Homogenization Construction of Three-Level Teaching Bases for General Practice Medicine Under the Internet+Model

With the continuous expansion of medical student enrollment,the number of clinical teaching bases is gradually increasing.However,there are significant differences in clinical teaching management models and teaching levels among different bases.Most clinical teaching bases have incomplete teaching management systems,inadequate teaching management institutions,insufficient teaching personnel,and inadequate implementation of teaching rules and regulations.This article combines the construction practice of three-level clinical teaching base of the General Medicine College and the First Affiliated Hospital of Xi’an Medical University.We establish a standardized management system for the three-level clinical teaching base;implement a teaching supervision system and strengthen the monitoring of teaching quality;adopt multiple evaluations to test the effectiveness of clinical teaching implementation;explore the path of homogenization construction of teaching bases in terms of unified teacher training,promoting the development of teacher teaching abilities with equal quality and excellence,and providing a reference for improving the quality of medical talent training.

Physiological and molecular bases of the boron deficiency response in tomatoes

Boron is an essential microelement for plant growth.Tomato is one of the most cultivated fruits and vegetables in the world,and boron deficiency severely inhibits its yield and quality.However,the mechanism of tomato in response to boron deficiency remains largely unclear.Here,we investigated the physiological and molecular bases of the boron deficiency response in hydroponically grown tomato seedlings.Boron deficiency repressed the expression of genes associated with nitrogen metabolism,while it induced the expression of genes related to the pentose phosphate pathway,thereby altering carbon flow to provide energy for plants to cope with stress.Boron deficiency increased the accumulation of copper,manganese and iron,thereby maintaining chlorophyll content and photosynthetic efficiency at the early stage of stress.In addition,boron deficiency downregulated the expression of genes involved in cell wall organization and reduced the contents of pectin and cellulose in roots,ultimately retarding root growth.Furthermore,boron deficiency markedly altered phytohormone levels and signaling pathways in roots.The contents of jasmonic acid,jasmonoy1-L-isoleucine,trans-zeatin riboside,abscisic acid,salicylic acid,and SA glucoside were decreased;in contrast,the contents of isopentenyladenine riboside and ethylene precursor 1-aminocyclopropane-1-carboxylic acid were increased in the roots of boron-deficient tomato plants.These results collectively indicate that tomato roots reprogram carbon/nitrogen metabolism,alter cell wall components and modulate phytohormone pathways to survive boron deficiency.This study provides a theoretical basis for further elucidating the adaptive mechanism of tomato in response to boron deficiency.

Synthesis, Characterization and Biological Activity Evaluation of Schiff Bases Derived from 1,8-Diaminonaphtalène

The compounds have been synthesized and characterized by routine MS, IR and NMR spectrometry methods. The compounds are all active on bacterial strains with the exception of Salmonella typhimirium, with a MIC value of 7.5 mg/mL. They show a percentage of anti-radical activity of 75.476 ± 5.070 for the compound DAN-S and of 68.142 ± 6.539 for the compound DAN-OV. The compounds are sensitive to the two champions used. DAN-S compound is then the most active.

Solving the k-Independent Sets Problem of Graphs by Gröbner Bases

The aim of this paper is to given an algebraic computational method for finding maximal independent sets as well as the independent number of an arbitrary finite graph of n vertices G by strengthening the problem of finding maximal independent sets of G to the problem of finding k-independent sets in G for. It is shown that the existence of k-independent sets in G is equivalent to the existence of solutions of a system of multivariate polynomial equations. It follows that the problem of finding k-independent sets can be realized by using Gröbner bases of polynomial ideals. Since the number of k-independent sets is finite, the triangular equations composed by Gröbner bases are easier to be solved. Consequently, the maximal independent sets and the independent number of G are obtained after solving at most n such equations. Finally, the numerical example is presented to illustrate the effectiveness of this algebraic computational method.

