Introduction Chirality is defined as the absence of inversion symmetry,however,it is actually a pseudo-scalar of objects or figures,and does not depend for its definition on any connection to the physical world[1-5]. ...Introduction Chirality is defined as the absence of inversion symmetry,however,it is actually a pseudo-scalar of objects or figures,and does not depend for its definition on any connection to the physical world[1-5]. Logically,chiral molecules may possess other inherent physical quantity that guarantees the connection to the physical world[6,7].展开更多
Axially chiral N-arylindoles bearing a stereogenic C—N axis are unique important scaffolds in natural products,advance materials,pharmaceuticals and privileged chiral ligands or catalysts.Herein,we report the direct ...Axially chiral N-arylindoles bearing a stereogenic C—N axis are unique important scaffolds in natural products,advance materials,pharmaceuticals and privileged chiral ligands or catalysts.Herein,we report the direct synthesis of C—N axially chiral N-arylindoles through a Pd-catalyzed free amine-directed atroposelective C—H olefination enabled by a spiro phosphoric acid(SPA)ligand.A wide range of enantioenriched N-aromatic amine indoles were obtained in high yields with good enantioselectivities(35 examples,up to 91%yield and up to 96%ee).The chiral products with free amine group offer an effective functional handle for down-stream diversity-oriented synthesis.展开更多
Chiral molecules, which may contain one or more different type(s) of stereocentres, such as central, axial, planar, and helical chiralities, etc., are indispensable in chemistry, pharmaceutical industry, and life sc...Chiral molecules, which may contain one or more different type(s) of stereocentres, such as central, axial, planar, and helical chiralities, etc., are indispensable in chemistry, pharmaceutical industry, and life science. Despite many advances for the preparation of chiral molecules usually with a single type of chirality have been realized, simultaneous construction of different types of chiralities is still a significant challenge. Here, we wish to report a protocol for preparation of chiral allenes with both central and axial chiralities via a catalytic asymmetric allenylation of different biologically or syn- thetically useful fluorinated or non-fluorinated nucleophiles with readily available racemic allenes by using a single chiral ligand. An echoing between the central chirality and axial chirality for the enantioselectivity was observed. This strategy provides a general and practical approach to functionalized optically active allenes bearing both central and axial chiralities with an excellent enantioselectivity under mild conditions.展开更多
This highlight summarizes a recent development of a catalytic enantioselective Catellani-type reaction for the synthesis of axially chiral biaryls.The chirality induction is solely governed by chiral norbornene ligand...This highlight summarizes a recent development of a catalytic enantioselective Catellani-type reaction for the synthesis of axially chiral biaryls.The chirality induction is solely governed by chiral norbornene ligand in the Pd mediated ortho C–H functionalization and ipso cross-coupling transformation.The preparative power of the methodology is demonstrated as a powerful manifold for the divergent synthesis of structurally diverse axially chiral biaryls and chiral fluorenols.展开更多
A new metal-organic coordination polymer [Pb(mfpdc)(CH3OH)]n (1, mfpdc = 2,6-dimethyl-4-(2-furanyl) pyridine-3,5-dicarboxylate) was synthesized and characterized by single-crystal X-ray analyses. The crystal i...A new metal-organic coordination polymer [Pb(mfpdc)(CH3OH)]n (1, mfpdc = 2,6-dimethyl-4-(2-furanyl) pyridine-3,5-dicarboxylate) was synthesized and characterized by single-crystal X-ray analyses. The crystal is orthorhombic, space group Pbca, a = 15.6297(18), b = 9.4803(11), c = 18.598(2) A, V= 2755.8(6) A3, Z = 8, Mr= 498.44, Dc= 2.403 Mg/m3, F(000) = 1872, the final R = 0.0275 and wR = 0.0726 (1 〉 2σ(I)). There are interesting polynuclear zigzag (PbOs)n chains in the structure of 1, and there have interesting axially chiral S- and R-unit Pb4L units constructed from prochiral organic ligands through C-H...O bonding. The (R/S)-Pb4L units by sharing Pb centers generate a 2-D coordination network, in which there exist rare n65Pb (3.2610 A) interactions. The solid-state photoluminescent emission of compound 1 appears at 487 nm.展开更多
