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Path Planning and Tracking Control for Parking via Soft Actor-Critic Under Non-Ideal Scenarios 被引量:1
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作者 Xiaolin Tang Yuyou Yang +3 位作者 Teng Liu Xianke Lin Kai Yang Shen Li 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第1期181-195,共15页
Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adja... Parking in a small parking lot within limited space poses a difficult task. It often leads to deviations between the final parking posture and the target posture. These deviations can lead to partial occupancy of adjacent parking lots, which poses a safety threat to vehicles parked in these parking lots. However, previous studies have not addressed this issue. In this paper, we aim to evaluate the impact of parking deviation of existing vehicles next to the target parking lot(PDEVNTPL) on the automatic ego vehicle(AEV) parking, in terms of safety, comfort, accuracy, and efficiency of parking. A segmented parking training framework(SPTF) based on soft actor-critic(SAC) is proposed to improve parking performance. In the proposed method, the SAC algorithm incorporates strategy entropy into the objective function, to enable the AEV to learn parking strategies based on a more comprehensive understanding of the environment. Additionally, the SPTF simplifies complex parking tasks to maintain the high performance of deep reinforcement learning(DRL). The experimental results reveal that the PDEVNTPL has a detrimental influence on the AEV parking in terms of safety, accuracy, and comfort, leading to reductions of more than 27%, 54%, and 26%respectively. However, the SAC-based SPTF effectively mitigates this impact, resulting in a considerable increase in the parking success rate from 71% to 93%. Furthermore, the heading angle deviation is significantly reduced from 2.25 degrees to 0.43degrees. 展开更多
关键词 Automatic parking control strategy parking deviation(APS) soft actor-critic(SAC)
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Smart Parking Management System “MOTAH”
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作者 Iman Alansari Ghadah Alnamlah +2 位作者 Razan Abduallah Jumana Alluqmani Alaa Alzahrani 《Journal of Software Engineering and Applications》 2024年第6期541-552,共12页
With a surge in the university’s student and staff population, parking problems and congestion have rapidly intensified. The recent inclusion of women drivers, particularly during official working hours, has exacerba... With a surge in the university’s student and staff population, parking problems and congestion have rapidly intensified. The recent inclusion of women drivers, particularly during official working hours, has exacerbated these challenges. This pressing issue underscores the critical necessity for a structured approach to managing university entries and overseeing parking at the gates. The proposed smart parking management system aims to address these concerns by introducing a design concept that restricts unauthorized access and provides exclusive parking privileges to authorized users. Through image processing, the system identifies available parking spaces, relaying real-time information to users via a mobile application. This comprehensive solution also generates detailed reports (daily, weekly, and monthly), aiding university safety authorities in future gate management decisions. 展开更多
关键词 Car parking Traffic Density Estimation Intelligent Transportation CONGESTION CONTROL parking Arrangement parking Behavior
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Application of Connected Truck Data to Evaluate Spatiotemporal Impact of Rest Area Closures on Ramp Parking
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作者 Jijo K. Mathew Jairaj Desai +1 位作者 Edward D. Cox Darcy M. Bullock 《Journal of Transportation Technologies》 2024年第3期289-307,共19页