Novel Mannich Bases of Benzimidazole Derivatives: An Antibacterial Study of Environmental Bacterial Strains

A previous study was conducted on the synthesis and antibacterial evaluation of Mannich bases of 2-(thioalkyl)-1H-methylbenzimidazole derivatives. The results of this study showed that certain 2-(thioalkyl)-1H-methylbenzimidazole and 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl)benzimidazole derivatives possess antibacterial activities against clinical strains, such as Escherichia coli, Klebsiella pneumonia (Gram-negative bacteria), Staphylococcus aureus and Pseudomonas aeruginosa (Gram-positive bacteria). Following these favorable results, we extended the antibacterial evaluation of this series of molecules to environmental strains. The aim of this study was to assess the impact of the methyl-piperidine group fixed at position-1 of this new series of benzimidazoles on the antibacterial activity of environmental strains. In addition, we first evaluated the antibacterial activity of four 2-(thioalkyl)methylbenzimidazole derivatives and then that of five 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives. This study allowed us to show that compounds 1d and 1e could inhibit bacterial growth in vitro of the Enterobacteria P1 strain with inhibition diameters of 17.3 ± 0.6 mm and 10 ± 0.0 mm, respectively. However, addition of methyl-piperidinyl in this series showed that five (5) of 2-(thioalkyl)-methyl-1-(piperidin-1-ylmethyl) benzimidazole derivatives had an inhibitory effect on the in vitro growth of bacterial strains used except on Enterobacteria P2 with inhibition diameters between 10.0 ± 0.8 mm and 27.9 ± 1.4 mm. The introduction of the methyl-piperidinyl group at the 1-position of 2-(thioalkyl)-1H-methylbenzimidazole derivatives greatly improved the antibacterial activity against environmental bacteria such as Escherichia coli A1, A2, A3, and A4 and two Enterobacteria P1.

Discussion on Construction and Mechanism of Practice Bases for Professional Degree Postgraduates Based on the Integration of Production and Education in Local Universities

Under the background of emerging agricultural education,practice bases are an important place to train profession talented person that match social needs,so it is very important to build stable and long-term practice bases.At present,the main problems in the construction of practice bases for postgraduates in local colleges and universities are mainly focusing on construction and neglecting management,imperfect cooperation mechanism and lack of teaching management effectively.It is of great significance to build a long-term management mechanism to ensure the education quality of practice bases.Therefore,constructing the mode of"double integration and double promotion of production and education"with practice bases as the carrier and realizing the organic combination of industrial needs and postgraduate projects is an important idea for local colleges and universities to train professional degree postgraduates to"know agriculture,love agriculture,strengthen agriculture and promote agriculture",and it also provides a reference for the mechanism construction of postgraduate bases.

切顶沿空留巷充填体—矸石协同承载机理及控制技术研究

针对深部沿空留巷顶底板移近量大、充填体大变形破坏失稳等问题,采用数值模拟和现场实践相结合的方法,分析了传统沿空留巷和切顶卸压协同承载沿空留巷围岩应力演化规律和变形特征,揭示了切顶沿空留巷充填体—矸石协同承载机理。在此基础上,以朱庄煤矿Ⅲ635工作面沿空留巷为工程背景,提出了一种巷旁充填体—矸石组合结构体协同承载的切顶卸压沿空留巷技术,建立充填体—矸石协同支撑顶板力学模型、推导出顶板挠度方程,并进行工程应用。数值模拟结果表明:采用切顶卸压协同承载沿空留巷技术后,实体煤帮和充填体的垂直应力峰值分别降低了28.3%、44.4%,巷道顶底板移近量降低了58.2%。现场应用结果表明:采用该技术后,顶底板和两帮移近量分别为382.9、253.6 mm,工作面支架平均支撑力下降了45.3%,有效控制了巷道变形。可为类似条件下沿空留巷围岩控制提供参考。