This study optimized the TADF feature of axial chiral enantiomers through precise donor engineering,and multicolor CP-TADFwas achieved in the axial chiral framework.Three pairs of axial enantiomers with donor-regulate...This study optimized the TADF feature of axial chiral enantiomers through precise donor engineering,and multicolor CP-TADFwas achieved in the axial chiral framework.Three pairs of axial enantiomers with donor-regulated TADF feature,namely(R/S)-TPCBD,(R/S)-DPCBD,and(R/S)-DPACBD,were synthesized by introducing carbazole donors with different substituents onto biphenyl cyanide acceptors.As the electron-donating ability of donors increases,the emission of these axial enantiomers ranges from 455,476 to 552 nm,their singlet-triplet energy gaps(ΔE_(ST))gradually decrease from 0.30,0.22 to 0.02 e V,accompanied by an increasement in the transition rate(k_(RISC))of RISC process,and the k_(RISC)of DPACBD could reach up to 7.16×10^(5)s^(-1).These axial enantiomers also exhibit mirror-image CD and circularly polarized luminescence(CPL)properties.Moreover,OLEDs based on TPCBD,DPCBD,and DPACBD as emitter were then fabricated,which displayed blue,green,and orange electroluminescence with EQE_(max)of 13.0%,16.4%,and 25.0%,respectively.The results also exhibited a phenomenon of device efficiency increasing with the enhancement of donor abilities.Notably,the CP-OLEDs using(R/S)-TPCBD,(R/S)-DPCBD and(R/S)-DPACBD as emitters displayed intense CPEL signals with g_(EL)values of 3.4×10^(-3)/-4.1×10^(-3),3.2×10^(-3)/-3.1×10^(-3)and2.3×10^(-3)/-2.1×10^(-3),respectively.By convenient molecular engineering of donor regulation in the same molecular skeleton,CP-TADF materials with multicolor CPEL and improved device performance could be conveniently achieved.展开更多
Catalytic enantioselective preparation of axially chiral molecules has gained considerable interest over the past decades, due to their numerous applications in bioactive molecules, natural products, pharmaceuticals, ...Catalytic enantioselective preparation of axially chiral molecules has gained considerable interest over the past decades, due to their numerous applications in bioactive molecules, natural products, pharmaceuticals, materials, ligands, and catalysts. Compared with the well-established synthetic approaches for six-membered axially chiral skeletons, methodologies directed towards five-membered axially chiral compounds are relatively rare. Among these, axially chiral arylpyrroles are especially important structural motifs with wide utility, and the atroposelective synthesis of them is highly desirable. In recent years, novel strategies have been developed based on transition-metal catalysis and organocatalysis. This review summarizes the recent achievements in atroposelective preparation of arylpyrroles, by emphasizing the synthetic methods for each axially chiral framework, reaction mechanisms, and applications.展开更多
The catalytic asymmetric construction of axially chiral indole-based frameworks is an important area of research due to the unique characteristics of such frameworks.Nevertheless,research in this area is still in its ...The catalytic asymmetric construction of axially chiral indole-based frameworks is an important area of research due to the unique characteristics of such frameworks.Nevertheless,research in this area is still in its infancy and has some challenges,such as designing and constructing new classes of axially chiral indole-based scaffolds and developing their applications in chiral catalysts,ligands,etc.To overcome these challenges,we present herein the design and atroposelective synthesis of aryl-pyrroloindoles as a new class of axially chiral indole-based scaffolds via the strategy of organocatalytic asymmetric(2+3)cyclization between 3-arylindoles and propargylic alcohols.More importantly,this new class of axially chiral scaffolds was derived into phosphines,which served as efficient chiral ligands in palladium-catalyzed asymmetric reactions.Moreover,theoretical calculations provided an in-depth understanding of the reaction mechanism.This work offers a new strategy for constructing axially chiral indole-based scaffolds,which are promising for finding more applications in asymmetric catalysis.展开更多
Secondary alcohols bearing both axial and central chirality comprise attractive biological activity and exhibit excellent chiral induction in asymmetric reactions.However,only very limited asymmetric catalytic approac...Secondary alcohols bearing both axial and central chirality comprise attractive biological activity and exhibit excellent chiral induction in asymmetric reactions.However,only very limited asymmetric catalytic approaches were developed for their synthesis.We herein describe visible light-mediated cobalt-catalyzed asymmetric reductive Grignard-type addition of aryl iodides with axially prochiral biaryl dialdehydes leading to the direct construction of axially chiral secondary alcohols.Preliminary mechanistic studies indicate that efficient kinetic recognition of diastereomers might occur for axially prochiral dialdehydes to improve the stereoselectivity,which might open a new avenue for the challenging cascade construction of multiple chiral elements.This protocol features excellent enantio-and diastereoselectivity,green and mild conditions,simple operation,and broad substrate scope,providing a modular platform for the synthesis of secondary axially chiral alcohols.展开更多
