Bennett's linkage is a spatial fourlink linkage,and has an extensive application prospect in the deployable linkages.Its kinematic and dynamic characteristics analysis has a great significance in its synthesis and...Bennett's linkage is a spatial fourlink linkage,and has an extensive application prospect in the deployable linkages.Its kinematic and dynamic characteristics analysis has a great significance in its synthesis and application. According to the geometrical conditions of Bennett 's linkage,the motion equations are established,and the expressions of angular displacement,angular velocity and angular acceleration of the followers and the displacement,velocity and acceleration of mass center of link are shown. Based on Lagrange's equation,the multi-rigid-body dynamic model of Bennett's linkage is established. In order to solve the reaction forces and moments of joint,screw theory and reciprocal screw method are combined to establish the computing method.The number of equations and unknown reaction forces and moments of joint are equal through adding link deformation equations. The influence of the included angle of adjacent axes on Bennett 's linkage 's kinematic characteristics,the dynamic characteristics and the reaction forces and moments of joint are analyzed.Results show that the included angle of adjacent axes has a great effect on velocity,acceleration,the reaction forces and moments of Bennett's linkage. The change of reaction forces and moments of joint are apparent near the singularity configuration.展开更多
Order analysis for multi-Bennett linkages is a difficult topic in kinematics. Traditional methods fail to obtain the order of multi-Bennett linkages due to considering the special geometric distributions among joint a...Order analysis for multi-Bennett linkages is a difficult topic in kinematics. Traditional methods fail to obtain the order of multi-Bennett linkages due to considering the special geometric distributions among joint axes. An order principle for multi-Bennett linkages is presented. For a summated multi-Bennett linkage, three procedures are included in the order principle. Firstly, a homogeneous screw equation is obtained by taking linear superposition operations and then the maximum order is determined according to linear dependency of all screws. Secondly, two theorems are employed to determine the maximum order, where the first is used to judge the linear independency of four-system screws and the second is fit for identifying the linear independency of five-system screws. Lastly, all possible cases in the order range are considered until the valid order is screened out. For a syncopated multi-Bennett linkage, an equivalent summated model is built and then the order analysis is the same as that of summated linkages. In order to verify the effectiveness of the presented order principle, the orders of summated 5R and 6R linkages as well as a syncopated 6R linkage are analyzed. The computed orders of the former two summated linkages are both 4 and the computed order of the last syncopated 6R linkage is 5. The results coincide with the prototype data. The advantage of the proposed principle is that it can get the correct order of a multi-Bennett linkage without solving the geometric conditions of joint axes and has wide application in variety of multi-Bennett linkages.展开更多
AIM:To establish the hospitalized prevalence of severe Crohn's disease(CD) and ulcerative colitis(UC) in Wales from 1999 to 2007;and to investigate long-term mortality after hospitalization and associations with s...AIM:To establish the hospitalized prevalence of severe Crohn's disease(CD) and ulcerative colitis(UC) in Wales from 1999 to 2007;and to investigate long-term mortality after hospitalization and associations with social deprivation and other socio-demographic factors.METHODS:Record linkage of administrative inpatient and mortality data for 1467 and 1482 people hospitalised as emergencies for ≥ 3d for CD and UC,respectively.The main outcome measures were hospitalized prevalence,mortality rates and standardized mortality ratios for up to 5 years follow-up after hospitalization.RESULTS:Hospitalized prevalence was 50.1 per 100 000 population for CD and 50.6 for UC.The hospitalized prevalence of CD was significantly higher(P < 0.05) in females(57.4) than in males(42.2),and was highest in people aged 16-29 years,but the prevalence of UC was similar in males(51.0) and females(50.1),and increased continuously with age.The hospital-ized prevalence of CD was slightly higher in the most deprived areas,but there was no association between social deprivation and hospitalized prevalence of UC.Mortality was 6.8% and 14.6% after 1 and 5 years follow-up for CD,and 9.2% and 20.8% after 1 and 5 years for UC.For both CD and UC,there was little discernible association between mortality and social deprivation,distance from hospital,urban/rural residence and geography.CONCLUSION:CD and UC have distinct demographic profiles.The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency.展开更多
