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基于功能连接分析对基底节区卒中患者的偏侧化研究
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作者 茆倩倩 陈宇辰 +3 位作者 陈慧铀 姜亮 姜海龙 殷信道 《磁共振成像》 CAS CSCD 北大核心 2024年第3期13-18,共6页
目的 探究左侧基底节区卒中患者(left-sided basal ganglia stroke,L-BGS)与右侧基底节区卒中患者(right-sided basal ganglia stroke,R-BGS)大脑静态和动态功能连接的改变,进一步探索卒中偏侧化机制。材料与方法 选取23名L-BGS患者、18... 目的 探究左侧基底节区卒中患者(left-sided basal ganglia stroke,L-BGS)与右侧基底节区卒中患者(right-sided basal ganglia stroke,R-BGS)大脑静态和动态功能连接的改变,进一步探索卒中偏侧化机制。材料与方法 选取23名L-BGS患者、18名R-BGS患者和20名健康对照(healthy controls,HCs),分别对三组受试者进行静息态功能MRI (resting-state functional MRI,rs-fMRI)扫描。基于rs-fMRI和滑动窗口技术分别对两组患者和HCs进行静态功能连接分析和动态功能连接分析。结果 在静态脑网络连接分析中,同HCs组相比,L-BGS组患者表现为更广泛的网络内连通性增加及减弱(P<0.001,团块水平FWE校正);R-BGS组患者则有着更为广泛的网络间连接受损(P<0.016 7,FDR校正)。在动态连接分析中,相较于HCs组,L-BGS组患者表现出更积极的网络连接重组(P<0.05,FDR校正)。结论 本研究证实在基底节区卒中发生的1个月内,L-BGS患者表现出更积极的静态与动态脑网络连接的代偿性改变。 展开更多
关键词 基底节区卒中 静息态功能磁共振成像 磁共振成像 动态功能网络连接 偏侧化
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Optimization of Parameters for the Production of Lipase from Pseudomonas sp. BUP6 by Solid State Fermentation 被引量:1
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作者 Panichikkal Abdul Faisal Erandapurthukadumana Sreedharan Hareesh +5 位作者 Prakasan Priji Kizhakkepowathial Nair Unni Sreedharan Sajith Sasidharan Sreedevi Moolakkariyil Sarath Josh Sailas Benjamin 《Advances in Enzyme Research》 2014年第4期125-133,共9页
Solid-state fermentation (SSF) holds tremendous potentials for the production of industrially significant enzymes. The present study describes the production of lipase by a novel rumen bacterium, Pseudomonas sp. strai... Solid-state fermentation (SSF) holds tremendous potentials for the production of industrially significant enzymes. The present study describes the production of lipase by a novel rumen bacterium, Pseudomonas sp. strain BUP6 on agro-industrial residues. Pseudomonas sp. strain BUP6 showed higher lipase production when grown in Basal salt medium (BSM) supplemented with oil cakes. Initially, five different oil cakes (obtained after extracting oil from coconut, groundnut, cotton seed, gingelly or soybean) were screened to find out the most suitable substrate-cum-inducer for the production of lipase. Among them, groundnut cake supported the maximum production of lipase (107.44 U/gds). Box-Behnken Design (BBD), followed by response surface methodology (RSM) was employed to optimize the culture parameters for maximizing the production of lipase. Using the software Minitab 14, four different parameters like temperature, pH, moisture content and incubation time were selected for the statistical optimization, which resulted in 0.7 fold increase (i.e., 180.75 U/gds) in production of lipase under the optimum culture conditions (temperature 28&#176C, pH 5.9, moisture 33% and incubation 2 d). Thus, this study signifies the importance of SSF for the production of industrially-significant lipase using agro-industrial residues as solid support. 展开更多
关键词 LIPASE SOLID-state FERMENTATION basal SALT Medium Oil CAKES Response Surface Methodology
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基于GIS的大庆油田电力系统连锁过负荷故障分析系统 被引量:9