The well-defined conformational properties of axially chiral compounds bring extraordinary values to an assortment of bioactive molecules,advanced materials,organocatalysts as well as chiral ligands in asymmetric tran...The well-defined conformational properties of axially chiral compounds bring extraordinary values to an assortment of bioactive molecules,advanced materials,organocatalysts as well as chiral ligands in asymmetric transformations.The demonstrated usefulness and untapped potential of axially chiral structural motifs stimulate increasing efforts to develop novel and efficient approaches for their preparation.In this regard,the chiral phosphoric acids broadly used in asymmetric Brønsted acid catalysis have shown high relevance for atroposelective synthesis as well.Our strong interest in reaction chemistry of atropisomers has established a rewarding research programme in our group.The course of studies will be recounted in this account,with discussion focused on the use of chiral phosphoric acids to catalyze construction of several key axially chiral structures such as BINAM,BINOL,NOBIN,arylquinones,SPINOL,arylpyrrole analogues and axially chiral alkenes.展开更多
Comprehensive Summary A new strategy for the enantioselective synthesis of axially chiral 3,3'-bisindoles was devised by the direct coupling of two indole rings.This strategy makes use of the C3-umpolung reactivit...Comprehensive Summary A new strategy for the enantioselective synthesis of axially chiral 3,3'-bisindoles was devised by the direct coupling of two indole rings.This strategy makes use of the C3-umpolung reactivity of 2-indolylmethanols,which enables the catalytic asymmetric addition reaction of 2-indolylmethanols with rationally designed 2-substituted indoles,thus constructing axially chiral 3,3'-bisindole scaffolds in overall excellent yields(up to 98%)with high enantioselectivities(up to 96:4 er).This approach not only has overcome the challenges in constructing axially chiral five-five-membered heterobiaryls,but also represents a new application of the C3-umpolung reactivity of 2-indolylmethanols in asymmetric catalysis.More importantly,this class of axially chiral 3,3'-bisindoles can undergo a variety of post-functionalizations to give axially chiral 3,3'-bisindole-based organocatalysts,which have found their preliminary applications in asymmetric catalysis.展开更多
The catalytic atroposelective synthesis of axially chiral isochromenone-indoles has been established by the strategy of designing homophthalic anhydride-based indole derivatives as a new type of indole-based platform ...The catalytic atroposelective synthesis of axially chiral isochromenone-indoles has been established by the strategy of designing homophthalic anhydride-based indole derivatives as a new type of indole-based platform molecules for dynamic kinetic resolution.By this strategy,a wide range of axially chiral isochromenone-indoles were synthesized in high yields with excellent enantioselectivities(up to 98% yield,97% ee) via the catalytic asymmetric sulfonylation reaction of homophthalic anhydridebased indole derivatives with aryl sulfonyl chlorides under the catalysis of chiral quaternary ammonium salt as a phase-transfer catalyst.展开更多
Atroposelective construction of axially chiral alkene-heteroaryl scaffolds is highly desired but challenging.In this work,we established an atroposelective construction of axially chiral alkene-indole scaffolds via th...Atroposelective construction of axially chiral alkene-heteroaryl scaffolds is highly desired but challenging.In this work,we established an atroposelective construction of axially chiral alkene-indole scaffolds via the strategy of catalytic enantioselective addition reaction of 3-alkynyl-2-indolylmethanols with bulky nucleophiles.展开更多
Via the bottom-up synthetic strategy,we synthesized a pair of dodecanuclear metal clusters of Eu_(12)(C_(2)O_(4))_(9)(R/S-BNP)_(18)(EtOH)_(6)-(H_(2)0)_(6)·8EtOH-7H_(2)0(complex 2),which represent the largest axia...Via the bottom-up synthetic strategy,we synthesized a pair of dodecanuclear metal clusters of Eu_(12)(C_(2)O_(4))_(9)(R/S-BNP)_(18)(EtOH)_(6)-(H_(2)0)_(6)·8EtOH-7H_(2)0(complex 2),which represent the largest axial chiral lanthanide metal clusters.In the structure,rare four-pointed star coordination mode of oxalic acid is reported by this work.In addition,as a fluorescence sensor,the complex 2 exhibits high enantioselectivity for R-/S-BINOL-TF_(2)(EF=2.87)and other chiral binaphthyl derivatives.展开更多
Indole-based atropisomers are a very important class of axially chiral compounds.However,the atroposelective synthesis of axially chiral 2-arylindole remains largely unexplored.In this study,we report the successful s...Indole-based atropisomers are a very important class of axially chiral compounds.However,the atroposelective synthesis of axially chiral 2-arylindole remains largely unexplored.In this study,we report the successful synthesis of atropisomeric 2-arylindoles using direct amination of indoles with p-quinonediimines in the presence of chiral phosphoric acid as a catalyst.Quinonediimine acts as an aminating reagent through formal polarity inversion of imine.The malonate group on the 2-aryl of 2-indoles was found to be essen-tial for high enantioselectivity of the products.This could be due to the additional interaction between the ester group and the cata-lyst,as well as the intramolecular hydrogen bonding.Our findings provide a new strategy for the asymmetric construction of 2-arylindole atropisomers.展开更多