For a spherical four-bar linkage,the maximum number of the spherical RR dyad(R:revolute joint)of five-orientation motion generation can be at most 6.However,complete real solution of this problem has seldom been st...For a spherical four-bar linkage,the maximum number of the spherical RR dyad(R:revolute joint)of five-orientation motion generation can be at most 6.However,complete real solution of this problem has seldom been studied.In order to obtain six real RR dyads,based on Strum's theorem,the relationships between the design parameters are derived from a 6th-degree univariate polynomial equation that is deduced from the constraint equations of the spherical RR dyad by using Dixon resultant method.Moreover,the Grashof condition and the circuit defect condition are taken into account.Given the relationships between the design parameters and the aforementioned two conditions,two objective functions are constructed and optimized by the adaptive genetic algorithm(AGA).Two examples with six real spherical RR dyads are obtained by optimization,and the results verify the feasibility of the proposed method.The paper provides a method to synthesize the complete real solution of the five-orientation motion generation,which is also applicable to the problem that deduces to a univariate polynomial equation and requires the generation of as many as real roots.展开更多
Although great differences exist between the trade systems of different countries,internationaltrade must go on in line with the customary international trade rules.As China’s economy developsand the socialist market...Although great differences exist between the trade systems of different countries,internationaltrade must go on in line with the customary international trade rules.As China’s economy developsand the socialist market economic system emerges,China is basically qualified to link up withcustomary international trade rules.In the Ninth Five-Year Plan period,China’s reform of its foreigntrade system aims at setting up a trade system that conforms with international trade practice.Forthe purpose,the author of this article suggests that a neutral trade policy should be adopted inaccordance with the international practice since it does not hinder exports,nor restrict imports toan excessive degree.展开更多
Association of fracture of trapezium with Bennett'sfracture is very rare and makes reduction and stabilisation more difficult. We are reporting a rare case of Bennett's fracture with fracture of the trapezium ...Association of fracture of trapezium with Bennett'sfracture is very rare and makes reduction and stabilisation more difficult. We are reporting a rare case of Bennett's fracture with fracture of the trapezium and subluxation of the carpo-metacarpal joint(CMC) joint. The patient was a 47-year-old school teacher who fell from his motorbike on his outstretched right dominant hand. Radiographs and computed tomography showed fracture of the trapezium with subluxation of the CMC joint, associated with Bennett's fracture. Open reduction and internal fixation was carried out. Trapezium was reduced first and secured with a 2 mm diameter screw. Bennett's fracture was then reduced and fixed with two per-cutaneously placed Kirchner's wires. CMC was stabilised with percutaneous Kirchner's wires. Latest follow up at 12 mo showed a healed fracture with good reduction of the CMC joint. Clinically patient had no pain and normal extension, abduction and opposition of the thumb. QuickD ASH score was 3.9/100. Thus, fracture of trapezium associated with a Bennett's fracture is a rare injury and if ignored it may lead to poor results. This injury is more challenging to manage than an isolated Bennett's fracture as anatomical reduction of the trapezium with reduction of the first CMC is needed. Fracture of the trapezium should be fixed first as this will provide a stable base for reduction of the Bennett's fracture.展开更多
为了实现对高职毕业生就业数据的信息化管理,为班主任方便、准确、快捷地录入就业数据提供服务,特别是为各职能部门及时、方便地了解学校就业情况,提出构建基于Web的高职毕业生就业数据管理系统。基于三层的B/S体系结构,采用ASP.NET(C#)...为了实现对高职毕业生就业数据的信息化管理,为班主任方便、准确、快捷地录入就业数据提供服务,特别是为各职能部门及时、方便地了解学校就业情况,提出构建基于Web的高职毕业生就业数据管理系统。基于三层的B/S体系结构,采用ASP.NET(C#)+SQL Server 2000等网站开发技术,设计系统总体架构、功能模块和后台数据库,给出安全访问控制、DropDownList无刷新三级联动显示数据、导入导出数据、自动统计就业率等关键问题解决方案,实现集班主任就业数据录入和各类就业率查询统计为一体的网络应用平台。展开更多
目的通过筛查GSTM1基因SNPs位点,研究该基因编码区单核苷酸多态位点T1270533G与鼻咽癌易感性和临床表型的关系。方法用PCR方法对中国人群27个个体DNA标本进行扩增、纯化及测序,从中获得GSTM1编码区、调控区和侧翼区及部分内含子区SNP位...目的通过筛查GSTM1基因SNPs位点,研究该基因编码区单核苷酸多态位点T1270533G与鼻咽癌易感性和临床表型的关系。方法用PCR方法对中国人群27个个体DNA标本进行扩增、纯化及测序,从中获得GSTM1编码区、调控区和侧翼区及部分内含子区SNP位点,所获数据进行LD分析。选择编码区多态性位点T1270533G(该位点在中国人群罕见等位基因频率为22.2%),用tetra-Primer ARMS-PCR结合测序方法对鼻咽癌患者和对照人群进行相关性分析。结果通过测序共获取29个SNPs;其中13个SNPs位点之间均呈高度连锁不平衡;编码区多态性位点T1270533G的变异与鼻咽癌临床表型之间无明显关联(RR=0.170,95%CI=0.95-0.306 for homozygoteTT)。结论编码区多态位点T1270533G虽然发生了碱基顛换,产生了错义突变,导致了氨基酸的改变,但并没有影响其解毒功能。该位点在鼻咽癌患者和对照人群中等位基因型频率差别很小,与中国广东地区鼻咽癌易感性无明显关联。展开更多