Ensuring adequate access to truck parking is critical to the safe and efficient movement of freight traffic. There are strict federal guidelines for commercial truck driver rest periods. Rest areas and private truck s... Ensuring adequate access to truck parking is critical to the safe and efficient movement of freight traffic. There are strict federal guidelines for commercial truck driver rest periods. Rest areas and private truck stops are the only places for the trucks to stop legally and safely. In locations without sufficient parking areas, trucks often park on interstate ramps, which create safety risks for other interstate motorists. Historically, agencies have employed costly and time intensive manual counting methods, camera surveillance, and driver surveys to assess truck parking. Connected truck data, available in near real-time, offers an efficient alternative to practitioners to assess truck parking patterns and identify areas where there may be insufficient safe parking spaces. This paper presents a case study of interstate I-70 in east central Indiana and documents the observed spatiotemporal impacts of a rest area closure on truck parking on nearby interstate ramps. Results showed that there was a 28% increase in parking on ramps during the rest area closure. Analysis also found that ramps closest to the rest area were most impacted by the closure, seeing a rise in truck parking sessions as high as 2.7 times. Parking duration on the ramps during rest area closure also increased drastically. Although it was expected that this would result in increased parking by trucks on adjacent ramps, this before, during, after scenario provided an ideal scenario to evaluate the robustness of these techniques to assess changing parking characteristics of long-haul commercial trucks. The data analytics and visualization tools presented in this study are scalable nationwide and will aid stakeholders in informed data-driven decision making when allocating resources towards improving the nations commercial vehicle parking infrastructure. 展开更多
关键词 Connected Truck Data Rest Areas Exit Ramps Truck parking Commercial Vehicles
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Path Tracking Controller Design of Automated Parking Systems via NMPC with an Instructible Solution
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作者 Liang Chen Zhaobo Qin +2 位作者 Manjiang Hu Yougang Bian Xiaoyan Peng 《Chinese Journal of Mechanical Engineering》 SCIE EI CAS CSCD 2024年第3期353-367,共15页
Parking difficulties have become a social issue that people have to solve.Automated parking system is practicable for quick par operations without a driver which can also greatly reduces the probability of parking acc... Parking difficulties have become a social issue that people have to solve.Automated parking system is practicable for quick par operations without a driver which can also greatly reduces the probability of parking accidents.The paper proposes a Lyapunov-based nonlinear model predictive controller embedding an instructable solution which is generated by the modified rear-wheel feedback method(RF-LNMPC)in order to improve the overall path tracking accuracy in parking conditions.Firstly,A discrete-time RF-LNMPC considering the position and attitude of the parking vehicle is proposed to increase the success rate of automated parking effectively.Secondly,the RF-LNMPC problem with a multi-objective cost function is solved by the Interior-Point Optimization,of which the iterative initial values are described as the instructable solutions calculated by combining modified rear-wheel feedback to improve the performance of local optimal solution.Thirdly,the details on the computation of the terminal constraint and terminal cost for the linear time-varying case is presented.The closed-loop stability is verified via Lyapunov techniques by considering the terminal constraint and terminal cost theoretically.Finally,the proposed RF-LNMPC is implemented on a selfdriving Lincoln MKZ platform and the experiment results have shown improved performance in parallel and vertical parking conditions.The Monte Carlo analysis also demonstrates good stability and repeatability of the proposed method which can be applied in practical use in the near future. 展开更多