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作者 闫丽梅 赵国成 +3 位作者 陈娟 安小龙 张艳 薛晨光 《电力系统保护与控制》 EI CSCD 北大核心 2010年第23期75-81,共7页
为满足大庆油田电网调度和信息管理的需要,同时为了避免大庆油田发生由于过负荷连锁故障而导致的大停电造成过大的经济损失,开发了基于GIS的大庆油田电力系统连锁过负荷故障分析系统软件。该软件利用美国ERSI(环境系统研究所)开发的MapO... 为满足大庆油田电网调度和信息管理的需要,同时为了避免大庆油田发生由于过负荷连锁故障而导致的大停电造成过大的经济损失,开发了基于GIS的大庆油田电力系统连锁过负荷故障分析系统软件。该软件利用美国ERSI(环境系统研究所)开发的MapObjects组件及C#进行集成二次开发,并进行必要的扩充,完成了如下的功能:大庆电网主接线图的主界面,基态潮流计算,初始故障的求取,开断潮流的计算,连锁故障路径的显示,故障图的分区显示以及故障率的计算等。通过其显示的连锁故障路径,可以清晰地看出易出现连锁故障的线路,为大庆油田的安全可靠供电提出了有益的警示和参考,为避免更大的经济损失提供了依据。结果表明:求出的关键路径是大庆油田电力系统故障率比较高的路径。证明了结果的正确性。 展开更多
关键词 GIS 基态潮流 连锁故障 过负荷 开断潮流 故障树
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支护开挖基底抗隆起的概率分析 被引量:2
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作者 徐超 杨林德 《水文地质工程地质》 CAS CSCD 1997年第6期33-36,共4页
基底隆起导致墙后土体位移是基坑失稳的模式之一。本文在分析了引起基底隆起的因素之后,对土性参数的变异特性和分布特征进行了研究。结合上海地区的工程实践,采用极限状态设计方法,对引起基底隆起的因素进行了评价。
关键词 支护开挖 基底隆起 深基础 概率分析 地基变形
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基底节梗死患者静息态功能磁共振ReHo研究
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作者 阮杏林 林海龙 邓丽霞 《福建医药杂志》 CAS 2020年第6期29-31,F0004,共4页
目的运用静息态功能磁共振成像(rs-fMRI)的局部一致性(ReHo)方法探究基底节梗死神经元活动的同步性特征。方法选取12例基底节梗死患者为观察组,选择12例健康体检者为健康对照组,对两组入选者进行静息态功能磁共振扫描,比较两组ReHo值的... 目的运用静息态功能磁共振成像(rs-fMRI)的局部一致性(ReHo)方法探究基底节梗死神经元活动的同步性特征。方法选取12例基底节梗死患者为观察组,选择12例健康体检者为健康对照组,对两组入选者进行静息态功能磁共振扫描,比较两组ReHo值的差异。结果与对照组相比,观察组ReHo值在双侧额上回、双侧额中回、左侧额下回显著增高,在双侧小脑后叶显著降低,差异有统计学意义(均P<0.001)。结论基底节梗死后额叶及小脑神经元活动同步性发生变化,通过刺激以上脑区,可能有助于基底节梗死的功能恢复。 展开更多
关键词 基底节梗死 静息态功能磁共振成像 局部一致性
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母体基础状态和伴随疾病与B群链球菌感染的相关性研究 被引量:5
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作者 欧阳惠君 李康生 +2 位作者 廖奔兵 靖吉芳 黄雪霞 《国际检验医学杂志》 CAS 2019年第15期1865-1867,共3页
目的研究妊娠母体的基础状态及伴随疾病与B群链球菌感染的相关性。方法选择某院213例经传统培养法鉴定为GBS感染患者,作为GBS(+)组;从GBS培养鉴定结果为阴性的所有患者中,随机抽取213例GBS阴性者为GBS(-)组。对两组对象的年龄、产次、... 目的研究妊娠母体的基础状态及伴随疾病与B群链球菌感染的相关性。方法选择某院213例经传统培养法鉴定为GBS感染患者,作为GBS(+)组;从GBS培养鉴定结果为阴性的所有患者中,随机抽取213例GBS阴性者为GBS(-)组。对两组对象的年龄、产次、孕次、体质量指数(BMI)及妊娠期糖尿病、妊娠期高血压病、子宫平滑肌瘤、贫血的发生率进行统计分析。结果GBS(+)组孕妇的BMI明显高于GBS(-)组,差异具有统计学意义(P<0.05)。GBS(+)组、GBS(-)组的孕妇年龄、产次、孕次及伴随疾病之间的差异无统计学意义(P>0.05)。结论B群链球菌感染与妊娠母体的BMI有明显的相关性。体质量监测对控制孕妇B群链球菌感染有积极意义。 展开更多
关键词 基础状态 体质量指数 伴随疾病 B群链球菌
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用潜在疏密度评价林分长势 被引量:2
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作者 刘瑞红 惠刚盈 +4 位作者 张岗岗 刘文桢 张弓乔 胡艳波 杨瑷铭 《北京林业大学学报》 CAS CSCD 北大核心 2019年第8期13-18,共6页
【目的】林分长势是林分活力的直接体现,疏密度是反映林分密度和长势的重要指标之一。计算疏密度的关键是对标准断面积的准确求算,但在实际应用中标准林分难以判定,标准断面积的可获得性较差,削弱了其可应用性,探求新的指标是解决这一... 【目的】林分长势是林分活力的直接体现,疏密度是反映林分密度和长势的重要指标之一。计算疏密度的关键是对标准断面积的准确求算,但在实际应用中标准林分难以判定,标准断面积的可获得性较差,削弱了其可应用性,探求新的指标是解决这一问题的有效途径,因此本研究旨在探究可以替代疏密度的新指标。【方法】一定的立地条件下,林地生产力是有限的,基于最终产量恒定法则,本研究以长期连续监测且经营数表齐全的杉木试验林分为材料,1989年编制的全国分区杉木标准表为参照,以林分内不同比例较大林木个体的平均断面积与全部林木株数的乘积表示林分生长能够达到的潜在最大断面积,即在50%~80%林木株数比例范围内,以5%为梯度,依次比较不同比例较大林木个体所得潜在最大断面积与标准断面积的差值,求使潜在最大断面积与标准断面积偏差率最小时所对应林木株数比例,并以此为基础,分析天然林中林分断面积与潜在最大断面积的关系,检验潜在最大断面积的计算方法在天然林中的适用性。【结果】当较大林木株数占总株数比例为70%时,所有试验样地的潜在最大断面积与标准断面积的偏差最小,均在±10%左右,此时,潜在疏密度与疏密度的差值最小;天然林中70%较大林木个体断面积之和与林分断面积呈显著线性关系,故可用70%较大个体的平均断面积与总株数乘积作为潜在最大断面积,来求算潜在疏密度。【结论】林分潜在最大断面积可以70%较大林木个体平均断面积与林木总株数的乘积表示,所求潜在疏密度可替代疏密度来表征林分长势。 展开更多
关键词 林分长势 潜在疏密度 潜在最大断面积 立地生产力 林分状态
