目的探讨基于注意力机制的ResNet34模型(Attention based ResNet 34 model,AttRes34)在食管鳞状细胞癌诊断中的应用价值。方法对2016年1月-2020年1月新疆医科大学附属肿瘤医院病理科收治的40例食管鳞状细胞癌患者资料进行回顾性研究。采...目的探讨基于注意力机制的ResNet34模型(Attention based ResNet 34 model,AttRes34)在食管鳞状细胞癌诊断中的应用价值。方法对2016年1月-2020年1月新疆医科大学附属肿瘤医院病理科收治的40例食管鳞状细胞癌患者资料进行回顾性研究。采用AttRes34模型对食管鳞状细胞癌进行辅助诊断。首先,将改进后的滑动窗口算法应用于原切片图像以生成众多的补丁图像;其次,通过AttRes34模型的Softmax分类器输出补丁图像的预测结果;最后,通过汇总补丁图像的预测结果(正常、鳞癌)推断出原切片的诊断结果。计算AttRes34模型的精度、召回率、F1分数、准确率,以及绘制受试者工作特征曲线(Receiver operating characteristic curve,ROC)和混淆矩阵,对模型的泛化性能进行评估,并与ResNet18、ResNet50模型进行比较。结果AttRes34模型对食管鳞癌组织和正常对照组织的总体分类准确率达到89.58%,ROC曲线下的面积(Area under curve,AUC)值达到0.975,其中阳性分类的精度、召回率以及F1分数分别为0.979、0.839和0.903。结论AttRes34模型对食管鳞状细胞癌的辅助诊断具有一定的临床价值。展开更多
As the key feature of land resource allocation and the core index of micro density control,floor area ratio(FAR) regulation should simultaneously implement macro density policies,guide urban development policies and m...As the key feature of land resource allocation and the core index of micro density control,floor area ratio(FAR) regulation should simultaneously implement macro density policies,guide urban development policies and maintain social equity.This is possible because of its technical,social and property attributes.However,lacking systematic theoretical guidance,it becomes a focus of debate in planning administration.This paper analyzes the attributes of FAR in order to discuss regulation methods,countermeasures and suggestions on FAR which best fit current planning and administration.展开更多
Objective： Our aim was to investigate clinical and laboratory characteristics of osteoarthritic patients who had amyloid deposition in their knee joints. Methods： Synovial membranes were obtained from 36 patients wi...Objective： Our aim was to investigate clinical and laboratory characteristics of osteoarthritic patients who had amyloid deposition in their knee joints. Methods： Synovial membranes were obtained from 36 patients with knee osteoarthritis （OA） who underwent joint replacement surgery. From this sample, the diagnosis of amyloid was deter- mined by Congo red staining, which demonstrated apple-green birefringence under a polarized microscope. All syn- ovial membranes were immunohistochemically characterized for the expressions of amyloid immunoglobulin light chain （AL-K and AL-,k）, serum amyloid-A （SAA）, amyloidogenic transthyretin （ATTR）, and amyloidogenic 152- microglobulin （A152M）. Matrix-assisted laser desorption-ionizaton/time of flight mass spectrometry （MALDI-TOF MS） was used to analyze transthyretin （TTR） isoforms in the serum of each patient. Results： Nine cases （25%） were found to be amyloid-positive. Immunohistochemicaliy, eight cases （88.9%） had ATTR deposition, and one sample （11.1%） was shown to be AL-K-positive. MALDI-TOF MS identified that the TTR in the serum of the patients was unmodified wild-type TTR, TTR-Cys-S-S-Cys, and TTR-Cys-S-S-CysGly. The age at surgery and the disease duration were sig- nificantly higher in the ATTR-positive group than in the ATTR-negative group. Knee score and function score were significantly lower in the ATTR-positive group than in the ATTR-negative group. Conclusions： Amyloid deposition in synovial membranes of OA patients was found to be ATTR and AL-K. TTR in the serum of the patients was unmodified wild-type TTR together with two isoforms. The high age at surgery, long disease duration, and a deteriorated knee function were associated with ATTR amyloid deposition in the osteoarthritic knee joints.展开更多
文摘目的探讨基于注意力机制的ResNet34模型(Attention based ResNet 34 model,AttRes34)在食管鳞状细胞癌诊断中的应用价值。方法对2016年1月-2020年1月新疆医科大学附属肿瘤医院病理科收治的40例食管鳞状细胞癌患者资料进行回顾性研究。采用AttRes34模型对食管鳞状细胞癌进行辅助诊断。首先,将改进后的滑动窗口算法应用于原切片图像以生成众多的补丁图像;其次,通过AttRes34模型的Softmax分类器输出补丁图像的预测结果;最后,通过汇总补丁图像的预测结果(正常、鳞癌)推断出原切片的诊断结果。计算AttRes34模型的精度、召回率、F1分数、准确率,以及绘制受试者工作特征曲线(Receiver operating characteristic curve,ROC)和混淆矩阵,对模型的泛化性能进行评估,并与ResNet18、ResNet50模型进行比较。结果AttRes34模型对食管鳞癌组织和正常对照组织的总体分类准确率达到89.58%,ROC曲线下的面积(Area under curve,AUC)值达到0.975,其中阳性分类的精度、召回率以及F1分数分别为0.979、0.839和0.903。结论AttRes34模型对食管鳞状细胞癌的辅助诊断具有一定的临床价值。
文摘As the key feature of land resource allocation and the core index of micro density control,floor area ratio(FAR) regulation should simultaneously implement macro density policies,guide urban development policies and maintain social equity.This is possible because of its technical,social and property attributes.However,lacking systematic theoretical guidance,it becomes a focus of debate in planning administration.This paper analyzes the attributes of FAR in order to discuss regulation methods,countermeasures and suggestions on FAR which best fit current planning and administration.
文摘Objective： Our aim was to investigate clinical and laboratory characteristics of osteoarthritic patients who had amyloid deposition in their knee joints. Methods： Synovial membranes were obtained from 36 patients with knee osteoarthritis （OA） who underwent joint replacement surgery. From this sample, the diagnosis of amyloid was deter- mined by Congo red staining, which demonstrated apple-green birefringence under a polarized microscope. All syn- ovial membranes were immunohistochemically characterized for the expressions of amyloid immunoglobulin light chain （AL-K and AL-,k）, serum amyloid-A （SAA）, amyloidogenic transthyretin （ATTR）, and amyloidogenic 152- microglobulin （A152M）. Matrix-assisted laser desorption-ionizaton/time of flight mass spectrometry （MALDI-TOF MS） was used to analyze transthyretin （TTR） isoforms in the serum of each patient. Results： Nine cases （25%） were found to be amyloid-positive. Immunohistochemicaliy, eight cases （88.9%） had ATTR deposition, and one sample （11.1%） was shown to be AL-K-positive. MALDI-TOF MS identified that the TTR in the serum of the patients was unmodified wild-type TTR, TTR-Cys-S-S-Cys, and TTR-Cys-S-S-CysGly. The age at surgery and the disease duration were sig- nificantly higher in the ATTR-positive group than in the ATTR-negative group. Knee score and function score were significantly lower in the ATTR-positive group than in the ATTR-negative group. Conclusions： Amyloid deposition in synovial membranes of OA patients was found to be ATTR and AL-K. TTR in the serum of the patients was unmodified wild-type TTR together with two isoforms. The high age at surgery, long disease duration, and a deteriorated knee function were associated with ATTR amyloid deposition in the osteoarthritic knee joints.