基金Sponsored by the National Natural Science Foundation of China(Grant No.51175422)
文摘Bennett's linkage is a spatial fourlink linkage,and has an extensive application prospect in the deployable linkages.Its kinematic and dynamic characteristics analysis has a great significance in its synthesis and application. According to the geometrical conditions of Bennett 's linkage,the motion equations are established,and the expressions of angular displacement,angular velocity and angular acceleration of the followers and the displacement,velocity and acceleration of mass center of link are shown. Based on Lagrange's equation,the multi-rigid-body dynamic model of Bennett's linkage is established. In order to solve the reaction forces and moments of joint,screw theory and reciprocal screw method are combined to establish the computing method.The number of equations and unknown reaction forces and moments of joint are equal through adding link deformation equations. The influence of the included angle of adjacent axes on Bennett 's linkage 's kinematic characteristics,the dynamic characteristics and the reaction forces and moments of joint are analyzed.Results show that the included angle of adjacent axes has a great effect on velocity,acceleration,the reaction forces and moments of Bennett's linkage. The change of reaction forces and moments of joint are apparent near the singularity configuration.
基金supported by National Natural Science Foundation of China(Grant Nos. 51105004, 51175006)Specialized Research Fund for the Doctoral Program of Higher Education of China(Grant No.20111103120001)Beijing Municipal Education Commission Research Project, China(Grant No. KM201310005016)
文摘Order analysis for multi-Bennett linkages is a difficult topic in kinematics. Traditional methods fail to obtain the order of multi-Bennett linkages due to considering the special geometric distributions among joint axes. An order principle for multi-Bennett linkages is presented. For a summated multi-Bennett linkage, three procedures are included in the order principle. Firstly, a homogeneous screw equation is obtained by taking linear superposition operations and then the maximum order is determined according to linear dependency of all screws. Secondly, two theorems are employed to determine the maximum order, where the first is used to judge the linear independency of four-system screws and the second is fit for identifying the linear independency of five-system screws. Lastly, all possible cases in the order range are considered until the valid order is screened out. For a syncopated multi-Bennett linkage, an equivalent summated model is built and then the order analysis is the same as that of summated linkages. In order to verify the effectiveness of the presented order principle, the orders of summated 5R and 6R linkages as well as a syncopated 6R linkage are analyzed. The computed orders of the former two summated linkages are both 4 and the computed order of the last syncopated 6R linkage is 5. The results coincide with the prototype data. The advantage of the proposed principle is that it can get the correct order of a multi-Bennett linkage without solving the geometric conditions of joint axes and has wide application in variety of multi-Bennett linkages.
文摘AIM:To establish the hospitalized prevalence of severe Crohn's disease(CD) and ulcerative colitis(UC) in Wales from 1999 to 2007;and to investigate long-term mortality after hospitalization and associations with social deprivation and other socio-demographic factors.METHODS:Record linkage of administrative inpatient and mortality data for 1467 and 1482 people hospitalised as emergencies for ≥ 3d for CD and UC,respectively.The main outcome measures were hospitalized prevalence,mortality rates and standardized mortality ratios for up to 5 years follow-up after hospitalization.RESULTS:Hospitalized prevalence was 50.1 per 100 000 population for CD and 50.6 for UC.The hospitalized prevalence of CD was significantly higher(P < 0.05) in females(57.4) than in males(42.2),and was highest in people aged 16-29 years,but the prevalence of UC was similar in males(51.0) and females(50.1),and increased continuously with age.The hospital-ized prevalence of CD was slightly higher in the most deprived areas,but there was no association between social deprivation and hospitalized prevalence of UC.Mortality was 6.8% and 14.6% after 1 and 5 years follow-up for CD,and 9.2% and 20.8% after 1 and 5 years for UC.For both CD and UC,there was little discernible association between mortality and social deprivation,distance from hospital,urban/rural residence and geography.CONCLUSION:CD and UC have distinct demographic profiles.The higher prevalence of hospitalized CD in more deprived areas may reflect higher prevalence and higher hospital dependency.