关键词 Automated parking Path tracking controller Nonlinear model predictive control Monte Carlo analysis
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Determinants of COVID-19 Face Mask Litter in Coastal Urban Parking Lots: Implications for Source Modelling of Potential Microplastic Pollution
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作者 Robert France Brandon Heung 《Journal of Environmental Protection》 2024年第8期874-886,共13页
Despite cities being recognized as being potential sources of microplastic pollution to the wider environment, most surveys of COVID-19 plastic-based litter have been undertaken through linear transects of marine beac... Despite cities being recognized as being potential sources of microplastic pollution to the wider environment, most surveys of COVID-19 plastic-based litter have been undertaken through linear transects of marine beaches. For the far fewer number of studies conducted on inland and urban locations, the site-specific focus has primarily been surveys along the length of streets. The present study is the first to specifically assess the standing stock (i.e., moment-in-time) of littered face masks for the entire surface area of urban parking lots. The density of face masks in 50 parking lots in a Canadian coastal town (0.00054 m2 ± 0.00051 m2) was found to be significantly greater than the background level of littering of town streets. Face mask density was significantly related to visitation “usage” of parking lots as gauged by the areal size of the lots and of their onsite buildings, as well as the number of vehicles present. Neither parking lot typology nor estimates of inferred export (various measures of wind exposure) and entrapment (various metrics of obstruction) of face masks had a significant influence on the extent of whole-lot littering. In consequence, modelling of the potential input of mask-derived microplastics to the marine environment from coastal communities can use the areal density of face masks found here in association with the total surface area of lots for individual municipalities as determined through GIS analysis. 展开更多
关键词 COVID Face Masks parking Lot Litter Prediction Areal Abundance
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Collision-free parking recommendation based on multi-agent reinforcement learning in vehicular crowdsensing
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作者 Xin Li Xinghua Lei +1 位作者 Xiuwen Liu Hang Xiao 《Digital Communications and Networks》 SCIE CSCD 2024年第3期609-619,共11页
The recent proliferation of Fifth-Generation(5G)networks and Sixth-Generation(6G)networks has given rise to Vehicular Crowd Sensing(VCS)systems which solve parking collisions by effectively incentivizing vehicle parti... The recent proliferation of Fifth-Generation(5G)networks and Sixth-Generation(6G)networks has given rise to Vehicular Crowd Sensing(VCS)systems which solve parking collisions by effectively incentivizing vehicle participation.However,instead of being an isolated module,the incentive mechanism usually interacts with other modules.Based on this,we capture this synergy and propose a Collision-free Parking Recommendation(CPR),a novel VCS system framework that integrates an incentive mechanism,a non-cooperative VCS game,and a multi-agent reinforcement learning algorithm,to derive an optimal parking strategy in real time.Specifically,we utilize an LSTM method to predict parking areas roughly for recommendations accurately.Its incentive mechanism is designed to motivate vehicle participation by considering dynamically priced parking tasks and social network