Prevalence of daily or near daily aspirin use by US adults with diabetes: A cross-sectional study using a multi-year national database

Introduction: For persons with diabetes, cardiovascular disease is the major cause of morbidity and mortality that is reflected in a two-to- four times greater risk for both heart disease and stroke when compared to adults without diabetes. Although not without controversy, diabetes and cardiovascular disease (CVD) management guidelines in the US recommend the use of once-daily aspirin. This epidemiological study was undertaken to fill the knowledge gap regarding the prevalence of daily or near daily aspirin use for US age-appropriate adults with diabetes. Methods: Using bivariate and multivariate techniques, a cross-sectional analysis of an amalgamated database using 2005, 2007, and 2009 Behavioral Risk Factor Surveillance Survey data was performed. The dependent variable for this analysis was daily or near daily aspirin use. The population of interest was US adults, men >= 45 - 79 and women >= 55 - 79 years of age. Results: Overall the prevalence of daily or near daily aspirin use by age-appropriate US adults with diabetes was 62.5%;it was 41.0% for similar non-diabetic adults. Logistic regression analysis yielded that age-appropriate adults, of both genders, with diabetes taking daily or near daily aspirin were more likely to be: physically active, male, live in rural locales, not have a health care provider, have deferred medical care because of cost, have an elevated BMI, a smoker, and have hypertension. Conclusion: It was determined that the age-appropriate use of aspirin in the US adult population with diabetes is underutilized. The role of the pharmacist through- out the continuum of care is one way to improve appropriate aspirin use in patients with diabetes.

尼美舒利和肠溶阿司匹林治疗牙科手术后疼痛的疗效对比

目的比较研究尼美舒利（ＮＩＭ）和肠溶阿司匹林（ＡＳＰ）治疗牙科手术后疼痛的疗效和安全性。方法试验设计为随机单盲对照。试验组１２０例病例，于手术后疼痛时一次口服ＮＩＭ２００ｍｇ，过２４ｈ再口服２００ｍｇ；对照组６０例病例，于手术后疼痛时一次口服ＡＳＰ６００ｍｇ，过２４ｈ再口服６００ｍｇ。结果ＮＩＭ总有效率为９１６７％，ＡＳＰ总有效率为８６６７％。两药均能改善患者的症状和体征。经安全性评价，ＮＩＭ和ＡＳＰ的耐受性相近，不良反应以胃肠道反应为主。结论ＮＩＭ治疗牙科的疗效优于ＡＳＰ，在用药８ｈ内ＮＩＭ对症状和体征的改善优于ＡＳＰ，两药的耐受性无明显差异。

噁丙嗪和肠溶阿司匹林治疗牙科手术后疼痛的对照研究

目的 比较研究口恶丙口秦（ ＯＸＰ） 和肠溶阿司匹林（ＡＳＰ） 治疗牙科手术后疼痛（ＰＤＳＰ） 的疗效和安全性。方法 随机单盲对照试验。试验组１００ 例，于手术后疼痛时顿服ＯＸＰ６００ ｍｇ ，２４ ｈ 再顿服６００ ｍ ｇ ；对照组５０ 例，于手术后疼痛时顿服ＡＳＰ６００ ｍｇ ，２４ ｈ 再顿服６００ ｍｇ 。结果 ＯＸＰ 总有效率为８２－００ ％ ，ＡＳＰ 总有效率为６６－００ ％ 。两药均能改善患者的症状和体征。经安全性评价，ＯＸＰ 和ＡＳＰ 的耐受性相近，不良反应以胃肠道及神经系统为主。结论 ＯＸＰ治疗ＰＤＳＰ 的疗效优于ＡＳＰ，两药的耐受性无差异。主题词 阿司匹林／ 治疗应用；疼痛， 手术后／ 药物疗法；

合用赖氨匹林和呋喃苯胺酸的平喘作用

目的探讨合用赖氨匹林和呋喃苯胺酸的平喘作用。方法采用整体动物引喘法和兔改良肺溢流法观察合用赖氨匹林和呋喃苯胺酸（超声雾化给药）的平喘作用和对兔支气管平滑肌张力的影响。结果赖氨匹林１５０ｍｇｋｇ－１＋呋喃苯胺酸２０ｍｇｋｇ－１，赖氨匹林３００ｍｇｋｇ－１＋呋喃苯胺酸２０ｍｇｋｇ－１均可明显延长豚鼠的引喘潜伏期及减少兔肺溢流量。