论基于“病、证、征结合”方剂的主治表述

目前对方剂主治的规范性研究较少,通过对方剂主治源流的梳理并分析《方剂学》教材中方剂主治描述中存在的问题,提出“病、证、征结合”3个层次的方剂主治描述规范,从而有利于临证依法用方、规范教材和规范方剂的科学研究。

相邻空区影响下三软巷道变形破坏规律与煤柱留设宽度研究

为了探究相邻空区影响下三软煤层巷道掘进时不同煤柱宽度下巷道围岩变形破坏规律,采用理论计算、数值模拟、物理相似模拟与现场实测相结合的研究方法,分析存在临空区后不同区段煤柱宽度下巷道围岩应力演化规律、塑性破坏范围以及位移分布特征。结果表明:临空区是造成巷道掘进后非对称破坏的主要原因,使煤柱主应力方向与垂向夹角增大,巷道两帮应力呈煤柱侧大于实体煤侧的非对称分布特征;三软巷道破坏形式以剪切破坏为主,破坏主体为两帮,随着煤柱宽度增大,主应力方向与垂向夹角减小,巷道围岩破坏程度降低,临空区对巷道不同位置的影响程度不同,巷道中部围岩破坏程度大于端头处且煤柱侧破坏程度大于实体煤侧;煤柱宽度增大对巷道围岩应力以及煤柱破坏的改善程度有限,现场结果显示当煤柱宽度为20 m时巷道正常维护满足需求。

深部沿空巷道锚固围岩破坏失稳能量驱动机理

深部沿空巷道受侧向顶板断裂所产生的动载影响,锚固围岩易产生大变形,甚至破坏失稳。以山东省孙村煤矿31120工作面上平巷为工程背景,首先采用YTJ20型岩层探测记录仪获得了锚固顶板裂隙发育规律及以脆性张裂破坏为主的破坏方式。然后,通过相似材料模拟试验方法获得了深部沿空巷道侧向顶板前期、过渡期和后期3个运动阶段典型特征,并分析了不同阶段锚固围岩破裂演化及能量释放规律;其中过渡期运动阶段锚固围岩内部应力、变形量急剧增大,裂隙发育明显,能量释放显著,对沿空巷道锚固围岩稳定性影响最大。最后,构建了侧向顶板断裂运动下沿空巷道结构力学模型,给出了锚固围岩输入能量与可抵抗能量定量计算方法,揭示了侧向顶板断裂诱发锚固围岩破坏失稳能量驱动机理,并定义了失稳能量判据,即当作用在沿空巷道锚固围岩上的能量大于锚固围岩可抵抗能量时,将发生破坏失稳。进一步地,提出了锚固围岩失稳风险等级划分方法和相应地控制技术,计算结果表明,31120工作面沿空巷道锚固围岩失稳风险等级为中风险。采取加强支护措施后,沿空巷道顶底板及两帮移近量分别减小35.47%和35.71%,锚索受力减小23.43%,变形速度明显降低,锚固围岩能量积聚程度减小。

基于循证证据的脑卒中相关性肺炎预防措施在ICU急性缺血性脑卒中病人中的应用效果

目的:总结预防脑卒中相关性肺炎的循证证据并评价其临床应用效果。方法:选择2022年1月—12月安徽省某三级甲等医院神经内科ICU收治的59例急性缺血性脑卒中病人为研究对象,将2022年1月—5月收治的29例重症脑卒中病人为基线组,2022年8月—12月收治的30例重症脑卒中病人为循证实践组。以基于证据的持续质量改进模型作为理论框架,通过证据获取、现状审查、证据引入和效果评价4个阶段将脑卒中相关性肺炎预防的证据转化为临床实践。比较循证实践前后两组脑卒中病人脑卒中相关性肺炎的发生率、炎症指标和临床结局指标,以及循证实践前后医护人员预防脑卒中相关性肺炎证据认知水平变化。结果:最终纳入18条证据,并转化为10条审查指标。循证实践后,病人脑卒中相关性肺炎发生率及白细胞计数、C反应蛋白、ICU住院时间均明显降低(P<0.05)。循证实践后医护人员预防脑卒中相关性肺炎知识审查指标执行率均提高(P<0.05)。结论:以证据为基础的循证护理实践能够提高医护人员循证知识知晓率及对最佳证据的依从性,改善脑卒中病人的炎症指标,缩短ICU住院时间,降低脑卒中病人脑卒中相关性肺炎的发生率。

