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miRNA-99b、LL-37、IP-10在耐多药肺结核患者中表达及早期疗效预测价值
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作者 周贵忠 黄远江 +1 位作者 翁敏华 张振云 《临床肺科杂志》 2025年第1期92-97,共6页
目的 分析微小RNA-99b(miRNA-99b)、抗菌肽LL-37、干扰素-γ诱导蛋白10(IP-10)在耐多药肺结核(MDR-PTB)患者中表达及早期疗效预测价值。方法 研究纳入医院2022年11月-2024年2月临床收治MDR-PTB患者108例为MDR-PTB组,Bandim TBscore评分... 目的 分析微小RNA-99b(miRNA-99b)、抗菌肽LL-37、干扰素-γ诱导蛋白10(IP-10)在耐多药肺结核(MDR-PTB)患者中表达及早期疗效预测价值。方法 研究纳入医院2022年11月-2024年2月临床收治MDR-PTB患者108例为MDR-PTB组,Bandim TBscore评分法将其划分为轻度组(n=71)与中-重度组(n=37);纳入同期非耐药肺结核患者(DS-PTB)87例为DS-PTB组,健康体检志愿者90例为健康对照组,检测、评估组间miRNA-99b、LL-37、IP-10表达水平及治疗8周后临床疗效,采用Pearson评估miRNA-99b、LL-37、IP-10表达水平与MDR-PTB患者临床疗效相关性,指标预测价值行多因素Logistic回归,作ROC曲线分析模型预测价值。结果 MDR-PTB组miRNA-99b、LL-37、IP-10均高于DS-PTB组与健康对照组(P<0.05),且DS-PTB组miRNA-99b、LL-37、IP-10高于健康对照组(P<0.05);MDR-PTB组内,中-重度组miRNA-99b、LL-37、IP-10表达水平均高于轻度组(P<0.05);治疗4周、治疗8周后,MDR-PTB患者miRNA-99b、LL-37、IP-10均低于治疗前(P<0.05);108例MDR-PTB患者经8周治疗后临床有效率为88.89%;miRNA-99b、LL-37、IP-10均与有效率呈负相关关系(r=-0.693、-0.706、-0.497,P<0.05);miRNA-99b、LL-37、IP-10高水平表达为MDR-PTB发生发展独立危险因素,有统计学意义(P<0.05),ROC曲线分析显示,miRNA-99b、LL-37、IP-10联合检测AUC为0.937(95%CI:0.863~0.974)高于单一检测结果(Z=7.691、7.069、8.068,P均<0.001);且联合检测敏感度(96.91%)与特异度(96.34%)均最高。结论 miRNA-99b、LL-37、IP-10高水平表达参与MDR-PTB发生与发展,三项联合在MDR-PTB患者早期疗效预测中应用价值高。 展开更多
关键词 miRNA-99b ll-37 IP-10 耐多药肺结核 早期疗效 预测价值
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Survey and Recommendations for Land Use of Agricultural Machinery Service Organization Facilities in Guizhou Province
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作者 Xingyuan QI Chunbo LIU +2 位作者 Zhifei JIN Yingfen WANG Shuyun LIN 《Asian Agricultural Research》 2025年第1期14-17,共4页
With the advancement of agricultural modernization, agricultural machinery service organizations, as an important part of the rural operating entities, show an increasing trend year by year, and need new facilities la... With the advancement of agricultural modernization, agricultural machinery service organizations, as an important part of the rural operating entities, show an increasing trend year by year, and need new facilities land in the process of development and growth. Based on the written survey of 597 agricultural machinery service organizations in Guizhou Province, the demand and demand gap of various facilities land use in agricultural machinery service organizations were analyzed and compared. In addition, based on the field survey and policy background, the main practices and experiences of agricultural machinery service organizations in Guizhou Province in the approval and use of facility land were sorted out, and the problems and causes of large gap in facility agricultural land, lack of standards and difficulty in policy implementation were analyzed. Finally, it recommended that the site selection of agricultural machinery service organization facilities needs to be standardized, the land demand needs to be coordinated, the land scale needs to be scientifically demonstrated, and financial support should be sought to promote Guizhou agricultural machinery service organization to become bigger, better and stronger. 展开更多
关键词 Agricultural machinery service organization Facility land use Current situation survey Agricultural mechanization Guizhou Province
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血清PD-1、LL-37、TSLP与白细胞、降钙素原的关系及对小儿细菌性肺炎的诊断意义
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作者 陈晨 王立平 +1 位作者 俞霄凌 贾亦斐 《临床肺科杂志》 2025年第2期183-188,共6页