The stereocontrol of chiral metal clusters and nanoclusters has become a focus of interest in metal cluster chemistry due to their promising applications in asymmetric catalysis.Despite being a general chirality trans...The stereocontrol of chiral metal clusters and nanoclusters has become a focus of interest in metal cluster chemistry due to their promising applications in asymmetric catalysis.Despite being a general chirality transfer strategy,the ion-pairing process is still ambiguous in the course of bestowing chirality to metal clusters.Here we construct a biaryl-centered axially chiral gold-cluster system to study an outside-in ion-pairing chirality transfer process.Four hexanuclear gold(I)clusters,centered by two types of biaryl ligands[(2-indolyl)aniline(L^(1))and biindole(L^(2))],were synthesized via in situ cyclization reactions.In the crystalline state,the biaryl centers showed axial chirality in which the gold atoms were in an asymmetric arrangement.In solution,the chiral phosphates induced an outside-in chirality transfer by significant interactions with the periphery of the biaryl-centered gold clusters.Finally,the chiral resolution of hexa-aurated biindoliums was accomplished via an efficient outside-in chirality transfer process relying on strong aurophilic interaction and extra peripheral coordination.This study not only deepens the understanding of the outside-in ion-pairing chirality transfer process but also provides a new approach for fabricating desired chiral metal clusters by a combination of organometallic transformation and chirality transfer.展开更多
An unprecedented atroposelective Catellani reaction between phosphine oxide-containing aryl bromides,aryliodides,and nucleophiles for the construction of phosphine-containing biaryl atropisomers was established using ...An unprecedented atroposelective Catellani reaction between phosphine oxide-containing aryl bromides,aryliodides,and nucleophiles for the construction of phosphine-containing biaryl atropisomers was established using an enantiopure norbornene derivative as the chiral mediator.A broad range of atropisomeric biaryl-based monophosphine oxides were obtained in good efficiency with excellent enantioselectivity.展开更多
A family of tropos ligands bearing a N-heterocyclic carbene and a chiral oxazoline coordination group with a N-phenyl framework were easily prepared,and their coordination behavior with Pd(Ⅱ)acetate was performed,a...A family of tropos ligands bearing a N-heterocyclic carbene and a chiral oxazoline coordination group with a N-phenyl framework were easily prepared,and their coordination behavior with Pd(Ⅱ)acetate was performed,affording a series of axially chiral palladium complexes in good yields.展开更多
The chemistry of axially chiral compounds has emerged as a subject of increasing interest due to their widespread presence in natural products,bioactive molecules,advanced materials,and chiral ligands/catalysts.On the...The chemistry of axially chiral compounds has emerged as a subject of increasing interest due to their widespread presence in natural products,bioactive molecules,advanced materials,and chiral ligands/catalysts.On the other hand,catalytic asymmetric radical-based transformations provide a complementary platform for the construction of enantiomerically enriched molecules that are in growing demand in the chemical and pharmaceutical in-dustries.In recent years,considerable research efforts have been devoted to the development of catalytic asymmetric radical reactions for the construction of axially chiral compounds based on the unique reactivity modes of diverse radicals.In this review,we critically illustrate these recent achievements according to different radical precursors and catalytic activation modes.Wherever possible,special emphasis is also placed on the discussion of mechanistic features underlying these works and substrate scopes.This review should be of great interest to the experts in this area,but also serve as a helpful starting point for new researchers in this field.展开更多
Atropisomeric anilides are one of important C-N axially chiral compounds.Compared with the A/-terminal functionalization to prepare such compounds,C-terminal functionalization strategies have been rarely reported.We d...Atropisomeric anilides are one of important C-N axially chiral compounds.Compared with the A/-terminal functionalization to prepare such compounds,C-terminal functionalization strategies have been rarely reported.We describe herein an efficient synthesis of axially chiral anilides enabled by Pd-catalyzed desymmetric Sonogashira cross-coupling reactions with the use of a newly identified Ming-Phos.Moderate to high yields with high enantioselectivities(up to 98%ee)were obtained.展开更多
基金Supported by the National Natural Science Foundation of China(No.60171008)Shanghai Science and Technology Commit-tee(No.0452nm087).
