Malaria remains the most serious infectious disease and is one of the leading causes of death among children in malaria endemic areas.The development of malaria vaccines has been underway since 1960s.Significant progr...Malaria remains the most serious infectious disease and is one of the leading causes of death among children in malaria endemic areas.The development of malaria vaccines has been underway since 1960s.Significant progress in the development of vaccine has been made in the last decade.On 6 October 2021,World Health Organization recommended widespread use of the RTS,S/AS01 malaria vaccine.The level of acceptance of RTS,S/AS01 malaria vaccine is relatively low in middle-income countries.This might be because of lack of information regarding vaccine implementation in such countries.The proper and efficient execution of the malaria vaccination program necessitates careful consideration of each community's socio-cultural setting.The most prominent RTS,S/AS01 vaccine trial was conducted from 2009 to 2011 in which eleven sites in seven African countries participated.Results of the trial,published in 2015,provided a promising advance in the development of a malaria vaccine for African children.As of 2019,large-scale pilot studies of the vaccine have been conducted in Ghana,Kenya,and Malawi,involving several hundreds of thousands of infants.The RTS,S/AS01 vaccine shows modest efficacy against malaria and has a feasible mode of administration.Although there is increased risk of meningitis,cerebral malaria,pneumonia,anemia,febrile convulsions and gastroenteritis,the vaccine still has a feasible mode of administration and high cost effectiveness and can be easily implemented in resource-limited settings.展开更多
韩泰轮胎旗下的路欧锋Laufenn新品牌,产品继承了韩泰轮胎一贯的高性价比特点,品牌定位更年轻一些,在舒适度、噪声、操控、制动等各方面表现得很均衡,具备一定的驾驶乐趣路欧锋是韩泰轮胎旗下的新品牌,品牌定位更年轻一些,但是产品还是...韩泰轮胎旗下的路欧锋Laufenn新品牌,产品继承了韩泰轮胎一贯的高性价比特点,品牌定位更年轻一些,在舒适度、噪声、操控、制动等各方面表现得很均衡,具备一定的驾驶乐趣路欧锋是韩泰轮胎旗下的新品牌,品牌定位更年轻一些,但是产品还是继承了韩泰一贯的高性价比的特点,用下来无论从舒适度、噪声、操控、制动等方面都比较均衡,价格在进口品牌中很有竞争力。我们使用了操控非常优异的国内第一款速腾2.0MT轿车,使用路欧锋G FIT as01轮胎,展开更多
Latent varicella-zoster virus(VZV)may be reactivated to cause herpes zoster,which affects one in three people during their lifetime.The currently available subunit vaccine Shingrix^(TM) is superior to the attenuated v...Latent varicella-zoster virus(VZV)may be reactivated to cause herpes zoster,which affects one in three people during their lifetime.The currently available subunit vaccine Shingrix^(TM) is superior to the attenuated vaccine Zostavax®in terms of both safety and efficacy,but the supply of its key adjuvant component QS21 is limited.With ionizable lipid nanoparticles(LNPs)that were recently approved by the FDA for COVID-19 mRNA vaccines as carriers,and oligodeoxynucleotides containing CpG motifs(CpG ODNs)approved by the FDA for a subunit hepatitis B vaccine as immunostimulators,we developed a LNP vaccine encapsulating VZV-glycoprotein E(gE)and CpG ODN,and compared its immunogenicity with Shingrix^(TM) in C57BL/6J mice.The results showed that the LNP vaccine induced comparable levels of gE-specific IgG antibodies to Shingrix^(TM) as determined by enzymelinked immunosorbent assay(ELISA).Most importantly,the LNP vaccine induced comparable levels of cellmediated immunity(CMI)that plays decisive roles in the efficacy of zoster vaccines to Shingrix^(TM) in a VZVprimed mouse model that was adopted for preclinical studies of Shingrix^(TM) .Number of IL-2 and IFN-γsecreting splenocytes and proportion of T helper 1(Th1)cytokine-expressing CD4^(+)T cells in LNP-CpG-adjuvanted VZV-gE vaccinated mice were similar to that of Shingrix^(TM) boosted mice.All of the components in this LNP vaccine can be artificially and economically synthesized in large quantities,indicating the potential of LNP-CpGadjuvanted VZV-gE as a more cost-effective zoster vaccine.展开更多
文摘Malaria remains the most serious infectious disease and is one of the leading causes of death among children in malaria endemic areas.The development of malaria vaccines has been underway since 1960s.Significant progress in the development of vaccine has been made in the last decade.On 6 October 2021,World Health Organization recommended widespread use of the RTS,S/AS01 malaria vaccine.The level of acceptance of RTS,S/AS01 malaria vaccine is relatively low in middle-income countries.This might be because of lack of information regarding vaccine implementation in such countries.The proper and efficient execution of the malaria vaccination program necessitates careful consideration of each community's socio-cultural setting.The most prominent RTS,S/AS01 vaccine trial was conducted from 2009 to 2011 in which eleven sites in seven African countries participated.Results of the trial,published in 2015,provided a promising advance in the development of a malaria vaccine for African children.As of 2019,large-scale pilot studies of the vaccine have been conducted in Ghana,Kenya,and Malawi,involving several hundreds of thousands of infants.The RTS,S/AS01 vaccine shows modest efficacy against malaria and has a feasible mode of administration.Although there is increased risk of meningitis,cerebral malaria,pneumonia,anemia,febrile convulsions and gastroenteritis,the vaccine still has a feasible mode of administration and high cost effectiveness and can be easily implemented in resource-limited settings.