沥青基碳纤维的制备工艺、反应机理及调控方法

沥青基碳纤维是重要的工程碳纤维之一,在航空航天、国防军工等领域具有广泛应用。沥青基碳纤维制备流程长、影响因素多,归咎于对其制备工艺、反应机理及调控方法的认识不足,迄今工业化生产强度性能优异的沥青基碳纤维仍面临诸多困难。以碳纤维生产流程为主线,针对原料预处理、沥青前驱体调制、熔融纺丝、预氧化及炭化与石墨化的现状、方法、机理及调控进行深入探讨分析。沥青基碳纤维的原料有煤系、石油系、生物质系、高分子系和纯化合物,原料预处理方法主要有蒸馏和萃取;沥青前驱体的调制本质是以氢转移反应和自由基反应并行的液相炭化反应,包括环化、芳构化、低聚和缩聚等复杂的反应过程。芳烃低聚物在高温下缩聚形成稠环芳烃片状大分子的基本结构单元,基本结构单元经过热运动不断聚集,形成聚集体;由于范德华力作用使基本结构单元相互堆叠,形成平行堆积体,进而通过层积、堆积等过程形成基本构筑单元聚集体。基本构筑单元聚集体在不同反应条件下可以转变为长程无序、短程有序的难石墨化结构,也可以转变为长程有序、短程有序的易石墨化结构。以煤系、石油系和生物质系物质为原料调制沥青前驱体时,因其反应活性好,通常选用设备简单、操作容易、成本低廉的热缩聚法;而当以萘、甲基萘等纯化合物为原料时,因其反应活性差,需要较高的温度才能引发自由基反应,故通常采用催化合成法。熔融纺丝宏观上起到塑型的作用,通过改变纺丝参数和喷丝板的形状分别可以调节碳纤维的直径和形状;此外,熔融纺丝对中间相沥青前驱体的重排分子作用尤为明显,使得石墨微晶更易沿轴向一维排列形成有序的石墨晶体结构。为使沥青纤维在炭化过程中不发生融化,需要将沥青纤维由热塑性转变为热固性,即通过轻微的氧化反应,让沥青中的稠环芳烃分子经历氧化、缩合、分解和脱水,从而形成特定的交联结构,最终在纤维结构中生成一定量的含氧官能团。炭化是使预氧化后的纤维经过复杂的化学反应和结构转变形成具有炭材料分子结构特征的碳纤维。炭化过程中,石墨微晶发生重排,非碳原子被移除,碳元素含量进一步升高;经过石墨化后,石墨晶体结构更加完整、取向度更高,使碳纤维向石墨纤维转变,强度性能更加优异。另外,针对沥青基碳纤维的突破方向,提出了从分子维度定向可控制备的思路;并为碳纤维生产过程中耗时耗能的预氧化步骤的优化改进提供了具体方法。

