The auditory steady state response （ASSR） may reflect activity from different regions of the brain, depending on the modulation frequency used. In general, responses induced by low rates （_〈40 Hz） emanate mostly ...The auditory steady state response （ASSR） may reflect activity from different regions of the brain, depending on the modulation frequency used. In general, responses induced by low rates （_〈40 Hz） emanate mostly from central structures of the brain, and responses from high rates （〉80 Hz） emanate mostly from the peripheral auditory nerve or brainstem structures. Besides, it was reported that the gamma band ASSR （30-90 Hz） played an important role in working memory, speech understanding and recognition. This paper investigated the 40 Hz ASSR evoked by modulated speech and reversed speech. The speech was Chinese phrase voice, and the noise-like reversed speech was obtained by temporally reversing the speech. Both auditory stimuli were modulated with a frequency of 40 Hz. Ten healthy subjects and 5 patients with hallucination symptom participated in the experiment. Results showed re- duction in left auditory cortex response when healthy subjects listened to the reversed speech compared with the speech. In contrast, when the patients who experienced auditory hallucinations listened to the reversed speech, the auditory cortex of left hemispheric responded more actively. The ASSR results were consistent with the behavior results of patients. Therefore, the gamma band ASSR is expected to be helpful for rapid and objective diagnosis of hallucination in clinic.展开更多
目的:分析婴幼儿的Tb-ABR和chirp-ASSR反应阈的相关性和在听力评估中的应用。方法:对听力正常婴幼儿8例和不正常婴幼儿8例进行Tb-ABR和chirp-ASSR反应阈值测试。分别记录0.5、1、2、4 k Hz的反应阈,比较这两种不同测试方法所得反应阈的...目的:分析婴幼儿的Tb-ABR和chirp-ASSR反应阈的相关性和在听力评估中的应用。方法:对听力正常婴幼儿8例和不正常婴幼儿8例进行Tb-ABR和chirp-ASSR反应阈值测试。分别记录0.5、1、2、4 k Hz的反应阈,比较这两种不同测试方法所得反应阈的相关性及chirp-ASSR的优点。结果:短纯音ABR与chirp-ASSR反应阈比较差异无统计学意义(P>0.05)。结论:短纯音ABR与chirp-ASSR有较好的相关性,可以有效地用于临床评估。展开更多
目的:明确21例(42耳)听性脑干反应(auditory brainstem response,ABR)未引出的低月龄儿的听觉稳态诱发电位(auditory steady state response,ASSR)、40Hz听觉相关电位(40Hz auditory event related potential,40Hz-AERP)的引出率。方法...目的:明确21例(42耳)听性脑干反应(auditory brainstem response,ABR)未引出的低月龄儿的听觉稳态诱发电位(auditory steady state response,ASSR)、40Hz听觉相关电位(40Hz auditory event related potential,40Hz-AERP)的引出率。方法:选取听力复筛未通过、诊断型中耳分析仪1000Hz鼓室声导抗正常、ABR未引出的低月龄婴儿21例(42耳),进一步检测ASSR及40Hz-AERP。结果:ASSR在500、1000、2000、4000 Hz引出率分别为45.29%、61.90%、66.67%、80.95%。40Hz-AERP(500Hz)的引出率为52.38%。结论:ASSR及40Hz-AERP检查可以弥补ABR未引出的低月龄听力损失儿听力评估的不足。展开更多