effects.In order to cope with stochastic parking collisions,its non-cooperative VCS game further analyzes the uncertain interactions between vehicles in parking decision-making.Then its multi-agent reinforcement learning algorithm models the VCS campaign as a multi-agent Markov decision process that not only derives the optimal collision-free parking strategy for each vehicle independently,but also proves that the optimal parking strategy for each vehicle is Pareto-optimal.Finally,numerical results demonstrate that CPR can accomplish parking tasks at a 99.7%accuracy compared with other baselines,efficiently recommending parking spaces. 展开更多
关键词 Incentive mechanism Non-cooperative VCS game Multi-agent reinforcement learning Collision-free parking strategy Vehicular crowdsensing
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基于障碍物和车位检测的单阶段多任务YOLO-Parking算法研究
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作者 张炳力 王焱辉 +3 位作者 潘泽昊 王怿昕 杨程磊 王欣雨 《合肥工业大学学报(自然科学版)》 CAS 北大核心 2024年第1期1-6,61,共7页
文章提出一种基于YOLOv4的端到端多任务网络模型用于自动泊车系统中的感知任务,以环视图像(around view monitor, AVM)作为网络输入,基于卷积网络提取图像特征信息,通过YOLO和DMPR-PS(directional marking-point regression-parking sl... 文章提出一种基于YOLOv4的端到端多任务网络模型用于自动泊车系统中的感知任务,以环视图像(around view monitor, AVM)作为网络输入,基于卷积网络提取图像特征信息,通过YOLO和DMPR-PS(directional marking-point regression-parking slot)检测头实现停车位与障碍物并行检测。在PS 2.0公开数据集上进行验证的结果表明,所提出的多任务检测方法能够同时检测停车位和障碍物,障碍物识别平均精度均值达到89.72%,车位识别查准率达到93.53%,网络检测速率为34.0帧/s,在满足自动泊车感知任务需求的同时提升了系统的检测效率。该文研究成果对自动泊车感知技术的发展具有一定的意义。 展开更多
关键词 自动泊车 环视图像(AVM) 多任务网络 障碍物识别 停车位识别
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Research on Planning and Design of Multi-Story Prefabricated Electric Bicycle Charging Parking Lot in Urban and Rural Areas
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作者 Liya Fang 《Journal of Architectural Research and Development》 2024年第4期77-91,共15页
In recent years,disorderly parking and difficult charging of electric bicycles have been challenges in urban management.The rapid growth of electric bicycles is in contradiction with the lack of dedicated parking spac... In recent years,disorderly parking and difficult charging of electric bicycles have been challenges in urban management.The rapid growth of electric bicycles is in contradiction with the lack of dedicated parking spaces and charging service facilities in towns and villages.To solve the issue of parking and charging electric bicycles in limited urban and rural spaces,prefabricated building technology is applied to the design of a multi-story electric bicycle parking lot.The multi-story prefabricated electric bicycle parking lot is utilized in urban and rural planning and design to upgrade parking facilities in old urban areas,land-constrained commercial areas,as well as counties,towns,and rural areas with inadequate municipal facilities.Multi-story prefabricated electric bicycle parking lots are the application exploration of industrial buildings,and promote the high-quality development planning and construction of towns and counties and villages.Compared with the single-story metal charging station,the multi-story assembled electric bicycle parking lot has the characteristics of integrating parking and charging,being more durable and safer in structure,accommodating a large number of vehicles,and improving the space utilization rate. 展开更多
关键词 Prefabricated building Electric bicycle parking lot
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PARK2介导的帕金森病中帕金蛋白对α-突触核蛋白的作用 被引量:2
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作者 肖琪 樊慧杰 +8 位作者 李艳荣 范丽珊 和璐璐 谢良骐 贾璐 王青 肖保国 马存根 柴智 《中国老年学杂志》 CAS 北大核心 2024年第4期999-1005,共7页
帕金森病(PD)是常见的神经退行性疾病之一,主要表现为运动障碍,伴有主要运动症状,如运动迟缓、僵直性和静息性震颤,还可能表现为多种非运动症状,如自主神经功能障碍、认知障碍、睡眠障碍和神经精神症状〔1〕。
关键词 帕金森病 帕金蛋白 Α-突触核蛋白 park2基因突变
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高分辨MRI在肛瘘诊断及Parks分型中的应用价值
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作者 罗项超 周永进 +3 位作者 程淑芳 应海峰 陈玲 王祖飞 《医学影像学杂志》 2024年第4期159-161,共3页