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双侧基底节筛孔状态的MRI表现及可能的临床意义
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作者 冯结映 黄飚 +3 位作者 谭婉嫦 王金花 张奕昭 胡海菁 《放射学实践》 北大核心 2017年第2期122-125,共4页
目的:探讨双侧基底节筛孔状态的MRI表现及可能的临床意义。方法:选取63例双侧基底节筛孔状态患者作为病例组,并通过MRI评价其病灶形态、信号特点;同时选取63例性别、年龄相匹配的正常志愿者作为对照组,病例组及对照组均进行中文版简易... 目的:探讨双侧基底节筛孔状态的MRI表现及可能的临床意义。方法:选取63例双侧基底节筛孔状态患者作为病例组,并通过MRI评价其病灶形态、信号特点;同时选取63例性别、年龄相匹配的正常志愿者作为对照组,病例组及对照组均进行中文版简易智能状态检查量表(MMSE)评分;并按性别分层,研究高血压与双侧基底节筛孔状态的关系。结果:所有病灶集中于双侧壳核、豆状核,且呈双侧对称性、筛孔状分布;病灶在T_2WI上呈高信号,T_1WI及FLAIR T_2WI上呈低信号,无明确壁或胶质增生表现,扩散未见明确受限表现。病例组的MMSE总评分[(26.00±1.95)分]较对照组[(28.44±1.15)分]低,且两者间差异具有统计学意义(Z=-7.15,P<0.001)。分层χ2检验结果提示两性高血压与筛孔状态均存在相关性(χ_M^2=19.19,P_M<0.001;χ_F^2=13.60,P_F=0.001)。结论:双侧基底节筛孔状态是一种病理改变,与患者认知功能损伤有一定关系,高血压可能是其中一个危险因素,应引起临床重视。 展开更多
关键词 神经节 基底 筛孔状态 磁共振成像 简易智能状态检查量表 认知障碍
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经阴道彩色多普勒超声在不孕女性卵巢储备功能评价中的应用价值 被引量:8
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作者 李朝阳 李海霞 李艳群 《当代医学》 2017年第14期78-79,共2页
目的探讨经阴道彩色多普勒超声在不孕女性卵巢储备功能评价中的应用价值。方法选择不孕患者80例的临床资料进行回顾性分析。根据性激素检测结果分为卵巢储备功能正常组(正常组,44例)和卵巢储备功能下降组(下降组,36例)。比较两组患者彩... 目的探讨经阴道彩色多普勒超声在不孕女性卵巢储备功能评价中的应用价值。方法选择不孕患者80例的临床资料进行回顾性分析。根据性激素检测结果分为卵巢储备功能正常组(正常组,44例)和卵巢储备功能下降组(下降组,36例)。比较两组患者彩色多普勒超声相关指标结果以及周期妊娠率,分析PSV、RI及PI与优势卵泡数目的关系。结果卵巢储备功能正常的患者MOD高于下降组,AFC更多,PSV更快,两组比较差异有统计学意义(P<0.05);正常组患者后期妊娠率显著高于下降组,两组比较差异有统计学意义(P<0.05)。两组RI、PI比较差异无统计学意义。卵巢储备功能下降的患者,卵巢间质动脉血流信号少,而正常患者血流信号丰富。PSV与优势卵泡数目有正相关的关系(r=0.421);RI、PI与优势卵泡数目没有相关性(r=0.021,0.044)。结论经阴道彩色多普勒超声能够评估不孕患者卵巢储备功能,指导医生治疗,并且具有经济、方便、无创等优点。 展开更多
关键词 经阴道彩色多普勒超声 卵巢储备功能 卵巢基础状态
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初诊2型糖尿病单纯药物与联合基础胰岛素治疗对血糖控制及微炎症状态的影响 被引量:11
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作者 吴刚 刘栋梁 +1 位作者 李襄君 范小云 《海南医学院学报》 CAS 2016年第12期1207-1209,1213,共4页
目的:研究2型糖尿病单纯药物与联合基础胰岛素治疗对血糖控制及微炎症状态的影响。方法:2014年5月~2015年6月期间收集重庆市第六人民医院确诊的2型糖尿病128例,采用随机数字法随机分为观察组与对照组2组,观察组予二甲双胍(格华止,0.... 目的:研究2型糖尿病单纯药物与联合基础胰岛素治疗对血糖控制及微炎症状态的影响。方法:2014年5月~2015年6月期间收集重庆市第六人民医院确诊的2型糖尿病128例,采用随机数字法随机分为观察组与对照组2组,观察组予二甲双胍(格华止,0.25g,3次/d)联合基础胰岛素(甘精胰岛素)治疗,对照组予二甲双胍(格华止,0.25g,3次/d起始,最大总剂量2g,必要时加用非胰岛素增敏剂降糖药物),调整剂量控制血糖达标,疗程6个月。比较2组治疗前后的血糖控制情况、胰岛功能及微炎症指标。结果:观察组、对照组治疗后FPG、HbA1c分别相比较差异具有统计学意义(均P〈0.05)。观察组予联合基础胰岛素治疗后与对照组治疗后AUCc-p、HOMA-β、HOMA-IR差异具有统计学意义(均P〈0.05)。观察组予联合基础胰岛素治疗后与对照组治疗后hs-CRP、IGF-1、IL-6、TNF-α差异均具有统计学意义(均P〈0.05)。结论:2型糖尿病合二甲双胍联合基础胰岛素治疗不仅能够控制血糖,且血糖平稳,微炎症状态指标也有明显降低。 展开更多
关键词 2型糖尿病 基础胰岛素 血糖控制 微炎症状态
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Developing a dynamic growth model for teak plantations in India 被引量:2
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作者 Vindhya Prasad Tewari Juan Gabriel lvarez-gonzález Oscar García 《Forestry Studies in China》 CAS 2014年第2期71-80,共10页
Background: Tectono grandis (teak) is one of the most important tropical timber species occurring naturally in India. Appropriate growth models, based on advanced modeling techniques, are not available but are nece... Background: Tectono grandis (teak) is one of the most important tropical timber species occurring naturally in India. Appropriate growth models, based on advanced modeling techniques, are not available but are necessary for the successful management of teak stands in