Mass spectrometry detection of basic drugs in fast chiral analyses with vancomycin stationary phases

Current trends in chiral analysis of pharmaceutical drugs are focused on faster separations and higher separation efficiencies, Core-shell or superficially porous particles （SPP） based chiral stationary phases （CSPs） provide reduced analysis times while maintaining high column efficiencies and sensitivity. In this study, mobile phase conditions suitable for chiral analyses with electrospray ionization LC-MS were systematically investigated using vancomycin as a representative CSP. The performance of a 2.7 μm SPP based vancomycin CSP （SPP-V） 10 cm ×0.21 cm column was compared to that of a corresponding 5 μm fully porous particles based analogue column. The results demonstrated that the SPP-V column provides higher efficiencies, 2-5 time greater sensitivity and shorter analysis time for a set of 22 basic pharma- ceutical drugs. The SPP-V was successfully applied for the analysis of the degradation products of racemic citalopram whose enantiomers could be selectively identified by MS.

ON THE POSITION AND ROLE OF BASIC RESEARCH EXEMPLIFIED BY THE DEVELOPMENT OF THE DRUG "DI'AOXINXUEKANG

Basic research features its indelible contribution to and energetic promotion of scientific cause and advancing social progress. This article explores its vital position and rewarding role in creating socio-economic benefits by reviewing the development and marketing success of a new drug, "Di’ aoxinxuekang".

泸州市12所非基层医疗机构实施基本药物制度的成效分析

目的通过对四川省泸州市非基层医疗机构基本药物使用情况调查,评价国家基本药物制度的实施现状,向卫生行政部门优化基本药物品种目录提供参考数据。方法将泸州市3所三级医疗机构和9所二级医疗机构作为样本,对2010年1月1日~2012年12月31日使用的基本药物品种数及销售金额进行汇总、统计、分析。结果非基层医疗机构配备基本药物品种数,2010~2012年,三甲医院平均配备率分别是15.62%、17.84%、20.01%;二甲医院平均配备率分别是29.35%、32.16%、35.07%;二乙医院平均配备率分别是34.73%、37.05%、40.02%;基本药物销售百分比,三甲医院平均分别为10.43%、12.38%、15.04%;二甲医院平均分别为25.08%、27.24%、30.12%;二乙医院平均分别为29.24%、32.08%、35.03%。结论非基层医疗机构应切实执行国家基本药物制度,加强基本药物政策宣传,努力提高基本药物的配备率;监督医师的用药行为,提高基本药物使用率,保证基本药物制度的顺利实施。建议进一步优化完善基本药物目录,促进合理用药。

基于医院抢救车药品使用分析的配备建议

目的通过分析抢救车药品的使用记录,为合理配备医院抢救车及抢救车药品的品种与基数提供一些建议。方法收集2017年各科室急救用药使用及补充记录,在医院内网系统核对后,用Excel表格登记相关信息,统计抢救车使用情况和药品使用情况,应用四分位法统计每种药品的单人次75%分位点用量。结果全院57辆抢救车35辆有使用记录,使用药品34个品规6004支/瓶,其中登记34个品规4983支/瓶,未登记28个品规1021支/瓶;80%以上科室使用了医院统一的急救用药使用及补充专用记录;抢救车之外的药品共计使用52种575支/瓶,使用最广泛的为0.9%氯化钠50 mL;应用四分位法得到的肾上腺素、多巴胺等的单人次75%分位点用量分别为5支、10支等。结论部分科室抢救车配备的必要性有待探讨,建议推广使用急救用药使用及补充专用记录;本院配备的抢救车药品基本能满足临床抢救需要,但配备品种和基数有待优化,建议普通临床科室统一配备肾上腺素、多巴胺等10个药品品规,根据科室特点再选择其他药品备用;建议急诊抢救室、ICU、儿科等科室个性化配备抢救药品;建议各科室根据科室抢救情况以药品的单人次75%分位点用量的不同倍数配备药品基数。

Separation of Basic Drugs Using Pressurized Capillary Electrochromatography

A novel pressurized capillary electrochromatography (PCEC) was developed to separate basic drugs on strong cation exchange (SCX) column. The separation result by using PCEC was better than that by using micro-HPLC. The effects of electrical field and pressure on plate height and resolution were investigated. Influences of organic modifier, ionic strength and pH value of buffer on retention behavior were evaluated, and the separation mechanism was also discussed.

A Novel Polybrene/Chondroitin Sulfate C Double Coated Capillary and Its Application in Capillary Electrophoresis

A new capillary coated by double polymer, polybrene/chondroitin sulfate C (P/CC), was developed using a simple procedure. The P/CC double coated capillary showed long lifetime, strong chemical stability and good reproducibility. It endured during more than 100 replicated analyses and was also tolerant to HCl (1 mol/L), NaOH (0.01 mol/L), CH3OH and CH3CN. The P/CC double coated capillary can be applied to basic drug analyses. The adsorption of basic drugs to the capillary wall was suppressed and the peak tailing greatly decreased. The use of the P/CC double coated capillary allowed excellent separation of the enantiomers of some basic drugs by using chondroitin sulfate C as the chiral selector, and the peak symmetry of basic drugs was further improved under these conditions.