目的通过对极重度听力损失的大前庭水管综合征婴幼儿进行听性脑干反应（ABR）和多频稳态反应（ASSR）测试，探讨其ABR检查过程中出现的声诱发短潜伏期负向波（acoustically evoked short latency negative response，ASNR）及其ASSR特...目的通过对极重度听力损失的大前庭水管综合征婴幼儿进行听性脑干反应（ABR）和多频稳态反应（ASSR）测试，探讨其ABR检查过程中出现的声诱发短潜伏期负向波（acoustically evoked short latency negative response，ASNR）及其ASSR特点。方法回顾性研究22例（42耳）极重度听力损失的大前庭水管综合征（LVAS）婴幼儿，另选择28例（56耳）极重度听力损失的非LVAS的感音神经性耳聋婴幼儿作为对照组，研究其ABR及ASSR相关性。结果①LVAS婴幼儿组ABR测试中，36耳（85．7％）记录到AsNR，在109．6 dB nHL刺激强度引出的ASNR平均潜伏期在3．04±0．22msT对照组中婴幼儿无一例记录到ASNR。②LVAS婴幼儿组ASSRNI]试在250、500和1000Hz引出率明显高于对照组，两组间差异有统计学意义（P〈0．01）。结论相比于普通的极重度感音神经性耳聋患儿，极重度听损LVAS患儿进行听力学检查时，ABR容易出现ASNR负向波，ASSR测试结果显示较高的中低频的电位反应引出率，此结果可用于临床辅助诊断大前庭水管综合征。展开更多
目的探究正常比格犬的短声听性脑干反应(click Auditory Brainstem Response,c-ABR)和听性稳态反应(Auditory steady-state response,ASSR)的正常值。与人的c-ABR与ASSR进行比较,为临床试验提供听力学基础。方法对6只正常比格犬(12耳)...目的探究正常比格犬的短声听性脑干反应(click Auditory Brainstem Response,c-ABR)和听性稳态反应(Auditory steady-state response,ASSR)的正常值。与人的c-ABR与ASSR进行比较,为临床试验提供听力学基础。方法对6只正常比格犬(12耳)麻醉后进行c-ABR和ASSR测试,记录c-ABR的波形、反应阈、潜伏期和波间期以及ASSR的0.5、1、2和4 kHz的反应阈,记录并比较这两种测试方法的阈值。结果比格犬的c-ABR阈值为27.1±10.1 dB nHL,80 dB nHL时Ⅰ波潜伏期平均为1.09±0.1ms,振幅为1.98±1.2μV;Ⅱ波的潜伏期平均为1.98±0.11ms,振幅为1.3±0.65μV,Ⅴ波的潜伏期为3.74±0.32ms,振幅为1.45±0.88μV,Ⅰ-Ⅴ波间期为2.65±0.31ms。ASSR的500 Hz、1 kHz、2 kHz、4 kHz的阈值分别为55.42±11.48 dB HL、57.83±11.48 dB HL、48.75±13.34 dB HL、37.5±10.11 dB HL。结论比格犬c-ABR波形与人相比,潜伏期较人的短,Ⅱ波振幅高,V波振幅低,两者振幅相反。比格犬ASSR的阈值较高频率低于较低频率,其ASSR 4 kHz的阈值更接近c-ABR的阈值。展开更多
目的探讨听性稳态反应(ASSR)在小儿听神经病谱系障碍(auditory neuropathy spectrum disorder,ANSD)患者中的临床意义。方法选取45例(85耳)诊断为ANSD的患儿(观察组),其中40例为双耳ANSD,4例为单耳ANSD,还有1例双侧ANSD患者仅右耳纳入研...目的探讨听性稳态反应(ASSR)在小儿听神经病谱系障碍(auditory neuropathy spectrum disorder,ANSD)患者中的临床意义。方法选取45例(85耳)诊断为ANSD的患儿(观察组),其中40例为双耳ANSD,4例为单耳ANSD,还有1例双侧ANSD患者仅右耳纳入研究(其左耳ABR阈值为80 dB nHL)。选取32例(64耳)诊断为双侧极重度感音神经性聋的患儿为对照组。采用美国GSI Audera对两组患儿进行ASSR测试。对比两组患儿各频率ASSR阈值。结果观察组左耳500、1000、2000和4000 Hz ASSR阈值分别为100.71±15.49、98.81±13.84、96.67±14.42、87.62±13.24d BHL,右耳对应频率ASSR阈值分别为100.70±18.48、101.86±17.82、91.40±17.60、88.26±14.86 dB HL;对照组左耳对应频率ASSR阈值分别为114.52±7.55、114.84±6.66、116.13±5.49、118.06±4.34 dB HL,右耳对应频率ASSR阈值分别为113.87±7.04、113.55±6.50、114.84±7.13、117.16±5.51 dB HL。观察组双耳对应各频率ASSR阈值均明显低于对照组,差异有显著统计学意义(P<0.01)。结论虽然两组患儿的ABR最大强度刺激未能引出反应,但听神经病谱系障碍患儿各频率ASSR阈值明显低于感音神经性聋患儿;ASSR可以检测出听神经病谱系障碍患者的听觉反应阈值,可以反映出这类患者的听觉系统对持续稳定声音的处理能力。展开更多
Transcranial electrical stimulation(tES)is a non-invasive nerve stimulation technique that modulates changes in neural activities in cerebral cortex through a weak current of specific intensity(and frequency).It has b...Transcranial electrical stimulation(tES)is a non-invasive nerve stimulation technique that modulates changes in neural activities in cerebral cortex through a weak current of specific intensity(and frequency).It has become a valuable tool for the study of human behavior and cognitive neurophysiological processes.As a brain stimulation technology with broad development prospects,it is not mature enough in the field of human