目的 探讨高分辨MRI在肛瘘诊断及Parks分型中的应用价值。方法 选取肛瘘接受手术治疗患者108例,均行MRI检查,以手术结果为金标准,分析患者MRI特征及Parks分型。结果 108例中总计检出内口112个、瘘管124个、外口112个、肛周脓肿35个,与... 目的 探讨高分辨MRI在肛瘘诊断及Parks分型中的应用价值。方法 选取肛瘘接受手术治疗患者108例,均行MRI检查,以手术结果为金标准,分析患者MRI特征及Parks分型。结果 108例中总计检出内口112个、瘘管124个、外口112个、肛周脓肿35个,与手术确诊结果对比差异无统计学意义(P>0.05),其中括约肌间型64例、经括约肌型30例、括约肌上型11例、括约肌外型3例,与手术确诊结果对比差异无统计学意义(P>0.05)。结论 MRI应用于肛瘘诊断并进行Parks分型,能清晰显示出内口、外口、瘘管、脓肿位置以及数目信息。 展开更多
关键词 肛瘘 parks分型 磁共振成像
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The Role of Deep Learning in Parking Space Identification and Prediction Systems
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作者 Faizan Rasheed Yasir Saleem +2 位作者 Kok-Lim Alvin Yau Yung-Wey Chong Sye Loong Keoh 《Computers, Materials & Continua》 SCIE EI 2023年第4期761-784,共24页
In today’s smart city transportation,traffic congestion is a vexing issue,and vehicles seeking parking spaces have been identified as one of the causes leading to approximately 40%of traffic congestion.Identifying pa... In today’s smart city transportation,traffic congestion is a vexing issue,and vehicles seeking parking spaces have been identified as one of the causes leading to approximately 40%of traffic congestion.Identifying parking spaces alone is insufficient because an identified available parking space may have been taken by another vehicle when it arrives,resulting in the driver’s frustration and aggravating traffic jams while searching for another parking space.This explains the need to predict the availability of parking spaces.Recently,deep learning(DL)has been shown to facilitate drivers to find parking spaces efficiently,leading to a promising performance enhancement in parking identification and prediction systems.However,no work reviews DL approaches applied to solve parking identification and prediction problems.Inspired by this gap,the purpose of this work is to investigate,highlight,and report on recent advances inDLapproaches applied to predict and identify the availability of parking spaces.Ataxonomy of DL-based parking identification and prediction systems is established as a methodology by classifying and categorizing existing literature,and by doing so,the salient and supportive features of different DL techniques for providing parking solutions are presented.Moreover,several open research challenges are outlined.This work identifies that there are various DL architectures,datasets,and performance measures used to address parking identification and prediction problems.Moreover,there are some open-source implementations available that can be used directly either to extend existing works or explore a new domain.This is the first short survey article that focuses on the use of DL-based techniques in parking identification and prediction systems for smart cities.This study concludes that although the deployment of DL in parking identification and prediction systems provides various benefits,the convergence of these two types of systems and DL brings about new issues that must be resolved in the near future. 展开更多
关键词 Convolutional neural network deep learning neural networks parking identification parking prediction smart city
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PARK7基因对氧化应激的调控研究进展
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作者 樊庆灿 王倩倩 +2 位作者 杨虎 郑路程 胡威 《中国畜牧杂志》 CAS CSCD 北大核心 2024年第5期8-12,共5页
在规模化养殖模式下,畜禽在生长过程中会不可避免地面对各种不利因素,导致体内产生氧化应激,严重影响其生长发育。畜禽体内存在多种抗氧化因子来应对氧化应激。其中,帕金森相关蛋白7(Parkinson’s Disease-Associated Protein 7,PARK7)... 在规模化养殖模式下,畜禽在生长过程中会不可避免地面对各种不利因素,导致体内产生氧化应激,严重影响其生长发育。畜禽体内存在多种抗氧化因子来应对氧化应激。其中,帕金森相关蛋白7(Parkinson’s Disease-Associated Protein 7,PARK7)基因是细胞氧化应激中重要的调控因子之一。PARK7通过自身半胱氨酸的氧化水平感受氧化应激信号,并通过Nrf2、ERK1/2和PI3K/Akt等途径促进抗氧化酶的生成,提高细胞的抗氧化能力,从而减轻氧化应激引起的损伤。本文对PARK7基因在氧化应激中的调控作用和通路进行综述,将有助于畜禽氧化应激的调节机制研究。 展开更多
关键词 park7 DJ-1 氧化应激 Nrf2通路
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改良Park法重睑术治疗上睑松弛的疗效观察
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作者 许杰 张建文 《中国医疗美容》 2024年第7期37-40,共4页