基金Supported by National Natural Science Foundation of China(Grant Nos.51375059,61105103)National Hi-tech Research and Development Program of China(863 Program,Grant No.2011AA040203)Beijing Municipal Natural Science Foundation of China(Grant No.4132032)
文摘For a spherical four-bar linkage,the maximum number of the spherical RR dyad(R:revolute joint)of five-orientation motion generation can be at most 6.However,complete real solution of this problem has seldom been studied.In order to obtain six real RR dyads,based on Strum's theorem,the relationships between the design parameters are derived from a 6th-degree univariate polynomial equation that is deduced from the constraint equations of the spherical RR dyad by using Dixon resultant method.Moreover,the Grashof condition and the circuit defect condition are taken into account.Given the relationships between the design parameters and the aforementioned two conditions,two objective functions are constructed and optimized by the adaptive genetic algorithm(AGA).Two examples with six real spherical RR dyads are obtained by optimization,and the results verify the feasibility of the proposed method.The paper provides a method to synthesize the complete real solution of the five-orientation motion generation,which is also applicable to the problem that deduces to a univariate polynomial equation and requires the generation of as many as real roots.
文摘Although great differences exist between the trade systems of different countries,internationaltrade must go on in line with the customary international trade rules.As China’s economy developsand the socialist market economic system emerges,China is basically qualified to link up withcustomary international trade rules.In the Ninth Five-Year Plan period,China’s reform of its foreigntrade system aims at setting up a trade system that conforms with international trade practice.Forthe purpose,the author of this article suggests that a neutral trade policy should be adopted inaccordance with the international practice since it does not hinder exports,nor restrict imports toan excessive degree.
文摘Association of fracture of trapezium with Bennett'sfracture is very rare and makes reduction and stabilisation more difficult. We are reporting a rare case of Bennett's fracture with fracture of the trapezium and subluxation of the carpo-metacarpal joint(CMC) joint. The patient was a 47-year-old school teacher who fell from his motorbike on his outstretched right dominant hand. Radiographs and computed tomography showed fracture of the trapezium with subluxation of the CMC joint, associated with Bennett's fracture. Open reduction and internal fixation was carried out. Trapezium was reduced first and secured with a 2 mm diameter screw. Bennett's fracture was then reduced and fixed with two per-cutaneously placed Kirchner's wires. CMC was stabilised with percutaneous Kirchner's wires. Latest follow up at 12 mo showed a healed fracture with good reduction of the CMC joint. Clinically patient had no pain and normal extension, abduction and opposition of the thumb. QuickD ASH score was 3.9/100. Thus, fracture of trapezium associated with a Bennett's fracture is a rare injury and if ignored it may lead to poor results. This injury is more challenging to manage than an isolated Bennett's fracture as anatomical reduction of the trapezium with reduction of the first CMC is needed. Fracture of the trapezium should be fixed first as this will provide a stable base for reduction of the Bennett's fracture.
文摘为了实现对高职毕业生就业数据的信息化管理,为班主任方便、准确、快捷地录入就业数据提供服务,特别是为各职能部门及时、方便地了解学校就业情况,提出构建基于Web的高职毕业生就业数据管理系统。基于三层的B/S体系结构,采用ASP.NET(C#)+SQL Server 2000等网站开发技术,设计系统总体架构、功能模块和后台数据库,给出安全访问控制、DropDownList无刷新三级联动显示数据、导入导出数据、自动统计就业率等关键问题解决方案,实现集班主任就业数据录入和各类就业率查询统计为一体的网络应用平台。
文摘目的通过筛查GSTM1基因SNPs位点,研究该基因编码区单核苷酸多态位点T1270533G与鼻咽癌易感性和临床表型的关系。方法用PCR方法对中国人群27个个体DNA标本进行扩增、纯化及测序,从中获得GSTM1编码区、调控区和侧翼区及部分内含子区SNP位点,所获数据进行LD分析。选择编码区多态性位点T1270533G(该位点在中国人群罕见等位基因频率为22.2%),用tetra-Primer ARMS-PCR结合测序方法对鼻咽癌患者和对照人群进行相关性分析。结果通过测序共获取29个SNPs;其中13个SNPs位点之间均呈高度连锁不平衡;编码区多态性位点T1270533G的变异与鼻咽癌临床表型之间无明显关联(RR=0.170,95%CI=0.95-0.306 for homozygoteTT)。结论编码区多态位点T1270533G虽然发生了碱基顛换,产生了错义突变,导致了氨基酸的改变,但并没有影响其解毒功能。该位点在鼻咽癌患者和对照人群中等位基因型频率差别很小,与中国广东地区鼻咽癌易感性无明显关联。