Rapid progress in tissue engineering research in past decades has opened up vast possibilities to tackle the challenges of generating tissues or organs that mimic native structures. The success of tissue engineered co...Rapid progress in tissue engineering research in past decades has opened up vast possibilities to tackle the challenges of generating tissues or organs that mimic native structures. The success of tissue engineered constructs largely depends on the incorporation of a stable vascular network that eventually anastomoses with the host vasculature to support the various biological functions of embedded cells. In recent years, significant progress has been achieved with respect to extrusion, laser, micro-molding, and electrospinning-based techniques that allow the fabrication of any geometry in a layer-by-layer fashion. Moreover, decellularized matrix, self-assembled structures, and cell sheets have been explored to replace the biopolymers needed for scaffold fabrication. While the techniques have evolved to create specific tissues or organs with outstanding geometric precision, formation of interconnected, functional, and perfused vascular networks remains a challenge. This article briefly reviews recent progress in 3D fabrication approaches used to fabricate vascular networks with incorporated cells, angiogenic factors, proteins, and/or peptides. The influence of the fabricated network on blood vessel formation, and the various features, merits, and shortcomings of the various fabrication techniques are discussed and summarized.展开更多
In order to investigate the energy absorption characteristics of multi-cell polygonal tubes with different cross-sectional configurations,firstly,the theoretical formulae of the mean crushing force under axial load fo...In order to investigate the energy absorption characteristics of multi-cell polygonal tubes with different cross-sectional configurations,firstly,the theoretical formulae of the mean crushing force under axial load for four multi-cell polygonal tubes were derived by combining the Super Folding Element theory with Zhang’s research results.These formulae can be used to validate the numerical model and quickly evaluate the energy absorption ability of multi-cell polygonal tubes.Furthermore,a comparative study on the energy absorption performance of eight multi-cell polygonal tubes under axial and oblique loads was conducted.The results show that all tubes have a stable mixed deformation mode under axial load.The multi-cell decagon tube has better energy-absorption ability compared with other tubes.Whenθis less than 10°,all the tubes maintain a stable deformation mode,and the multi-cell decagon tube also has the biggest crushing force efficiency and specific energy absorption among these eight tubes;meanwhile compared with the results atθ=0°,the specific energy absorption of all tubes decreases by about 8%-21%,while the crushing force efficiency increases by 20%-56%.However,at large angles 20°and 30°,all of the tubes collapse in bending modes and lose their effectiveness at energy absorption.展开更多
Tube thinning control without wrinkling occurring is a key problem urgently to be solved for improving the forming qualities in numerical control （NC） bending processes of large-diameter Al-alloy thin-walled tubes ...Tube thinning control without wrinkling occurring is a key problem urgently to be solved for improving the forming qualities in numerical control （NC） bending processes of large-diameter Al-alloy thin-walled tubes （AATTs）. It may be a way solving this problem to exert axial compression loads （ACL） on the tube end in the bending. Thus, this article establishes a three-dimensional （3D） elastic-plastic explicit finite element （FE） model for the bending under ACL and has its reliability verified. Through a multi-index orthogonal experiment design, a combination of process parameters, each expressed by a proper range, for this FE model is derived to overcome the compression instability on tube ends. By combining the FE model with a wrinkling energy prediction model, an in-depth study is conducted on the forming characteristics of large-diameter AATTs with small bending radii and it can be concluded that （1） The larger the tube diameters and the smaller the bending radii, the larger the induced tangent tension stress zones on tube intrados, by which the tube maximum tangent compression stress zones will be partitioned in the bending processes; thus, the smaller the ACL roles in decreasing thinning degrees and the larger the compression instability possibilities on tube ends. （2） The tube wrinkling possibilities under ACL are larger than without ACL acting in the earlier forming periods, and smaller in the later ones. （3） For the tubes with a size factor less than 80, the ACL roles in decreasing thinning degrees are stronger than in increasing wrinkling possibilities.展开更多