目的探讨血清程序性死亡蛋白-1(programmed cell death 1,PD-1)、亮氨酸leucine-37(Leucine leucine-37,LL-37)、胸腺基质淋巴细胞生成素(Thymic stromal lymphopoietin,TSLP)与白细胞(white blood cell,WBC)、降钙素原(procalcitonin,P... 目的探讨血清程序性死亡蛋白-1(programmed cell death 1,PD-1)、亮氨酸leucine-37(Leucine leucine-37,LL-37)、胸腺基质淋巴细胞生成素(Thymic stromal lymphopoietin,TSLP)与白细胞(white blood cell,WBC)、降钙素原(procalcitonin,PCT)的相关性以及在小儿细菌性肺炎中的诊断价值。方法回顾性分析2023年2月至2024年2月在本院儿科住院治疗和门诊健康体检儿童的临床资料,共700例。其中317例细菌性肺炎患儿(重症105例,轻症212例)作为细菌性肺炎组,236例病毒性肺炎作为病毒性肺炎组,147例健康体检儿童作为对照组。采用全自动血细胞分析仪检测血WBC计数;电化学发光法检测血清PCT的水平;酶联免疫吸附法(ELISA)检测血清PD-1、LL-37、TSLP的水平。Pearson相关性分析轻、重症细菌性肺炎患儿血清PD-1、LL-37、TSLP与WBC、PCT的相关性。使用受试者工作特征(receiver operating characteristic,ROC)曲线分析PD-1、LL-37、TSLP单独及三者联合对小儿细菌性肺炎的诊断效能。结果与对照组、病毒性肺炎组相比,细菌性肺炎组血清PD-1、LL-37、TSLP以及WBC、PCT的水平显著升高,差异有统计学意义(F=205.220、185.200、712.300、266.000、3432.000,P均<0.05)。与轻症组相比,重症组血清PD-1、LL-37、TSLP以及WBC、PCT水平显著升高(t=22.180、17.000、19.220、10.560、22.400,P均<0.05)。Pearson相关性分析显示,轻、重症细菌性肺炎患儿血清中PD-1、LL-37、TSLP与WBC计数呈正相关(r=0.328、0.351、0.179、0.187、0.472、0.486,P均<0.05),PD-1、TSLP与PCT呈正相关(r=0.581、0.603、0.503、0.524,P均<0.05),LL-37与PCT无明显相关性。ROC曲线分析显示,血清PD-1、LL-37、TSLP三者联合诊断小儿细菌性肺炎的曲线下面积(area under the curve,AUC)为0.940(0.917~0.963)、灵敏度为90.53%、特异度为84.46%,血清PD-1、LL-37、TSLP三者联合诊断的AUC高于三者单独检查,但差异无统计学意义(Z=1.325、1.033、1.278,P=0.188、0.113、0.159)。结论细菌性肺炎患儿血清PD-1、LL-37、TSLP水平显著升高,且与病情严重程度有关,可反映患儿炎症和细菌感染状态,三者联用可作为诊断细菌性肺炎的有价值生物标志物。 展开更多
关键词 程序性死亡蛋白-1 亮氨酸leucine-37 胸腺基质淋巴细胞生成素 白细胞 降钙素原 小儿细菌性肺炎
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Technical Regulation of Foxtail Millet Production by Combining Machinery and Agronomy 被引量:1
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作者 夏雪岩 杨志杰 +8 位作者 程汝宏 师志刚 吴海岩 刘焕新 刘猛 赵宇 李霄鹤 焦海涛 李顺国 《Agricultural Science & Technology》 CAS 2016年第5期1106-1109,共4页
In order to solve the problems of low production efficiency,great loss and low yield,Millet Research Institute of Hebei Academy of Agriculture and Forestry Sciences integrated the plastic film mulching technique and m... In order to solve the problems of low production efficiency,great loss and low yield,Millet Research Institute of Hebei Academy of Agriculture and Forestry Sciences integrated the plastic film mulching technique and mechanized production technique,forming a foxtail millet production technique combining machinery and agronomy.The foxtail millet production technique combining machinery and agronomy regulates millet production from the links of soil preparation,fertilization,variety selection,seeding,intertillage and fertilization and harvest,so as to achieve the effects of promoting the matching between agro-machinery and agronomy,improving the level of millet production mechanization,realizing light simplified production and saving labor cost.This technical regulation has a broad application prospect. 展开更多
关键词 Foxtail millet Combination of agricultural machinery and agronomy SIMPLIFICATION
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Analysis on the Mode of Trans-Regional Allocation of Agricultural Machinery 被引量:2
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作者 Li Liu Tong Chen +1 位作者 Shuguo Yang Xinli Wang 《American Journal of Plant Sciences》 2020年第7期1049-1056,共8页
With the continuous progress of agricultural technology, agricultural mechanization presents a good development trend after half a century development. But agricultural machinery equipment and the level of agricultura... With the continuous progress of agricultural technology, agricultural mechanization presents a good development trend after half a century development. But agricultural machinery equipment and the level of agricultural mechanization are imbalances in different regions</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> the structure of agricultural machinery equipment is unreasonable</span><span style="font-family:Verdana;">;</span><span style="font-family:Verdana;"> there are great differences in agricultural mechanization level of different operations and different crops and the whole level of agricultural mechanization social service is not high. Through cross regional allocation of existing agricultural machinery</span><span style="font-family:Verdana;"> to</span><span style="font-family:Verdana;"> improve the working efficiency of agricultural machinery;we can extend the operation time of the agricultural machinery and improve the operation effect and income of agricultural machinery. 展开更多