the country. Long-term forest planning requires mathematical models and the principles of Dynamical System Theory provide a solid foundation for these. Methods: The state-space approach makes it possible to accommodate disturbances and avarying environment. In this paper, an attempt has been made to develop a dynamic growth model based on the limited data, consisting of three annual measurements, collected from 22 teak sample plots in Karnataka, Southern India. Results: A biologically consistent whole-stand growth model has been presented which uses the state-space approach for modelling rates of change of three state-variables viz., dominant height, stems per hectare and stand basal area. Moreover, the model includes a stand volume equation as an output function to estimate this variable at any point in time. Transition functions were fitted separately and simultaneously. Moreover, a continuous autoregressive error structure is also included in the modelling process. For fitting volume equation, generalized method of moments was used to get efficient parameter estimates under heteroscedastic conditions. Conclusions: A simple model containing few free parameters performed well and is particularly well suited to situations where available data is scarce. 展开更多
关键词 MORTALITY basal area Canopy closure Relative occupancy state-space approach Tectona grandis
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小骨窗经侧裂岛叶入路血肿清除术治疗基底节HICH患者的效果分析 被引量:1
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作者 柯志通 《齐齐哈尔医学院学报》 2021年第15期1324-1326,共3页
目的研究分析小骨窗经侧裂岛叶入路血肿清除术应用于基底节高血压性脑出血(HICH)患者的效果。方法选择2019年4月—2020年4月在本院治疗的56例基底节HICH患者为研究对象,采用随机数表法分为对照组(n=27)和实验组(n=29)两组。对照组接受... 目的研究分析小骨窗经侧裂岛叶入路血肿清除术应用于基底节高血压性脑出血(HICH)患者的效果。方法选择2019年4月—2020年4月在本院治疗的56例基底节HICH患者为研究对象,采用随机数表法分为对照组(n=27)和实验组(n=29)两组。对照组接受小骨窗经颞叶皮质入路手术治疗,实验组接受小骨窗经侧裂岛叶入路血肿清除术,比较两组预后情况、血肿清除率、治疗前后意识状态、生活能力评分及并发症发生率。结果实验组预后优良率高于对照组(P<0.05)。实验组治疗后血肿清除率、意识状态评分及生活能力评分均高于对照组(P<0.05)。实验组并发症发生率低于对照组(P<0.05)。结论小骨窗经侧裂岛叶入路血肿清除术可有效改善基底节HICH患者预后,促进血肿清除并提高治疗后患者生活能力,促进患者意识恢复并减少并发症发生情况。 展开更多
关键词 高血压性脑出血 意识状态 小骨窗 基底节
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The role of temperature as a driver of metabolic flexibility in the Red-billed Leiothrix(Leiothrix lutea) 被引量:3
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作者 Danqi Cui Na Wang +3 位作者 Jingru Ge Jiaying Xu Weihong Zheng Jinsong Liu 《Avian Research》 CSCD 2019年第4期485-496,共12页
Background:The thermoregulatory ability of animals is strongly influenced by the temperature of their environment.Acclimation to cold requires a range of physiological and morphological adjustments.In this study,we te... Background:The thermoregulatory ability of animals is strongly influenced by the temperature of their environment.Acclimation to cold requires a range of physiological and morphological adjustments.In this study,we tested the hypothesis that a small passerine,the Red-billed Leiothrix(Leiothrix lutea),can maintain homeothermy in cold conditions by adjusting the physiology and biochemistry of its tissue and organs and return to its former physiological and biochemical state when moved to a warm temperature.Methods:Phenotypic variation