目的探讨改良Park法重睑术治疗上睑松弛的临床疗效。方法以2023年1月至2023年12月在郑州缔莱美医疗美容医院就诊的31例上睑松弛患者为研究对象,所有患者均行改良Park法重睑术治疗,分析手术效果和手术并发症发生情况。结果31例患者中手... 目的探讨改良Park法重睑术治疗上睑松弛的临床疗效。方法以2023年1月至2023年12月在郑州缔莱美医疗美容医院就诊的31例上睑松弛患者为研究对象,所有患者均行改良Park法重睑术治疗,分析手术效果和手术并发症发生情况。结果31例患者中手术效果为完全改善18例,明显改善12例,有改善1例,无效0例,明显改善率为96.77%。术后感染2例(6.45%)、血瘀3例(9.68%)、重睑皱褶过窄2例(6.45%)、重睑线不对称1例(3.23%)。结论改良Park法重睑术治疗上睑松弛临床疗效较好,且不会造成严重的术后并发症,其临床应用价值较高。 展开更多
关键词 上睑松弛 改良park法重睑术 手术效果 并发症
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改良Park法重睑术与传统切开法重睑术治疗上睑松弛伴臃肿患者的效果对比 被引量:1
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作者 史迅 周彦鹏 李九旭 《临床医学工程》 2024年第4期431-432,共2页
目的探讨改良Park法重睑术与传统切开法重睑术治疗上睑松弛伴臃肿患者的效果。方法45例上睑松弛伴臃肿患者按治疗方法的不同分为对照组(传统切开法重睑术)和观察组(改良Park法重睑术),比较两组的手术情况、眼睑形态、修复满意度及并发... 目的探讨改良Park法重睑术与传统切开法重睑术治疗上睑松弛伴臃肿患者的效果。方法45例上睑松弛伴臃肿患者按治疗方法的不同分为对照组(传统切开法重睑术)和观察组(改良Park法重睑术),比较两组的手术情况、眼睑形态、修复满意度及并发症。结果观察组的手术时间、拆线时间及术后恢复时间均短于对照组,术后3个月的眼睑形态评分及修复满意度评分均高于对照组(P<0.05)。两组的并发症总发生率相比,差异无统计学意义(P>0.05)。结论与传统切开法重睑术相比,改良Park法重睑术治疗上睑松弛伴臃肿的效果更显著,安全性更高,可改善患者眼睑形态,提高修复满意度。 展开更多
关键词 上睑松弛 臃肿 改良park法重睑术 眼睑形态
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内眦开大术联合改良Park法重睑成形术在双侧单睑伴内眦赘皮患者中的应用效果观察 被引量:1
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作者 杜兴隆 张远其 《中国医疗美容》 2024年第2期11-15,共5页
目的观察内眦开大术联合改良Park法重睑成形术在双侧单睑伴内眦赘皮患者中的应用效果。方法选取82例于2020年9月至2023年9月在贵州医科大学附属乌当医院就诊的有求美需求的双侧单睑伴内眦赘皮患者,均为女性,按照治疗方式不同分为研究组... 目的观察内眦开大术联合改良Park法重睑成形术在双侧单睑伴内眦赘皮患者中的应用效果。方法选取82例于2020年9月至2023年9月在贵州医科大学附属乌当医院就诊的有求美需求的双侧单睑伴内眦赘皮患者,均为女性,按照治疗方式不同分为研究组和对照组,各41例(82只眼)。对照组采取内眦开大术联合传统Park重睑成形术,研究组采取内眦开大术联合改良Park法重睑成形术。比较两组患者术中出血量、瘢痕消失时间、术后满意度和临床疗效。结果研究组术中出血量少于对照组,手术时间短于对照组,瘢痕消失时间早于对照组,术后总满意度高于对照组患者,术后7天眼睑宽度小于对照组,眼裂高度大于对照组,术后半年上睑提肌肌力大于对照组,临床疗效总有效率高于对照组,并发症总发生率小于对照组,差异有统计学意义(P均<0.05)。结论内眦开大术联合改良Park法重睑成形术用于治疗双侧单睑伴内眦赘皮临床疗效较好,术中出血量少,术后并发症少,瘢痕消失时间早,恢复速度快,重睑形态对称自然,患者满意度高,值得临床应用。 展开更多
关键词 改良park 重睑成形术 内眦开大术 单睑 内眦赘皮
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Asymmetric Consortium Blockchain and Homomorphically Polynomial-Based PIR for Secured Smart Parking Systems
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作者 T.Haritha A.Anitha 《Computers, Materials & Continua》 SCIE EI 2023年第5期3923-3939,共17页
In crowded cities,searching for the availability of parking lots is a herculean task as it results in the wastage of drivers’time,increases air pollution,and traffic congestion.Smart parking systems facilitate the dr... In crowded cities,searching for the availability of parking lots is a herculean task as it results in the wastage of drivers’time,increases air pollution,and traffic congestion.Smart parking systems facilitate the drivers to determine the information about the parking lot in real time and book them depending on the requirement.But the existing smart parking systems necessitate the drivers to reveal their sensitive information that includes their mobile number,personal identity,and desired destination.This disclosure of sensitive information makes the existing centralized smart parking systems more vulnerable to service providers’security breaches,single points of failure,and bottlenecks.In this paper,an Improved Asymmetric Consortium Blockchain and Homomorphically Computing Univariate Polynomial-based private information retrieval(IACB-HCUPPIR)scheme is proposed to ensure parking lots’availability with transparency security in a privacy-preserving smart parking system.In specific,an improved Asymmetric Consortium Blockchain is used for achieving secure transactions between different parties interacting in the smart parking environment.It further adopted the method of Homomorphically Computing Univariate Polynomial-based private information retrieval(HCUPPIR)scheme for preserving the location privacy of drivers.The results of IACB-HCUPPIR confirmed better results in terms of minimized computation and communication overload with throughput,latency,and response time with maximized drivers’privacy preservation.Moreover,the proposed fully homomorphic algorithm(FHE)was compared against partial-homomorphic encryption(PHE)and technique without encryption and found that the proposed model has quick communication in allocating the parking slots starting with 24.3 s,whereas PHE starts allocating from 24.7 s and the technique without encryption starts at 27.4 s.Thus,we ensure the proposed model performs well in allocating parking slots with less time and high security with privacy preservation. 展开更多
