A good wound dressing needs to promote wound healing and tissue repair when the skin is injured.In this study,a self-made spherical section free surface electrospinning device was used to produce large quantities of e...A good wound dressing needs to promote wound healing and tissue repair when the skin is injured.In this study,a self-made spherical section free surface electrospinning device was used to produce large quantities of electrospun porous polylactic acid(PLA)/chitosan(CS)/aloin nanofiber membranes(NFMs)for antibacterial wound dressing.The porous structures of PLAbased nanofibers were controlled by adjusting the weight ratios of mixed solvent and solute.The results showed that highquality porous PLA/CS/aloin(PCA)NFMs were obtained when the weight ratios of chloroform/N,N-dimethylformamide and PLA:CS were 90/10 and 7:1,respectively.The porous PCA NFMs exhibited high porosity,acceptable mechanical properties,moderate hydrophobicity,good swelling property,and high water vapor transmission rate.Moreover,they also showed excellent blood coagulative,antibacterial,biocompatible properties,which had the potential to be used in the application of antibacterial wound dressings.展开更多
基金The work is supported financially by National Natural Science Foundation of China(Grant no.11672198)Jiangsu Higher Education Institutions of China(Grant no.20KJA130001)+1 种基金Six Talent Peaks Project of Jiangsu Province(Grant no.GDZB-050)PAPD(A Project Funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions).
文摘A good wound dressing needs to promote wound healing and tissue repair when the skin is injured.In this study,a self-made spherical section free surface electrospinning device was used to produce large quantities of electrospun porous polylactic acid(PLA)/chitosan(CS)/aloin nanofiber membranes(NFMs)for antibacterial wound dressing.The porous structures of PLAbased nanofibers were controlled by adjusting the weight ratios of mixed solvent and solute.The results showed that highquality porous PLA/CS/aloin(PCA)NFMs were obtained when the weight ratios of chloroform/N,N-dimethylformamide and PLA:CS were 90/10 and 7:1,respectively.The porous PCA NFMs exhibited high porosity,acceptable mechanical properties,moderate hydrophobicity,good swelling property,and high water vapor transmission rate.Moreover,they also showed excellent blood coagulative,antibacterial,biocompatible properties,which had the potential to be used in the application of antibacterial wound dressings.