in thermogenic activity of the Red-billed Leiothrixs(Leiothrix lutea)was investigated under warm(35℃),normal(25℃)or cold(15℃)ambient temperature conditions.Oxygen consumption was measured using an open-circuit respirometry system.Mitochondrial state-4 respiration and cytochrome-c oxidase(COX)activity in liver,kidney heart and pectoral muscle were measured with a Clark electrode.Results:Birds acclimated to an ambient temperature of 15℃ for 4 weeks significantly increased their basal metabolic rate(BMR)compared to a control group kept at 25℃.Birds acclimated to 35℃ decreased their BMR,gross energy intake(GEI)and digestible energy intake(DEI).Furthermore,birds acclimated to 15℃ increased state-4 respiration in their pectoral muscles and cytochrome-c oxidase(COX)activity in their liver and pectoral muscle,compared to the 25℃ control group.Birds acclimated to 35℃ also displayed lower state-4 respiration and COX activity in the liver,heart and pectoral muscles,compared to those kept at 25℃.There was a positive correlation between BMR and state-4 respiration,and between BMR and COX activity,in all of the above organs except the liver and heart.Conclusions:Our study illustrates that the morphological,physiological,and enzymatic changes are associated with temperature acclimation in the Red-billed Leiothrix,and supports the notion that the primary means by which small birds meet the energetic challenges of cold conditions is through metabolic adjustments. 展开更多
关键词 basal metabolic rate Cold acclimation Cytochrome C oxidase Leiothrix lutea state-4 respiration
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Relationships between interspecific differences in the mass of internal organs,biochemical markers of metabolic activity,and the thermogenic properties of three smallpasserines 被引量:2
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作者 Minlan Bai Xujian Wu +2 位作者 Kejing Cai Weihong Zheng Jinsong Liu 《Chinese Birds》 CSCD 2016年第2期116-124,共9页
Background:The capacity for thermogenesis is considered part of an animal's adaptive strategy for survival,and basal metabolic rate(BMR) is one of the fundamental physiological standards for assessing the energy c... Background:The capacity for thermogenesis is considered part of an animal's adaptive strategy for survival,and basal metabolic rate(BMR) is one of the fundamental physiological standards for assessing the energy cost of thermoregulation in endotherms.BMR has been shown to be a highly flexible phenotypic trait both between,and within,species,but the metabolic mechanisms involved in the regulation of BMR,which range from variation in organ mass to biochemical adjustments,remain unclear.In this study,we investigated the relationship between organ mass,biochemical markers of metabolic tissue activity,and thermogenesis,in three species of small passerines:wild Bramblings(Fringilla montifringilla),Little Buntings(Emberiza pusilla) and Eurasian Tree Sparrows(Passer montanus),caught in Wenzhou,southeastern China.Methods:Oxygen consumption was measured using an open-circuit respirometry system.Mitochondrial state-4 respiration and cytochrome c oxidase(COX) activity in