An intermolecular two C-C bond formation procedure for the synthesis of carbocycles mediated by hyperva-lent iodine(III)reagents was developed.This metal free protocol provided a new approach for the synthesis of use-...An intermolecular two C-C bond formation procedure for the synthesis of carbocycles mediated by hyperva-lent iodine(III)reagents was developed.This metal free protocol provided a new approach for the synthesis of use-ful substituted 1-amino-2-naphthoic acid derivatives via benzannulation reactions.Various N-unsubstituted and N-alkyl substituted aromatic enamines with terminal alkynes and non-terminal alkynes can be converted into corre-sponding 1-amino-2-naphthoic acid derivatives under mild reaction conditions.When meta-substituted phenyl enamines were employed in the reaction,two cyclization paths were detected in the reaction and ortho-cyclization products were the only or major products.Good functional group tolerance,readily available material and high atom utilization efficiency make this method a potential procedure which may find broad application in organic synthesis.展开更多
A new dual plldium/scandium catalysis starting fromβ-alkynyl ketones and o alkynyl anilines is reported for the first time,leading to the atom-economic synthesis of rotationally hindered C3-naphthylated indoles in mo...A new dual plldium/scandium catalysis starting fromβ-alkynyl ketones and o alkynyl anilines is reported for the first time,leading to the atom-economic synthesis of rotationally hindered C3-naphthylated indoles in moderate to good yields and high regioselectivi-ty.This method can tolerate normal air conditions,and features the use of palladium/scandium cooperative catalysts without any ligand,facile double annulation involving various internal alkynes,and good functional group tolerance.展开更多
基金support of this work by Baoji University of Arts and Sciences(No.ZK15046).
文摘An intermolecular two C-C bond formation procedure for the synthesis of carbocycles mediated by hyperva-lent iodine(III)reagents was developed.This metal free protocol provided a new approach for the synthesis of use-ful substituted 1-amino-2-naphthoic acid derivatives via benzannulation reactions.Various N-unsubstituted and N-alkyl substituted aromatic enamines with terminal alkynes and non-terminal alkynes can be converted into corre-sponding 1-amino-2-naphthoic acid derivatives under mild reaction conditions.When meta-substituted phenyl enamines were employed in the reaction,two cyclization paths were detected in the reaction and ortho-cyclization products were the only or major products.Good functional group tolerance,readily available material and high atom utilization efficiency make this method a potential procedure which may find broad application in organic synthesis.
基金We are grateful for financial support from the National Natural Science Foundation of China(Nos.21871112 and 21971090).
文摘A new dual plldium/scandium catalysis starting fromβ-alkynyl ketones and o alkynyl anilines is reported for the first time,leading to the atom-economic synthesis of rotationally hindered C3-naphthylated indoles in moderate to good yields and high regioselectivi-ty.This method can tolerate normal air conditions,and features the use of palladium/scandium cooperative catalysts without any ligand,facile double annulation involving various internal alkynes,and good functional group tolerance.
