World Medical Association Declaration of HelsinkiE thical Principles for Medical Research Involving Human Subjects

Document Of World Medical AssociationWorld medical association declaration of Helsinki Ethical principles for medical research involving human subjects

On a Conjecture of an Invariance Principle for Sequences of Associated Random Variables

A finite collection of random variables, X1} —, Xm, is said to be associated if any two coordinatewise nondecreasing functions /i and /a on Rm such that Jt = fj(Xi} , Xm~) has finite variance for j = l, 2, Oov(/i,fa)>0; an infinite collection is said to be associated if every finite subcollection is. associated. Thus the concept of "association" is introduced as dependence in probability (Esary, Proschan and Walkup (1967)). It is relative to a lot of practical models, such as the percolation models, the Ising models of statistical mechanics. Therefore, some people are

Synthesis of oleanolic disaccharide derivatives

Oleanolic acid 1 exists widely in food,medicinal herbs and other plants and possesses many attractive biological activities. Recently,some oleanolic derivatives were reported to have interesting anti-tumor activities.Herein,using association principle of drug design,OA disaccharide 17 was designed and synthesized by coupling a-L-rhamnopyranosyl-（1→2）-a-L-arabinopyranosyl disaccharide moiety,which has proved to be a unique sugar sequence with strongly antitumor activity,and modified OA with a nitrile at C-17.

Synthesis of a novel class of cyclophosphamide bis-spiropiperazinium salts

Based on the principle of association, a novel class of cyclophosphamide bis-spiropiperazinium compounds was designed and synthesized. A new method of synthesis, separation and purification for this kind of compounds was also developed.