关键词 Smart parking asymmetric consortium blockchain privacy preservation homomorphic encryption private information retrieval
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显微镜下改良Parks切口斜视矫正术治疗水平共同性斜视患儿的效果及其对泪膜功能的影响
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作者 高锦展 王素萍 何利 《实用防盲技术》 2024年第1期41-43,F0003,共4页
目的探探讨显微镜下改良Parks切口斜视矫正术治疗水平共同性斜视患儿的效果及其对泪膜功能的影响。方法选取我科2017年6月至2019年11月期间95例水平共同性斜视患儿作为研究对象,按照随机数字表法分成两组,均行斜视矫正术,对照组47例给... 目的探探讨显微镜下改良Parks切口斜视矫正术治疗水平共同性斜视患儿的效果及其对泪膜功能的影响。方法选取我科2017年6月至2019年11月期间95例水平共同性斜视患儿作为研究对象,按照随机数字表法分成两组,均行斜视矫正术,对照组47例给予术中作角膜缘梯形结膜瓣切口,观察组48例给予显微镜下改良Parks切口,1个月后对比两组患儿视功能改善效果、手术效果、泪膜功能。结果观察组治疗后总有效率95.83%高于对照组89.36%(χ^(2)=0.6632,P=0.4154);观察组水平共同性斜视患儿手术时间明显短于对照组(t=11.9892,P=0.0000);观察组患儿治疗后泪液分泌量高于对照组(t=15.0051,P=0.0000),泪膜破裂时间较对照组上升(t=9.2228,P=0.0000),角膜荧光染色评分较对照组降低(t=10.7815,P=0.0000)。结论显微镜下改良Parks切口斜视矫正术治疗水平共同性斜视效果确切,能够显著矫正眼部,改善患儿视功能及泪膜功能,安全可靠,值得应用。 展开更多
关键词 微镜下改良parks切口斜视矫正术 水平共同性斜视 泪膜功能
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PARK9基因rs207663位点突变与早期帕金森病认知改善治疗应答相关性
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作者 王俊英 王静 +1 位作者 李亚萍 张永志 《中华老年心脑血管病杂志》 CAS 北大核心 2024年第6期670-673,共4页
目的探讨PARK9基因rs207663位点突变与早期帕金森病认知改善治疗应答相关性。方法选取2020年10月至2023年10月于邯郸市第四医院神经内科接受治疗的100例早期帕金森病患者为研究组,以100例健康体检者为对照组。检测PARK9基因rs207663位... 目的探讨PARK9基因rs207663位点突变与早期帕金森病认知改善治疗应答相关性。方法选取2020年10月至2023年10月于邯郸市第四医院神经内科接受治疗的100例早期帕金森病患者为研究组,以100例健康体检者为对照组。检测PARK9基因rs207663位点基因多态性,比较2组等位基因、基因型分布,以及分析不同基因型患者经治疗后的疗效情况。结果PARK9基因rs207663位点存在3种基因型:GG、GA、AA,研究组GG基因型、G等位基因频率高于对照组(40.0%vs 26.0%,P<0.05;63.0%vs 50.0%,P<0.01)。治疗后,3种基因型简易智能状态检查量表(MMSE)、蒙特利尔认知评估量表(MoCA)评分均呈增加趋势,其中GG基因型MMSE评分低于GA基因型[(22.95±1.34)分vs(23.89±1.68)分,P<0.05],GG基因型MoCA评分低于GA基因型[(24.86±1.83)分vs(25.12±1.48)分,P<0.05]。GA基因型总资产、安全选项次数、负反馈利用率均高于GG基因型[(-1541.50±537.24)元vs(-3102.00±1274.38)元,P<0.01;(9.24±3.27)次vs(7.11±2.14)次,P<0.05;(0.51±0.23)vs(0.35±0.15),P<0.05];AA基因型风险选项次数低于GA基因型,GA基因型风险选项次数低于GG基因型,差异有统计学意义(P<0.05)。结论PARK9基因rs207663位点多态性与早期帕金森病认知改善治疗应答存在显著相关性,其中GG基因型患者治疗应答较差,GG基因型患者偏爱高风险和高回报选项,负反馈利用率较低。 展开更多
关键词 帕金森病 认知 数据相关性 park9基因 rs207663位点突变
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Fuzzy Controller-Based Design and Simulation of an Automatic Parking System
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作者 Meiyan Gao Yuanzhou Wei +4 位作者 Ya He Dan Zhang Yuanhao Tian Bolin Huang Changyang Zheng 《Journal of Software Engineering and Applications》 2023年第9期505-520,共16页
With the development of automatic driving and fuzzy theory, people pay more and more attention to the application of fuzzy logic in engineering technology. The automatic parking module in the automatic driving system ... With the development of automatic driving and fuzzy theory, people pay more and more attention to the application of fuzzy logic in engineering technology. The automatic parking module in the automatic driving system has always been the focus of research. Automatic parking modules can greatly assist drivers in parking operations, greatly reduce parking difficulties and make people more convenient and fast parking. In this paper, an automatic parking system based on the fuzzy controller is proposed. The fuzzy controller of automatic parking system is constructed by using fuzzy theory, and the robustness of the whole system is examined by fuzzy logic. Firstly, the vehicle motion rules and trajectory changes are analyzed in detail, and the real parking lot model is simulated. Then, the input and output variables of the whole system are analyzed by fuzzy theory and the membership function is constructed. Based on the experience of human experts, the parking rules are tested and summarized, and a reasonable and practical rule base is established. Finally, MATLAB is used to code, build the visual interface of parking lot and vehicles, and draw the cyclic iterative function to detect the vehicle position and direction angle, so as to act as a sensor. The results show that using a fuzzy controller to construct an automatic parking system can effectively improve the parking level. 展开更多
