Enantioselective conjugate addition of diethylzinc to chalcone was carried out in the presence of Ni(acac) 2 complexed with five pyrrolidinylmethanols derived from L proline. ( S ) N Benzyl 2 (1 hydro...Enantioselective conjugate addition of diethylzinc to chalcone was carried out in the presence of Ni(acac) 2 complexed with five pyrrolidinylmethanols derived from L proline. ( S ) N Benzyl 2 (1 hydroxy 1 methylethyl) pyrrolidine was found to be the best ligand in asymmetric conjugate addition among the five ligands. The products were obtained with up to 70% ee . The configuration of the product was determined jointly by the substituents on the carbon of the hydroxy group and the nitrogen atom.展开更多
基金theNationalNaturalScienceFoundationofChina (No .2 9972 0 16andQTProgram ) theTeachingandResearchAwardProgramforOutstandingYoungTeachersinHigherEducationInstitutionsoftheMinistryofEducationofChina
文摘Enantioselective conjugate addition of diethylzinc to chalcone was carried out in the presence of Ni(acac) 2 complexed with five pyrrolidinylmethanols derived from L proline. ( S ) N Benzyl 2 (1 hydroxy 1 methylethyl) pyrrolidine was found to be the best ligand in asymmetric conjugate addition among the five ligands. The products were obtained with up to 70% ee . The configuration of the product was determined jointly by the substituents on the carbon of the hydroxy group and the nitrogen atom.
