baldness的委婉说法

英语国家的禁忌范围很广泛,主要有死亡、两性关系、某些生理功能(上厕所、例假)、年老等等。这些社会禁忌(social taboo)反映在语言上便是禁忌语。委婉语的使用是避开禁忌的有效途径。还有一种禁忌是个人禁忌(per-sonal taboo),如某些个人缺陷——“秃顶”(baldness)。

An Improved Bald Eagle Search Algorithm with Cauchy Mutation and Adaptive Weight Factor for Engineering Optimization

The Bald Eagle Search algorithm(BES)is an emerging meta-heuristic algorithm.The algorithm simulates the hunting behavior of eagles,and obtains an optimal solution through three stages,namely selection stage,search stage and swooping stage.However,BES tends to drop-in local optimization and the maximum value of search space needs to be improved.To fill this research gap,we propose an improved bald eagle algorithm(CABES)that integrates Cauchy mutation and adaptive optimization to improve the performance of BES from local optima.Firstly,CABES introduces the Cauchy mutation strategy to adjust the step size of the selection stage,to select a better search range.Secondly,in the search stage,CABES updates the search position update formula by an adaptive weight factor to further promote the local optimization capability of BES.To verify the performance of CABES,the benchmark function of CEC2017 is used to simulate the algorithm.The findings of the tests are compared to those of the Particle Swarm Optimization algorithm(PSO),Whale Optimization Algorithm(WOA)and Archimedes Algorithm(AOA).The experimental results show that CABES can provide good exploration and development capabilities,and it has strong competitiveness in testing algorithms.Finally,CABES is applied to four constrained engineering problems and a groundwater engineeringmodel,which further verifies the effectiveness and efficiency of CABES in practical engineering problems.

Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy

BACKGROUND Myotonic dystrophy(MD)is sometimes accompanied by metabolic/endocrine disorders,including dyslipidemia,central obesity,and hypogonadism.Due to considerable individual differences in the severity and progression of myopathy,MD patients with minimal-to-mild muscle symptoms might be followed as having other diseases,such as non-alcoholic fatty liver disease(NAFLD).CASE SUMMARY A 40-year-old non-obese man without a history of regular ethanol consumption was referred to our hospital due to persistent liver dysfunction and hyperlipidemia.His body mass index was 23.4 kg/m2.Liver histology demonstrated macrovesicular steatosis,ballooned hepatocytes with eosinophilic inclusion bodies,and perisinusoidal fibrosis,leading to the diagnosis of nonalcoholic steatohepatitis(NASH).Although he had no discernable muscle pain or weakness,persistently high serum creatine kinase(CK)and myoglobin levels as well as the presence of frontal baldness,a hatched face,history of cataract surgery,and grip myotonia indicated the possibility of MD.Southern blotting of the patient’s DNA revealed the presence of CTG repeats,confirming the diagnosis.CONCLUSION When gastroenterologists encounter NAFLD/NASH patients,serum CK should be verified.If hyperCKemia,frontal baldness,a hatched face,history of cataract surgery,and grip myotonia are noted,the possibility of MD may be considered.

Therapeutic angiomyogenesis using human non-viral transduced VEGF₁₆₅-myoblasts

This article reviews the scientific development of angiomyogenesis using VEGF165-myoblasts, a patented biotechnology platform in regenerative medicine associated with Human Myoblast Genome Therapy (HMGT), also known as Myoblast Transfer Therapy (MTT). VEGF165-myoblasts are the leading biologics for angiomyogenesis. This review also compares the safety and efficacy of VEGF165-myoblasts transduced using adenoviral vectors, nanoparticles or liposomes, in anticipation of their application in clinical trials in the near future. VEGF165-myoblasts are differentiated myogenic cells capable of extensive division, natural cell fusion, nucleus transfer, cell therapy and genome therapy. Following transplantation they survive, develop and function to revitalize degenerative myocardium in heart failure and ischemic cardiomyopathy animal studies. VEGF165-myoblasts are second generation products of HMGT/MTT which replenishes live cells and genetically repairs degenerating myofibers in Type II diabetes, muscular dystrophies, aging dysfunction and disfigurement. Myoblasts have also been used to enhance skin and muscle appearance in cosmetology. We envision that VEGF165-myoblasts will provide better outcome than their non-tranduced counterparts. Myoblasts are not stem cells. Their competitive advantages over stem cells are presented.