liver and pectoral muscle were measured with a Clark electrode.Results:Our results show that Eurasian Tree Sparrows had significantly higher BMR,digestive organ mass,mitochondrial state-4 respiration capacity and COX activity in liver and muscle,than Bramblings and Little Buntings.Furthermore,interspecific differences in BMR were strongly correlated with those indigestive tract mass,state-4 respiration and COX activity.Conclusions:Our findings suggest that the digestive organ mass,state-4 respiration and COX activity play an important role in determining interspecific differences in BMR. 展开更多
关键词 basal metabolic rate(BMR) CYTOCHROME c oxidase(COX) state-4 respiration Fringilla montifringilla EMBERIZA pusilla PASSER montanus
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Food restriction decreases BMR,body and organ mass,and cellular energetics,in the Chinese Bulbul(Pycnonotus sinensis) 被引量:1
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作者 Yiying Zhang Ke Yang +3 位作者 Peipei Yang Yingshi Su Weihong Zheng Jinsong Liu 《Avian Research》 CSCD 2018年第4期370-380,共11页
Background: Food is an important environmental factor that affects animals' energy metabolism and food shortage has significant effects on animals' behavior, physiology and biochemistry. However, to date few s... Background: Food is an important environmental factor that affects animals' energy metabolism and food shortage has significant effects on animals' behavior, physiology and biochemistry. However, to date few studies have focused on the thermogenesis and its effects on the body condition of birds. In this study, we examined the effects of food restriction on the body mass, basal metabolic rate(BMR) and body composition, and several physiological, biochemical and molecular markers potentially related to thermogenesis, in the Chinese Bulbul(Pycnonotus sinensis).Methods: Birds in the control group were provided with food ad libitum whereas those in the food restriction group were provided with one-half of the usual quantity of food for 12 days. Oxygen consumption was measured using an open-circuit respirometry system. Mitochondrial state 4 respiration and cytochrome c oxidase(COX) activity in the liver and pectoral muscle were measured with a Clark electrode. Avian uncoupling protein(avUCP) mRNA expression was determined in pectorals muscle with quantitative Real-time PCR.Results:Chinese Bulbuls in food restriction group decreased in body mass,BMR and internal organ(heart,kidneys,small intestine and total digestive tract)mass compared with the control group over the 12-day period of food restriction.Bulbuls in the food restriction group also had lower levels of state-4 respiration,COX activity in the liver and muscle,and mitochondrial avUCP gene expression in muscle compared to the control group.BMR was positively correlated with body mass,state 4 respiration in the liver and COX activity in the muscle.Conclusions:Our data indicate that Chinese Bulbuls not only sustain food shortage through simple passive mechanisms,such as reducing body and organ mass and energy expenditure,but also by reducing energetic metabolism in the liver and muscle. 展开更多