文摘Introduction Chirality is defined as the absence of inversion symmetry,however,it is actually a pseudo-scalar of objects or figures,and does not depend for its definition on any connection to the physical world[1-5]. Logically,chiral molecules may possess other inherent physical quantity that guarantees the connection to the physical world[6,7].
基金We thank the support from National Key R&D Program of China(2022YFA1504302,2021YFF0701603)National Natural Science Foundation of China(U22A20388,92256302,21925109 for B.-F.S.,22271250 for T.Z.)+1 种基金Fundamental Research Funds for the Central Universities(226-2023-00115,226-2022-00224,226-2022-00175)Zhejiang Provincial NSFC(LD22B030003)。
文摘Axially chiral N-arylindoles bearing a stereogenic C—N axis are unique important scaffolds in natural products,advance materials,pharmaceuticals and privileged chiral ligands or catalysts.Herein,we report the direct synthesis of C—N axially chiral N-arylindoles through a Pd-catalyzed free amine-directed atroposelective C—H olefination enabled by a spiro phosphoric acid(SPA)ligand.A wide range of enantioenriched N-aromatic amine indoles were obtained in high yields with good enantioselectivities(35 examples,up to 91%yield and up to 96%ee).The chiral products with free amine group offer an effective functional handle for down-stream diversity-oriented synthesis.
文摘Chiral molecules, which may contain one or more different type(s) of stereocentres, such as central, axial, planar, and helical chiralities, etc., are indispensable in chemistry, pharmaceutical industry, and life science. Despite many advances for the preparation of chiral molecules usually with a single type of chirality have been realized, simultaneous construction of different types of chiralities is still a significant challenge. Here, we wish to report a protocol for preparation of chiral allenes with both central and axial chiralities via a catalytic asymmetric allenylation of different biologically or syn- thetically useful fluorinated or non-fluorinated nucleophiles with readily available racemic allenes by using a single chiral ligand. An echoing between the central chirality and axial chirality for the enantioselectivity was observed. This strategy provides a general and practical approach to functionalized optically active allenes bearing both central and axial chiralities with an excellent enantioselectivity under mild conditions.
基金Financial support was provided by the National Instittue of General Medical Sciences(No.5R01GM125920-04).
文摘This highlight summarizes a recent development of a catalytic enantioselective Catellani-type reaction for the synthesis of axially chiral biaryls.The chirality induction is solely governed by chiral norbornene ligand in the Pd mediated ortho C–H functionalization and ipso cross-coupling transformation.The preparative power of the methodology is demonstrated as a powerful manifold for the divergent synthesis of structurally diverse axially chiral biaryls and chiral fluorenols.
基金supported by Science and Technology Projects of Chongqing Municipal Education Commission(No.KJ100602)Chongqing Normal University Scientific Research Foundation Project(Nos.10XLZ005and2011XLS30)
文摘A new metal-organic coordination polymer [Pb(mfpdc)(CH3OH)]n (1, mfpdc = 2,6-dimethyl-4-(2-furanyl) pyridine-3,5-dicarboxylate) was synthesized and characterized by single-crystal X-ray analyses. The crystal is orthorhombic, space group Pbca, a = 15.6297(18), b = 9.4803(11), c = 18.598(2) A, V= 2755.8(6) A3, Z = 8, Mr= 498.44, Dc= 2.403 Mg/m3, F(000) = 1872, the final R = 0.0275 and wR = 0.0726 (1 〉 2σ(I)). There are interesting polynuclear zigzag (PbOs)n chains in the structure of 1, and there have interesting axially chiral S- and R-unit Pb4L units constructed from prochiral organic ligands through C-H...O bonding. The (R/S)-Pb4L units by sharing Pb centers generate a 2-D coordination network, in which there exist rare n65Pb (3.2610 A) interactions. The solid-state photoluminescent emission of compound 1 appears at 487 nm.