auditory research.However,the research on tES has obtained preliminary results in regulating motor ability.This article mainly introduces the effects of tES and auditory steady state response on auditory,and the applications of tES in auditory diseases.By summarizing and discussing tES during auditory processing as comprehensively as possible,the potential application value of tES in the treatment of auditory diseases could be illustrated.展开更多
目的探讨多种听力学检测方法在听性脑干反应(ABR)最大输出未引出患儿的听力学诊断中的应用价值。方法回顾性分析69例(138耳)ABR最大强度未引出患儿的临床资料,年龄42天到5岁,平均1岁6个月,鼓室导抗图均为A型或正向单峰,声反射均未引出,...目的探讨多种听力学检测方法在听性脑干反应(ABR)最大输出未引出患儿的听力学诊断中的应用价值。方法回顾性分析69例(138耳)ABR最大强度未引出患儿的临床资料,年龄42天到5岁,平均1岁6个月,鼓室导抗图均为A型或正向单峰,声反射均未引出,影像学检查内耳无畸形。69例患儿均进行ABR、耳蜗微音电位(CM)、畸变产物耳声发射(DPOAE)和听性稳态反应(ASSR)测试。结果69例138耳中,8例16耳(11.59%)记录到CM,其中10耳(7.25%)记录到DPOAE,0.5、1、2、4 kHz ASSR反应阈值分别为83.2±13.1、82.9±13.0、75.3±12.4、63.1±9.1 dB nHL,结合其他检查结果诊断为听神经病。余61例(122耳)CM和DPOAE均未引出,0.5、1、2、4 kHz的ASSR引出率分别为82.3%、81.9%、76.9%、60.2%,其中20耳ASSR各频率均未引出,102耳至少一个频率引出,0.5、1、2、4 kHz ASSR反应阈分别为93.2±6.1、99.8±7.0、105.4±5.4、108.2±9.8 dB nHL,诊断为极重度感音神经性聋。结论对于ABR最大输出强度未引出的患儿,CM和/或DPOAE引出且ASSR各频率反应阈低于感音神经性聋患儿,有助于听神经病的诊断;CM和DPOAE均未引出有助于极重度感音神经性聋的诊断,ASSR测试有助于评估其残余听力。展开更多
基金supported by the National Natural Science Foundation of China(No.90820304,61105123,and 31100714)National Basic Research Program of China(No.2011CB933204)
文摘The auditory steady state response （ASSR） may reflect activity from different regions of the brain, depending on the modulation frequency used. In general, responses induced by low rates （_〈40 Hz） emanate mostly from central structures of the brain, and responses from high rates （〉80 Hz） emanate mostly from the peripheral auditory nerve or brainstem structures. Besides, it was reported that the gamma band ASSR （30-90 Hz） played an important role in working memory, speech understanding and recognition. This paper investigated the 40 Hz ASSR evoked by modulated speech and reversed speech. The speech was Chinese phrase voice, and the noise-like reversed speech was obtained by temporally reversing the speech. Both auditory stimuli were modulated with a frequency of 40 Hz. Ten healthy subjects and 5 patients with hallucination symptom participated in the experiment. Results showed re- duction in left auditory cortex response when healthy subjects listened to the reversed speech compared with the speech. In contrast, when the patients who experienced auditory hallucinations listened to the reversed speech, the auditory cortex of left hemispheric responded more actively. The ASSR results were consistent with the behavior results of patients. Therefore, the gamma band ASSR is expected to be helpful for rapid and objective diagnosis of hallucination in clinic.
