Clinical Study on Kangquan Recipe (康泉方) for Benign Prostatic Hyperplasia Patients:A Randomized Controlled Trial

Objective：To observe the effectiveness and safety of Kangquan Recipe（康泉方,KQR） for benign prostatic hyperplasia（BPH） patients.Methods：One hundred and six BPH patients were randomly assigned to the treatment group（53 cases） and the control group（53 cases） according to a random number table.The treatment group was given KQR orally;the control group was given cemilton orally.After 24-week treatment,the clinical effect and safety were evaluated using the International Prostatic Symptom Score（l-PSS）,quality of life（QOL）,maximum flow rate（Qmax）,average flow rate（Qave）,residual urine volume（RUV）,total prostatic volume（TPV）,etc.Results：After treatment,the score of l-PSS was decreased from 16.9 ±5.6 to 12.5 ±4.6in the treatment group,significantly lower compared with the control group;the levels of Qmax and Qave were from 10.9 ±3.5 to 15.6 ±4.5 and 5.4 ±2.1 to 7.3 ±2.5（mL/s） in the treatment group,significantly higher compared with the control group;the levels of RUV and TPV were from 70.8 ±28.2 to 35.2 ±21.8 and37.2 ± 16.9 to 30.1 ± 10.8（mL） in the treatment group,significantly lower compared with the control group（all P〈0.05）.The incidence rate of adverse reaction was similar between the two groups（P〉0.05）.Conclusion：KQR is effective and safe for the treatment of BPH.

Effect of Kangquan Recipe(康泉方)on BAMBI Expression in Hypothalamic-Pituitary-Prostate in Rats with Benign Prostatic Hyperplasia

Objective:To investigate the effect of Kangquan Recipe(康泉方,KQR)on bone morphogenetic protein and activin membrane-bound inhibitor(BAMBI)expression and its mechanism in rats with benign prostatic hyperplasia(BPH).Methods:Forty-eight male Sprague-Dawley rats were divided into 6 groups using a random number table,with 8 in each group:the normal group(normal saline 10 m L/kg),the model group(normal saline 10 m L/kg),the finasteride group(0.5 mg/kg),the low-dose KQR group(3.5 g/kg),the middle-dose KQR group(7 g/kg),and the high-dose KQR group(14 g/kg).The 40 rats were subcutaneously injected with testosterone propionate after castration for 30 days to establish the BPH rat model except for those in the normal group.At the same time,the corresponding drugs were administered by gavage for 30 consecutive days.The effects of different doses of KQR on the protate wet weight,prostate volume and prostate index(PI)were observed.The changes in histopathology were monitored with hematoxylin-eosin staining.BAMBI protein and m RNA expression contents were determined by Western blot and quantitative real-time polymerase chain reaction,respectively.Results:All doses of KQR could decrease prostatic epithelial tissue proliferation.Compared to the model group,the high and middle-dose KQR significantly reduced prostate wet weight,prostate volume and PI;increased BAMBI protein expression in the hypothalamus,pituitary and prostate tissue;all doses of KQR up-regulated BAMBI m RNA expression in serum,prostatic fluid and prostate tissue(P<0.05 or P<0.01).Conclusions:KQR could inhibit the proliferation of rat prostatic tissue,promote BAMBI protein expression in the hypothalamic-pituitary-prostate of rats with BPH;and increase BAMBI m RNA expression in the blood,prostatic fluid and prostate tissue of rats with BPH,showing a dose-effect relationship.KQR can be used as a potential drug for the treatment of BPH.

良性前列腺增生中医证型与尿动力学参数相关性研究

目的:探讨良性前列腺增生(BPH)中医证型与尿动力学参数的相关性。方法:152例BPH患者,中医辨证分为肾阴不足、肾阳虚弱、瘀阻水道、脾气虚弱、肺热气郁、湿热下注、痰浊郁结七型,均进行尿动力学检查。结果:152例BPH患者中,肾阳虚弱型71例(46.71%),瘀阻水道型40例(26.31%),肾阴不足型14例(9.21%)。膀胱出口梗阻为III～VI度肾阳虚弱型有58例,瘀阻水道型有38例,其中严重梗阻(V～VI)26例。膀胱逼尿肌收缩功能极弱中(n=12),肾阳虚弱型4例,占33.33%(4/12),瘀阻水道型7例,占58.33%(7/12);膀胱逼尿肌收缩功能弱者中(n=48),肾阳虚弱型为27例,占56.25%(27/48),瘀阻水道型17例,占35.42%(17/48)。结论:BPH中医各辨证分型与膀胱出口梗阻和膀胱逼尿肌收缩力有一定的相关性,从而为中医证型的量化和客观化提供相应的证据。

癃闭舒胶囊联合中药穴位贴敷治疗良性前列腺增生症临床研究

目的:观察癃闭舒胶囊联合中药穴位贴敷治疗良性前列腺增生症的临床疗效。方法:选取60例良性前列腺增生症患者作为研究对象,随机分为对照组和观察组各30例。对照组给予坦索罗辛缓释片联合非那雄胺片治疗,观察组在对照组基础上加用癃闭舒胶囊联合中药穴位贴敷治疗,2组疗程均为1月。对比分析2组临床疗效,观察治疗前后患者的前列腺体积(PV)、最大尿流率(Qmax)及残余尿量(PVR)的变化,记录不良反应情况。结果:观察组治疗总有效率93.33%,对照组治疗总有效率70.00%,2组比较,差异有统计学意义(P <0.05)。治疗后,2组PV均较治疗前缩小,Qmax均较治疗前提升,PVR均较治疗前减少,差异均有统计学意义(P <0.05);观察组PV小于对照组,Qmax大于对照组,PVR少于对照组,差异均有统计学意义(P <0.05)。结论:在常规西药治疗基础上加用癃闭舒胶囊联合中药穴位贴敷治疗良性前列腺增生症临床疗效显著,可明显改善患者的症状,无不良反应,值得临床推广应用。