关键词 Agricultural machinery Trans-Regional Work Agricultural machinery Allocation
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Effect of different machinery and rolling times on the microbial activity of reclamation soil in coal area 被引量:1
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作者 Xiangyu Min Xinju Li +3 位作者 Ning Liu Xiaona Huang Kejin Dong Feng Gao 《International Journal of Coal Science & Technology》 EI CAS 2014年第2期241-247,共7页
Mechanical construction will put influence on the biological characters of reclaimed soils,as well as the soil quality.In order to explore the changing rule of soil microbial quantity and respiratory capacity under di... Mechanical construction will put influence on the biological characters of reclaimed soils,as well as the soil quality.In order to explore the changing rule of soil microbial quantity and respiratory capacity under different construction machineries and rolling times,and find the optimal processing conditions,an experiment was set up and a simulation experimental area was chosen,in which we simulated the main types of reclamation in coal mine area.After 2 years’natural aging,we collected surface soil samples(0-20 cm)that can be used for experimental analysis.The result shows that changing rules of soil biological factors are different with different construction machineries,and soil properties are closest to the normal soil when adopting the combination of“crawler dozer×5 compaction times”and“dump truck×3 compaction times”,which shows that the soil quality is better under this condition. 展开更多
关键词 Construction machinery Compaction times Reclamation soil Microbial quantity Respiratory capacity
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Intelligent Control Scheme of Engineering Machinery of Cluster Hybrid System 被引量:1
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作者 高强 王洪礼 《Transactions of Tianjin University》 EI CAS 2005年第3期194-198,共5页
In a hybrid system, the subsystems with discrete dynamics play a central role in a hybrid system. In the course of engineering machinery of cluster construction, the discrete control law is hard to obtain because the ... In a hybrid system, the subsystems with discrete dynamics play a central role in a hybrid system. In the course of engineering machinery of cluster construction, the discrete control law is hard to obtain because the construction environment is complex and there exist many affecting factors. In this paper, hierarchically intelligent control, expert control and fuzzy control are introduced into the discrete subsystems of engineering machinery of cluster hybrid system, so as to rebuild the hybrid system and make the discrete control law easily and effectively obtained. The structures, reasoning mechanism and arithmetic of intelligent control are replanted to discrete dynamic, conti- nuous process and the interface of the hybrid system. The structures of three types of intelligent hybrid system are presented and the human experiences summarized from engineering machinery of cluster are taken into account. 展开更多
关键词 engineering machinery of cluster hybrid systems (HS) hierarchically intelligent control expert control fuzzy control
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Compound Fault Diagnosis for Rotating Machinery:State-of-the-Art,Challenges,and Opportunities 被引量:4