文摘目的:分析婴幼儿的Tb-ABR和chirp-ASSR反应阈的相关性和在听力评估中的应用。方法:对听力正常婴幼儿8例和不正常婴幼儿8例进行Tb-ABR和chirp-ASSR反应阈值测试。分别记录0.5、1、2、4 k Hz的反应阈,比较这两种不同测试方法所得反应阈的相关性及chirp-ASSR的优点。结果:短纯音ABR与chirp-ASSR反应阈比较差异无统计学意义(P>0.05)。结论:短纯音ABR与chirp-ASSR有较好的相关性,可以有效地用于临床评估。
文摘目的通过对极重度听力损失的大前庭水管综合征婴幼儿进行听性脑干反应（ABR）和多频稳态反应（ASSR）测试，探讨其ABR检查过程中出现的声诱发短潜伏期负向波（acoustically evoked short latency negative response，ASNR）及其ASSR特点。方法回顾性研究22例（42耳）极重度听力损失的大前庭水管综合征（LVAS）婴幼儿，另选择28例（56耳）极重度听力损失的非LVAS的感音神经性耳聋婴幼儿作为对照组，研究其ABR及ASSR相关性。结果①LVAS婴幼儿组ABR测试中，36耳（85．7％）记录到AsNR，在109．6 dB nHL刺激强度引出的ASNR平均潜伏期在3．04±0．22msT对照组中婴幼儿无一例记录到ASNR。②LVAS婴幼儿组ASSRNI]试在250、500和1000Hz引出率明显高于对照组，两组间差异有统计学意义（P〈0．01）。结论相比于普通的极重度感音神经性耳聋患儿，极重度听损LVAS患儿进行听力学检查时，ABR容易出现ASNR负向波，ASSR测试结果显示较高的中低频的电位反应引出率，此结果可用于临床辅助诊断大前庭水管综合征。
文摘目的探究正常比格犬的短声听性脑干反应(click Auditory Brainstem Response,c-ABR)和听性稳态反应(Auditory steady-state response,ASSR)的正常值。与人的c-ABR与ASSR进行比较,为临床试验提供听力学基础。方法对6只正常比格犬(12耳)麻醉后进行c-ABR和ASSR测试,记录c-ABR的波形、反应阈、潜伏期和波间期以及ASSR的0.5、1、2和4 kHz的反应阈,记录并比较这两种测试方法的阈值。结果比格犬的c-ABR阈值为27.1±10.1 dB nHL,80 dB nHL时Ⅰ波潜伏期平均为1.09±0.1ms,振幅为1.98±1.2μV;Ⅱ波的潜伏期平均为1.98±0.11ms,振幅为1.3±0.65μV,Ⅴ波的潜伏期为3.74±0.32ms,振幅为1.45±0.88μV,Ⅰ-Ⅴ波间期为2.65±0.31ms。ASSR的500 Hz、1 kHz、2 kHz、4 kHz的阈值分别为55.42±11.48 dB HL、57.83±11.48 dB HL、48.75±13.34 dB HL、37.5±10.11 dB HL。结论比格犬c-ABR波形与人相比,潜伏期较人的短,Ⅱ波振幅高,V波振幅低,两者振幅相反。比格犬ASSR的阈值较高频率低于较低频率,其ASSR 4 kHz的阈值更接近c-ABR的阈值。
文摘目的探讨听性稳态反应(ASSR)在小儿听神经病谱系障碍(auditory neuropathy spectrum disorder,ANSD)患者中的临床意义。方法选取45例(85耳)诊断为ANSD的患儿(观察组),其中40例为双耳ANSD,4例为单耳ANSD,还有1例双侧ANSD患者仅右耳纳入研究(其左耳ABR阈值为80 dB nHL)。选取32例(64耳)诊断为双侧极重度感音神经性聋的患儿为对照组。采用美国GSI Audera对两组患儿进行ASSR测试。对比两组患儿各频率ASSR阈值。结果观察组左耳500、1000、2000和4000 Hz ASSR阈值分别为100.71±15.49、98.81±13.84、96.67±14.42、87.62±13.24d BHL,右耳对应频率ASSR阈值分别为100.70±18.48、101.86±17.82、91.40±17.60、88.26±14.86 dB HL;对照组左耳对应频率ASSR阈值分别为114.52±7.55、114.84±6.66、116.13±5.49、118.06±4.34 dB HL,右耳对应频率ASSR阈值分别为113.87±7.04、113.55±6.50、114.84±7.13、117.16±5.51 dB HL。