关键词 Avian UNCOUPLING protein basal metabolic rate CYTOCHROME c OXIDASE Food restriction Pycnonotus sinensis state-4 respiration
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Regional homogeneity abnormalities in patients with tensiontype headache:a resting-state fMRI study 被引量:7
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作者 Pian Wang Handan Du +4 位作者 Ning Chen Jian Guo Qiyong Gong Junran Zhang Li He 《Neuroscience Bulletin》 SCIE CAS CSCD 2014年第6期949-955,共7页
Tension-type headache(TTH) is the most prevalent type of primary headache. Many studies have shown that the pathogenesis of primary headache is associated with fine structural or functional changes. However, these s... Tension-type headache(TTH) is the most prevalent type of primary headache. Many studies have shown that the pathogenesis of primary headache is associated with fine structural or functional changes. However, these studies were mainly based on migraine. The present study aimed to investigate whether TTH patients show functional disturbances compared with healthy subjects. We used restingstate functional magnetic resonance imaging(f MRI) and regional homogeneity(Re Ho) analysis to identify changes in the local synchronization of spontaneous activity in patients with TTH. Ten patients with TTH and 10 age-, gender-, and education-matched healthy controls participated in the study. After demographic and clinical characteristics were acquired, a 3.0-T MRI system was used to obtain restingstate f MRIs. Compared with healthy controls, the TTH group exhibited significantly lower Re Ho values in the bilateral caudate nucleus, the precuneus, the putamen, the left middle frontal gyrus, and the superior frontal gyrus. There was no correlation between mean Re Ho values in TTH patients and duration of TTH, number of attacks, duration of daily attacks, Visual Analogue Scale score, or Headache Impact Test-6 score. These results suggest that TTHpatients exhibit reduced synchronization of neuronal activity in multiple regions involved in the integration and processing of pain signals. 展开更多
关键词 tension-type headache resting-state fMRI ReHo basal ganglia
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经皮耳穴迷走神经刺激治疗难治性抑郁症的脑机制fMRI研究 被引量:17
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作者 陈丽梅 李小娇 +10 位作者 许可 郭春蕾 张国雷 韩铭 王智 荣培晶 何家恺 孙继飞 许凤全 王红星 方继良 《针刺研究》 CAS CSCD 北大核心 2021年第10期869-874,共6页
目的:探索经皮耳穴迷走神经刺激(taVNS)治疗难治性抑郁症(TRD)的脑功能网络机制。方法:28例TRD患者均给予8周taVNS耳甲部治疗,采集治疗前后汉密尔顿抑郁(HAMD-17)量表评分和fMRI静息态脑功能磁共振数据进行统计分析。结果:24例患者完成... 目的:探索经皮耳穴迷走神经刺激(taVNS)治疗难治性抑郁症(TRD)的脑功能网络机制。方法:28例TRD患者均给予8周taVNS耳甲部治疗,采集治疗前后汉密尔顿抑郁(HAMD-17)量表评分和fMRI静息态脑功能磁共振数据进行统计分析。结果:24例患者完成了临床研究,其中23例完成脑fMRI试验。患者治疗后HAMD-17评分降低(P<0.01),平均减分率为66.95%,其中11例痊愈,7例显著进步,5例进步,1例无效,总有效率为95.83%。8周治疗后,TRD患者的右侧岛叶、壳核的低频振幅(ALFF)和局部一致性(ReHo)值,前扣带回、右侧尾状核、右侧丘脑ReHo值,右侧岛叶与左侧额上回、额中回静息态功能连接(rs-FC)值均低于治疗前(P<0.05)。TRD患者治疗前后ALFF差异脑区与HAMD-17减分率无相关关系。右侧岛叶ReHo差值与HAMD-17减分率呈显著负相关(P=0.001,r=-0.633);右侧岛叶与左侧额上回的rs-FC差值与HAMD-17减分率呈显著负相关(P=0.012,r=-0.512)。结论:右脑岛-左额上回功能变化可能是taVNS治疗TRD的脑网络机制,taVNS还对基底节及边缘叶脑区产生了效应。 展开更多
关键词 经皮耳穴迷走神经刺激 难治性抑郁症 静息态功能磁共振成像 基底节 岛叶-前额叶功能网络
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