基金supported by the Natural Sciences and Engineering Research Council of Canada [NSERC RGPIN-2014-05648]
文摘Rapid progress in tissue engineering research in past decades has opened up vast possibilities to tackle the challenges of generating tissues or organs that mimic native structures. The success of tissue engineered constructs largely depends on the incorporation of a stable vascular network that eventually anastomoses with the host vasculature to support the various biological functions of embedded cells. In recent years, significant progress has been achieved with respect to extrusion, laser, micro-molding, and electrospinning-based techniques that allow the fabrication of any geometry in a layer-by-layer fashion. Moreover, decellularized matrix, self-assembled structures, and cell sheets have been explored to replace the biopolymers needed for scaffold fabrication. While the techniques have evolved to create specific tissues or organs with outstanding geometric precision, formation of interconnected, functional, and perfused vascular networks remains a challenge. This article briefly reviews recent progress in 3D fabrication approaches used to fabricate vascular networks with incorporated cells, angiogenic factors, proteins, and/or peptides. The influence of the fabricated network on blood vessel formation, and the various features, merits, and shortcomings of the various fabrication techniques are discussed and summarized.
基金Projects(U1334208,51405516,51275532)supported by the National Natural Science Foundation of ChinaProjects(2015zzts210,2016zzts331)supported by the Fundamental Research Funds for the Central Universities,China
文摘In order to investigate the energy absorption characteristics of multi-cell polygonal tubes with different cross-sectional configurations,firstly,the theoretical formulae of the mean crushing force under axial load for four multi-cell polygonal tubes were derived by combining the Super Folding Element theory with Zhang’s research results.These formulae can be used to validate the numerical model and quickly evaluate the energy absorption ability of multi-cell polygonal tubes.Furthermore,a comparative study on the energy absorption performance of eight multi-cell polygonal tubes under axial and oblique loads was conducted.The results show that all tubes have a stable mixed deformation mode under axial load.The multi-cell decagon tube has better energy-absorption ability compared with other tubes.Whenθis less than 10°,all the tubes maintain a stable deformation mode,and the multi-cell decagon tube also has the biggest crushing force efficiency and specific energy absorption among these eight tubes;meanwhile compared with the results atθ=0°,the specific energy absorption of all tubes decreases by about 8%-21%,while the crushing force efficiency increases by 20%-56%.However,at large angles 20°and 30°,all of the tubes collapse in bending modes and lose their effectiveness at energy absorption.
基金National Natural Science Foundation of China (59975076, 50175092)National Science Fund of China for Distinguished Young Scholars (50225518)
文摘Tube thinning control without wrinkling occurring is a key problem urgently to be solved for improving the forming qualities in numerical control （NC） bending processes of large-diameter Al-alloy thin-walled tubes （AATTs）. It may be a way solving this problem to exert axial compression loads （ACL） on the tube end in the bending. Thus, this article establishes a three-dimensional （3D） elastic-plastic explicit finite element （FE） model for the bending under ACL and has its reliability verified. Through a multi-index orthogonal experiment design, a combination of process parameters, each expressed by a proper range, for this FE model is derived to overcome the compression instability on tube ends. By combining the FE model with a wrinkling energy prediction model, an in-depth study is conducted on the forming characteristics of large-diameter AATTs with small bending radii and it can be concluded that （1） The larger the tube diameters and the smaller the bending radii, the larger the induced tangent tension stress zones on tube intrados, by which the tube maximum tangent compression stress zones will be partitioned in the bending processes; thus, the smaller the ACL roles in decreasing thinning degrees and the larger the compression instability possibilities on tube ends. （2） The tube wrinkling possibilities under ACL are larger than without ACL acting in the earlier forming periods, and smaller in the later ones. （3） For the tubes with a size factor less than 80, the ACL roles in decreasing thinning degrees are stronger than in increasing wrinkling possibilities.
