Thrombin Generation Increasing with Age and Decreasing with Use of Heparin Indicated by Calibrated Automated Thrombogram Conducted in Chinese

Objective Calibrated Automated Thrombogram（CAT） is a test to monitor the generation of thrombin. It can be described by four parameters： lag time, peak thrombin, endogenous thrombin potential （ETP） and time to peak （ttPeak）. This study aims to determine the normal ranges of CAT parameters in Chinese, and evaluate whether thrombin generation is correlated with the concentration of heparin/Iow molecular weight heparin. Methods Plasma from 120 healthy subjects were collected to determine the normal rangea of CAT parameters in Chinese. Normal plasma pool （NPP, n=25） spiked with different concentrations of heparin or enoxaparin were used to detecte CAT parameters. The overall and age specific normal ranges of CAT parameters were calculated using descriptive statistics method with mean＋-2SD. The correlation between CAT parameters and age or concentrations of heparin, enoxaparin were analyzed with linear regression model. Results The normal ranges for lag time, peak thrombin, ETP, ttPeak in the subjects were 3.648＋2.465 min, 367.39＋151.93 nmol/L, 2277＋_1030 nmol/L.min and 6.372＋_4.280 min respectively. Age was linearly correlated with lag time （r=-0.6583, P〈0.0002）, peak thrombin （r=0.4863, P〈0.0002）, ETP （r=0.3608, P〈0.0014） and ttPeak （r=-0.6323, P〈0.0002）. The values of ETP/peak ratio were linearly correlated with concentrations of heparin. Conclusion The normal ranges of four CAT parameters for Chinese were determined. CAT parameters are associated with age. ETP/peak ratio could be used to monitor the process of anticoagulation therapy.

Autonomous vicarious calibration based on automated test-site radiometer

We employ the in-site automated observation radiometric calibration（AORC） approach to perform vicarious calibration, which does not require the manual efforts of a field team to measure the surface conditions. By using an automated test-site radiometer（ATR）, the surface radiance at any moment in time can be obtained. This Letter describes the AORC approach and makes use of data to compute top-of-atmosphere radiance and compare it to measurements from the Moderate Resolution Imaging Spectroradiometer. The result shows that the relative deviation is less than 5% and the uncertainty is less than 6.2%, which indicates that the in-site AORC maintains an accuracy level on par with traditional calibration.

Development and application of automated vicarious calibration system

In order to improve the frequency and precision of radiometric calibration, the automated vicarious calibration system（AVCS） is developed and deployed at the Dunhuang test site to perform vicarious calibration without the in situ manned measurements. The surface and atmospheric parameters are automatically collected by AVCS.An absolute radiometric calibration approach based on AVCS is proposed. Six successful calibrations of the Aqua Moderate Resolution Imaging Spectroradiometer（MODIS） are conducted. The results are in good agreement with the on-board calibration system with all the relative differences less than 4%. It enables us to monitor the change of a sensor over long time scales.

Online calibration of combustion phase in a diesel engine

In this work, an online calibration mechanism is proposed for the combustion phase in a diesel engine. In particular, a simplified event-based engine model, of which the output predicts the optimum combustion phase, is used to aid the calibration, and the model is updated online along with the engine operation to keep the integrity high so as to improve the quality of optimum combustion phase prediction. It is found this mechanism can be applied to develop an online automated calibration process when the engine system shifts to a new operating point. of the proposed mechanism. Engine test results are included to demonstrate the effectiveness