关键词 Automatic parking Controller Theory Fuzzy Logic MATLAB System Optimization
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Dysfunction of synaptic endocytic trafficking in Parkinson's disease
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作者 Xin Yi Ng Mian Cao 《Neural Regeneration Research》 SCIE CAS CSCD 2024年第12期2649-2660,共12页
Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.The precise reasons behind the specific degeneration of t... Parkinson's disease is characterized by the selective degeneration of dopamine neurons in the nigrostriatal pathway and dopamine deficiency in the striatum.The precise reasons behind the specific degeneration of these dopamine neurons remain largely elusive.Genetic investigations have identified over 20 causative PARK genes and 90 genomic risk loci associated with both familial and sporadic Parkinson's disease.Notably,several of these genes are linked to the synaptic vesicle recycling process,particularly the clathrinmediated endocytosis pathway.This suggests that impaired synaptic vesicle recycling might represent an early feature of Parkinson's disease,followed by axonal degeneration and the eventual loss of dopamine cell bodies in the midbrain via a"dying back"mechanism.Recently,several new animal and cellular models with Parkinson's disease-linked mutations affecting the endocytic pathway have been created and extensively characterized.These models faithfully recapitulate certain Parkinson's disease-like features at the animal,circuit,and cellular levels,and exhibit defects in synaptic membrane trafficking,further supporting the findings from human genetics and clinical studies.In this review,we will first summarize the cellular and molecular findings from the models of two Parkinson's disease-linked clathrin uncoating proteins:auxilin(DNAJC6/PARK19)and synaptojanin 1(SYNJ1/PARK20).The mouse models carrying these two PARK gene mutations phenocopy each other with specific dopamine terminal pathology and display a potent synergistic effect.Subsequently,we will delve into the involvement of several clathrin-mediated endocytosis-related proteins(GAK,endophilin A1,SAC2/INPP5 F,synaptotagmin-11),identified as Parkinson's disease risk factors through genome-wide association studies,in Parkinson's disease pathogenesis.We will also explore the direct or indirect roles of some common Parkinson's disease-linked proteins(alpha-synuclein(PARK1/4),Parkin(PARK2),and LRRK2(PARK8))in synaptic endocytic trafficking.Additionally,we will discuss the emerging novel functions of these endocytic proteins in downstream membrane traffic pathways,particularly autophagy.Given that synaptic dysfunction is considered as an early event in Parkinson's disease,a deeper understanding of the cellular mechanisms underlying synaptic vesicle endocytic trafficking may unveil novel to rgets for early diagnosis and the development of interventional therapies for Parkinson's disease.Future research should aim to elucidate why generalized synaptic endocytic dysfunction leads to the selective degeneration of nigrostriatal dopamine neurons in Parkinson's disease. 展开更多
关键词 AUTOPHAGY auxilin/park19 clathrin-mediated endocytosis dopamine neurons NEURODEGENERATION nigrostriatal pathway parkinson's disease synaptic vesicle recycling synaptojanin1/park20
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