Neurophysiological, histological, and behavioral characterization of animal models of distraction spinal cord injury: a systematic review

Distraction spinal cord injury is caused by some degree of distraction or longitudinal tension on the spinal cord and commonly occurs in patients who undergo corrective operation for severe spinal deformity.With the increased degree and duration of distraction,spinal cord injuries become more serious in terms of their neurophysiology,histology,and behavior.Very few studies have been published on the specific characteristics of distraction spinal cord injury.In this study,we systematically review 22 related studies involving animal models of distraction spinal cord injury,focusing particularly on the neurophysiological,histological,and behavioral characteristics of this disease.In addition,we summarize the mechanisms underlying primary and secondary injuries caused by distraction spinal cord injury and clarify the effects of different degrees and durations of distraction on the primary injuries associated with spinal cord injury.We provide new concepts for the establishment of a model of distraction spinal cord injury and related basic research,and provide reference guidelines for the clinical diagnosis and treatment of this disease.

Relationship between parenting stress and behavioral and emotional problems in preschool children: A mediation effect analysis

BACKGROUND Emotional reactions,such as anxiety,irritability,and aggressive behavior,have attracted clinical attention as behavioral and emotional problems in preschool-age children.AIM To investigate the current status of family rearing,parental stress,and behavioral and emotional problems of preschool children and to analyze the mediating effect of the current status of family rearing on parental stress and behavioral/emo-tional problems.METHODS We use convenience sampling to select 258 preschool children in the physical examination center of our hospital from October 2021 to September 2023.The children and their parents were evaluated using a questionnaire survey.Pearson's correlation was used to analyze the correlation between child behavioral and emotional problems and parental stress and family rearing,and the structural equation model was constructed to test the mediating effect.RESULTS The score for behavioral/emotional problems of 258 preschool children was(27.54±3.63),the score for parental stress was(87.64±11.34),and the score for parental family rearing was(31.54±5.24).There was a positive correlation between the behavioral and emotional problems of the children and the“hostile/mandatory”parenting style;meanwhile,showed a negative correlation with the“support/participation”parenting style(all P<0.05).The intermediary effect value between the family upbringing of parents in parental stress and children's behavior problems was 29.89%.CONCLUSION Parental family upbringing has a mediating effect between parental stress and behavioral and emotional problems of children.Despite paying attention to the behavioral and emotional problems of preschool-age children,clinical medical staff should provide correct and reasonable parenting advice to their parents to promote the mental health of preschool-age children.

Behavioral gastroenterology: An emerging system and new frontier of action

Behavioral gastroenterology is a new interdisciplinary science that explores the influence of unhealthy lifestyles and psychological factors on the digestive system and addresses the prevention,diagnosis,treatment,and rehabilitation of digestive diseases. Moreover,the concept of whole-course intervention with a focus on disease prevention and a new model of integrated therapy based on alterations of lifestyle and psychology are being gradually established. This paradigm may substantively impact the prevention and treatment of digestive diseases.

Reinforcement Learning Behavioral Control for Nonlinear Autonomous System

Behavior-based autonomous systems rely on human intelligence to resolve multi-mission conflicts by designing mission priority rules and nonlinear controllers.In this work,a novel twolayer reinforcement learning behavioral control(RLBC)method is proposed to reduce such dependence by trial-and-error learning.Specifically,in the upper layer,a reinforcement learning mission supervisor(RLMS)is designed to learn the optimal mission priority.Compared with existing mission supervisors,the RLMS improves the dynamic performance of mission priority adjustment by maximizing cumulative rewards and reducing hardware storage demand when using neural networks.In the lower layer,a reinforcement learning controller(RLC)is designed to learn the optimal control policy.Compared with existing behavioral controllers,the RLC reduces the control cost of mission priority adjustment by balancing control performance and consumption.All error signals are proved to be semi-globally uniformly ultimately bounded(SGUUB).Simulation results show that the number of mission priority adjustment and the control cost are significantly reduced compared to some existing mission supervisors and behavioral controllers,respectively.

