One-pot simultaneous debrominative decarboxylation and sulfamation of anti-2,3-dibromo-3-（4-chlorosulfonylphenyl）propa- noic acid in DMF （for alkyl amines） or DMF-pyridine （for aryl amines） using a diverse range...One-pot simultaneous debrominative decarboxylation and sulfamation of anti-2,3-dibromo-3-（4-chlorosulfonylphenyl）propa- noic acid in DMF （for alkyl amines） or DMF-pyridine （for aryl amines） using a diverse range of alkyl and aryl amines under microwave irradiation condition stereoselectively afforded （Z）-4-（2-bromovinyl）benzenesulfonamides in good yields.展开更多
Thirteen new ethyl 2-（N-substituted-arylsulfonamido）-2-oxoacetates（3a-3m）, based on the structure of Ketol-acid reductoisomerase（KARI） inhibitor IpOHA, were designed and synthesized. Their structures were establ...Thirteen new ethyl 2-（N-substituted-arylsulfonamido）-2-oxoacetates（3a-3m）, based on the structure of Ketol-acid reductoisomerase（KARI） inhibitor IpOHA, were designed and synthesized. Their structures were established on the basis of ^1H NMR, IR, MS, and elemental analyses. The bioassay result reveals that the structural changes from hydroxyl group on the N atom of IpOHA to arylsulfonyl groups does not enhance the inhibitory activity of the compounds to KARI in vitro. Compounds 3c, 3h, 3k, and 3m are more effective than IpOHA against the monocotyledonous bamygrass at 100 ug/mL in herbicidal tests.展开更多
Three-component reaction of arylsulfonamides,dialkyl acetylenedicarboxylates,and ethyl chlorooxoacetate promoted by triphenylphosphine and triethylamine provides a sufficient route for the synthesis of dialkyl N-（ary...Three-component reaction of arylsulfonamides,dialkyl acetylenedicarboxylates,and ethyl chlorooxoacetate promoted by triphenylphosphine and triethylamine provides a sufficient route for the synthesis of dialkyl N-（arylsulfonyl）-4-ethoxy-5-oxo-2,5-dihydro -1H-pyrolle-2,3-dicarboxylates in good yields.展开更多
基金KZ acknowledges supports from the National Young Scholar Award of the NSFC(#30125043)from the Chung Kong Scholars Program administered by the Ministry of Education,PRC and the Li Ka Shing Foundation,Hong Kong.
基金supported by the Natural Science Foundation of Shanghai,China(No.06ZR14085)by the Scientific Research Foundation for the Returned Overseas Chinese Scholars,State Education Ministry
文摘One-pot simultaneous debrominative decarboxylation and sulfamation of anti-2,3-dibromo-3-（4-chlorosulfonylphenyl）propa- noic acid in DMF （for alkyl amines） or DMF-pyridine （for aryl amines） using a diverse range of alkyl and aryl amines under microwave irradiation condition stereoselectively afforded （Z）-4-（2-bromovinyl）benzenesulfonamides in good yields.
基金the National Basic Research Program of China(No.2003CB114406)Tianjin Natural Science Founda- tion(No.08JCYBJ00800)
文摘Thirteen new ethyl 2-（N-substituted-arylsulfonamido）-2-oxoacetates（3a-3m）, based on the structure of Ketol-acid reductoisomerase（KARI） inhibitor IpOHA, were designed and synthesized. Their structures were established on the basis of ^1H NMR, IR, MS, and elemental analyses. The bioassay result reveals that the structural changes from hydroxyl group on the N atom of IpOHA to arylsulfonyl groups does not enhance the inhibitory activity of the compounds to KARI in vitro. Compounds 3c, 3h, 3k, and 3m are more effective than IpOHA against the monocotyledonous bamygrass at 100 ug/mL in herbicidal tests.
基金the financial support from the Research Council of Islamic Azad University,Mahshahr Branch
文摘Three-component reaction of arylsulfonamides,dialkyl acetylenedicarboxylates,and ethyl chlorooxoacetate promoted by triphenylphosphine and triethylamine provides a sufficient route for the synthesis of dialkyl N-（arylsulfonyl）-4-ethoxy-5-oxo-2,5-dihydro -1H-pyrolle-2,3-dicarboxylates in good yields.