基金supported by the National Natural Science Foundation of China(22122111,92256304)the Ministry of Science and Technology of China(2022YFA1204401)。
文摘This study optimized the TADF feature of axial chiral enantiomers through precise donor engineering,and multicolor CP-TADFwas achieved in the axial chiral framework.Three pairs of axial enantiomers with donor-regulated TADF feature,namely(R/S)-TPCBD,(R/S)-DPCBD,and(R/S)-DPACBD,were synthesized by introducing carbazole donors with different substituents onto biphenyl cyanide acceptors.As the electron-donating ability of donors increases,the emission of these axial enantiomers ranges from 455,476 to 552 nm,their singlet-triplet energy gaps(ΔE_(ST))gradually decrease from 0.30,0.22 to 0.02 e V,accompanied by an increasement in the transition rate(k_(RISC))of RISC process,and the k_(RISC)of DPACBD could reach up to 7.16×10^(5)s^(-1).These axial enantiomers also exhibit mirror-image CD and circularly polarized luminescence(CPL)properties.Moreover,OLEDs based on TPCBD,DPCBD,and DPACBD as emitter were then fabricated,which displayed blue,green,and orange electroluminescence with EQE_(max)of 13.0%,16.4%,and 25.0%,respectively.The results also exhibited a phenomenon of device efficiency increasing with the enhancement of donor abilities.Notably,the CP-OLEDs using(R/S)-TPCBD,(R/S)-DPCBD and(R/S)-DPACBD as emitters displayed intense CPEL signals with g_(EL)values of 3.4×10^(-3)/-4.1×10^(-3),3.2×10^(-3)/-3.1×10^(-3)and2.3×10^(-3)/-2.1×10^(-3),respectively.By convenient molecular engineering of donor regulation in the same molecular skeleton,CP-TADF materials with multicolor CPEL and improved device performance could be conveniently achieved.
基金supported by the National Natural Science Foundation of China (22125108, 92056104)the Fundamental Research Funds for the Central Universities (20720210002, 20720230003)the National Science Fund for Fostering Talents in Basic Science (J1310024)。
文摘Catalytic enantioselective preparation of axially chiral molecules has gained considerable interest over the past decades, due to their numerous applications in bioactive molecules, natural products, pharmaceuticals, materials, ligands, and catalysts. Compared with the well-established synthetic approaches for six-membered axially chiral skeletons, methodologies directed towards five-membered axially chiral compounds are relatively rare. Among these, axially chiral arylpyrroles are especially important structural motifs with wide utility, and the atroposelective synthesis of them is highly desirable. In recent years, novel strategies have been developed based on transition-metal catalysis and organocatalysis. This review summarizes the recent achievements in atroposelective preparation of arylpyrroles, by emphasizing the synthetic methods for each axially chiral framework, reaction mechanisms, and applications.
基金support from the National Natural Science Foundation of China (22125104 and 21831007)Natural Science Foundation of Jiangsu Province (BK20210916)High Education Natural Science Foundation of Jiangsu Province (21KJB150009).
文摘The catalytic asymmetric construction of axially chiral indole-based frameworks is an important area of research due to the unique characteristics of such frameworks.Nevertheless,research in this area is still in its infancy and has some challenges,such as designing and constructing new classes of axially chiral indole-based scaffolds and developing their applications in chiral catalysts,ligands,etc.To overcome these challenges,we present herein the design and atroposelective synthesis of aryl-pyrroloindoles as a new class of axially chiral indole-based scaffolds via the strategy of organocatalytic asymmetric(2+3)cyclization between 3-arylindoles and propargylic alcohols.More importantly,this new class of axially chiral scaffolds was derived into phosphines,which served as efficient chiral ligands in palladium-catalyzed asymmetric reactions.Moreover,theoretical calculations provided an in-depth understanding of the reaction mechanism.This work offers a new strategy for constructing axially chiral indole-based scaffolds,which are promising for finding more applications in asymmetric catalysis.
基金Natural Science Foundation of Jilin Province(20230101047JC,YDZJ202201ZYTS338)NSFC(22001157,21831002,22193012,and 22201033)+1 种基金Jilin Educational Committee(JJKH20231295KJ,JJKH20231302KJ)the Fundamental Research Funds for the Central Universities(2412022ZD012,2412022QD016,2412021QD007)for generous financial support.
文摘Secondary alcohols bearing both axial and central chirality comprise attractive biological activity and exhibit excellent chiral induction in asymmetric reactions.However,only very limited asymmetric catalytic approaches were developed for their synthesis.We herein describe visible light-mediated cobalt-catalyzed asymmetric reductive Grignard-type addition of aryl iodides with axially prochiral biaryl dialdehydes leading to the direct construction of axially chiral secondary alcohols.Preliminary mechanistic studies indicate that efficient kinetic recognition of diastereomers might occur for axially prochiral dialdehydes to improve the stereoselectivity,which might open a new avenue for the challenging cascade construction of multiple chiral elements.This protocol features excellent enantio-and diastereoselectivity,green and mild conditions,simple operation,and broad substrate scope,providing a modular platform for the synthesis of secondary axially chiral alcohols.