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作者 Ruyi Huang Jingyan Xia +2 位作者 Bin Zhang Zhuyun Chen Weihua Li 《Journal of Dynamics, Monitoring and Diagnostics》 2023年第1期13-29,共17页
Compound fault,as a primary failure leading to unexpected downtime of rotating machinery,dramatically increases the difficulty in fault diagnosis.To deal with the difficulty encountered in implementing compound fault ... Compound fault,as a primary failure leading to unexpected downtime of rotating machinery,dramatically increases the difficulty in fault diagnosis.To deal with the difficulty encountered in implementing compound fault diagnosis(CFD),researchers and engineers from industry and academia have made numerous significant breakthroughs in recent years.Admittedly,many systematic surveys focused on fault diagnosis have been conducted by reputable researchers.Nevertheless,previous review articles paid more attention to fault diagnosis with several single or independent faults,resulting in that there is still lacking a comprehensive survey on CFD.Therefore,to fulfill the above requirements,it is necessary to provide an in-depth overview of fault diagnosis methods or algorithms for compound faults of rotating machinery and uncover potential challenges or opportunities that would guide and inspire readers to devote their efforts to promoting fault diagnosis technology more effective and practical.Specifically,the backgrounds,including the related definitions and a new taxonomy of CFD methods,are detailed according to the way of implementing compound fault recognition.Then,the stateof-the-art applications of CFD are overviewed based on relevant publications in the past decades.Finally,the challenges and opportunities associated with implementing CFD are concluded and followed by a conclusion for ending this survey.We believe that this review article can provide a systematic guideline of CFD from different aspects for potential readers and seasoned researchers. 展开更多
关键词 fault diagnosis compound fault signal processing artificial intelligence rotating machinery
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足三里穴位注射黄芪注射液联合肺康复训练对老年慢性阻塞性肺疾病病人抗菌肽LL-37和免疫功能的影响 被引量:2
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作者 邓在勤 周海波 《实用老年医学》 CAS 2024年第1期44-48,共5页
目的 研究足三里穴位注射黄芪注射液联合肺康复训练对老年COPD稳定期病人的疗效、血清抗菌肽LL-37水平、炎症因子及外周血T淋巴细胞亚群的影响。方法 选择98例老年COPD稳定期病人,根据治疗方法分为黄芪组(50例)和对照组(48例)。对照组... 目的 研究足三里穴位注射黄芪注射液联合肺康复训练对老年COPD稳定期病人的疗效、血清抗菌肽LL-37水平、炎症因子及外周血T淋巴细胞亚群的影响。方法 选择98例老年COPD稳定期病人,根据治疗方法分为黄芪组(50例)和对照组(48例)。对照组予以肺康复训练及常规西药治疗,黄芪组在对照组基础上予以足三里穴位注射黄芪注射液,疗程均为12周。比较2组治疗前后肺功能、6分钟步行试验(6MWT)结果、改良版英国医学研究委员会呼吸问卷(mMRC)呼吸困难程度分级,血清抗菌肽LL-37、TNF-α、IL-6、CRP水平及T淋巴细胞亚群变化。结果 2组治疗后肺功能(FVC、FEV1、FEV1%pred、FEV1/FVC)、6MWT结果及mMRC分级均较治疗前明显改善(P<0.05),且黄芪组较对照组改善更为明显(P<0.05)。2组治疗后血清抗菌肽LL-37、CD3^(+)T淋巴细胞、CD4^(+)T淋巴细胞及CD4^(+)/CD8^(+)水平均较治疗前升高,且黄芪组高于对照组(P<0.05);2组治疗后TNF-α、IL-6、CRP水平均低于治疗前,且黄芪组低于对照组(P<0.05)。结论 足三里穴位注射黄芪注射液联合肺康复训练可改善老年COPD稳定期病人的肺功能和运动耐力,提高血清抗菌肽LL-37水平并改善免疫功能。 展开更多
关键词 慢性阻塞性肺疾病 肺康复 抗菌肽ll-37 T淋巴细胞亚群 黄芪注射液 穴位注射
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Automation 5.0: The Key to Systems Intelligence and Industry 5.0 被引量:1
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作者 Ljubo Vlacic Hailong Huang +10 位作者 Mariagrazia Dotoli Yutong Wang Petros A.Ioannou Lili Fan Xingxia Wang Raffaele Carli Chen Lv Lingxi Li Xiaoxiang Na Qing-Long Han Fei-Yue Wang 《IEEE/CAA Journal of Automatica Sinica》 SCIE EI CSCD 2024年第8期1723-1727,共5页
AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with machinery.The rise of steam engines and water wheels represented the f... AUTOMATION has come a long way since the early days of mechanization,i.e.,the process of working exclusively by hand or using animals to work with machinery.The rise of steam engines and water wheels represented the first generation of industry,which is now called Industry Citation:L.Vlacic,H.Huang,M.Dotoli,Y.Wang,P.Ioanno,L.Fan,X.Wang,R.Carli,C.Lv,L.Li,X.Na,Q.-L.Han,and F.-Y.Wang,“Automation 5.0:The key to systems intelligence and Industry 5.0,”IEEE/CAA J.Autom.Sinica,vol.11,no.8,pp.1723-1727,Aug.2024. 展开更多
关键词 AUTOMATION machinery INTEllIGENCE
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Overview of the Importance of Intelligent Approaches on Machinery Faults Diagnosis and Prediction Based on Prognostic and Health Management/Condition-Based Maintenance 被引量:1
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作者 OMIDI Ali LIU Shujie 《Journal of Donghua University(English Edition)》 EI CAS 2018年第3期270-273,共4页
Condition monitoring is increasingly used to anticipate and detect failures of industrial machines.Failures of machines can cause high maintenance or replacement costs.If neglected,it may result in catastrophic accide... Condition monitoring is increasingly used to anticipate and detect failures of industrial machines.Failures of machines can cause high maintenance or replacement costs.If neglected,it may result in catastrophic accidents leading to production shrinkage.The potential failure would negatively affect the profitability of the company,including production shut down,cost of spare parts,cost of labor,damage of reputation,risk of injury to people and the environment.In recent years,condition-based maintenance( CBM) and prognostic and health management( PHM) are developed and formed a strong connection among science,engineering,computer,reliability,communication,management,etc.Computerized maintenance management systems( CMMS) store a lot of data regarding the fault diagnosis and life prediction of the machinery equipment.It's too necessary to uncover useful knowledge from the huge amount of data.It's vital to find the ways to obtain useful and concise information from these data.This information can be of great influence in the decision making of managers.This article is a review of intelligent approaches in machinery faults diagnosis and prediction based on PHM and CBM. 展开更多
关键词 condition-based maintenance(CBM) prognostic and health management(PHM) machinery fault diagnosis data mining data processing
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Innovative Precision Machinery Manufacturer:To Top the Industry Globally——Interview with Eric Y.T.Chuo,Global Chairman & CEO of HIWIN Group
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作者 Gao Chao 《China's Foreign Trade》 2014年第7期56-59,共4页
Although HIWIN has been established for only 24years and went public just about four years ago,it has become the largest machinery manufacturer,in Taiwan and one of the world leading companies in linear motion control... Although HIWIN has been established for only 24years and went public just about four years ago,it has become the largest machinery manufacturer,in Taiwan and one of the world leading companies in linear motion control and system technology.HIWIN’s self-developed products,including ballscrews,linear guideways and industrial robots,have been widely applied to industries like bio-medical,semiconductor,optoelectronics,3C,automation,precision machinery,energy saving and transportation.With strong market performance。 展开更多
关键词 MANUFACTURER Chairman machinery COMPANIES automati
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植物乳杆菌Zhang-LL与马克斯克鲁维酵母菌M3共发酵葡萄汁酵素的工艺优化
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作者 董双佳 刘慧 +3 位作者 金君华 张红星 杨竹娘 谢远红 《北京农学院学报》 2024年第1期77-83,共7页