大倾角走向长壁工作面局部充填无煤柱开采理论与技术

大倾角煤层走向长壁采场围岩结构及应力环境异化,工作面不同位置“支架-围岩”系统的构成因素及灾变模式不同,导致工作面安全事故频发、煤炭采出率较低、巷道掘进率高。通过对大倾角采场围岩采动力学行为的分析,提出了大倾角走向长壁工作面局部充填无煤柱开采技术构想,工作面走向推进过程中沿倾向对采空区下部进行局部充填,充填体既与巷旁支护作用形成沿空巷道,取消区段保护煤柱,实现大倾角煤层无煤柱开采,又增大了工作面倾向下部充填压实区长度,加强了工作面“支架-围岩”系统稳定性。根据大倾角走向长壁采场特点,优选确定了大倾角膏体局部充填工艺,设计了大倾角局部充填回采系统、采充工艺。并采用理论分析、模拟实验、数值计算等相结合的方法,分析了局部充填对大倾角走向长壁采场围岩采动力学行为的调节机制。结果表明:充填体影响基本顶岩梁的变形破坏及采场倾向下侧煤岩体承载特征,基本顶、运输巷顶板变形量及运输巷倾向下侧煤岩体所受约束均随充填长度的增大而减小;为防止采空区未充填区悬顶灾害,充填长度不应超过工作面长度的1/3。局部充填体限制了工作面下部区域顶板破断,降低覆岩关键域形成层位,形成稳定的巷帮,减小沿空留巷围岩变形量;同时工作面倾向下部充填区长度增大,中、上部围岩结构不稳定区域的长度缩小,“支架-围岩”系统稳定性提升。充填体改变了采场围岩应力传递路径,承担了部分覆岩载荷,工作面下侧支承压力及超前支承压力均随充填长度的增大而减小,工作面倾向下部充填区域的超前支承压力降幅最大,沿空巷道及工作面应力状态得到改善。大倾角走向长壁工作面局部充填无煤柱开采技术具有提高资源采出率、降低掘进率、缓解采掘接替紧张、加强工作面“支架-围岩”系统稳定性等优势。

贵州沿空留巷支护技术的分析与改进

针对贵州某煤矿沿空留巷在原有支护条件下,靠上帮一侧顶板以及下帮底角的岩层变形破坏较严重的情况,对巷道支护方式进行改进。利用数值模拟软件,对改进支护后的巷道围岩变形破坏情况进行分析。研究发现:改进支护后的巷道围岩变形破坏情况得到明显改善,改进后的支护方式能够较好地阻滞巷道上帮一侧顶板和下帮底角的岩层严重变形破坏,从而保持巷道围岩的完整性和稳定性,研究可为类似条件矿井沿空留巷的支护方式提供参考。

喷施不同浓度海藻叶面肥对茶叶产量和品质的影响

研究不同浓度的海藻叶面肥(Organic-based biostimulant formulas,OBFs)喷施下茶青产量和品质的变化,为红壤区茶树高产优质栽培提供理论指导。在常规施肥的基础上,以不喷施OBFs为对照(T0),在茶园设置5个OBFs叶面肥喷施体积分数0.33%、0.66%、0.99%、1.32%、1.65%,分别记为T_(1)、T_(2)、T_(3)、T_(4)、T_(5),研究喷施不同浓度OBFs对茶树嫩叶吸收养分、以及茶产量与品质的影响。结果表明,喷施OBFs可以改善茶树农艺性状、促进嫩叶吸收养分和增产提质。与T0相比,T_(1)、T_(2)、T_(3)、T_(4)、T_(5)处理茶青产量分别增加1.4、1.4、1.3、2.1、2.4倍(P<0.05)。随着OBFs喷施浓度增加,茶青总生物碱、咖啡碱和氨基酸的含量先升后降。与T0相比,T_(1)和T_(2)处理茶青总生物碱分别增加9.6%和9.3%,咖啡碱分别增加9.3%和11.4%,氨基酸含量分别增加5.0%和12.4%(P<0.05)。此外,T_(1)和T_(2)处理下茶青氮含量分别增加5.5%和6.1%,磷含量分别增加19.9%和13.3%,钾含量分别增加20.9%和10.0%;T_(1)处理下茶青硅含量增加14.8%(P<0.05)。茶青产量与芽头密度、百芽重、节间长、叶面积、叶绿素含量均显著正相关;茶青咖啡碱、总生物碱与茶青氮、磷、钾和硅含量呈显著正相关,茶青非必需氨基酸、必需氨基酸含量与茶青氮、磷、钾含量均有显著的正相关关系。综上所述,喷施OBFs可以提高茶青产量,其中以喷施1.65%OBFs茶青产量较高,喷施0.33%、0.66%OBFs可以提高茶树嫩叶氮、磷、钾和硅元素的含量,改善茶树农艺性状,实现茶青产量和品质的双提升。