文摘The well-defined conformational properties of axially chiral compounds bring extraordinary values to an assortment of bioactive molecules,advanced materials,organocatalysts as well as chiral ligands in asymmetric transformations.The demonstrated usefulness and untapped potential of axially chiral structural motifs stimulate increasing efforts to develop novel and efficient approaches for their preparation.In this regard,the chiral phosphoric acids broadly used in asymmetric Brønsted acid catalysis have shown high relevance for atroposelective synthesis as well.Our strong interest in reaction chemistry of atropisomers has established a rewarding research programme in our group.The course of studies will be recounted in this account,with discussion focused on the use of chiral phosphoric acids to catalyze construction of several key axially chiral structures such as BINAM,BINOL,NOBIN,arylquinones,SPINOL,arylpyrrole analogues and axially chiral alkenes.
基金supported by NSFC(22125104,21831007 and 22101103)the Natural Science Foundation of Jiangsu Province(BK20201018)the Natural Science Foundation of Xuzhou City(KC21021).
文摘Comprehensive Summary A new strategy for the enantioselective synthesis of axially chiral 3,3'-bisindoles was devised by the direct coupling of two indole rings.This strategy makes use of the C3-umpolung reactivity of 2-indolylmethanols,which enables the catalytic asymmetric addition reaction of 2-indolylmethanols with rationally designed 2-substituted indoles,thus constructing axially chiral 3,3'-bisindole scaffolds in overall excellent yields(up to 98%)with high enantioselectivities(up to 96:4 er).This approach not only has overcome the challenges in constructing axially chiral five-five-membered heterobiaryls,but also represents a new application of the C3-umpolung reactivity of 2-indolylmethanols in asymmetric catalysis.More importantly,this class of axially chiral 3,3'-bisindoles can undergo a variety of post-functionalizations to give axially chiral 3,3'-bisindole-based organocatalysts,which have found their preliminary applications in asymmetric catalysis.
基金supported by the National Science Foundation of China (22125104,21831007,22101103)the Natural Science Foundation of Jiangsu Province (BK20201018)
文摘The catalytic atroposelective synthesis of axially chiral isochromenone-indoles has been established by the strategy of designing homophthalic anhydride-based indole derivatives as a new type of indole-based platform molecules for dynamic kinetic resolution.By this strategy,a wide range of axially chiral isochromenone-indoles were synthesized in high yields with excellent enantioselectivities(up to 98% yield,97% ee) via the catalytic asymmetric sulfonylation reaction of homophthalic anhydridebased indole derivatives with aryl sulfonyl chlorides under the catalysis of chiral quaternary ammonium salt as a phase-transfer catalyst.
基金We are grateful for financial support from the National Natural Science Foundation of China(Nos.21772069 and 21831007)the Postgraduate Research&Practice Innovation Program of Jiangsu Province(No.KYCX20_2235)the Natural Science Foundation of JSNU(No.19XSRX013)。
文摘Atroposelective construction of axially chiral alkene-heteroaryl scaffolds is highly desired but challenging.In this work,we established an atroposelective construction of axially chiral alkene-indole scaffolds via the strategy of catalytic enantioselective addition reaction of 3-alkynyl-2-indolylmethanols with bulky nucleophiles.
基金This work was supported by the National Natural Science Foundation of China(Nos.21971032,51725204,21771132,51972216).
文摘Via the bottom-up synthetic strategy,we synthesized a pair of dodecanuclear metal clusters of Eu_(12)(C_(2)O_(4))_(9)(R/S-BNP)_(18)(EtOH)_(6)-(H_(2)0)_(6)·8EtOH-7H_(2)0(complex 2),which represent the largest axial chiral lanthanide metal clusters.In the structure,rare four-pointed star coordination mode of oxalic acid is reported by this work.In addition,as a fluorescence sensor,the complex 2 exhibits high enantioselectivity for R-/S-BINOL-TF_(2)(EF=2.87)and other chiral binaphthyl derivatives.
基金support from the National Key R&D Program of China (2022YFA1503703,2021YFF0701604)the National Natural Science Foundation of China (21825105,22231004,22271135)+1 种基金Guangdong Innovative Program (2019BT02Y335)Shenzhen Science and Technology Program (KQTD20210811090112004,JCYJ20210324120205016,JCYJ20210324105005015).