【目的】以葡萄汁为原料,植物乳杆菌Zhang-LL及马克斯克鲁维酵母M3为发酵菌株,优化葡萄汁酵素的发酵工艺条件。【方法】比较植物乳杆菌Zhang-LL和马克斯克鲁维酵母M3在葡萄汁中的不同接种方式对益生菌活菌数和DPPH清除率的影响,筛选葡... 【目的】以葡萄汁为原料,植物乳杆菌Zhang-LL及马克斯克鲁维酵母M3为发酵菌株,优化葡萄汁酵素的发酵工艺条件。【方法】比较植物乳杆菌Zhang-LL和马克斯克鲁维酵母M3在葡萄汁中的不同接种方式对益生菌活菌数和DPPH清除率的影响,筛选葡萄汁酵素最优接种发酵方式。进一步通过单因素试验及响应面试验,优化葡萄汁酵素最佳发酵工艺条件。【结果】植物乳杆菌Zhang-LL和马克斯克鲁维酵母M3共发酵可以显著提高葡萄汁酵素中益生菌活菌数和DPPH清除率;植物乳杆菌Zhang-LL和马克斯克鲁维酵母M3共发酵的最佳工艺条件为:按照1∶1比例接种,初始接种量5.00 lg CFU/mL、大豆蛋白胨添加量0.46%、34℃发酵18 h,植物乳杆菌Zhang-LL活菌数达6.60×10^(8)CFU/mL,马克斯克鲁维酵母M3活菌数达8.20×10^(7)CFU/mL,酵素DPPH清除率85.25%。【结论】乳酸菌与酵母菌协同发酵,在缩短发酵时间的同时还能达到较高的活菌数和DPPH清除率,可为葡萄汁酵素的工业化制备及后续多功能产品研发提供理论依据。 展开更多
关键词 葡萄酵素 植物乳杆菌Zhang-ll 马克斯克鲁维酵母M3 共培养
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老年慢性心力衰竭患者血清LL37和SSC5D水平检测对预后的评估价值
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作者 安国印 陈润祥 +1 位作者 吴晶晶 廖占玲 《现代检验医学杂志》 CAS 2024年第5期80-84,91,共6页
目的探讨血清抗菌肽LL37(LL37)和人可溶性富含半胱氨酸结构域的清道夫受体蛋白(soluble scavengerreceptor cysteine-rich domain-containing protein,SSC5D)在老年慢性心力衰竭(chronic heart failure,CHF)中的表达及对预后的评估价值... 目的探讨血清抗菌肽LL37(LL37)和人可溶性富含半胱氨酸结构域的清道夫受体蛋白(soluble scavengerreceptor cysteine-rich domain-containing protein,SSC5D)在老年慢性心力衰竭(chronic heart failure,CHF)中的表达及对预后的评估价值。方法选取上海交通大学医学院附属苏州九龙医院2017年1月~2022年1月收治的100例CHF患者为CHF组,根据预后情况将患者分为预后良好组(n=60)和预后不良组(n=40)。另选取100例健康体检者为对照组。酶联免疫吸附试验(ELISA)检测血清LL37和SSC5D水平。比较CHF组和对照组血清LL37和SSC5D水平差异;Spearman分析血清LL37和SSC5D相关性;Kaplan-Meier生存曲线分析血清LL37和SSC5D表达与CHF患者预后的关系;COX分析影响CHF患者预后的因素。采用ROC曲线分析血清LL37和SSC5D对老年CHF患者预后不良的预测价值。结果CHF组血清LL37(771.38±158.25 ng/ml)和SSC5D(15789.35±1306.25 pg/ml)水平高于对照组(526.23±115.58ng/ml,8938.72±858.29 pg/ml),差异具有统计学意义(t=12.510,43.830,均P<0.001)。Spearman相关性分析结果显示,CHF患者血清LL37与SSC5D水平呈显著正相关(r=0.629,P<0.001);CHF患者血清LL37,SSC5D水平与NYHA心功能分级呈显著正相关(r=0.776,0.751,均P<0.001)。高水平LL37组生存率显著低于低水平LL37组(38.18%vs 86.67%),差异具有统计学意义(Log rankχ^(2)=24.242,P<0.001);高水平SSC5D组生存率显著低于低水平SSC5D组(37.74%vs 85.10%),差异具有统计学意义(Log rankχ^(2)=23.291,P<0.001)。预后不良组>70岁占比、NYHA心功能分级Ⅲ+Ⅳ级占比、血清LL37和SSC5D水平高于预后良好组,差异具有统计学意义(χ^(2)=10.774,4.118,t=4.723,14.059,均P<0.05)。多因素COX分析结果表明,年龄>70岁(OR=1.515,95%CI:1.224~1.858)、NYHA心功能Ⅲ+Ⅳ分级(OR=1.236,95%CI:1.198~1.963)、高水平LL37(OR=1.705,95%CI:1.163~2.582)和高水平SSC5D(OR=1.591,95%CI:1.052~1.916)是影响CHF患者预后的独立危险因素(均P<0.05)。ROC曲线分析显示,血清LL37和SSC5D联合预测老年CHF预后不良的曲线下面积大于血清LL37和SSC5D单独检测,差异具有统计学意义(Z=2.834,2.168,P=0.005,0.030)。结论CHF患者血清LL37和SSC5D水平升高,两者均是CHF患者预后不良危险因素,可作为临床评估CHF预后指标。 展开更多
关键词 抗菌肽ll37 人可溶性富含半胱氨酸结构域的清道夫受体蛋白 慢性心力衰竭
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抗菌肽LL⁃37在骨质疏松症中的作用机制研究进展
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作者 冷鹏 唐晓军 《中国骨质疏松杂志》 CAS CSCD 北大核心 2024年第3期454-457,共4页
抗菌肽(antimicrobial peptides,AMPS)是一种宿主防御肽,既往主要关注其抗细菌及抗病毒作用,进一步研究发现AMPS可在成骨、破骨、免疫、促进血管生成等多个途径调控骨代谢、参与骨质疏松症的发生发展。本文旨在总结AMPS在骨代谢中的调... 抗菌肽(antimicrobial peptides,AMPS)是一种宿主防御肽,既往主要关注其抗细菌及抗病毒作用,进一步研究发现AMPS可在成骨、破骨、免疫、促进血管生成等多个途径调控骨代谢、参与骨质疏松症的发生发展。本文旨在总结AMPS在骨代谢中的调控机制,探讨其对骨质疏松症的影响为AMPS治疗骨质疏松症提供理论依据。 展开更多
关键词 抗菌肽ll⁃37 骨质疏松症 骨代谢
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Agricultural Machinery Input,Labor Resource Allocation,and Rural Household Land Transfers
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作者 Zhao Lei Liu Li 《Contemporary Social Sciences》 2022年第6期1-18,共18页
This paper explores the impact of agricultural machinery input on rural households’land transfers,which is conducive to the acceleration of agricultural modernization,agricultural production at scale,and rural revita... This paper explores the impact of agricultural machinery input on rural households’land transfers,which is conducive to the acceleration of agricultural modernization,agricultural production at scale,and rural revitalization.By using the micro-data on rural households(2014–2018)from China Family Panel Studies(CFPS),we made an empirical analysis of the impact of agricultural machinery input on land transfers