无机化学中“酸碱解离”教学内容的重构探讨

依据素质教育中知识-能力-素质有机融合的思想指导,对《无机化学》酸碱解离内容进行重组,构建新的课程设计模块。内容重组扩充为5个模块,包括电解质溶液基础、酸碱理论概述、酸碱强度、弱酸弱碱解离平衡和酸碱滴定与误差基本概念。教学内容的重构在保证基本面知识结构完整的前提下与时俱进,从专业能力方面促进学生发展。

千米深井切顶卸压自成巷支护技术及应用

为了解决深部复杂条件下的切顶卸压自成巷难题,以红阳三矿703工作面运输巷道为研究对象,从恒阻大变形锚索超前支护、切顶巷内支护、切顶巷旁支护三个方面研究了切顶卸压沿空成巷支护技术,并对现场试验巷道顶板受力以及巷道围岩变形量进行了监测。结果表明:在超前工作面实施爆破切顶能够极大降低巷道所受应力,成巷区巷道顶板整体下沉量较小,巷中顶板最大下沉量约385 mm,平均下沉量约280 mm,巷中底鼓最大值545 mm,碎石巷帮无明显侧鼓现象,实体煤帮无明显片帮现象,满足安全和使用要求,巷道围岩变形在可控范围内,留巷效果良好。

TBL-CBL-PBL三轨联合教学模式在血液科住院医师规范化培训中的应用

目的探讨基于团队的学习(TBL)-基于案例的学习(CBL)-基于问题的学习(PBL)三轨联合教学模式在血液科住院医师规范化培训中的应用。方法选取在新乡医学院第一附属医院轮转的192名住培医师为研究对象,随机将其分为试验组和对照组,各96名。试验组实施TBL-CBL-PBL三轨联合教学模式,对照组实施传统教学模式。比较两组的教学效果。结果试验组的理论考试、客观结构化临床考试(OSCE)及教学查房总成绩均高于对照组(P<0.05)。试验组的学习兴趣、临床思维能力、自学能力提高度均高于对照组(P<0.05)。结论TBL-CBL-PBL三轨联合教学模式在血液科住院医师规范化培训中的应用效果较好。

基于OBE理念的药物临床试验课程教学改革研究

首都医科大学将成果导向型教学(OBE)理念引入药物临床试验课程教学改革中。教师针对课程教学内容更新速度快、教学方式传统陈旧、考评模式较为单一等普遍存在的问题,以学生为中心组织和引导教学过程,优化教学大纲、改善教学方法、提升自身教学能力、完善学生评价体系,有效提升了教学产出和学生的创新性学习能力,可为相关课程教学改革提供借鉴。

基于力学模型构建的留巷切顶高度确定与围岩控制技术

以顺和煤矿2401运输巷道沿空留巷为工程背景,分析巷道围岩结构特征,基于巷道局部空间结构稳定性,分别构建了沿空留巷未切顶与切顶力学结构模型,并以巷道不同切顶高度进行物理相似模拟试验。结果表明:巷旁采空区切落的矸石增加对关键块的支撑力,同时弱化关键块对直接顶悬壁端部挤压,巷旁支护阻力减少35.78%;随着切顶高度增加,巷道顶板采空区侧端部悬臂由F型缓慢过渡到大I型,同时大保护结构具有向上平移趋势,相比于未切顶1巷,4 cm切顶2巷、8 cm切顶3巷与16 cm切顶4巷叠加应力峰值分别下降9.38%,28.13%,25.00%。结合巷道顶板岩性,最终确定切顶高度为8.2 m,留巷段采用三列单体液压支柱作巷旁支护,长短锚索超前补强,巷道围岩稳定,较好满足使用要求。