Establishment and validation of an adherence prediction system for lifestyle interventions in non-alcoholic fatty liver disease

BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is the most common liver disease worldwide,affecting about 1/4th of the global population and causing a huge global economic burden.To date,no drugs have been approved for the treatment of NAFLD,making the correction of unhealthy lifestyles the principle method of treatment.Identifying patients with poor adherence to lifestyle correction and attempting to improve their adherence are therefore very important.AIM To develop and validate a scale that can rapidly assess the adherence of patients with NAFLD to lifestyle interventions.METHODS The Exercise and Diet Adherence Scale(EDAS)was designed based on com-pilation using the Delphi method,and its reliability was subsequently evaluated.Demographic and laboratory indicators were measured,and patients completed the EDAS questionnaire at baseline and after 6 months.The efficacy of the EDAS was evaluated in the initial cohort.Subsequently,the efficacy of the EDAS was internally verified in a validation cohort.RESULTS The EDAS consisted of 33 items in six dimensions,with a total of 165 points.Total EDAS score correlated significantly with daily number of exercise and daily reduction in calorie intake(P<0.05 each),but not with overall weight loss.A total score of 116 was excellent in predicting adherence to daily reduction in calorie intake(>500 kacl/d),(sensitivity/specificity was 100.0%/75.8%),while patients score below 97 could nearly rule out the possibility of daily exercise(sensitivity/specificity was 89.5%/44.4%).Total EDAS scores≥116,97-115,and<97 points were indicative of good,average,and poor adherence,respectively,to diet and exercise recommendations.CONCLUSION The EDAS can reliably assess the adherence of patients with NAFLD to lifestyle interventions and have clinical application in this population.

Non-Overlapping Conditions to Enable Multi- Dimensional Behavioral Models/DPDs for Multi-Band or Non-Continuous Carrier Aggregation Systems

To linearize the multi.band PAs/transmitters, a serial of multi.band predistortion models based on multi.dimensional architecture have been proposed. However, most of these models work properly only for the signals whose harmonic and intermodulation products of carriers' non.overlap with the interested fundamental bands. In this paper, the non.overlapping conditions for dual.band and tri.band signals are derived and denoted in the form of closed.form expression. It can be used to verify whether a given dual.band/multi.band signals can be linearized properly by these multi.dimensional behavioral models. Also the conditions can be used to plan the frequency spacing and maximum bandwidth of a multi.band or non.continuous carrier aggregation signal. Several dual.band and triband signals were tested on the same PA, by employing 2.D DPD and 3.D DPD behavioral models. The measurement results show that the signals which don't satisfy the non.overlapping conditions cannot be linearized well by the multi.dimensional behavioral models which does not take the harmonic and intermodulation products of carriers' into account.

Validation of Symptom Dimensions and Sub-Type Responses in Cognitive Behavioral Therapy in Obsessive Compulsive Disorder: A Systemic Review and Meta-Analysis

Background: Obsessive-compulsive disorder (OCD) is a clinically heterogeneous condition without a conclusivesubtype dimension. This study will focus on the meta-analysis of the clinical responses of OCD subtypes to cognitivebehavioral therapy (CBT), which might clarify this issue. Methods: We performed a systematic search and ameta-analysis for the studies of OCD subtypes and the response to CBT in PubMed, ScienceDirect, Embase, Webof Science, and Scopus databases. The selective criteria were the OCD without significant medical or psychiatricco-morbidities and pre-and post-treatment changes in scores of OCD dimension. In addition, different subtypesof OCD in symptom dimensions, such as symmetry, contamination, unacceptable thoughts, and hoarding, werecompared to find the most significant subtype using the treatment response parameters by CBT. After limitedselection, four studies and 479 OCD subjects were enrolled. The meta-analysis was performed by Review Manager5.4, and only significant results were reported. Results: Among the OCD subtypes, the meta-analysis favors thehoarding subtype with poorer responses to CBT than symmetry, contamination, and unacceptable thoughts.The meta-analysis results were negative mean differences, significant tests for overall effect, and limited heterogeneitiesin the random effects model. In addition, the results were more significant when the hoarding subtypewas compared with non-hoarding subtypes. Conclusion: The hoarding subtype might be the most significantrepresentative subtype of OCD symptom dimension under the impression of unfavorable clinical response toCBT. However, future studies with more treatment parameters will be warranted to confirm this finding.

Conversion of Object Oriented System into Software Product Line with Delta Modeling Abstract Behavioral Specification

This article contains a system conversion from object oriented design into Software Product Line (SPL) using delta modeling of Abstract Behavioral Specification (ABS). ABS is a modeling language which targets system with high level of variety and supports SPL development with delta modeling. The case study of this thesis is a digital library system called Library Automation and Digital Archive (LONTAR). Originally, LONTAR only uses SOAP-based web service. With ABS, LONTAR will be converted into SPL and implement another web service called REST. The motivation of this conversion of LONTAR from object oriented into SPL is because it is easier to develop system with ABS than using regular object oriented. Product definition in ABS is relatively easier than creating a new subclass and do customization to make it works well.