and drew three conclusions.First,agricultural machinery input has a positive impact on land transfers,which means the more rural households invest in agricultural machinery,the more willing they are to participate in land transfers.Second,the impact of agricultural machinery input on land transfers is mainly exerted by adjusting the allocation of labor resources for rural households,or rather by increasing the number of farmers engaged in agriculture and reducing the number of farmers-turned traders and workers to facilitate land transfers.Third,the impact of agricultural machinery input on land transfers concerns both the positive transfers-in and the negative transfers-out,and such an impact stays stable across income groups.Accordingly,we should further increase agricultural machinery-related subsidies,improve the agricultural machinery service outsourcing market,and help rural households to reasonably allocate their labor resource endowments and invest in agricultural machinery to increase land transfers. 展开更多
关键词 agricultural machinery input CMP model land transfers labor resource allocation
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Research on Rotating Machinery Fault Diagnosis Based on Improved Multi-target Domain Adversarial Network 被引量:1
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作者 Haitao Wang Xiang Liu 《Instrumentation》 2024年第1期38-50,共13页
Aiming at the problems of low efficiency,poor anti-noise and robustness of transfer learning model in intelligent fault diagnosis of rotating machinery,a new method of intelligent fault diagnosis of rotating machinery... Aiming at the problems of low efficiency,poor anti-noise and robustness of transfer learning model in intelligent fault diagnosis of rotating machinery,a new method of intelligent fault diagnosis of rotating machinery based on single source and multi-target domain adversarial network model(WDMACN)and Gram Angle Product field(GAPF)was proposed.Firstly,the original one-dimensional vibration signal is preprocessed using GAPF to generate the image data including all time series.Secondly,the residual network is used to extract data features,and the features of the target domain without labels are pseudo-labeled,and the transferable features among the feature extractors are shared through the depth parameter,and the feature extractors of the multi-target domain are updated anatomically to generate the features that the discriminator cannot distinguish.The modelt through adversarial domain adaptation,thus achieving fault classification.Finally,a large number of validations were carried out on the bearing data set of Case Western Reserve University(CWRU)and the gear data.The results show that the proposed method can greatly improve the diagnostic efficiency of the model,and has good noise resistance and generalization. 展开更多
关键词 multi-target domain domain-adversarial neural networks transfer learning rotating machinery fault diagnosis
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Plant Protection Machine of CAAMS Tillage and Planting Machinery Institute
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《农业机械》 北大核心 2007年第01A期I0009-I0009,共1页
关键词 Plant Protection Machine of CAAMS Tillage and Planting machinery Institute
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A stepwise optimization method for topology structure of fluid machinery network
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作者 Wei Gao Xuliang Jing +3 位作者 Jing Chen Hongxiong Li Yubin Sun Dongyuan Yang 《Chinese Journal of Chemical Engineering》 SCIE EI CAS CSCD 2024年第11期35-45,共11页
