Poly[(S)-3-vinyl-2,2'-dihydroxy-1,1'-binaphthyl](L*)was obtained by taking off the protecting groups of poly[(S)-3-vinyl-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl](poly-1).L*was proved to keep a stable ...Poly[(S)-3-vinyl-2,2'-dihydroxy-1,1'-binaphthyl](L*)was obtained by taking off the protecting groups of poly[(S)-3-vinyl-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl](poly-1).L*was proved to keep a stable helical con-formation in solution.The application of helical L*in the asymmetric addition of diethylzinc to aldehydes has been studied.The catalytic system employing 10 mol%of L*and 150 mol%of Ti(OiPr)_(4) was found to promote the addi-tion of diethylzinc to a wide range of aromatic aldehydes,giving up to 99%enantiomeric excess(ee)and up to 93%yield of the corresponding secondary alcohol at 0℃.The chiral polymer can be easily recovered and reused with-out loss of catalytic activity as well as enantioselectivity.展开更多
A series of enantiomencally pure (4R,5R)-(-)-4-alkryloxy-5-[(1R,2dihydro-2(5H)-furanones (2) have been synthesized in excellent yields via asymmetric conjugateadditions of primary alcohols to (R)-(-)-5-[(1R,2S,5R)-men...A series of enantiomencally pure (4R,5R)-(-)-4-alkryloxy-5-[(1R,2dihydro-2(5H)-furanones (2) have been synthesized in excellent yields via asymmetric conjugateadditions of primary alcohols to (R)-(-)-5-[(1R,2S,5R)-menthyloxy]-2(5H)-furanone (1) in the presenceof a catalytic amount of sodium in DMF, which provides access to new multifunctional homochiralbuilding blocks, optically. pure (R) or (S)-2-alkyloxy- 1,4-butanediols (3).展开更多
A simple and efficient asymmetric synthesis of the sex pheromone of the southern corn rootworm is discribed. The key step is the asymmetric Michael addition of enoylsultam with virtually complete asymmetric induction(...A simple and efficient asymmetric synthesis of the sex pheromone of the southern corn rootworm is discribed. The key step is the asymmetric Michael addition of enoylsultam with virtually complete asymmetric induction( e.e. %>99%)展开更多
基金National Natural Science Foundation of China(No.21172186)Doctor Student Research Foundation of Chinese Education Ministry(No.20134301110004)for financial support of this work.
文摘Poly[(S)-3-vinyl-2,2'-dihydroxy-1,1'-binaphthyl](L*)was obtained by taking off the protecting groups of poly[(S)-3-vinyl-2,2'-bis(methoxymethoxy)-1,1'-binaphthyl](poly-1).L*was proved to keep a stable helical con-formation in solution.The application of helical L*in the asymmetric addition of diethylzinc to aldehydes has been studied.The catalytic system employing 10 mol%of L*and 150 mol%of Ti(OiPr)_(4) was found to promote the addi-tion of diethylzinc to a wide range of aromatic aldehydes,giving up to 99%enantiomeric excess(ee)and up to 93%yield of the corresponding secondary alcohol at 0℃.The chiral polymer can be easily recovered and reused with-out loss of catalytic activity as well as enantioselectivity.
文摘A series of enantiomencally pure (4R,5R)-(-)-4-alkryloxy-5-[(1R,2dihydro-2(5H)-furanones (2) have been synthesized in excellent yields via asymmetric conjugateadditions of primary alcohols to (R)-(-)-5-[(1R,2S,5R)-menthyloxy]-2(5H)-furanone (1) in the presenceof a catalytic amount of sodium in DMF, which provides access to new multifunctional homochiralbuilding blocks, optically. pure (R) or (S)-2-alkyloxy- 1,4-butanediols (3).
文摘A simple and efficient asymmetric synthesis of the sex pheromone of the southern corn rootworm is discribed. The key step is the asymmetric Michael addition of enoylsultam with virtually complete asymmetric induction( e.e. %>99%)
