The progressive degeneration of nigral dopaminergic（DA）neurons and the biochemical reduction of striatal dopamine levels are associated with major clinical symptoms,including tremor at rest,rigidity of the limbs,slo...The progressive degeneration of nigral dopaminergic（DA）neurons and the biochemical reduction of striatal dopamine levels are associated with major clinical symptoms,including tremor at rest,rigidity of the limbs,slowness and paucity of voluntary movement（bradykinesia）.展开更多
基金supported by grants from the Korea Healthcare Technology R&D Project, Ministry of Health & Welfare (HI15C1928)the National Research Foundation of Korea (NRF-2017R1A2B4002675)
文摘The progressive degeneration of nigral dopaminergic（DA）neurons and the biochemical reduction of striatal dopamine levels are associated with major clinical symptoms,including tremor at rest,rigidity of the limbs,slowness and paucity of voluntary movement（bradykinesia）.