The circulating water system is widely used as the cooling system in the process industry,which has the characteristics of high water and power consumption,and its energy consumption level has an important impact on t... The circulating water system is widely used as the cooling system in the process industry,which has the characteristics of high water and power consumption,and its energy consumption level has an important impact on the economic performance of the whole system.Pump network and water turbine network constitute the work network of the circulating water system,that is,the fluid machinery network.Based on the previous studies,this paper proposes a stepwise method to optimize the fluid machinery network,that is,to optimize the network structure by using the recoverable pressure-head curve of the branch,and consider the recovery of adjustable resistance at the valve of each branch,so as to further reduce energy consumption and water consumption.The calculation result of the case shows that the topology structure optimization can further reduce the operation cost and the annual capital cost on the basis of the fixed structure optimization,and the total annualized cost can be reduced by 30.04%.The optimization result of different flow shows that both the pump network and the water turbine network tend to series structure at a low flow rate whereas to parallel structure at a high flow rate. 展开更多
关键词 Fluid machinery network Recoverable pressure head Topology structure MODEL OPTIMIZATION Systems engineering
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Weak Fault Feature Extraction of the Rotating Machinery Using Flexible Analytic Wavelet Transform and Nonlinear Quantum Permutation Entropy
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作者 Lili Bai Wenhui Li +3 位作者 He Ren Feng Li TaoYan Lirong Chen 《Computers, Materials & Continua》 SCIE EI 2024年第6期4513-4531,共19页
Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery,where weak fault characteristic signals hinder accurate fault state representation,we propose a novel feature extrac... Addressing the challenges posed by the nonlinear and non-stationary vibrations in rotating machinery,where weak fault characteristic signals hinder accurate fault state representation,we propose a novel feature extraction method that combines the Flexible Analytic Wavelet Transform(FAWT)with Nonlinear Quantum Permutation Entropy.FAWT,leveraging fractional orders and arbitrary scaling and translation factors,exhibits superior translational invariance and adjustable fundamental oscillatory characteristics.This flexibility enables FAWT to provide well-suited wavelet shapes,effectively matching subtle fault components and avoiding performance degradation associated with fixed frequency partitioning and low-oscillation bases in detecting weak faults.In our approach,gearbox vibration signals undergo FAWT to obtain sub-bands.Quantum theory is then introduced into permutation entropy to propose Nonlinear Quantum Permutation Entropy,a feature that more accurately characterizes the operational state of vibration simulation signals.The nonlinear quantum permutation entropy extracted from sub-bands is utilized to characterize the operating state of rotating machinery.A comprehensive analysis of vibration signals from rolling bearings and gearboxes validates the feasibility of the proposed method.Comparative assessments with parameters derived from traditional permutation entropy,sample entropy,wavelet transform(WT),and empirical mode decomposition(EMD)underscore the superior effectiveness of this approach in fault detection and classification for rotating machinery. 展开更多
关键词 Rotating machinery quantum theory nonlinear quantum permutation entropy Flexible Analytic Wavelet Transform(FAWT) feature extraction
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