BACKGROUND Autism is the most common clinical developmental disorder in children.The childhood autism rating scale(CARS)and autistic autism behavior checklist(ABC)are the most commonly used assessment scales for diagn...BACKGROUND Autism is the most common clinical developmental disorder in children.The childhood autism rating scale(CARS)and autistic autism behavior checklist(ABC)are the most commonly used assessment scales for diagnosing autism.However,the diagnostic validations and the corresponding cutoffs for CARS and ABC in individuals with suspected autism spectrum disorder(ASD)remain unclear.Furthermore,for suspected ASD in China,it remains unclear whether CARS is a better diagnostic tool than ABC.Also unclear is whether the current cutoff points for ABC and CARS are suitable for the accurate diagnosis of ASD.AIM To investigate the diagnostic validity of CARS and ABC based on a large Chinese sample.METHODS A total of 591 outpatient children from the ASD Unit at Beijing Children’s Hospital between June and November 2019 were identified.First,the Clancy autism behavior scale(CABS)was used to screen out suspected autism from these children.Then,each suspected ASD was evaluated by CARS and ABC.Receiver operating characteristic(ROC)curve analysis was used to compare diagnostic validations.We also calculated the area under the curve(AUC)for both CARS and ABC.RESULTS We found that the Cronbach alpha coefficients of CARS and ABC were 0.772 and 0.426,respectively.Therefore,the reliability of the CARS was higher than that of the ABC.In addition,we found that the correlation between CARS and CABS was 0.732.Next,we performed ROC curve analysis for CARS and ABC,which yielded AUC values of 0.846 and 0.768,respectively.The cutoff value,which is associated with the maximum Youden index,is usually applied as a decision threshold.We found that the cutoff values of CARS and ABC were 34 and 67,respectively.CONCLUSION This result indicated that CARS is superior to ABC in the Chinese population with suspected ASD.展开更多
目的观察针刺配合康复训练治疗儿童孤独症的临床疗效。方法将86例儿童孤独症患者随机分为治疗组和对照组,每组43例。对照组采用常规康复训练治疗,治疗组在对照组基础上采用针刺治疗。观察两组治疗前后各项量表[儿童孤独症评定量表(child...目的观察针刺配合康复训练治疗儿童孤独症的临床疗效。方法将86例儿童孤独症患者随机分为治疗组和对照组,每组43例。对照组采用常规康复训练治疗,治疗组在对照组基础上采用针刺治疗。观察两组治疗前后各项量表[儿童孤独症评定量表(childhood autism rating scale,CARS)、孤独症行为量表(autism behavior checklist,ABC)和婴儿-初中学生社会生活能力量表(infant-junior high school student’s social living ability scale,S-M量表)]评分、语言能力各项评分(语言表达、语言理解和语言沟通)及各项生化指标[血清组织型纤溶酶原激活剂(tissue-type plasminogenactivator,t-PA)、谷胱甘肽(glutathione,GSH)水平和全血中5-羟色胺(5-hydroxytryptamine,5-HT)水平]的变化情况,并比较两组临床疗效。结果治疗组总有效率为90.7%,明显高于对照组的76.7%(P<0.05)。两组治疗后CARS评分、ABC评分、语言能力各项评分及血5-HT水平均较同组治疗前显著下降,S-M量表评分及血清t-PA、GSH水平均显著上升,差异均具有统计学意义(P<0.05)。治疗组治疗后各项量表评分、语言能力各项评分及各项生化指标与对照组比较,差异均具有统计学意义(P<0.05)。结论针刺配合康复训练治疗儿童孤独症疗效确切,能改善患者语言能力,降低CARS评分、ABC评分,调节t-PA、GSH和5-HT水平。展开更多
文摘BACKGROUND Autism is the most common clinical developmental disorder in children.The childhood autism rating scale(CARS)and autistic autism behavior checklist(ABC)are the most commonly used assessment scales for diagnosing autism.However,the diagnostic validations and the corresponding cutoffs for CARS and ABC in individuals with suspected autism spectrum disorder(ASD)remain unclear.Furthermore,for suspected ASD in China,it remains unclear whether CARS is a better diagnostic tool than ABC.Also unclear is whether the current cutoff points for ABC and CARS are suitable for the accurate diagnosis of ASD.AIM To investigate the diagnostic validity of CARS and ABC based on a large Chinese sample.METHODS A total of 591 outpatient children from the ASD Unit at Beijing Children’s Hospital between June and November 2019 were identified.First,the Clancy autism behavior scale(CABS)was used to screen out suspected autism from these children.Then,each suspected ASD was evaluated by CARS and ABC.Receiver operating characteristic(ROC)curve analysis was used to compare diagnostic validations.We also calculated the area under the curve(AUC)for both CARS and ABC.RESULTS We found that the Cronbach alpha coefficients of CARS and ABC were 0.772 and 0.426,respectively.Therefore,the reliability of the CARS was higher than that of the ABC.In addition,we found that the correlation between CARS and CABS was 0.732.Next,we performed ROC curve analysis for CARS and ABC,which yielded AUC values of 0.846 and 0.768,respectively.The cutoff value,which is associated with the maximum Youden index,is usually applied as a decision threshold.We found that the cutoff values of CARS and ABC were 34 and 67,respectively.CONCLUSION This result indicated that CARS is superior to ABC in the Chinese population with suspected ASD.
文摘目的观察针刺配合康复训练治疗儿童孤独症的临床疗效。方法将86例儿童孤独症患者随机分为治疗组和对照组,每组43例。对照组采用常规康复训练治疗,治疗组在对照组基础上采用针刺治疗。观察两组治疗前后各项量表[儿童孤独症评定量表(childhood autism rating scale,CARS)、孤独症行为量表(autism behavior checklist,ABC)和婴儿-初中学生社会生活能力量表(infant-junior high school student’s social living ability scale,S-M量表)]评分、语言能力各项评分(语言表达、语言理解和语言沟通)及各项生化指标[血清组织型纤溶酶原激活剂(tissue-type plasminogenactivator,t-PA)、谷胱甘肽(glutathione,GSH)水平和全血中5-羟色胺(5-hydroxytryptamine,5-HT)水平]的变化情况,并比较两组临床疗效。结果治疗组总有效率为90.7%,明显高于对照组的76.7%(P<0.05)。两组治疗后CARS评分、ABC评分、语言能力各项评分及血5-HT水平均较同组治疗前显著下降,S-M量表评分及血清t-PA、GSH水平均显著上升,差异均具有统计学意义(P<0.05)。治疗组治疗后各项量表评分、语言能力各项评分及各项生化指标与对照组比较,差异均具有统计学意义(P<0.05)。结论针刺配合康复训练治疗儿童孤独症疗效确切,能改善患者语言能力,降低CARS评分、ABC评分,调节t-PA、GSH和5-HT水平。