秃顶与新型生发剂敏乐定

本文首次在国内综述了近年来国外研究敏乐定型生发剂的概况,论述了秃顶的原因以及用敏乐定治疗情况和敏乐定类型生发剂配方.

Mercury concentrations in blood and feathers of nestling Bald Eagles in coastal and inland Virginia

Background:Mercury(Hg) and methylmercury are widely considered significant issues for wildlife,and in particular,piscivorous birds due to their widespread availability and neurotoxic properties.Whereas a substantial number of studies of Hg contamination of Bald Eagles(Haliaeetus leucocephalus) have been conducted throughout the east coast of the United States,little has been done that directly addresses Hg contamination in Bald Eagles in Virginia,particularly the inland population.Methods:We collected blood and feather samples from nestling Bald Eagles in the coastal plain,piedmont,and western regions of Virginia in an effort to determine which areas of the state were more likely to contain populations showing evidence of Hg toxicity.We analyzed the samples for total Hg using a Milestone DMA-80.Results:Samples collected from individuals located in the coastal region exhibited low concentrations of Hg compared to those further inland located on freshwater rivers and reservoirs.Samples collected from the inland population exhibited levels in some areas that are approaching what may be considered to be sub-lethal to avian health(blood:mean 0.324 mg/kg,SE = 0.13,range = 0.06-0.97 mg/kg;feather:mean = 8.433 mg/kg,SE = 0.3,range = 3.811-21.14 mg/kg).Conclusions:Even after accounting for known point-sources of Hg,the inland eagle population in Virginia is susceptible to concentrations of Hg that are significantly higher than their coastal counterparts.Moreover,several locations besides those currently known to be impacted by point-sources are exhibiting concentrations that are approaching a sub-lethal level.

Evidence of arrested silk growth in maize at high planting density using phenotypic and transcriptional analyses

Increasing the planting density is an effective way to increase the yield of maize(Zea mays L.),although it can also aggravate ovary apical abortion-induced bald tips of the ears,which might,in turn,reduce the yield.While the mechanism underlying the regulation of drought-related abortion in maize is well established,high planting density-related abortion in maize remains poorly understood.Therefore,the present study was designed to investigate the mechanism underlying the ovary apical abortion response to high density.This was achieved by evaluating the effects of four different plant densities(60000 plants ha^(–1)(60 k),90 k,120 k,and 150 k)on plant traits related to plant architecture,the plant ear,flowering time,and silk development in two inbred lines(Zheng58 and PH4CV)and two hybrid lines(Zhengdan958 and Xianyu335).The phenotypes of both inbred and hybrid plants were observed under different planting density treatments,and the high planting density was found to increase the phenotypic performance values of the evaluated traits.The anthesis–silking interval(ASI)was extended,and the amount of the silk extruded from husks was reduced upon increasing the planting density.Delayed silk emergence resulted in asynchronous flowering and ear bald tips.Observations of the silk cells revealed that the silk cells became smaller as planting density increased.The changes in transcript abundances in the silks involved the genes associated with expansive growth rather than carbon metabolism.These findings further our understanding of silk growth regulation under high planting density and provide a theoretical basis for further research on improving high planting density breeding in maize.

