Gamma band oscillation（GBO） and sensory gating（SG） are associated with many cognitive functions.Ketamine induces deficits of GBO and SG in the prefrontal cortex（PFC）. However, the time-courses of the effects of ...Gamma band oscillation（GBO） and sensory gating（SG） are associated with many cognitive functions.Ketamine induces deficits of GBO and SG in the prefrontal cortex（PFC）. However, the time-courses of the effects of different doses of ketamine on GBO power and SG are poorly understood. Studies have indicated that GBO power and SG have a common substrate for their generation and abnormalities. In this study, we found that（1） ketamine administration increased GBO power in the PFC in rats differently in the low-and high-dose groups;（2） auditory SG was significantly lower than baseline in the 30 mg/kg and 60 mg/kg groups, but not in the 15 mg/kg and 120 mg/kg groups; and（3） changes in SG and basal GBO power were significantly correlated in awake rats. These results indicate a relationship between mechanisms underlying auditory SG and GBO power.展开更多
基金supported by a grant from the First Affiliated Hospital of Kunming Medical University (2015BS015)grants from the joint projects of Yunnan Province (40215003, H-201639 and 2017FE468(-250))a grant from the Ministry of Science and Technology of the People’s Republic of China (2011BAK04B04)
文摘Gamma band oscillation（GBO） and sensory gating（SG） are associated with many cognitive functions.Ketamine induces deficits of GBO and SG in the prefrontal cortex（PFC）. However, the time-courses of the effects of different doses of ketamine on GBO power and SG are poorly understood. Studies have indicated that GBO power and SG have a common substrate for their generation and abnormalities. In this study, we found that（1） ketamine administration increased GBO power in the PFC in rats differently in the low-and high-dose groups;（2） auditory SG was significantly lower than baseline in the 30 mg/kg and 60 mg/kg groups, but not in the 15 mg/kg and 120 mg/kg groups; and（3） changes in SG and basal GBO power were significantly correlated in awake rats. These results indicate a relationship between mechanisms underlying auditory SG and GBO power.
基金supported by the National Natural Science Foundation of China(No.31972903)the Science and Technology Commission of Shanghai Municipality(No.18JC1420302)+1 种基金the Shanghai Pujiang Program(No.20PJ1401000)the Innovative Research Team of High-level Local Universities in Shanghai。
