Accumulated evidence indicates that the activating transcription factor 4（atf4） is a developmentally relevant gene.Here,we report on the characterization of atf4 in Xenopus embryos,which is differentially expressed ...Accumulated evidence indicates that the activating transcription factor 4（atf4） is a developmentally relevant gene.Here,we report on the characterization of atf4 in Xenopus embryos,which is differentially expressed in the central nervous system,eyes,blood,and the pronephros,as well as in developing endodermal organs such as the stomach,duodenum,liver,and pancreas.Ectopic expression of atf4 in the animal hemisphere of Xenopus embryos had no obvious effects on the induction of neural progenitors,but suppressed neurogenesis and eye formation without promoting apoptosis.Our data suggest that tightly controlled atf4 activities may be crucial for normal neurogenesis and early eye patterning.展开更多
基金supported in part by funds from the Key Project of Knowledge Innovation Program of the Chinese Academy of Sciences(KSCX2-YW-R-083)the National Basic Research Program of China(2009CB941202)
文摘Accumulated evidence indicates that the activating transcription factor 4（atf4） is a developmentally relevant gene.Here,we report on the characterization of atf4 in Xenopus embryos,which is differentially expressed in the central nervous system,eyes,blood,and the pronephros,as well as in developing endodermal organs such as the stomach,duodenum,liver,and pancreas.Ectopic expression of atf4 in the animal hemisphere of Xenopus embryos had no obvious effects on the induction of neural progenitors,but suppressed neurogenesis and eye formation without promoting apoptosis.Our data suggest that tightly controlled atf4 activities may be crucial for normal neurogenesis and early eye patterning.