Optimal FOPID Controllers for LFC Including Renewables by Bald Eagle Optimizer

In this study,a bald eagle optimizer(BEO)is used to get optimal parameters of the fractional-order proportional-integral-derivative(FOPID)controller for load frequency control(LFC).SinceBEOtakes only a very short time in finding the optimal solution,it is selected for designing the FOPID controller that improves the system stability and maintains the frequency within a satisfactory range at different loads.Simulations and demonstrations are carried out using MATLAB-R2020b.The performance of the BEOFOPID controller is evaluated using a two-zone interlinked power system at different loads and under uncertainty of wind and solar energies.The robustness of the BEO-FOPID controller is examined by testing its performance under varying system time constants.The results obtained by the BEOFOPID controller are compared with those obtained by BEO-PID and PID controllers based on recent metaheuristics optimization algorithms,namely the sine-cosine approach,Jaya approach,grey wolf optimizer,genetic algorithm,bacteria foraging optimizer,and equilibrium optimization algorithm.The results confirm that the BEO-FOPID controller obtains the finest result,with the lowest frequency deviation.The results also confirm that the BEOFOPID controller is stable and robust at different loads,under varying system time constants,and under uncertainty of wind and solar energies.

Bald Eagle Search Optimization Algorithm Combined with Spherical Random Shrinkage Mechanism and Its Application

Over the last two decades,stochastic optimization algorithms have proved to be a very promising approach to solving a variety of complex optimization problems.Bald eagle search optimization(BES)as a new stochastic optimization algorithm with fast convergence speed has the ability of prominent optimization and the defect of collapsing in the local best.To avoid BES collapse at local optima,inspired by the fact that the volume of the sphere is the largest when the surface area is certain,an improved bald eagle search optimization algorithm(INMBES)integrating the random shrinkage mechanism of the sphere is proposed.Firstly,the INMBES embeds spherical coordinates to design a more accurate parameter update method to modify the coverage and dispersion of the population.Secondly,the population splits into elite and non-elite groups and the Bernoulli chaos is applied to elite group to tap around potential solutions of the INMBES.The non-elite group is redistributed again and the Nelder-Mead simplex strategy is applied to each group to accelerate the evolution of the worst individual and the convergence process of the INMBES.The results of Friedman and Wilcoxon rank sum tests of CEC2017 in 10,30,50,and 100 dimensions numerical optimization confirm that the INMBES has superior performance in convergence accuracy and avoiding falling into local optimization compared with other potential improved algorithms but inferior to the champion algorithm and ranking third.The three engineering constraint optimization problems and 26 real world problems and the problem of extracting the best feature subset by encapsulated feature selection method verify that the INMBES’s performance ranks first and has achieved satisfactory accuracy in solving practical problems.

Prediction of network public opinion based on bald eagle algorithm optimized radial basis function neural network

Purpose-In the new era of highly developed Internet information,the prediction of the development trend of network public opinion has a very important reference significance for monitoring and control of public opinion by relevant government departments.Design/methodology/approach-Aiming at the complex and nonlinear characteristics of the network public opinion,considering the accuracy and stability of the applicable model,a network public opinion prediction model based on the bald eagle algorithm optimized radial basis function neural network(BES-RBF)is proposed.Empirical research is conducted with Baidu indexes such as“COVID-19”,“Winter Olympic Games”,“The 100th Anniversary of the Founding of the Party”and“Aerospace”as samples of network public opinion.Findings-The experimental results show that the model proposed in this paper can better describe the development trend of different network public opinion information,has good stability in predictive performance and can provide a good decision-making reference for government public opinion control departments.Originality/value-A method for optimizing the central value,weight,width and other parameters of the radial basis function neural network with the bald eagle algorithm is given,and it is applied to network public opinion trend prediction.The example verifies that the prediction algorithm has higher accuracy and better stability.

THE BALD TRUTH——ADD HAIR LOSS TO THE STRESSES FACING MILLENNIALS

Several weeks after starting his job with tech company Tencent,247-year-old Mr.Guo identified a problem:He was losing his hair.He now fears becoming as bald as colleagues who are decades his senior.

”Das Wunder ist bald zu Ende“

Der Vizeminister der staatlichen Umweltbehrde, Pan Yue, überdie Risiken des Wirtschaftswachstums und die gravierenden1kologischen Schden im