Correlation and pathways of behavioral activation systems mediating physical activity level and depressive symptoms among college students

BACKGROUND Depression is a common mental disorder among college students.The main symptoms include being persistent low mood,sad emotional experiences,lack of pleasure,listlessness,and impaired cognitive function accompanied by tendencies of self-harm and suicide.AIM To clarify the pathways and effects of the behavioral activation system between physical activity and depressive symptoms in college students with depressive symptoms.METHODS This cross-sectional research screened 3047 college students.Of these,472 had depressive symptoms,with a depression detection rate of 15.49%.Furthermore,442 college students with depressive symptoms were analyzed.A one-way analysis of variance and Pearson’s correlation,linear regression,and structural equation modeling analyses were used to explore the correlations and pathways of the interactions between the variables.RESULTS Depressive symptoms were significantly negatively correlated with physical activity(r=-0.175,P<0.001),the behavioral activation system(r=-0.197,P<0.001),and drive(r=-0.113,P=0.017).Furthermore,it was negatively correlated with fun-seeking(FS)(r=-0.055,P=0.251);however,it was not significant.Physical activity was significantly positively correlated with reward responsiveness(RR)(r=0.141,P=0.003)and drive(r=0.124,P=0.009)and not significantly positively correlated with FS(r=0.090,P=0.058).The mediating effect of RR between physical activity and depressive symptoms was significant[B=-0.025,95%confidence interval(95%CI):-0.051 to-0.008,P=0.001].The direct and total effects of physical activity on depressive symptoms and were significant(B=-0.150,95%CI:-0.233 to-0.073,P<0.001;B=-0.175,95%CI:-0.260 to-0.099,P<0.001),respectively.CONCLUSION As physical activity levels increased,depression scores among college students decreased.The mediating effect of RR between physical activity and depressive symptoms was significant.Therefore,colleges and universities should encourage college students with depression to increase their physical activity and improve their behavioral activation system.Particular attention should be paid to RR,which may reduce the prevalence of depressive symptoms.

Interventional effect of cognitive behavioral therapy on cancer-related fatigue in breast cancer patients: A systematic review

Objective:To evaluate the effect of cognitive behavioral therapy on cancer-related fatigue in breast cancer patients.Methods:Computer search for CNKI,VIP,Wanfang database,CBM,PubMed,Embase,CINAHL,The Cochrane library as of 2019 randomized controlled trials on October 20 for cognitive behavioral therapy intervention for breast cancer due to fatigue.Results:A total of 6 RCTs were included,472 patients.Cognitive Behavioral Therapy has a strong effect on cancer related fatigue compared with the usual care[SMD=-1.19,95%CI(-1.86,-0.53),P=0.0004].Results:Available evidence suggests that CBT can alleviate cancer-related fatigue in breast cancer patients,and the above studies still need to continue to conduct relevant studies for validation.

Role of Cognitive Behavioral Therapy in Fibromyalgia: A Systematic Review

A literature search of articles from 2002-2019 was performed using Medline, Embase, Cochrane, LILACS, IBECS, CRD, and Epistemonikos databases, to analyze the effects of Cognitive-Behavioral Therapy (CBT) in the treatment of fibromyalgia. Twenty-seven articles were selected in which CBT was performed exclusively by specialist physicians, associated or not with conventional pharmacological treatment and/or physical exercise. In most articles, CBT worked with self-knowledge and cognitive restructuring, attempting to reduce pain perception, and it showed a general improvement in daily activities by decreasing patient’s limitations, such as morning stiffness. The literature showed significant correlations of CBT in pain processing over time. When CBT was compared to conventional pharmacological therapy, a certain superiority of CBT could be observed concerning the quality of life, catastrophizing, and acceptance of pain. However, when they were simultaneously applied, this improvement in quality of life was not observed.

Inhibition in Action-Inhibitory Components in the Behavioral Activation System

Over the past two decades, the neurobiological substrates of the reinforcement theory have been discussed in terms of a behavioral activation system (BAS) and a behavioral inhibition system (BIS). While the BAS has been conceptualized as both an activating system and an approach-related system, the empirical evidence for either approach remains inconclusive. In the current study we hypothesize that the inclusion of self-regulatory capacity contributes to a better understanding of the BAS. In a sample of 29 volunteers motor response inhibition elicited by a stop-signal task and heart rate variability (HRV) as a proxy of self-regulatory capacity were related to BAS scores (BIS/BAS scales [1]). Results show significant positive associations between inhibitory capacity and the sensitivity of the behavioral activation system, suggesting markers of self-regulation as components of the BAS.

