaterials for contraception.Besides,some emerging technologies are also introduced,such as microfluidic chip,organ chip,3D printing,electrostatic spinning and stem cell therapy in the fundamental research and clinical application.We believe that this review will promote the interdisciplinary communication between biomaterial science and reproductive biology.展开更多
文摘Assisted reproduction provides a wide spectrum of treatments and strategies addressing infertility.However,distinct groups of infertile patients with unexplained infertility,congenital disorders,and other complex cases pose a challenge in in vitro fertilization(IVF)practices.This special cohort of patients is associated with futile attempts,IVF overuse,and dead ends in management.Cutting edge research on animal models introduced this concept,along with the development of artificial organs with the aim to mimic the respective physiological functions in reproduction.Extrapolation on clinical application leads to the future use of infertility management in humans.To date,the successful clinical application of artificial reproductive organs in humans is not feasible because further animal model studies are required prior to clinical trials.The application of these artificial organs could provide a solution to infertility cases with no other options.This manuscript presents an overview on the current status,future prospects,and considerations on the potential clinical application of artificial ovary,uterus,and gametes in humans.This paper presents how the IVF practice landscape may be shaped and challenged in the future,along with the subsequent concerns in assisted reproductive treatments.
基金supported by the China Postdoctoral Science Foundation funded project(2021M700141)Zhejiang Province Selected Funding for Postdoctoral Research Project(ZJ2021096)the Wenzhou Institute,University of Chinese Academy of Sciences startup fund(WIU-CASQD2022001).
文摘Reproduction is the most important event for the continuation of life.Unfortunately,infertility is a widespread problem.Recently,biomaterials have been widely used in reproductive biology,including tissue engineering,regenerative medicine and contraception.In this review,we summarize the research progress of biomaterials applied in follicle culture,artificial ovary,tissue engineering,and contraception.We first introduce the applications and advantages of different biomaterials in follicle culture and artificial ovary.Then,we summarize the biomaterials for tissue engineering in reproductive biology.Also,we introduce the applications of biomaterials for contraception.Besides,some emerging technologies are also introduced,such as microfluidic chip,organ chip,3D printing,electrostatic spinning and stem cell therapy in the fundamental research and clinical application.We believe that this review will promote the interdisciplinary communication between biomaterial science and reproductive biology.
