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人巨细胞病毒UL/b’区基因编码蛋白生物学功能的研究进展 被引量:1
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作者 刘畅(综述) 齐莹(审校) 《国际儿科学杂志》 2012年第6期591-595,共5页
人巨细胞病毒(human cytomegalovirus,HCMV)在人群中感染广泛,不仅是免疫抑制患者的严重致病原,也是引起新生儿先天及围生期感染最常见、危害最大的一种病原体。近年来,针对区别于实验室株的一个特殊区域UL/b’区基因编码蛋白生... 人巨细胞病毒(human cytomegalovirus,HCMV)在人群中感染广泛,不仅是免疫抑制患者的严重致病原,也是引起新生儿先天及围生期感染最常见、危害最大的一种病原体。近年来,针对区别于实验室株的一个特殊区域UL/b’区基因编码蛋白生物学功能的研究是国内外HCMV研究领域的一个热点。目前已经发现该区域基因产物在HCMV的毒力、传播、组织细胞嗜性及免疫逃避等方面发挥重要作用,其中的UL133-UL138位点可能促进HCMV潜伏感染的建立和维持,而pUL138是目前病毒基因组中鉴定出的惟一明确与HCMV潜伏感染相关的决定因子。因此,HCMVUL/b’区基因产物在HCMV感染过程中发挥重要作用。该文就HCMVUL/b’区部分基因,尤其是与HCMV潜伏感染相关的UL138基因结构及其编码蛋白生物学功能进行综述,为阐明HCMV感染致病机制奠定基础。 展开更多
关键词 人巨细胞病毒 UL b’区域 UL138基因 潜伏感染 生物学功能
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A modified simulated annealing algorithm and an excessive area model for floorplanning using fixed-outline constraints 被引量:5
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作者 De-xuan ZOU Gai-ge WANG +1 位作者 Gai PAN Hong-wei QI 《Frontiers of Information Technology & Electronic Engineering》 SCIE EI CSCD 2016年第11期1228-1244,共17页
Outline-free floorplanning focuses on area and wirelength reductions, which are usually meaningless, since they can hardly satisfy modern design requirements. We concentrate on a more difficult and useful issue, fixed... Outline-free floorplanning focuses on area and wirelength reductions, which are usually meaningless, since they can hardly satisfy modern design requirements. We concentrate on a more difficult and useful issue, fixed-outline floorplanning. This issue imposes fixed-outline constraints on the outline-free floorplanning, making the physical design more interesting and challenging. The contributions of this paper are primarily twofold. First, a modified simulated annealing(MSA) algorithm is proposed. In the beginning of the evolutionary process, a new attenuation formula is used to decrease the temperature slowly, to enhance MSA's global searching capacity. After a period of time, the traditional attenuation formula is employed to decrease the temperature rapidly, to maintain MSA's local searching capacity. Second, an excessive area model is designed to guide MSA to find feasible solutions readily. This can save much time for refining feasible solutions. Additionally, B*-tree representation is known as a very useful method for characterizing floorplanning. Therefore, it is employed to perform a perturbing operation for MSA. Finally, six groups of benchmark instances with different dead spaces and aspect ratios—circuits n10, n30, n50, n100, n200, and n300—are chosen to demonstrate the efficiency of our proposed method on fixed-outline floorplanning. Compared to several existing methods, the proposed method is more efficient in obtaining desirable objective function values associated with the chip area, wirelength, and fixed-outline constraints. 展开更多
关键词 Fixed-outline floorplanning Modified simulated annealing algorithm Global search Excessive area model b*-tree representation
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