A function-based behavioral modeling method for air combat simulation

Today’s air combat has reached a high level of uncertainty where continuous or discrete variables with crisp values cannot be properly represented using fuzzy sets. With a set of membership functions, fuzzy logic is well-suited to tackle such complex states and actions. However, it is not necessary to fuzzify the variables that have definite discrete semantics.Hence, the aim of this study is to improve the level of model abstraction by proposing multiple levels of cascaded hierarchical structures from the perspective of function, namely, the functional decision tree. This method is developed to represent behavioral modeling of air combat systems, and its metamodel,execution mechanism, and code generation can provide a sound basis for function-based behavioral modeling. As a proof of concept, an air combat simulation is developed to validate this method and the results show that the fighter Alpha built using the proposed framework provides better performance than that using default scripts.

Distributional and behavioral responses of the wintering Oriental Storks to drought in China’s largest freshwater lake

Extreme droughts are increasing in frequency and severity globally as a result of climate change.Developing understanding of species’responses to drought is crucial for their conservation,especially in regions experi-encing increased aridity.Although numerous studies have investigated birds’responses to drought,the emphasis has primarily been on landbirds.Drought can significantly alter the wetland environments that waterbirds inhabit,but the response of waterbirds to drought remains understudied.In this study,we surveyed the distri-bution and behavior of Oriental Storks(Ciconia boyciana)in Poyang Lake,which is the largest freshwater lake in China.Results indicate that drought-induced catchment areas at the lowest water level limited the total popu-lation size of Oriental Storks in the sub-lakes.Sub-lakes with large catchment areas at the lowest water level demonstrated a capacity to support a larger population of wintering Oriental Storks.Over time,Oriental Storks exhibited a gradual concentration in Changhu Lake,characterized by larger catchments,after resource depletion in sub-lakes with smaller catchments.Additionally,the duration of Oriental Storks’vigilance and moving be-haviors decreased significantly compared with that observed before the drought.After the drought,Oriental Storks increased their foraging efforts,as evidenced by increased presence in deeper water and reaching their heads and necks into deeper water to forage,higher search rates,but lower foraging rates.In accordance with area-restricted search theory,reductions in habitat quality resulting from drought,including extensive fish die-offs,forced Oriental Storks to increase their foraging efforts.Sustaining a specific water area in sub-lakes during droughts can preserve resource availability,which is crucial for the conservation of Oriental Storks.Imple-menting measures such as water level control and micro-modification of lake bottoms in sub-lakes might mitigate the impact of drought on the piscivorous Oriental Storks.

Female zebra finches are more vulnerable to social isolation stress than males:Involvement of the nonapeptide system

In group-living animals,chronic juvenile social isolation stress(SIS)can profoundly affect behavior and neuroendocrine regulation.However,its impact on social behavior in avian species,particularly regarding sexspecific neural circuit differences,remains underexplored.This study focused on zebra finches,a species known for its social clustering and cognitive abilities,to elucidate these influences.Results indicated that SIS significantly increased plasma corticosterone levels in females but not in males,suggesting a heightened stress response and susceptibility in females.Additionally,SIS disrupted sociality and flocking behavior in both sexes,with more severe impairments in social recognition observed in females.Mesotocin(MT)levels in the lateral septum of both sexes and in the ventromedial hypothalamus of females were found to mediate the SIS effect,while vasotocin(VT)levels within the social behavior network remained unchanged.Pharmacological interventions confirmed the critical role of MT in reversing SIS-induced impairments in sociality,flocking behavior,and social recognition,particularly in females.These findings highlight unique nucleus-and sex-dependent variations in MT and VT regulation,providing novel insights into the mechanisms governing avian social behavior.This study advances our understanding of the independent evolutionary pathways of neural circuits and neuroendocrine systems that modulate social behaviors across different taxonomic groups.

Mindfulness and mindful parenting:Strategies for preschoolers with behavioral issues

The behavior issues of preschoolers are closely related to their parents'parenting styles.This editorial discusses the value and strategies for solving behavior issues in preschoolers from the perspectives of mindfulness and mindful parenting.We expect that upcoming studies will place greater emphasis on the behavioral concerns of preschoolers and the parenting practices that shape them,particularly focusing on proactive interventions for preschoolers'behavioral issues.