文摘Indole-based atropisomers are a very important class of axially chiral compounds.However,the atroposelective synthesis of axially chiral 2-arylindole remains largely unexplored.In this study,we report the successful synthesis of atropisomeric 2-arylindoles using direct amination of indoles with p-quinonediimines in the presence of chiral phosphoric acid as a catalyst.Quinonediimine acts as an aminating reagent through formal polarity inversion of imine.The malonate group on the 2-aryl of 2-indoles was found to be essen-tial for high enantioselectivity of the products.This could be due to the additional interaction between the ester group and the cata-lyst,as well as the intramolecular hydrogen bonding.Our findings provide a new strategy for the asymmetric construction of 2-arylindole atropisomers.
基金National Natural Science Foundation of China(21772111,21821001,91956125,and 21661132006).
文摘The stereocontrol of chiral metal clusters and nanoclusters has become a focus of interest in metal cluster chemistry due to their promising applications in asymmetric catalysis.Despite being a general chirality transfer strategy,the ion-pairing process is still ambiguous in the course of bestowing chirality to metal clusters.Here we construct a biaryl-centered axially chiral gold-cluster system to study an outside-in ion-pairing chirality transfer process.Four hexanuclear gold(I)clusters,centered by two types of biaryl ligands[(2-indolyl)aniline(L^(1))and biindole(L^(2))],were synthesized via in situ cyclization reactions.In the crystalline state,the biaryl centers showed axial chirality in which the gold atoms were in an asymmetric arrangement.In solution,the chiral phosphates induced an outside-in chirality transfer by significant interactions with the periphery of the biaryl-centered gold clusters.Finally,the chiral resolution of hexa-aurated biindoliums was accomplished via an efficient outside-in chirality transfer process relying on strong aurophilic interaction and extra peripheral coordination.This study not only deepens the understanding of the outside-in ion-pairing chirality transfer process but also provides a new approach for fabricating desired chiral metal clusters by a combination of organometallic transformation and chirality transfer.
基金Financial support from National Natural Science Foundation of China(nos.21772046 and 2193103)is gratefully acknowledged.
文摘An unprecedented atroposelective Catellani reaction between phosphine oxide-containing aryl bromides,aryliodides,and nucleophiles for the construction of phosphine-containing biaryl atropisomers was established using an enantiopure norbornene derivative as the chiral mediator.A broad range of atropisomeric biaryl-based monophosphine oxides were obtained in good efficiency with excellent enantioselectivity.
基金the National Natural Science Foundation of China for financial support (Nos. 21372075 and 61376003)
文摘A family of tropos ligands bearing a N-heterocyclic carbene and a chiral oxazoline coordination group with a N-phenyl framework were easily prepared,and their coordination behavior with Pd(Ⅱ)acetate was performed,affording a series of axially chiral palladium complexes in good yields.
基金the NationalNatural Science Foundation of China(Nos.21820102003,91956201,21901081,22171099)the Open Research Fund of the School of Chemistry and Chemical Engineering,the Henan Normal University(No.2021YB02)+1 种基金the Program of Introducing Talents of Discipline to Universities of China(No.B17019)the Excellent Doctoral DissertationCultivation Grant to D.L.from Central China Normal University(CCNU).
文摘The chemistry of axially chiral compounds has emerged as a subject of increasing interest due to their widespread presence in natural products,bioactive molecules,advanced materials,and chiral ligands/catalysts.On the other hand,catalytic asymmetric radical-based transformations provide a complementary platform for the construction of enantiomerically enriched molecules that are in growing demand in the chemical and pharmaceutical in-dustries.In recent years,considerable research efforts have been devoted to the development of catalytic asymmetric radical reactions for the construction of axially chiral compounds based on the unique reactivity modes of diverse radicals.In this review,we critically illustrate these recent achievements according to different radical precursors and catalytic activation modes.Wherever possible,special emphasis is also placed on the discussion of mechanistic features underlying these works and substrate scopes.This review should be of great interest to the experts in this area,but also serve as a helpful starting point for new researchers in this field.
基金the funding support of NSFC(Nos.22031004,21921003,21901043)Shanghai Municipal Education Commission(No.20212308).
文摘Atropisomeric anilides are one of important C-N axially chiral compounds.Compared with the A/-terminal functionalization to prepare such compounds,C-terminal functionalization strategies have been rarely reported.We describe herein an efficient synthesis of axially chiral anilides enabled by Pd-catalyzed desymmetric Sonogashira cross-coupling reactions with the use of a newly identified Ming-Phos.Moderate to high yields with high enantioselectivities(up to 98%ee)were obtained.