文摘韩泰轮胎旗下的路欧锋Laufenn新品牌,产品继承了韩泰轮胎一贯的高性价比特点,品牌定位更年轻一些,在舒适度、噪声、操控、制动等各方面表现得很均衡,具备一定的驾驶乐趣路欧锋是韩泰轮胎旗下的新品牌,品牌定位更年轻一些,但是产品还是继承了韩泰一贯的高性价比的特点,用下来无论从舒适度、噪声、操控、制动等方面都比较均衡,价格在进口品牌中很有竞争力。我们使用了操控非常优异的国内第一款速腾2.0MT轿车,使用路欧锋G FIT as01轮胎,
文摘为了及时发现车辆热轴故障、防止热切轴,保证铁路运输安全,提高运输效率,设计了基于STM32的列车轴温无线监测系统.系统利用热电阻(Pt100)传感器和STM32单片机内置高精度AD转换器实时采集轴温,基于无线射频通信模块(AS01-ML01DP5)实现数据远距离通信,由接收装置显示轴温变化,并进行超限报警.实验测试表明系统工作可靠,测量误差不超过0.5℃,通信距离大约2 km.
基金supported by the Major Science and Technology Special Projects of Yunnan Province,China (202002AA100009)the Non-profit Central Research Institute Fund of Chinese Academy of Medical Sciences (2021-JKCS-012)+5 种基金the Special Biomedicine Projects of Yunnan Province (202102AA310035)National Natural Science Foundation of China (82104130)Fundamental Research Funds for the Central Universities (3332021072)the Basic Research Projects of Yunnan Province (202101AU070176, 202101AT070286)the Funds for the Training of High-level Health Technical Personnel in Yunnan Province(grant number H-2019063)the Funds for High-level Scientific and Technological Talents Selection Special Project of Yunnan Province(202205AC160015)
文摘Latent varicella-zoster virus(VZV)may be reactivated to cause herpes zoster,which affects one in three people during their lifetime.The currently available subunit vaccine Shingrix^(TM) is superior to the attenuated vaccine Zostavax®in terms of both safety and efficacy,but the supply of its key adjuvant component QS21 is limited.With ionizable lipid nanoparticles(LNPs)that were recently approved by the FDA for COVID-19 mRNA vaccines as carriers,and oligodeoxynucleotides containing CpG motifs(CpG ODNs)approved by the FDA for a subunit hepatitis B vaccine as immunostimulators,we developed a LNP vaccine encapsulating VZV-glycoprotein E(gE)and CpG ODN,and compared its immunogenicity with Shingrix^(TM) in C57BL/6J mice.The results showed that the LNP vaccine induced comparable levels of gE-specific IgG antibodies to Shingrix^(TM) as determined by enzymelinked immunosorbent assay(ELISA).Most importantly,the LNP vaccine induced comparable levels of cellmediated immunity(CMI)that plays decisive roles in the efficacy of zoster vaccines to Shingrix^(TM) in a VZVprimed mouse model that was adopted for preclinical studies of Shingrix^(TM) .Number of IL-2 and IFN-γsecreting splenocytes and proportion of T helper 1(Th1)cytokine-expressing CD4^(+)T cells in LNP-CpG-adjuvanted VZV-gE vaccinated mice were similar to that of Shingrix^(TM) boosted mice.All of the components in this LNP vaccine can be artificially and economically synthesized in large quantities,indicating the potential of LNP-CpGadjuvanted VZV-gE as a more cost-effective zoster vaccine.