Identification of optimal composition with superior electrochemical properties along the zero Mn^(3+)line in Na_(0.75)(Mn-Al-Ni)O_(2)pseudo ternary system

Biphasic layered oxide cathodes,known for their superior electrochemical performance,are prime candidates for commercializing in Na-ion batteries.Herein,we unveil a series of P3/P2 monophasic and biphasic Al-substituted Na_(3/4)Mn_(5-x/8)Al_(2x/8)Ni_(3-x/8)O_(2)layered oxide cathodes that lie along the‘zero Mn^(3+)line’in the Na_(3/4)(Mn-Al-Ni)O_(2)pseudo-ternary system.The structural analysis showed a larger Na^(+)conduction bottleneck area in both P3 and P2 structures with a higher Al3+content,which enhanced their rate performance.In each composition,the P3/P2 biphasic compound with nearly equal fractions of P3 and P2 phases outperformed their monophasic counterparts in almost all electrochemical performance parameters.Operando synchrotron XRD measurements obtained for the monophasic P3 and biphasic P2/P3 samples revealed the absence of the O3 phase during cycling.The high structure stability and faster Na^(+)transport kinetics in the biphasic samples underpins the enhancement of electrochemical properties in the Al-substituted P3/P2 cathodes.These results highlight fixed oxidation state lines as a novel tool to identify and design layered oxide cathodes for Na-ion batteries in pseudo-ternary diagrams involving Jahn-Teller active cations.

Information-motivation-behavioral guided nursing for stroke patients with pulmonary dysfunction:A randomized controlled trial

BACKGROUND Patients with stroke frequently experience pulmonary dysfunction.AIM To explore the effects of information-motivation-behavioral(IMB)skills modelbased nursing care on pulmonary function,blood gas indices,complication rates,and quality of life(QoL)in stroke patients with pulmonary dysfunction.METHODS We conducted a controlled study involving 120 stroke patients with pulmonary dysfunction.The control group received routine care,whereas the intervention group received IMB-model-based nursing care.Various parameters including pulmonary function,blood gas indices,complication rates,and QoL were assessed before and after the intervention.RESULTS Baseline data of the control and intervention groups were comparable.Post-intervention,the IMB model-based care group showed significant improvements in pulmonary function indicators,forced expiratory volume in 1 sec,forced vital capacity,and peak expiratory flow compared with the control group.Blood gas indices,such as arterial oxygen pressure and arterial oxygen saturation,increased significantly,and arterial carbon dioxide partial.pressure decreased significantly in the IMB model-based care group compared with the control group.The intervention group also had a lower complication rate(6.67%vs 23.33%)and higher QoL scores across all domains than the control group.CONCLUSION IMB model-based nursing care significantly enhanced pulmonary function,improved blood gas indices,reduced complication rates,and improved the QoL of stroke patients with pulmonary dysfunction.Further research is needed to validate these results and to assess the long-term efficacy and broader applicability of the model.

Protecting Protectors:Smartphone-Based Cognitive Behavioral Therapy for Mental Health in the Chinese Police

Background:The mental health challenges faced by police officers due to high-stress work environments necessitate effective interventions.Cognitive-behavioral therapy(CBT)has shown promise in addressing mental health issues,and this study aims to evaluate the efficacy of smartphone-based cognitive-behavioral therapy(SCBT)in improving mental health outcomes among police officers.This intervention could provide a reference for enhancing mental health literacy and resilience in this population.Methods:A randomized controlled trial(RCT)design was employed,involving 291 police officers who were randomly assigned to either the SCBT intervention group(n=145)or the control group(n=146).Participants completed pre-and post-intervention assessments using the Symptom Checklist-90(SCL-90),which measures multiple psychological symptoms including somatization,obsessive-compulsiveness,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoid ideation,and psychoticism.Statistical analyses were conducted to examine group differences in symptom severity and effect sizes.Results:Post-intervention results indicated significant reductions in somatization,obsessivecompulsiveness,interpersonal sensitivity,depression,anxiety,hostility,phobic anxiety,paranoid ideation,and psychoticism,with large effect sizes observed in the intervention group.Notably,the intervention group showed significantly greater improvements compared to the control group,particularly in overall psychological distress as measured by the total SCL-90 score.However,significant reductions in interpersonal sensitivity and paranoid ideation were also observed in the control group,suggesting external factors may have influenced these dimensions.Conclusion:SCBT demonstrated efficacy in reducing psychological distress among police officers,offering a flexible and accessible mental health intervention.However,challenges such as high dropout rates and the complex,dynamic nature of mental health warrant further investigation.Future studies should explore targeted interventions for specific behavioral issues and consider SCBT as a supplementary tool alongside traditional psychotherapy.

Exploration of Child-friendly Urban Park Design Strategies Based on Child Behavioral Psychology

By studying the behavioral psychology and needs of children,this paper analyzes the essence of child-friendly parks from the perspective of children,and discusses the design principles and key points of child-friendly parks,so as to provide a practical basis for the construction of child-friendly cities.