观察组双耳对应各频率ASSR阈值均明显低于对照组,差异有显著统计学意义(P<0.01)。结论虽然两组患儿的ABR最大强度刺激未能引出反应,但听神经病谱系障碍患儿各频率ASSR阈值明显低于感音神经性聋患儿;ASSR可以检测出听神经病谱系障碍患者的听觉反应阈值,可以反映出这类患者的听觉系统对持续稳定声音的处理能力。
文摘Transcranial electrical stimulation(tES)is a non-invasive nerve stimulation technique that modulates changes in neural activities in cerebral cortex through a weak current of specific intensity(and frequency).It has become a valuable tool for the study of human behavior and cognitive neurophysiological processes.As a brain stimulation technology with broad development prospects,it is not mature enough in the field of human auditory research.However,the research on tES has obtained preliminary results in regulating motor ability.This article mainly introduces the effects of tES and auditory steady state response on auditory,and the applications of tES in auditory diseases.By summarizing and discussing tES during auditory processing as comprehensively as possible,the potential application value of tES in the treatment of auditory diseases could be illustrated.
文摘目的探讨多种听力学检测方法在听性脑干反应(ABR)最大输出未引出患儿的听力学诊断中的应用价值。方法回顾性分析69例(138耳)ABR最大强度未引出患儿的临床资料,年龄42天到5岁,平均1岁6个月,鼓室导抗图均为A型或正向单峰,声反射均未引出,影像学检查内耳无畸形。69例患儿均进行ABR、耳蜗微音电位(CM)、畸变产物耳声发射(DPOAE)和听性稳态反应(ASSR)测试。结果69例138耳中,8例16耳(11.59%)记录到CM,其中10耳(7.25%)记录到DPOAE,0.5、1、2、4 kHz ASSR反应阈值分别为83.2±13.1、82.9±13.0、75.3±12.4、63.1±9.1 dB nHL,结合其他检查结果诊断为听神经病。余61例(122耳)CM和DPOAE均未引出,0.5、1、2、4 kHz的ASSR引出率分别为82.3%、81.9%、76.9%、60.2%,其中20耳ASSR各频率均未引出,102耳至少一个频率引出,0.5、1、2、4 kHz ASSR反应阈分别为93.2±6.1、99.8±7.0、105.4±5.4、108.2±9.8 dB nHL,诊断为极重度感音神经性聋。结论对于ABR最大输出强度未引出的患儿,CM和/或DPOAE引出且ASSR各频率反应阈低于感音神经性聋患儿,有助于听神经病的诊断;CM和DPOAE均未引出有助于极重度感音神经性聋的诊断,ASSR测试有助于评估其残余听力。
