Molecular biology of heart disease

Dr. Robert Roberts is currently Professor of Medicine and Director of the Ruddy Canadian Cardiovascular Genetics Centre along with being President and CEO of the University of Ottawa Heart Institute. Prior to this appointment, he was Chief of Cardiology for 23 years at Baylor College of Medicine, Houston, Texas. His original research was in cardiac enzymology which led to the development of the MBCK test which was the standard diagnostic assay for myocardial infarction for more than 3 decades. In the late 1970s, his research interests switched to molecular biology and the genet- ics of cardiomyopathies. He is regarded as one of the founders of molecular cardiology and has identified and sequenced more than 20 genes responsible for cardiovascular disorders. In the past 6 years, he has pursued genome-wide association studies to identify genes predisposing to coronary artery disease (CAD) and myocardial infarction. The first genetic variant for CAD, 9p21, was identified by Dr. Robert’s laboratory and, in collaboration with the international consortium, CARDIoGRAM, has identified 13 novel genes for CAD.

变应性小管间质肾炎

在与药物相关的急性小管间质肾炎（ATIN）中，通过变态反应机制引起ATIN，称为变应性小管间质肾炎，又称为急性过敏性小管间质肾炎，是常见的由免疫介导的肾脏损害。而药物所引起的非变态反应介导的急性小管间质损害不属于变应性小管间质肾炎。

药物引起免疫性小管间质性肾炎

药物引起免疫性小管间质性肾炎许国章上个世纪末，Ｃｏｕｎｃｉｌｍａｎ首次报道，死于脓毒血症引起急性肾功能衰竭（ＡＲＦ）尸体解剖有重度肾小管间质肾炎，但肾脏并无细菌侵入。本世纪３０～４０年代已公认，脓毒血症致ＡＲＦ可以由小管间质炎引起。目前已知能引起急性...

儿童特发性急性小管间质性肾炎1例及文献复习

特发性急性小管间质性肾炎是临床上非感染、非药物、非系统性疾病等引起的无明确病因可循的一类急性小管间质性肾炎(ATIN),临床上较少见,其发病率尚无确切的流行病学数据,无种族倾向,各年龄组均可见,平均年龄为15岁,以青少年为主,男女比例为1:3[1]。患者往往以全身非特异性症状为首发表现,容易被误诊、漏诊,以致延误治疗。现将我院收治的首例儿童急性特发性小管间质性肾炎报告如下,以引起儿科临床医生重视,对特发性ATIN有一个更好的认识,了解其临床表现、实验室特点及诊治方法。

肾小管间质肾炎-葡萄膜炎综合征的临床特征及研究现状

肾小管间质肾炎-葡萄膜炎综合征（tubulointerstitial nephritis and uveitis syndrome，TINU syndrome）是以特发性的急性肾小管间质肾炎（acute tubulointerstitial nephritis，ATIN）和眼部葡萄膜炎为典型表现的临床综合征，常伴有非特异的系统炎性反应征象。关于ATIN合并葡萄膜炎的病例最早报道于1975年前后。

加?夹?佳! atin V622“胡桃夹子”MP3随身听

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